GREMLIN Database
YHIT - Uncharacterized HIT-like protein SSO2163
UniProt: P95937 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (123)
Sequences: 4827 (3128)
Seq/√Len: 282.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_C5_C3.1581.00
43_T55_V3.0141.00
19_S42_R2.9921.00
22_R58_Y2.8841.00
5_C44_H2.6571.00
53_E64_R2.5731.00
2_C44_H2.4601.00
23_V62_A2.4481.00
52_S55_V2.3821.00
20_N58_Y2.3661.00
26_F40_V2.1161.00
63_V98_F2.1041.00
10_G16_I2.0851.00
6_N11_R2.0371.00
51_I96_S1.9731.00
15_Y126_E1.9621.00
23_V58_Y1.8671.00
16_I24_V1.8421.00
83_T98_F1.7541.00
17_V37_T1.7231.00
37_T66_I1.7101.00
77_D88_S1.7081.00
53_E61_T1.6911.00
43_T52_S1.6821.00
5_C9_E1.6771.00
57_P61_T1.6631.00
59_L98_F1.6001.00
18_Y62_A1.5801.00
56_I64_R1.5541.00
80_R103_T1.5491.00
69_A73_A1.5361.00
56_I60_C1.5261.00
14_G24_V1.5211.00
24_V42_R1.4701.00
15_Y27_L1.4621.00
45_Y52_S1.3921.00
64_R68_I1.3831.00
71_K79_I1.3601.00
34_P124_Y1.3531.00
47_N50_E1.3321.00
16_I19_S1.3251.00
45_Y55_V1.3031.00
88_S105_S1.2951.00
7_I14_G1.2361.00
39_V100_I1.2001.00
45_Y51_I1.1951.00
27_L37_T1.1751.00
48_F60_C1.1181.00
24_V40_V1.0841.00
49_L71_K1.0791.00
60_C98_F1.0701.00
47_N85_I1.0581.00
25_A37_T1.0561.00
59_L96_S1.0251.00
87_K94_F1.0091.00
47_N86_G1.0051.00
33_T104_W1.0031.00
46_E50_E0.9941.00
120_Q125_Y0.9791.00
83_T96_S0.9611.00
60_C63_V0.9531.00
22_R55_V0.9521.00
25_A66_I0.9341.00
58_Y62_A0.9241.00
47_N94_F0.9211.00
46_E86_G0.9121.00
67_S79_I0.9061.00
115_V118_K0.9051.00
4_F93_V0.9021.00
6_N12_D0.9021.00
35_G102_P0.8961.00
76_A104_W0.8931.00
111_M114_F0.8921.00
80_R84_N0.8921.00
20_N65_K0.8821.00
47_N71_K0.8801.00
8_V24_V0.8721.00
49_L79_I0.8581.00
53_E57_P0.8551.00
33_T101_V0.8531.00
63_V81_I0.8511.00
78_G88_S0.8491.00
77_D105_S0.8481.00
39_V63_V0.8421.00
45_Y96_S0.8321.00
15_Y125_Y0.8321.00
115_V119_E0.8291.00
77_D104_W0.7910.99
55_V58_Y0.7850.99
67_S71_K0.7850.99
117_R120_Q0.7830.99
23_V59_L0.7830.99
20_N62_A0.7820.99
46_E94_F0.7740.99
3_I6_N0.7730.99
120_Q124_Y0.7720.99
8_V40_V0.7680.99
79_I100_I0.7650.99
110_I113_D0.7540.99
51_I55_V0.7410.99
61_T65_K0.7340.99
114_F117_R0.7330.99
91_Q94_F0.7300.99
45_Y50_E0.7260.99
25_A62_A0.7260.99
70_V100_I0.7250.99
7_I29_K0.7230.99
113_D116_P0.7230.99
124_Y127_Y0.7160.99
18_Y65_K0.7150.99
3_I93_V0.7060.99
73_A76_A0.7040.98
51_I56_I0.6930.98
65_K68_I0.6930.98
3_I12_D0.6910.98
80_R101_V0.6830.98
3_I29_K0.6830.98
65_K69_A0.6790.98
80_R89_A0.6790.98
117_R124_Y0.6780.98
70_V74_L0.6770.98
32_I101_V0.6640.98
48_F83_T0.6620.98
61_T64_R0.6600.98
48_F81_I0.6540.98
58_Y61_T0.6530.98
114_F120_Q0.6530.98
8_V42_R0.6500.97
103_T107_D0.6430.97
71_K76_A0.6430.97
81_I98_F0.6430.97
103_T106_Q0.6380.97
20_N23_V0.6300.97
86_G89_A0.6250.97
63_V70_V0.6240.97
32_I82_L0.6170.97
15_Y29_K0.6110.96
27_L35_G0.6100.96
115_V120_Q0.6100.96
117_R125_Y0.6050.96
114_F119_E0.6040.96
7_I26_F0.6020.96
71_K86_G0.6010.96
48_F64_R0.6010.96
87_K105_S0.5920.96
78_G89_A0.5880.95
74_L104_W0.5880.95
114_F118_K0.5820.95
112_K118_K0.5820.95
59_L63_V0.5800.95
113_D117_R0.5720.95
32_I92_V0.5620.94
69_A72_K0.5580.94
3_I7_I0.5550.94
36_H99_H0.5510.94
28_D101_V0.5460.93
37_T70_V0.5440.93
48_F56_I0.5440.93
16_I42_R0.5420.93
2_C95_H0.5420.93
49_L68_I0.5400.93
10_G14_G0.5400.93
12_D29_K0.5330.93
63_V67_S0.5280.92
4_F40_V0.5270.92
70_V76_A0.5260.92
32_I111_M0.5250.92
109_D112_K0.5230.92
82_L89_A0.5230.92
22_R43_T0.5190.92
17_V25_A0.5160.91
116_P120_Q0.5160.91
67_S81_I0.5130.91
76_A79_I0.5120.91
7_I40_V0.5110.91
57_P60_C0.5110.91
81_I85_I0.5100.91
104_W107_D0.5090.91
37_T100_I0.5080.91
49_L100_I0.5080.91
17_V27_L0.5060.91
60_C64_R0.5030.90
78_G103_T0.5030.90
49_L67_S0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ksvA 2 0.9928 100 0.209 Contact Map
3lb5A 2 0.9496 100 0.239 Contact Map
3l7xA 2 0.9712 100 0.241 Contact Map
2eo4A 2 0.9856 100 0.245 Contact Map
3imiA 2 0.9856 100 0.251 Contact Map
3anoA 4 0.9928 100 0.263 Contact Map
3o0mA 2 0.9424 100 0.265 Contact Map
1y23A 2 1 100 0.266 Contact Map
1emsA 3 0.8849 100 0.285 Contact Map
1fitA 2 0.9065 100 0.294 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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