GREMLIN Database
PGP2 - Phosphoglycolate phosphatase 2
UniProt: P95931 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (210)
Sequences: 11992 (9662)
Seq/√Len: 666.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_E216_E4.0031.00
21_E210_N3.1701.00
171_A185_A2.9551.00
8_I168_K2.8251.00
208_N211_G2.5571.00
160_K169_I2.3881.00
157_L184_V2.3711.00
182_F188_K2.3611.00
183_R201_I2.3341.00
12_S44_F2.2811.00
30_I212_L2.2291.00
196_P200_E2.1651.00
167_G184_V2.1221.00
20_S26_V2.1191.00
28_S212_L2.1171.00
48_T55_I2.1151.00
30_I219_D1.9871.00
176_E197_Q1.9471.00
151_D180_A1.9081.00
85_C158_K1.8561.00
176_E195_I1.8471.00
158_K162_L1.7751.00
179_Y198_I1.7281.00
38_F42_Y1.7121.00
37_E219_D1.7101.00
39_S65_T1.6611.00
189_V217_I1.6491.00
188_K203_D1.6461.00
11_A156_V1.6371.00
179_Y201_I1.6361.00
7_E170_I1.6351.00
153_G184_V1.6321.00
190_A202_A1.6311.00
90_F93_D1.6191.00
187_I204_I1.6121.00
9_L45_V1.6041.00
158_K161_E1.5921.00
35_V44_F1.5761.00
22_E26_V1.5731.00
29_P33_Q1.5661.00
37_E40_K1.5631.00
187_I203_D1.5451.00
171_A181_L1.5431.00
207_E211_G1.5321.00
32_S61_G1.5281.00
154_V157_L1.5181.00
11_A47_V1.5131.00
77_F80_R1.5081.00
33_Q37_E1.4801.00
43_K163_T1.4731.00
204_I217_I1.4611.00
157_L161_E1.4491.00
14_Y19_A1.4131.00
87_K158_K1.4081.00
91_E95_K1.3861.00
32_S36_N1.3841.00
93_D96_K1.3831.00
179_Y183_R1.3771.00
156_V181_L1.3591.00
7_E42_Y1.3501.00
196_P199_K1.3461.00
30_I216_E1.3351.00
12_S172_L1.3181.00
204_I221_I1.3141.00
160_K167_G1.3061.00
198_I201_I1.2881.00
34_K215_V1.2871.00
172_L217_I1.2861.00
101_L115_L1.2861.00
28_S31_V1.2811.00
7_E168_K1.2781.00
31_V212_L1.2571.00
87_K147_P1.2551.00
172_L214_V1.2421.00
100_I104_L1.2421.00
190_A194_A1.2371.00
197_Q200_E1.2151.00
7_E187_I1.2051.00
214_V218_L1.2051.00
189_V206_T1.1931.00
217_I221_I1.1911.00
34_K219_D1.1731.00
127_L131_E1.1721.00
77_F81_E1.1711.00
199_K205_V1.1641.00
86_E111_G1.1641.00
204_I220_K1.1621.00
215_V219_D1.1611.00
45_V159_F1.1571.00
151_D154_V1.1491.00
30_I34_K1.1371.00
68_I155_G1.1331.00
96_K133_Y1.1011.00
122_S125_D1.0961.00
206_T217_I1.0961.00
36_N40_K1.0851.00
216_E220_K1.0791.00
9_L165_F1.0761.00
192_A208_N1.0751.00
182_F198_I1.0701.00
175_S195_I1.0651.00
104_L129_E1.0651.00
171_A182_F1.0641.00
170_I221_I1.0601.00
217_I220_K1.0431.00
189_V204_I1.0241.00
160_K184_V1.0221.00
20_S210_N1.0191.00
153_G180_A1.0161.00
10_V42_Y1.0151.00
11_A169_I1.0111.00
169_I185_A1.0111.00
36_N39_S1.0101.00
21_E209_P1.0051.00
75_I158_K0.9951.00
159_F163_T0.9861.00
170_I189_V0.9841.00
10_V38_F0.9761.00
75_I85_C0.9751.00
194_A199_K0.9711.00
10_V218_L0.9681.00
14_Y58_L0.9641.00
11_A45_V0.9631.00
206_T213_G0.9591.00
69_L74_L0.9571.00
170_I217_I0.9571.00
96_K99_E0.9561.00
167_G186_D0.9541.00
157_L167_G0.9521.00
73_S150_V0.9521.00
98_I102_D0.9501.00
75_I155_G0.9491.00
87_K149_G0.9471.00
136_I146_L0.9411.00
52_K69_L0.9401.00
9_L169_I0.9391.00
112_R144_M0.9381.00
45_V66_A0.9351.00
47_V68_I0.9331.00
95_K99_E0.9211.00
29_P32_S0.9151.00
124_L128_S0.9111.00
96_K100_I0.9111.00
195_I198_I0.9021.00
170_I187_I0.9001.00
9_L160_K0.8971.00
185_A188_K0.8951.00
18_L31_V0.8931.00
100_I103_N0.8901.00
12_S214_V0.8891.00
192_A207_E0.8861.00
156_V185_A0.8741.00
10_V170_I0.8711.00
193_N209_P0.8681.00
124_L127_L0.8571.00
52_K76_L0.8571.00
191_V213_G0.8561.00
216_E219_D0.8531.00
128_S131_E0.8531.00
176_E179_Y0.8521.00
51_E70_E0.8521.00
33_Q36_N0.8491.00
36_N63_K0.8441.00
192_A199_K0.8381.00
31_V215_V0.8231.00
18_L35_V0.8231.00
69_L76_L0.8211.00
153_G157_L0.8181.00
34_K37_E0.8171.00
147_P150_V0.8101.00
92_R96_K0.8071.00
146_L151_D0.8061.00
30_I215_V0.8041.00
160_K165_F0.8031.00
68_I159_F0.8001.00
31_V34_K0.7981.00
117_V122_S0.7941.00
197_Q201_I0.7941.00
48_T69_L0.7911.00
190_A198_I0.7901.00
131_E134_G0.7891.00
154_V158_K0.7871.00
89_W147_P0.7811.00
99_E103_N0.7771.00
160_K186_D0.7691.00
100_I129_E0.7671.00
186_D203_D0.7601.00
43_K65_T0.7571.00
207_E213_G0.7511.00
191_V194_A0.7481.00
123_K127_L0.7481.00
38_F44_F0.7461.00
125_D129_E0.7341.00
150_V154_V0.7331.00
168_K186_D0.7291.00
12_S18_L0.7261.00
169_I186_D0.7211.00
156_V171_A0.7211.00
52_K56_D0.7181.00
56_D60_V0.7161.00
191_V206_T0.7141.00
104_L125_D0.7101.00
49_G177_N0.7081.00
94_R98_I0.7031.00
157_L160_K0.7021.00
38_F218_L0.6951.00
182_F201_I0.6941.00
88_S111_G0.6941.00
47_V181_L0.6941.00
135_R145_I0.6931.00
103_N129_E0.6891.00
71_N144_M0.6881.00
46_V55_I0.6861.00
78_N81_E0.6851.00
74_L111_G0.6851.00
129_E133_Y0.6811.00
130_I133_Y0.6801.00
55_I69_L0.6781.00
76_L81_E0.6751.00
129_E132_K0.6731.00
7_E43_K0.6721.00
192_A211_G0.6721.00
20_S28_S0.6721.00
169_I184_V0.6701.00
31_V35_V0.6701.00
207_E220_K0.6691.00
22_E210_N0.6681.00
42_Y170_I0.6681.00
117_V123_K0.6651.00
14_Y46_V0.6641.00
18_L27_I0.6631.00
30_I33_Q0.6631.00
206_T216_E0.6531.00
67_W78_N0.6491.00
27_I32_S0.6461.00
14_Y18_L0.6431.00
180_A183_R0.6361.00
14_Y55_I0.6341.00
126_M130_I0.6321.00
114_I144_M0.6271.00
127_L137_E0.6241.00
204_I216_E0.6221.00
8_I42_Y0.6161.00
92_R95_K0.6141.00
75_I159_F0.6121.00
172_L189_V0.6081.00
193_N208_N0.6071.00
34_K38_F0.6051.00
70_E144_M0.6031.00
55_I67_W0.6031.00
84_L162_L0.6011.00
10_V172_L0.6011.00
9_L159_F0.5981.00
194_A198_I0.5961.00
204_I207_E0.5961.00
59_A67_W0.5961.00
149_G154_V0.5951.00
125_D128_S0.5951.00
188_K198_I0.5951.00
124_L137_E0.5941.00
135_R138_V0.5931.00
73_S147_P0.5921.00
174_D194_A0.5851.00
100_I133_Y0.5851.00
27_I31_V0.5831.00
71_N177_N0.5821.00
179_Y182_F0.5791.00
9_L43_K0.5791.00
188_K202_A0.5771.00
198_I202_A0.5741.00
70_E73_S0.5721.00
20_S209_P0.5661.00
51_E54_F0.5661.00
212_L215_V0.5651.00
18_L214_V0.5631.00
193_N199_K0.5621.00
172_L206_T0.5601.00
68_I75_I0.5601.00
182_F202_A0.5521.00
187_I217_I0.5521.00
174_D191_V0.5521.00
192_A206_T0.5511.00
114_I142_D0.5471.00
135_R143_A0.5471.00
59_A66_A0.5431.00
118_D122_S0.5411.00
56_D59_A0.5411.00
139_N142_D0.5391.00
70_E74_L0.5371.00
39_S63_K0.5361.00
46_V59_A0.5361.00
17_T177_N0.5321.00
138_V144_M0.5270.99
99_E102_D0.5270.99
207_E217_I0.5230.99
202_A205_V0.5230.99
100_I130_I0.5230.99
176_E198_I0.5210.99
212_L216_E0.5180.99
70_E111_G0.5150.99
117_V120_Y0.5150.99
77_F162_L0.5150.99
65_T78_N0.5140.99
66_A163_T0.5130.99
18_L46_V0.5120.99
101_L108_Y0.5120.99
190_A201_I0.5100.99
65_T79_D0.5090.99
19_A209_P0.5090.99
66_A77_F0.5060.99
26_V61_G0.5040.99
18_L209_P0.5040.99
39_S66_A0.5030.99
171_A188_K0.5020.99
159_F162_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nrwA 1 0.9142 100 0.268 Contact Map
2b30A 2 0.9442 100 0.283 Contact Map
3pgvA 3 0.9227 100 0.284 Contact Map
2pq0A 1 0.9227 100 0.295 Contact Map
3l7yA 1 0.9185 100 0.297 Contact Map
1rkqA 1 0.9356 100 0.297 Contact Map
3fzqA 2 0.927 100 0.302 Contact Map
4qjbA 1 0.9442 100 0.302 Contact Map
1rlmA 1 0.9399 100 0.307 Contact Map
3dnpA 2 0.9356 100 0.308 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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