GREMLIN Database
MAP2 - Methionine aminopeptidase
UniProt: P95963 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (289)
Sequences: 1156 (740)
Seq/√Len: 43.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_K35_D6.1961.00
8_K91_D4.3991.00
60_N80_A4.1851.00
139_E143_R3.7811.00
114_S281_S3.7251.00
79_G104_D3.6281.00
142_I192_A3.5131.00
37_C68_P3.2501.00
26_D39_E3.1821.00
19_A43_I2.9951.00
9_L185_V2.9811.00
57_I82_V2.8971.00
32_K75_R2.7951.00
18_K47_N2.7451.00
290_K293_S2.6261.00
42_S46_E2.5571.00
16_A88_A2.4971.00
62_E273_I2.4811.00
258_K262_K2.4261.00
20_R97_T2.4071.00
37_C57_I2.3851.00
22_E43_I2.2811.00
43_I46_E2.2161.00
10_L295_I2.1731.00
85_D156_H2.1671.00
31_A35_D2.0970.99
36_I76_I2.0290.99
65_H156_H2.0110.99
65_H85_D2.0080.99
114_S192_A2.0020.99
16_A97_T1.9510.99
133_E137_V1.9440.99
137_V141_V1.7710.98
289_V294_I1.7700.98
112_D115_K1.7250.98
56_N207_I1.6950.97
36_I84_L1.6810.97
65_H164_H1.6780.97
134_I180_I1.6730.97
15_I92_G1.6610.97
39_E42_S1.6520.97
182_S291_G1.6460.97
192_A281_S1.6420.97
120_A141_V1.6320.97
78_E104_D1.6080.97
274_E278_G1.5990.96
85_D164_H1.5880.96
59_I82_V1.5850.96
180_I186_Y1.5820.96
157_L167_V1.5730.96
107_Y279_V1.5650.96
221_R228_F1.5620.96
285_H296_V1.5490.96
77_P80_A1.5380.96
116_T120_A1.5350.95
23_V40_V1.5200.95
113_A145_Q1.5120.95
24_S101_I1.4830.95
31_A36_I1.4770.94
52_S237_P1.4530.94
27_V36_I1.4490.94
163_L166_G1.4490.94
229_I243_L1.4060.93
109_R112_D1.3900.92
43_I47_N1.3870.92
239_S242_W1.3770.92
209_S237_P1.3720.92
124_N134_I1.3610.92
228_F232_R1.3550.91
38_E42_S1.3530.91
85_D96_D1.3470.91
117_A141_V1.3370.91
142_I149_P1.3130.90
96_D164_H1.3060.90
93_F160_R1.2900.89
53_F65_H1.2880.89
217_G223_N1.2860.89
115_K283_F1.2720.88
53_F60_N1.2710.88
42_S45_I1.2660.88
167_V184_S1.2640.88
21_D25_L1.2610.88
163_L167_V1.2550.88
40_V55_C1.2500.88
110_L197_G1.2420.87
240_E254_R1.2380.87
125_F180_I1.2310.87
285_H294_I1.2240.86
14_K18_K1.2220.86
105_S109_R1.2200.86
233_F243_L1.2160.86
162_E165_A1.1870.85
259_N263_K1.1810.84
228_F246_F1.1750.84
153_L191_F1.1700.84
159_R165_A1.1650.84
218_L222_E1.1540.83
52_S297_S1.1520.83
23_V36_I1.1470.83
29_A78_E1.1460.83
39_E43_I1.1410.82
94_I236_L1.1390.82
227_D231_T1.1380.82
36_I57_I1.1380.82
79_G103_L1.1360.82
85_D272_L1.1340.82
33_V59_I1.1270.82
102_S111_L1.1260.81
44_I51_P1.1250.81
54_P67_S1.1240.81
255_N258_K1.1140.81
242_W246_F1.1110.81
38_E70_I1.1100.81
134_I137_V1.1090.80
133_E138_I1.1030.80
157_L165_A1.0980.80
57_I84_L1.0970.80
95_S297_S1.0960.80
37_C41_E1.0850.79
85_D284_E1.0840.79
150_I280_V1.0820.79
156_H164_H1.0740.78
57_I68_P1.0720.78
232_R246_F1.0700.78
22_E39_E1.0670.78
155_G164_H1.0580.77
287_V297_S1.0540.77
41_E45_I1.0470.76
119_E296_V1.0440.76
265_A275_I1.0430.76
16_A44_I1.0370.76
33_V37_C1.0280.75
210_L230_Y1.0240.75
138_I149_P1.0190.74
111_L283_F1.0120.74
164_H189_E1.0060.74
135_G155_G1.0010.73
126_K289_V0.9930.73
225_L229_I0.9890.72
162_E166_G0.9840.72
34_L73_E0.9820.72
27_V39_E0.9820.72
118_L285_H0.9790.71
59_I74_K0.9780.71
226_I230_Y0.9750.71
112_D116_T0.9720.71
96_D189_E0.9720.71
227_D230_Y0.9670.71
22_E26_D0.9650.70
11_L14_K0.9640.70
226_I229_I0.9630.70
173_Y176_G0.9620.70
221_R224_E0.9600.70
14_K47_N0.9540.69
7_N11_L0.9540.69
122_I287_V0.9500.69
10_L14_K0.9460.69
62_E202_G0.9450.69
257_I266_L0.9440.69
288_I297_S0.9430.69
185_V288_I0.9410.68
252_E255_N0.9410.68
23_V86_L0.9410.68
106_R147_Y0.9340.68
246_F254_R0.9340.68
223_N227_D0.9330.68
36_I82_V0.9310.68
285_H289_V0.9250.67
65_H98_A0.9230.67
6_L288_I0.9230.67
289_V292_D0.9220.67
94_I139_E0.9200.67
49_A88_A0.9160.66
237_P241_R0.9110.66
86_L95_S0.9110.66
218_L226_I0.9100.66
290_K294_I0.9070.66
45_I50_F0.9040.65
247_S253_L0.9020.65
219_S222_E0.8930.64
233_F242_W0.8930.64
13_G17_A0.8900.64
105_S108_Q0.8900.64
287_V290_K0.8840.64
48_K212_N0.8820.63
259_N262_K0.8710.62
32_K73_E0.8690.62
23_V84_L0.8620.62
172_V175_R0.8620.62
65_H96_D0.8620.62
11_L15_I0.8600.61
85_D94_I0.8590.61
130_S133_E0.8490.60
16_A86_L0.8470.60
147_Y192_A0.8430.60
188_I287_V0.8410.60
136_R173_Y0.8390.59
211_K267_R0.8390.59
161_Y196_G0.8360.59
258_K293_S0.8340.59
26_D36_I0.8260.58
58_S72_D0.8250.58
221_R227_D0.8240.58
222_E225_L0.8220.58
81_V100_T0.8180.57
85_D187_A0.8170.57
154_G168_F0.8170.57
89_H230_Y0.8160.57
5_E9_L0.8160.57
124_N137_V0.8130.57
18_K22_E0.8110.57
53_F85_D0.8070.56
27_V101_I0.8070.56
24_S84_L0.8030.56
287_V294_I0.8000.56
61_S202_G0.7990.56
25_L39_E0.7980.56
85_D282_Q0.7980.56
33_V76_I0.7960.55
224_E228_F0.7830.54
11_L90_I0.7810.54
81_V279_V0.7800.54
226_I265_A0.7800.54
26_D31_A0.7790.54
46_E231_T0.7780.54
65_H272_L0.7760.54
217_G226_I0.7740.53
43_I158_I0.7720.53
114_S283_F0.7710.53
129_L134_I0.7700.53
9_L160_R0.7680.53
9_L93_F0.7680.53
142_I281_S0.7680.53
245_E253_L0.7670.53
281_S289_V0.7630.52
174_E177_L0.7570.52
6_L183_D0.7570.52
154_G189_E0.7480.51
54_P92_G0.7470.51
109_R145_Q0.7450.51
76_I80_A0.7390.50
166_G169_I0.7350.50
75_R78_E0.7350.50
40_V43_I0.7320.49
62_E271_I0.7260.49
294_I297_S0.7250.49
122_I285_H0.7220.48
98_A191_F0.7200.48
54_P68_P0.7200.48
210_L234_N0.7200.48
132_G136_R0.7170.48
229_I266_L0.7130.48
103_L108_Q0.7120.47
265_A268_G0.7090.47
260_L272_L0.7080.47
218_L223_N0.7060.47
236_L239_S0.7060.47
222_E259_N0.7040.47
62_E66_Y0.7040.47
220_S224_E0.7030.47
220_S223_N0.7030.47
200_V203_K0.7000.46
92_G113_A0.6980.46
244_K253_L0.6940.46
34_L38_E0.6910.45
54_P80_A0.6910.45
107_Y158_I0.6880.45
124_N133_E0.6870.45
215_I218_L0.6860.45
101_I132_G0.6860.45
214_N217_G0.6840.45
9_L288_I0.6840.45
254_R257_I0.6830.45
187_A284_E0.6820.45
164_H167_V0.6820.45
53_F156_H0.6820.45
152_N164_H0.6800.44
6_L9_L0.6800.44
85_D98_A0.6780.44
187_A204_S0.6750.44
94_I284_E0.6720.44
155_G284_E0.6710.44
132_G177_L0.6690.43
153_L189_E0.6690.43
131_I135_G0.6690.43
153_L164_H0.6690.43
180_I184_S0.6660.43
127_A290_K0.6650.43
23_V101_I0.6650.43
20_R194_D0.6640.43
58_S83_K0.6610.43
65_H190_P0.6580.42
171_N175_R0.6570.42
179_V208_Y0.6570.42
236_L243_L0.6560.42
193_T200_V0.6550.42
188_I291_G0.6540.42
256_N259_N0.6530.42
96_D284_E0.6510.42
230_Y234_N0.6500.42
156_H272_L0.6470.41
81_V107_Y0.6470.41
205_I208_Y0.6450.41
164_H284_E0.6450.41
202_G297_S0.6450.41
56_N98_A0.6450.41
66_Y203_K0.6420.41
48_K190_P0.6400.41
85_D153_L0.6390.41
22_E25_L0.6390.41
121_A127_A0.6380.40
85_D189_E0.6360.40
60_N65_H0.6350.40
34_L267_R0.6350.40
87_G96_D0.6330.40
14_K17_A0.6320.40
65_H282_Q0.6290.40
202_G268_G0.6290.40
20_R127_A0.6280.40
63_A150_I0.6280.40
85_D236_L0.6280.40
31_A39_E0.6240.39
94_I282_Q0.6240.39
153_L156_H0.6230.39
49_A92_G0.6220.39
140_K145_Q0.6210.39
280_V292_D0.6180.39
30_S54_P0.6180.39
180_I289_V0.6160.38
110_L281_S0.6140.38
111_L115_K0.6130.38
80_A103_L0.6120.38
129_L133_E0.6120.38
267_R270_P0.6080.38
225_L243_L0.6070.38
170_P175_R0.6060.38
238_F241_R0.6050.37
64_A152_N0.6050.37
164_H190_P0.6050.37
166_G171_N0.6010.37
142_I147_Y0.5980.37
117_A138_I0.5970.37
135_G154_G0.5970.37
9_L297_S0.5970.37
56_N190_P0.5960.37
193_T291_G0.5960.37
48_K91_D0.5940.36
152_N191_F0.5930.36
128_G179_V0.5920.36
156_H187_A0.5910.36
109_R124_N0.5910.36
153_L199_V0.5910.36
259_N275_I0.5870.36
81_V206_T0.5860.36
233_F246_F0.5840.36
12_A204_S0.5830.35
6_L100_T0.5810.35
102_S105_S0.5800.35
110_L113_A0.5800.35
40_V44_I0.5780.35
221_R255_N0.5770.35
151_R172_V0.5770.35
203_K207_I0.5770.35
234_N243_L0.5760.35
13_G121_A0.5760.35
94_I187_A0.5740.35
37_C186_Y0.5740.35
273_I281_S0.5720.35
228_F233_F0.5710.34
96_D191_F0.5710.34
223_N226_I0.5680.34
217_G234_N0.5640.34
222_E263_K0.5640.34
118_L122_I0.5640.34
247_S295_I0.5620.34
244_K247_S0.5610.34
120_A137_V0.5610.34
224_E229_I0.5600.34
44_I52_S0.5600.34
236_L242_W0.5590.33
98_A272_L0.5580.33
138_I153_L0.5530.33
33_V36_I0.5530.33
51_P242_W0.5520.33
64_A284_E0.5520.33
35_D214_N0.5510.33
99_I146_G0.5510.33
261_V268_G0.5510.33
168_F171_N0.5500.33
51_P160_R0.5490.33
293_S296_V0.5490.33
91_D160_R0.5480.32
73_E257_I0.5470.32
191_F282_Q0.5420.32
157_L186_Y0.5410.32
155_G189_E0.5390.32
54_P60_N0.5390.32
54_P113_A0.5390.32
165_A169_I0.5380.32
164_H191_F0.5380.32
61_S277_K0.5380.32
290_K295_I0.5340.31
55_C89_H0.5340.31
34_L287_V0.5330.31
233_F236_L0.5320.31
23_V82_V0.5320.31
84_L103_L0.5280.31
9_L158_I0.5280.31
183_D290_K0.5260.31
61_S261_V0.5250.31
182_S243_L0.5240.31
86_L89_H0.5220.30
96_D156_H0.5210.30
76_I107_Y0.5200.30
107_Y147_Y0.5190.30
83_K94_I0.5180.30
119_E123_T0.5170.30
179_V182_S0.5170.30
152_N189_E0.5170.30
191_F284_E0.5160.30
240_E257_I0.5150.30
76_I102_S0.5150.30
263_K268_G0.5130.30
89_H94_I0.5130.30
109_R113_A0.5090.29
136_R177_L0.5080.29
224_E246_F0.5080.29
293_S297_S0.5080.29
28_K275_I0.5060.29
217_G222_E0.5040.29
259_N265_A0.5040.29
8_K92_G0.5040.29
70_I73_E0.5030.29
96_D155_G0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xgsA 2 0.9767 100 0.211 Contact Map
1b6aA 1 0.9934 100 0.211 Contact Map
4ipaA 1 0.9867 100 0.218 Contact Map
3fm3A 1 1 100 0.226 Contact Map
2q8kA 1 0.9734 100 0.295 Contact Map
4b6at 1 0.8837 100 0.314 Contact Map
3ctzA 2 0.9037 100 0.473 Contact Map
4s2rP 2 0.8904 100 0.477 Contact Map
3mx6A 1 0.7774 100 0.486 Contact Map
3s6bA 1 0.7741 100 0.487 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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