GREMLIN Database
Y099 - UPF0173 metal-dependent hydrolase SSO0099
UniProt: P95962 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (214)
Sequences: 5330 (3750)
Seq/√Len: 256.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_T190_I3.2341.00
111_L124_T3.1731.00
108_K129_S2.8551.00
129_S134_T2.8431.00
71_K94_I2.7001.00
112_T127_I2.6591.00
15_T20_N2.6521.00
159_A183_P2.5921.00
178_V187_A2.5091.00
101_F108_K2.4591.00
50_T137_H2.3841.00
172_Y208_L2.2761.00
143_L180_L2.2261.00
5_R224_T2.1861.00
220_Q223_Q2.1481.00
110_A129_S2.1021.00
103_E108_K2.0861.00
79_E95_P2.0851.00
157_D184_K2.0781.00
21_V46_I2.0681.00
3_Q15_T2.0141.00
135_V160_L2.0131.00
36_K39_Y2.0071.00
138_A162_P1.9941.00
19_K105_D1.9861.00
112_T125_G1.9741.00
169_M177_S1.9651.00
23_I50_T1.9611.00
148_K152_E1.9421.00
160_L188_I1.9221.00
127_I154_F1.9221.00
96_A111_L1.9131.00
165_G170_D1.8791.00
101_F110_A1.8591.00
148_K180_L1.8361.00
13_L20_N1.8251.00
12_T160_L1.8231.00
48_I126_A1.7771.00
48_I128_V1.7091.00
110_A154_F1.7011.00
186_G217_I1.6961.00
203_N207_K1.6741.00
178_V183_P1.6361.00
117_S167_F1.6261.00
79_E83_A1.6141.00
176_I180_L1.5891.00
204_D208_L1.5291.00
138_A161_L1.5211.00
4_L158_Y1.5181.00
176_I179_E1.5151.00
46_I71_K1.4821.00
158_Y188_I1.4361.00
16_F130_A1.4331.00
103_E106_G1.4121.00
28_K58_G1.3981.00
76_Y97_N1.3891.00
46_I104_V1.3871.00
46_I73_F1.3671.00
186_G215_N1.3221.00
23_I137_H1.3071.00
208_L211_N1.3011.00
3_Q224_T1.2941.00
99_G113_K1.2731.00
160_L190_I1.2621.00
163_I174_A1.2491.00
19_K45_D1.2461.00
14_L135_V1.2371.00
7_L34_P1.2301.00
23_I128_V1.2191.00
151_G182_K1.2151.00
11_A23_I1.2141.00
48_I109_L1.2131.00
60_T72_L1.2111.00
47_I72_L1.2101.00
137_H190_I1.2091.00
204_D207_K1.2081.00
4_L12_T1.1841.00
94_I102_V1.1611.00
111_L126_A1.1591.00
52_D81_H1.1431.00
27_I37_L1.1421.00
19_K107_I1.1411.00
109_L126_A1.1321.00
73_F102_V1.1291.00
74_A78_L1.1211.00
7_L11_A1.1201.00
147_M177_S1.1151.00
97_N117_S1.1101.00
170_D173_Q1.1091.00
209_V216_P1.1001.00
5_R15_T1.0731.00
71_K92_S1.0721.00
149_L153_V1.0721.00
174_A187_A1.0651.00
138_A159_A1.0571.00
74_A79_E1.0531.00
62_E66_M1.0521.00
72_L88_I1.0501.00
13_L44_L1.0501.00
96_A100_G1.0491.00
149_L152_E1.0441.00
112_T136_Y1.0401.00
207_K211_N1.0371.00
73_F96_A1.0271.00
143_L176_I1.0191.00
99_G153_V1.0091.00
158_Y186_G1.0081.00
60_T64_L1.0071.00
26_M31_P1.0051.00
159_A181_I0.9971.00
161_L177_S0.9971.00
40_F44_L0.9921.00
125_G138_A0.9881.00
13_L22_I0.9861.00
14_L23_I0.9851.00
22_I44_L0.9791.00
20_N44_L0.9781.00
4_L160_L0.9761.00
219_L224_T0.9681.00
175_S212_K0.9681.00
179_E212_K0.9651.00
205_F209_V0.9631.00
75_T124_T0.9551.00
208_L212_K0.9531.00
99_G154_F0.9511.00
178_V209_V0.9441.00
21_V107_I0.9441.00
97_N100_G0.9291.00
76_Y80_A0.9241.00
188_I217_I0.9131.00
20_N43_N0.9071.00
187_A216_P0.8991.00
7_L13_L0.8951.00
69_K92_S0.8881.00
127_I156_P0.8831.00
161_L181_I0.8811.00
94_I166_R0.8681.00
201_D204_D0.8671.00
115_V144_F0.8651.00
7_L27_I0.8570.99
200_V205_F0.8540.99
138_A141_T0.8510.99
96_A102_V0.8490.99
61_V65_R0.8480.99
74_A126_A0.8470.99
23_I48_I0.8450.99
20_N45_D0.8430.99
127_I150_I0.8380.99
130_A133_I0.8330.99
6_W190_I0.8320.99
206_V210_K0.8280.99
203_N206_V0.8200.99
202_V205_F0.8180.99
80_A83_A0.8180.99
125_G136_Y0.8170.99
19_K46_I0.8160.99
159_A178_V0.8090.99
133_I157_D0.8030.99
51_H140_D0.8000.99
59_D62_E0.7980.99
114_A141_T0.7960.99
145_E149_L0.7940.99
33_S36_K0.7910.99
12_T188_I0.7890.99
161_L178_V0.7860.99
130_A135_V0.7850.99
5_R13_L0.7840.99
186_G189_P0.7810.99
73_F109_L0.7810.99
109_L128_V0.7800.99
73_F126_A0.7780.99
63_L66_M0.7780.99
79_E93_I0.7710.99
151_G181_I0.7690.99
151_G156_P0.7690.99
170_D174_A0.7680.99
48_I124_T0.7680.99
145_E148_K0.7680.99
128_V135_V0.7670.99
192_Y206_V0.7650.99
72_L82_L0.7630.99
98_V124_T0.7630.99
75_T78_L0.7590.99
11_A27_I0.7520.99
161_L169_M0.7510.99
171_P204_D0.7500.99
27_I59_D0.7500.99
59_D63_L0.7460.99
134_T157_D0.7450.99
73_F104_V0.7450.99
163_I192_Y0.7450.99
10_A190_I0.7430.99
28_K59_D0.7390.98
171_P200_V0.7380.98
51_H191_H0.7350.98
64_L88_I0.7330.98
175_S179_E0.7320.98
74_A93_I0.7230.98
76_Y95_P0.7230.98
19_K106_G0.7200.98
7_L33_S0.7200.98
46_I109_L0.7160.98
141_T147_M0.7140.98
21_V109_L0.7120.98
60_T63_L0.7100.98
17_G130_A0.7080.98
134_T155_K0.7050.98
151_G159_A0.7020.98
164_G168_T0.7000.98
134_T154_F0.6930.98
165_G200_V0.6930.98
136_Y181_I0.6820.97
16_F21_V0.6810.97
206_V218_V0.6780.97
35_V39_Y0.6750.97
78_L82_L0.6730.97
50_T126_A0.6720.97
16_F107_I0.6720.97
4_L14_L0.6700.97
98_V142_G0.6680.97
38_D66_M0.6670.97
136_Y177_S0.6670.97
16_F131_E0.6640.97
11_A33_S0.6620.97
14_L21_V0.6590.97
207_K210_K0.6570.97
60_T82_L0.6570.97
133_I158_Y0.6560.97
10_A162_P0.6520.97
64_L72_L0.6510.97
175_S208_L0.6510.97
76_Y79_E0.6500.97
119_T122_D0.6490.97
60_T88_I0.6470.97
52_D78_L0.6470.97
15_T18_N0.6460.97
61_V64_L0.6450.96
87_K91_E0.6440.96
162_P174_A0.6410.96
129_S154_F0.6390.96
137_H160_L0.6390.96
59_D65_R0.6340.96
17_G132_G0.6320.96
53_H140_D0.6260.96
11_A58_G0.6240.96
187_A214_Y0.6240.96
88_I93_I0.6230.96
11_A26_M0.6210.96
99_G150_I0.6200.96
104_V107_I0.6160.95
134_T156_P0.6160.95
74_A82_L0.6110.95
81_H84_E0.6090.95
135_V158_Y0.6050.95
4_L188_I0.6050.95
163_I189_P0.6040.95
116_H191_H0.6000.95
75_T111_L0.5990.95
171_P175_S0.5980.95
51_H116_H0.5930.94
141_T169_M0.5930.94
61_V66_M0.5920.94
38_D62_E0.5850.94
110_A127_I0.5850.94
189_P218_V0.5850.94
128_V137_H0.5830.94
57_L82_L0.5810.94
143_L147_M0.5800.94
99_G112_T0.5790.94
17_G133_I0.5770.94
49_V78_L0.5740.93
173_Q176_I0.5730.93
64_L69_K0.5680.93
115_V142_G0.5680.93
83_A87_K0.5680.93
178_V214_Y0.5670.93
64_L70_A0.5660.93
183_P187_A0.5660.93
52_D119_T0.5630.93
118_S123_P0.5600.93
75_T126_A0.5590.92
83_A93_I0.5590.92
189_P205_F0.5590.92
214_Y217_I0.5560.92
189_P192_Y0.5530.92
219_L223_Q0.5520.92
112_T153_V0.5500.92
165_G197_L0.5460.92
6_W221_P0.5460.92
6_W192_Y0.5450.92
62_E65_R0.5400.91
22_I40_F0.5390.91
144_F150_I0.5380.91
127_I134_T0.5350.91
177_S189_P0.5350.91
35_V40_F0.5330.91
175_S209_V0.5280.90
99_G149_L0.5270.90
141_T144_F0.5270.90
16_F19_K0.5260.90
13_L40_F0.5240.90
16_F128_V0.5220.90
65_R69_K0.5210.90
57_L78_L0.5200.90
73_F81_H0.5200.90
6_W193_N0.5180.89
203_N220_Q0.5180.89
106_G131_E0.5160.89
179_E182_K0.5160.89
177_S181_I0.5150.89
196_D199_K0.5140.89
51_H55_D0.5140.89
195_W198_I0.5110.89
69_K91_E0.5080.88
201_D205_F0.5050.88
14_L128_V0.5050.88
144_F147_M0.5040.88
209_V218_V0.5020.88
142_G173_Q0.5010.88
6_W12_T0.5010.88
114_A150_I0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qn9A 2 0.978 100 0.338 Contact Map
3rpcA 2 0.9692 100 0.343 Contact Map
3bv6A 5 0.9868 100 0.417 Contact Map
2wylA 5 0.978 100 0.441 Contact Map
4jo0A 2 0.9692 100 0.472 Contact Map
2cbnA 2 0.9648 100 0.504 Contact Map
3kl7A 1 0.8722 100 0.508 Contact Map
1zkpA 2 0.9427 100 0.51 Contact Map
1y44A 2 0.9604 100 0.526 Contact Map
3zwfA 2 0.8899 100 0.539 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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