GREMLIN Database
Y103 - Protein SSO0103
UniProt: P95958 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (242)
Sequences: 2997 (2164)
Seq/√Len: 139.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_V95_K3.8661.00
100_N134_Y3.2581.00
99_V135_G3.0421.00
102_E134_Y2.9791.00
103_L131_Y2.9621.00
57_V92_G2.8501.00
29_V34_S2.8171.00
39_R42_S2.7231.00
14_A45_F2.6751.00
61_A95_K2.5081.00
209_E260_A2.4391.00
39_R173_E2.4391.00
15_E70_R2.4331.00
78_S168_M2.3431.00
243_E247_K2.2941.00
76_V161_T2.2761.00
108_F127_K2.2031.00
108_F112_L2.1901.00
240_G246_I2.1581.00
93_L160_A2.0581.00
105_K109_D2.0121.00
30_N33_A2.0111.00
103_L108_F1.9751.00
112_L116_M1.9611.00
35_H173_E1.9281.00
91_E128_K1.9051.00
15_E67_A1.8741.00
109_D112_L1.8591.00
150_Y179_M1.8571.00
18_T52_A1.8491.00
142_N175_F1.7901.00
36_I172_L1.7371.00
103_L127_K1.7141.00
109_D113_E1.6611.00
104_N107_A1.6401.00
35_H172_L1.6141.00
56_E59_E1.6031.00
99_V134_Y1.5961.00
191_D254_K1.5681.00
132_M138_P1.5281.00
30_N50_I1.4761.00
64_F96_A1.4751.00
124_E127_K1.4741.00
148_G171_V1.4611.00
49_R66_E1.4551.00
21_N217_Y1.4501.00
17_I67_A1.4341.00
57_V61_A1.4341.00
142_N174_N1.4321.00
68_I158_I1.4301.00
15_E71_K1.4201.00
62_S66_E1.4111.00
65_R68_I1.4031.00
150_Y159_L1.3991.00
256_E259_D1.3941.00
251_E255_F1.3901.00
191_D251_E1.3731.00
242_Q245_E1.3601.00
58_D62_S1.3451.00
61_A92_G1.3401.00
73_R156_I1.3391.00
43_L177_N1.3351.00
61_A65_R1.3281.00
37_G50_I1.3201.00
64_F75_I1.3201.00
33_A50_I1.3191.00
152_Y183_R1.3141.00
17_I63_A1.3021.00
60_I92_G1.2951.00
122_I127_K1.2861.00
15_E51_T1.2851.00
51_T66_E1.2741.00
215_D249_K1.2511.00
68_I96_A1.2491.00
77_S160_A1.2491.00
40_L76_V1.2471.00
115_Y126_R1.2421.00
149_I160_A1.2421.00
111_I130_A1.2391.00
247_K251_E1.2361.00
65_R69_D1.2191.00
159_L176_I1.2191.00
139_V150_Y1.2091.00
68_I156_I1.2061.00
112_L127_K1.2051.00
64_F77_S1.2031.00
53_V63_A1.1931.00
213_K252_K1.1921.00
254_K258_L1.1901.00
62_S70_R1.1821.00
204_A208_K1.1700.99
137_I179_M1.1600.99
193_I254_K1.1570.99
129_M145_I1.1520.99
37_G47_V1.1480.99
65_R96_A1.1410.99
245_E248_V1.1380.99
126_R129_M1.1360.99
97_L158_I1.1350.99
164_V170_N1.1250.99
90_A149_I1.1210.99
15_E49_R1.1210.99
194_Y231_I1.1190.99
191_D250_I1.1150.99
39_R177_N1.1130.99
35_H169_E1.1120.99
16_I78_S1.1110.99
139_V176_I1.1100.99
133_P149_I1.1070.99
54_M59_E1.1070.99
110_M140_E1.0950.99
99_V153_H1.0920.99
13_F46_T1.0850.99
114_K118_R1.0840.99
220_T234_I1.0780.99
28_T34_S1.0750.99
202_S206_Y1.0700.99
45_F180_L1.0660.99
172_L176_I1.0530.99
236_I254_K1.0530.99
209_E213_K1.0460.99
215_D245_E1.0360.99
18_T23_V1.0350.99
236_I250_I1.0350.99
99_V151_V1.0340.99
250_I254_K1.0310.99
198_V203_L1.0220.99
85_W208_K1.0220.99
51_T63_A1.0120.99
168_M172_L1.0100.98
77_S93_L1.0000.98
170_N174_N0.9990.98
238_G246_I0.9980.98
74_V159_L0.9960.98
139_V175_F0.9960.98
199_M202_S0.9940.98
64_F93_L0.9930.98
113_E117_T0.9920.98
14_A74_V0.9910.98
36_I168_M0.9890.98
191_D247_K0.9860.98
101_L131_Y0.9850.98
190_E237_A0.9780.98
104_N132_M0.9760.98
57_V88_K0.9740.98
126_R201_S0.9730.98
93_L158_I0.9700.98
248_V252_K0.9650.98
175_F179_M0.9620.98
46_T239_S0.9590.98
253_V256_E0.9550.98
61_A96_A0.9550.98
223_K233_E0.9540.98
172_L177_N0.9520.98
143_E170_N0.9470.98
244_E248_V0.9470.98
251_E254_K0.9420.98
115_Y122_I0.9410.98
152_Y155_N0.9410.98
39_R172_L0.9380.98
142_N170_N0.9340.97
67_A71_K0.9320.97
252_K256_E0.9210.97
94_A101_L0.9040.97
75_I158_I0.9020.97
34_S38_R0.8980.97
51_T70_R0.8970.97
108_F122_I0.8970.97
203_L234_I0.8920.97
105_K108_F0.8830.96
53_V59_E0.8800.96
18_T33_A0.8770.96
207_V218_I0.8760.96
138_P147_P0.8700.96
210_L257_L0.8630.96
161_T176_I0.8620.96
19_I221_H0.8580.96
19_I77_S0.8580.96
16_I36_I0.8580.96
75_I156_I0.8560.96
137_I152_Y0.8520.96
97_L151_V0.8510.96
214_Y252_K0.8460.96
19_I60_I0.8440.95
16_I47_V0.8420.95
161_T172_L0.8400.95
140_E175_F0.8310.95
105_K112_L0.8310.95
195_V203_L0.8290.95
194_Y233_E0.8270.95
113_E116_M0.8260.95
106_T109_D0.8230.95
160_A164_V0.8200.95
214_Y218_I0.8180.95
150_Y157_D0.8150.95
195_V198_V0.8080.94
144_G167_E0.8070.94
60_I64_F0.8060.94
85_W220_T0.8020.94
62_S69_D0.8010.94
204_A220_T0.7920.94
157_D183_R0.7900.94
141_N146_A0.7890.94
189_L243_E0.7850.93
17_I75_I0.7850.93
48_R59_E0.7800.93
67_A75_I0.7790.93
132_M149_I0.7750.93
152_Y157_D0.7740.93
215_D238_G0.7720.93
63_A67_A0.7710.93
99_V133_P0.7700.93
33_A37_G0.7680.93
90_A221_H0.7610.92
255_F258_L0.7590.92
56_E217_Y0.7530.92
159_L179_M0.7460.91
97_L133_P0.7430.91
123_T205_P0.7430.91
57_V91_E0.7350.91
256_E260_A0.7340.91
244_E247_K0.7310.91
107_A132_M0.7270.90
104_N138_P0.7260.90
143_E166_R0.7250.90
152_Y156_I0.7250.90
24_L221_H0.7220.90
141_N144_G0.7190.90
161_T168_M0.7190.90
182_N248_V0.7150.90
21_N222_P0.7150.90
35_H168_M0.7110.89
34_S37_G0.7080.89
192_F233_E0.7070.89
199_M232_L0.7020.89
30_N52_A0.7020.89
146_A167_E0.7010.89
132_M147_P0.6980.89
109_D116_M0.6980.89
18_T30_N0.6940.88
175_F178_K0.6930.88
27_K221_H0.6930.88
58_D95_K0.6910.88
211_V218_I0.6850.88
106_T140_E0.6840.88
63_A66_E0.6840.88
90_A160_A0.6830.87
51_T67_A0.6830.87
186_L241_K0.6810.87
161_T171_V0.6800.87
139_V148_G0.6740.87
209_E212_K0.6680.86
110_M113_E0.6650.86
255_F259_D0.6650.86
62_S65_R0.6620.86
249_K253_V0.6600.86
107_A110_M0.6570.85
43_L172_L0.6560.85
236_I253_V0.6530.85
211_V214_Y0.6420.84
81_L167_E0.6420.84
132_M136_A0.6410.84
48_R56_E0.6400.84
13_F48_R0.6390.84
136_A151_V0.6380.84
47_V50_I0.6360.83
19_I222_P0.6350.83
186_L239_S0.6320.83
252_K255_F0.6320.83
21_N54_M0.6280.83
248_V251_E0.6280.83
110_M114_K0.6270.83
107_A138_P0.6240.82
107_A141_N0.6240.82
85_W211_V0.6230.82
139_V171_V0.6230.82
210_L253_V0.6190.82
141_N148_G0.6190.82
187_K240_G0.6180.82
103_L130_A0.6170.82
55_D84_T0.6130.81
68_I154_N0.6120.81
17_I77_S0.6120.81
85_W212_K0.6100.81
189_L246_I0.6080.81
85_W204_A0.6080.81
164_V171_V0.6080.81
207_V211_V0.6020.80
93_L151_V0.5990.80
67_A70_R0.5990.80
27_K237_A0.5990.80
189_L250_I0.5970.79
14_A40_L0.5950.79
35_H39_R0.5950.79
157_D179_M0.5950.79
116_M121_P0.5880.78
34_S169_E0.5870.78
128_K131_Y0.5860.78
125_E205_P0.5860.78
32_N168_M0.5850.78
92_G96_A0.5850.78
164_V222_P0.5810.78
45_F74_V0.5800.77
23_V28_T0.5800.77
205_P208_K0.5800.77
123_T127_K0.5780.77
49_R63_A0.5780.77
31_T169_E0.5750.77
38_R42_S0.5740.77
83_P201_S0.5720.77
58_D61_A0.5720.77
24_L52_A0.5700.76
139_V179_M0.5650.76
153_H158_I0.5650.76
107_A111_I0.5640.76
32_N164_V0.5600.75
61_A64_F0.5590.75
238_G249_K0.5590.75
94_A100_N0.5580.75
110_M145_I0.5560.75
59_E63_A0.5560.75
18_T168_M0.5550.74
88_K92_G0.5530.74
53_V67_A0.5530.74
21_N220_T0.5500.74
40_L45_F0.5480.73
90_A219_K0.5480.73
29_V38_R0.5470.73
190_E217_Y0.5460.73
213_K256_E0.5450.73
145_I167_E0.5410.73
249_K252_K0.5410.73
99_V152_Y0.5400.72
19_I89_T0.5390.72
133_P151_V0.5370.72
38_R169_E0.5370.72
55_D86_D0.5360.72
25_S235_Q0.5350.72
185_N241_K0.5310.71
203_L206_Y0.5270.71
16_I33_A0.5260.70
244_E255_F0.5220.70
129_M146_A0.5210.70
210_L218_I0.5210.70
97_L153_H0.5200.70
146_A171_V0.5200.70
79_G82_G0.5180.69
92_G95_K0.5180.69
55_D163_G0.5170.69
49_R59_E0.5160.69
133_P145_I0.5150.69
204_A222_P0.5140.69
21_N172_L0.5110.68
59_E190_E0.5100.68
137_I150_Y0.5100.68
107_A171_V0.5090.68
123_T202_S0.5060.67
19_I164_V0.5050.67
189_L247_K0.5040.67
64_F158_I0.5040.67
195_V231_I0.5040.67
144_G162_P0.5010.67
161_T164_V0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uuwA 2 0.9081 100 0.266 Contact Map
3kbqA 2 0.625 100 0.46 Contact Map
1mkzA 2 0.6213 100 0.607 Contact Map
1y5eA 4 0.5809 100 0.61 Contact Map
2is8A 3 0.5846 100 0.614 Contact Map
3iwtA 4 0.5699 100 0.615 Contact Map
2g2cA 1 0.5478 100 0.617 Contact Map
4lhbA 4 0.5809 100 0.624 Contact Map
3pzyA 3 0.5478 100 0.629 Contact Map
3rfqA 5 0.5735 100 0.63 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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