MAP2 - SULSO - GREMLIN Contacts

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MAP2 - Methionine aminopeptidase

UniProt:	P95963	Sequences: MTEDELNKLLLAGKIAAKARDEVSLDVKASAKVLDICEEVESIIIENKAFPSFPCNISINSEAAHYSPTINDEKRIPEGAVVKLDLGAHIDGFISDTAITISLDSRYQRLLDASKTALEAAITNFKAGLSIGEIGRVIEKVIRAQGYKPIRNLGGHLIRRYELHAGVFIPNVYERGLGVIQSDSVYAIEPFATDGGGEVVEGKSITIYSLKNPNIKGLSSRENELIDFIYTRFNYLPFSERWLKEFSTNVDELRNNIKNLVKKGALRGYPILIEIKKGVVSQFEHTVIVKGDSIIVSTKSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (289)
Sequences:	1156 (740)
Seq/√Len:	43.5

HALSA - Q9HP03
SULSO - MAP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_K	35_D	6.196	1.00
8_K	91_D	4.399	1.00
60_N	80_A	4.185	1.00
139_E	143_R	3.781	1.00
114_S	281_S	3.725	1.00
79_G	104_D	3.628	1.00
142_I	192_A	3.513	1.00
37_C	68_P	3.250	1.00
26_D	39_E	3.182	1.00
19_A	43_I	2.995	1.00
9_L	185_V	2.981	1.00
57_I	82_V	2.897	1.00
32_K	75_R	2.795	1.00
18_K	47_N	2.745	1.00
290_K	293_S	2.626	1.00
42_S	46_E	2.557	1.00
16_A	88_A	2.497	1.00
62_E	273_I	2.481	1.00
258_K	262_K	2.426	1.00
20_R	97_T	2.407	1.00
37_C	57_I	2.385	1.00
22_E	43_I	2.281	1.00
43_I	46_E	2.216	1.00
10_L	295_I	2.173	1.00
85_D	156_H	2.167	1.00
31_A	35_D	2.097	0.99
36_I	76_I	2.029	0.99
65_H	156_H	2.011	0.99
65_H	85_D	2.008	0.99
114_S	192_A	2.002	0.99
16_A	97_T	1.951	0.99
133_E	137_V	1.944	0.99
137_V	141_V	1.771	0.98
289_V	294_I	1.770	0.98
112_D	115_K	1.725	0.98
56_N	207_I	1.695	0.97
36_I	84_L	1.681	0.97
65_H	164_H	1.678	0.97
134_I	180_I	1.673	0.97
15_I	92_G	1.661	0.97
39_E	42_S	1.652	0.97
182_S	291_G	1.646	0.97
192_A	281_S	1.642	0.97
120_A	141_V	1.632	0.97
78_E	104_D	1.608	0.97
274_E	278_G	1.599	0.96
85_D	164_H	1.588	0.96
59_I	82_V	1.585	0.96
180_I	186_Y	1.582	0.96
157_L	167_V	1.573	0.96
107_Y	279_V	1.565	0.96
221_R	228_F	1.562	0.96
285_H	296_V	1.549	0.96
77_P	80_A	1.538	0.96
116_T	120_A	1.535	0.95
23_V	40_V	1.520	0.95
113_A	145_Q	1.512	0.95
24_S	101_I	1.483	0.95
31_A	36_I	1.477	0.94
52_S	237_P	1.453	0.94
27_V	36_I	1.449	0.94
163_L	166_G	1.449	0.94
229_I	243_L	1.406	0.93
109_R	112_D	1.390	0.92
43_I	47_N	1.387	0.92
239_S	242_W	1.377	0.92
209_S	237_P	1.372	0.92
124_N	134_I	1.361	0.92
228_F	232_R	1.355	0.91
38_E	42_S	1.353	0.91
85_D	96_D	1.347	0.91
117_A	141_V	1.337	0.91
142_I	149_P	1.313	0.90
96_D	164_H	1.306	0.90
93_F	160_R	1.290	0.89
53_F	65_H	1.288	0.89
217_G	223_N	1.286	0.89
115_K	283_F	1.272	0.88
53_F	60_N	1.271	0.88
42_S	45_I	1.266	0.88
167_V	184_S	1.264	0.88
21_D	25_L	1.261	0.88
163_L	167_V	1.255	0.88
40_V	55_C	1.250	0.88
110_L	197_G	1.242	0.87
240_E	254_R	1.238	0.87
125_F	180_I	1.231	0.87
285_H	294_I	1.224	0.86
14_K	18_K	1.222	0.86
105_S	109_R	1.220	0.86
233_F	243_L	1.216	0.86
162_E	165_A	1.187	0.85
259_N	263_K	1.181	0.84
228_F	246_F	1.175	0.84
153_L	191_F	1.170	0.84
159_R	165_A	1.165	0.84
218_L	222_E	1.154	0.83
52_S	297_S	1.152	0.83
23_V	36_I	1.147	0.83
29_A	78_E	1.146	0.83
39_E	43_I	1.141	0.82
94_I	236_L	1.139	0.82
227_D	231_T	1.138	0.82
36_I	57_I	1.138	0.82
79_G	103_L	1.136	0.82
85_D	272_L	1.134	0.82
33_V	59_I	1.127	0.82
102_S	111_L	1.126	0.81
44_I	51_P	1.125	0.81
54_P	67_S	1.124	0.81
255_N	258_K	1.114	0.81
242_W	246_F	1.111	0.81
38_E	70_I	1.110	0.81
134_I	137_V	1.109	0.80
133_E	138_I	1.103	0.80
157_L	165_A	1.098	0.80
57_I	84_L	1.097	0.80
95_S	297_S	1.096	0.80
37_C	41_E	1.085	0.79
85_D	284_E	1.084	0.79
150_I	280_V	1.082	0.79
156_H	164_H	1.074	0.78
57_I	68_P	1.072	0.78
232_R	246_F	1.070	0.78
22_E	39_E	1.067	0.78
155_G	164_H	1.058	0.77
287_V	297_S	1.054	0.77
41_E	45_I	1.047	0.76
119_E	296_V	1.044	0.76
265_A	275_I	1.043	0.76
16_A	44_I	1.037	0.76
33_V	37_C	1.028	0.75
210_L	230_Y	1.024	0.75
138_I	149_P	1.019	0.74
111_L	283_F	1.012	0.74
164_H	189_E	1.006	0.74
135_G	155_G	1.001	0.73
126_K	289_V	0.993	0.73
225_L	229_I	0.989	0.72
162_E	166_G	0.984	0.72
34_L	73_E	0.982	0.72
27_V	39_E	0.982	0.72
118_L	285_H	0.979	0.71
59_I	74_K	0.978	0.71
226_I	230_Y	0.975	0.71
112_D	116_T	0.972	0.71
96_D	189_E	0.972	0.71
227_D	230_Y	0.967	0.71
22_E	26_D	0.965	0.70
11_L	14_K	0.964	0.70
226_I	229_I	0.963	0.70
173_Y	176_G	0.962	0.70
221_R	224_E	0.960	0.70
14_K	47_N	0.954	0.69
7_N	11_L	0.954	0.69
122_I	287_V	0.950	0.69
10_L	14_K	0.946	0.69
62_E	202_G	0.945	0.69
257_I	266_L	0.944	0.69
288_I	297_S	0.943	0.69
185_V	288_I	0.941	0.68
252_E	255_N	0.941	0.68
23_V	86_L	0.941	0.68
106_R	147_Y	0.934	0.68
246_F	254_R	0.934	0.68
223_N	227_D	0.933	0.68
36_I	82_V	0.931	0.68
285_H	289_V	0.925	0.67
65_H	98_A	0.923	0.67
6_L	288_I	0.923	0.67
289_V	292_D	0.922	0.67
94_I	139_E	0.920	0.67
49_A	88_A	0.916	0.66
237_P	241_R	0.911	0.66
86_L	95_S	0.911	0.66
218_L	226_I	0.910	0.66
290_K	294_I	0.907	0.66
45_I	50_F	0.904	0.65
247_S	253_L	0.902	0.65
219_S	222_E	0.893	0.64
233_F	242_W	0.893	0.64
13_G	17_A	0.890	0.64
105_S	108_Q	0.890	0.64
287_V	290_K	0.884	0.64
48_K	212_N	0.882	0.63
259_N	262_K	0.871	0.62
32_K	73_E	0.869	0.62
23_V	84_L	0.862	0.62
172_V	175_R	0.862	0.62
65_H	96_D	0.862	0.62
11_L	15_I	0.860	0.61
85_D	94_I	0.859	0.61
130_S	133_E	0.849	0.60
16_A	86_L	0.847	0.60
147_Y	192_A	0.843	0.60
188_I	287_V	0.841	0.60
136_R	173_Y	0.839	0.59
211_K	267_R	0.839	0.59
161_Y	196_G	0.836	0.59
258_K	293_S	0.834	0.59
26_D	36_I	0.826	0.58
58_S	72_D	0.825	0.58
221_R	227_D	0.824	0.58
222_E	225_L	0.822	0.58
81_V	100_T	0.818	0.57
85_D	187_A	0.817	0.57
154_G	168_F	0.817	0.57
89_H	230_Y	0.816	0.57
5_E	9_L	0.816	0.57
124_N	137_V	0.813	0.57
18_K	22_E	0.811	0.57
53_F	85_D	0.807	0.56
27_V	101_I	0.807	0.56
24_S	84_L	0.803	0.56
287_V	294_I	0.800	0.56
61_S	202_G	0.799	0.56
25_L	39_E	0.798	0.56
85_D	282_Q	0.798	0.56
33_V	76_I	0.796	0.55
224_E	228_F	0.783	0.54
11_L	90_I	0.781	0.54
81_V	279_V	0.780	0.54
226_I	265_A	0.780	0.54
26_D	31_A	0.779	0.54
46_E	231_T	0.778	0.54
65_H	272_L	0.776	0.54
217_G	226_I	0.774	0.53
43_I	158_I	0.772	0.53
114_S	283_F	0.771	0.53
129_L	134_I	0.770	0.53
9_L	160_R	0.768	0.53
9_L	93_F	0.768	0.53
142_I	281_S	0.768	0.53
245_E	253_L	0.767	0.53
281_S	289_V	0.763	0.52
174_E	177_L	0.757	0.52
6_L	183_D	0.757	0.52
154_G	189_E	0.748	0.51
54_P	92_G	0.747	0.51
109_R	145_Q	0.745	0.51
76_I	80_A	0.739	0.50
166_G	169_I	0.735	0.50
75_R	78_E	0.735	0.50
40_V	43_I	0.732	0.49
62_E	271_I	0.726	0.49
294_I	297_S	0.725	0.49
122_I	285_H	0.722	0.48
98_A	191_F	0.720	0.48
54_P	68_P	0.720	0.48
210_L	234_N	0.720	0.48
132_G	136_R	0.717	0.48
229_I	266_L	0.713	0.48
103_L	108_Q	0.712	0.47
265_A	268_G	0.709	0.47
260_L	272_L	0.708	0.47
218_L	223_N	0.706	0.47
236_L	239_S	0.706	0.47
222_E	259_N	0.704	0.47
62_E	66_Y	0.704	0.47
220_S	224_E	0.703	0.47
220_S	223_N	0.703	0.47
200_V	203_K	0.700	0.46
92_G	113_A	0.698	0.46
244_K	253_L	0.694	0.46
34_L	38_E	0.691	0.45
54_P	80_A	0.691	0.45
107_Y	158_I	0.688	0.45
124_N	133_E	0.687	0.45
215_I	218_L	0.686	0.45
101_I	132_G	0.686	0.45
214_N	217_G	0.684	0.45
9_L	288_I	0.684	0.45
254_R	257_I	0.683	0.45
187_A	284_E	0.682	0.45
164_H	167_V	0.682	0.45
53_F	156_H	0.682	0.45
152_N	164_H	0.680	0.44
6_L	9_L	0.680	0.44
85_D	98_A	0.678	0.44
187_A	204_S	0.675	0.44
94_I	284_E	0.672	0.44
155_G	284_E	0.671	0.44
132_G	177_L	0.669	0.43
153_L	189_E	0.669	0.43
131_I	135_G	0.669	0.43
153_L	164_H	0.669	0.43
180_I	184_S	0.666	0.43
127_A	290_K	0.665	0.43
23_V	101_I	0.665	0.43
20_R	194_D	0.664	0.43
58_S	83_K	0.661	0.43
65_H	190_P	0.658	0.42
171_N	175_R	0.657	0.42
179_V	208_Y	0.657	0.42
236_L	243_L	0.656	0.42
193_T	200_V	0.655	0.42
188_I	291_G	0.654	0.42
256_N	259_N	0.653	0.42
96_D	284_E	0.651	0.42
230_Y	234_N	0.650	0.42
156_H	272_L	0.647	0.41
81_V	107_Y	0.647	0.41
205_I	208_Y	0.645	0.41
164_H	284_E	0.645	0.41
202_G	297_S	0.645	0.41
56_N	98_A	0.645	0.41
66_Y	203_K	0.642	0.41
48_K	190_P	0.640	0.41
85_D	153_L	0.639	0.41
22_E	25_L	0.639	0.41
121_A	127_A	0.638	0.40
85_D	189_E	0.636	0.40
60_N	65_H	0.635	0.40
34_L	267_R	0.635	0.40
87_G	96_D	0.633	0.40
14_K	17_A	0.632	0.40
65_H	282_Q	0.629	0.40
202_G	268_G	0.629	0.40
20_R	127_A	0.628	0.40
63_A	150_I	0.628	0.40
85_D	236_L	0.628	0.40
31_A	39_E	0.624	0.39
94_I	282_Q	0.624	0.39
153_L	156_H	0.623	0.39
49_A	92_G	0.622	0.39
140_K	145_Q	0.621	0.39
280_V	292_D	0.618	0.39
30_S	54_P	0.618	0.39
180_I	289_V	0.616	0.38
110_L	281_S	0.614	0.38
111_L	115_K	0.613	0.38
80_A	103_L	0.612	0.38
129_L	133_E	0.612	0.38
267_R	270_P	0.608	0.38
225_L	243_L	0.607	0.38
170_P	175_R	0.606	0.38
238_F	241_R	0.605	0.37
64_A	152_N	0.605	0.37
164_H	190_P	0.605	0.37
166_G	171_N	0.601	0.37
142_I	147_Y	0.598	0.37
117_A	138_I	0.597	0.37
135_G	154_G	0.597	0.37
9_L	297_S	0.597	0.37
56_N	190_P	0.596	0.37
193_T	291_G	0.596	0.37
48_K	91_D	0.594	0.36
152_N	191_F	0.593	0.36
128_G	179_V	0.592	0.36
156_H	187_A	0.591	0.36
109_R	124_N	0.591	0.36
153_L	199_V	0.591	0.36
259_N	275_I	0.587	0.36
81_V	206_T	0.586	0.36
233_F	246_F	0.584	0.36
12_A	204_S	0.583	0.35
6_L	100_T	0.581	0.35
102_S	105_S	0.580	0.35
110_L	113_A	0.580	0.35
40_V	44_I	0.578	0.35
221_R	255_N	0.577	0.35
151_R	172_V	0.577	0.35
203_K	207_I	0.577	0.35
234_N	243_L	0.576	0.35
13_G	121_A	0.576	0.35
94_I	187_A	0.574	0.35
37_C	186_Y	0.574	0.35
273_I	281_S	0.572	0.35
228_F	233_F	0.571	0.34
96_D	191_F	0.571	0.34
223_N	226_I	0.568	0.34
217_G	234_N	0.564	0.34
222_E	263_K	0.564	0.34
118_L	122_I	0.564	0.34
247_S	295_I	0.562	0.34
244_K	247_S	0.561	0.34
120_A	137_V	0.561	0.34
224_E	229_I	0.560	0.34
44_I	52_S	0.560	0.34
236_L	242_W	0.559	0.33
98_A	272_L	0.558	0.33
138_I	153_L	0.553	0.33
33_V	36_I	0.553	0.33
51_P	242_W	0.552	0.33
64_A	284_E	0.552	0.33
35_D	214_N	0.551	0.33
99_I	146_G	0.551	0.33
261_V	268_G	0.551	0.33
168_F	171_N	0.550	0.33
51_P	160_R	0.549	0.33
293_S	296_V	0.549	0.33
91_D	160_R	0.548	0.32
73_E	257_I	0.547	0.32
191_F	282_Q	0.542	0.32
157_L	186_Y	0.541	0.32
155_G	189_E	0.539	0.32
54_P	60_N	0.539	0.32
54_P	113_A	0.539	0.32
165_A	169_I	0.538	0.32
164_H	191_F	0.538	0.32
61_S	277_K	0.538	0.32
290_K	295_I	0.534	0.31
55_C	89_H	0.534	0.31
34_L	287_V	0.533	0.31
233_F	236_L	0.532	0.31
23_V	82_V	0.532	0.31
84_L	103_L	0.528	0.31
9_L	158_I	0.528	0.31
183_D	290_K	0.526	0.31
61_S	261_V	0.525	0.31
182_S	243_L	0.524	0.31
86_L	89_H	0.522	0.30
96_D	156_H	0.521	0.30
76_I	107_Y	0.520	0.30
107_Y	147_Y	0.519	0.30
83_K	94_I	0.518	0.30
119_E	123_T	0.517	0.30
179_V	182_S	0.517	0.30
152_N	189_E	0.517	0.30
191_F	284_E	0.516	0.30
240_E	257_I	0.515	0.30
76_I	102_S	0.515	0.30
263_K	268_G	0.513	0.30
89_H	94_I	0.513	0.30
109_R	113_A	0.509	0.29
136_R	177_L	0.508	0.29
224_E	246_F	0.508	0.29
293_S	297_S	0.508	0.29
28_K	275_I	0.506	0.29
217_G	222_E	0.504	0.29
259_N	265_A	0.504	0.29
8_K	92_G	0.504	0.29
70_I	73_E	0.503	0.29
96_D	155_G	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1xgsA	2	0.9767	100	0.211	Contact Map
1b6aA	1	0.9934	100	0.211	Contact Map
4ipaA	1	0.9867	100	0.218	Contact Map
3fm3A	1	1	100	0.226	Contact Map
2q8kA	1	0.9734	100	0.295	Contact Map
4b6at	1	0.8837	100	0.314	Contact Map
3ctzA	2	0.9037	100	0.473	Contact Map
4s2rP	2	0.8904	100	0.477	Contact Map
3mx6A	1	0.7774	100	0.486	Contact Map
3s6bA	1	0.7741	100	0.487	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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