GREMLIN Database
APE2 - Leucyl aminopeptidase
UniProt: P95928 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 785 (767)
Sequences: 5214 (3659)
Seq/√Len: 132.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_D208_R3.8271.00
43_K79_E3.7701.00
10_F131_R3.6221.00
388_K405_E3.5201.00
205_Q209_N3.4641.00
6_R125_R3.4391.00
127_K160_E3.3781.00
180_R189_I3.2891.00
46_K77_E3.1891.00
134_K149_E3.1771.00
389_F402_S3.1691.00
8_E127_K3.1671.00
116_C126_F3.1581.00
131_R155_V3.1121.00
427_V438_L3.0661.00
756_E760_S3.0161.00
212_E216_K2.9761.00
438_L458_L2.9281.00
622_F651_E2.9251.00
129_T157_E2.9101.00
105_F113_F2.9081.00
439_E475_R2.8411.00
384_N405_E2.8041.00
45_V79_E2.7971.00
384_N388_K2.7891.00
132_V156_Y2.7651.00
48_K75_E2.7631.00
750_G753_R2.6181.00
178_E189_I2.5841.00
132_V138_V2.5711.00
377_N407_Y2.5191.00
720_K754_E2.5191.00
148_K155_V2.5031.00
23_Y75_E2.5021.00
49_V74_L2.4671.00
217_Y379_R2.4501.00
125_R160_E2.3701.00
427_V456_I2.3661.00
492_N514_S2.3461.00
429_V438_L2.3131.00
714_A718_W2.3061.00
134_K152_G2.3031.00
182_E185_I2.2921.00
379_R383_V2.2841.00
130_V171_L2.2761.00
259_S262_Y2.2711.00
128_L169_L2.2361.00
646_D650_D2.1821.00
26_I37_L2.1751.00
220_I386_L2.1601.00
437_S477_T2.1561.00
143_P225_P2.1431.00
114_I169_L2.1251.00
430_S439_E2.1091.00
340_I365_I2.0971.00
219_E387_K2.0941.00
180_R187_T2.0791.00
518_K549_D2.0731.00
373_V377_N2.0661.00
682_G721_M2.0551.00
370_E375_E2.0431.00
27_E71_S2.0341.00
380_R383_V2.0281.00
410_D413_P2.0261.00
592_K596_G2.0141.00
144_V147_E2.0081.00
147_E154_V1.9921.00
12_D131_R1.9871.00
12_D153_K1.9791.00
177_E197_V1.9771.00
442_R454_Y1.9631.00
145_V159_D1.9531.00
287_K395_Q1.9531.00
144_V156_Y1.9511.00
29_E71_S1.9341.00
23_Y77_E1.9291.00
130_V138_V1.9251.00
50_N72_G1.9241.00
25_K73_I1.9231.00
142_M225_P1.9101.00
177_E194_P1.9021.00
27_E73_I1.8981.00
10_F129_T1.8911.00
301_F370_E1.8881.00
645_E648_S1.8791.00
125_R163_K1.8781.00
229_L248_F1.8641.00
179_I200_G1.8591.00
619_S623_R1.8541.00
569_N573_Y1.8501.00
373_V403_I1.8471.00
126_F166_T1.8401.00
139_I245_A1.8391.00
146_R157_E1.8351.00
252_A266_R1.8311.00
25_K75_E1.8251.00
593_D596_G1.8151.00
756_E775_L1.7961.00
748_G751_A1.7881.00
134_K154_V1.7881.00
569_N576_I1.7871.00
172_G245_A1.7841.00
14_S17_T1.7821.00
189_I228_H1.7641.00
725_F761_N1.7611.00
36_V62_R1.7431.00
428_R500_F1.7381.00
648_S651_E1.7261.00
210_S272_A1.7251.00
389_F398_D1.7111.00
620_E624_F1.7051.00
682_G686_S1.6991.00
454_Y461_E1.6731.00
179_I201_R1.6631.00
20_Y80_G1.6521.00
569_N577_A1.6491.00
655_R658_K1.6491.00
116_C166_T1.6441.00
570_P573_Y1.6431.00
295_N354_F1.6391.00
409_S470_L1.6361.00
389_F392_S1.6361.00
175_N194_P1.6361.00
233_P250_E1.6291.00
219_E383_V1.6261.00
125_R159_D1.6251.00
7_Y124_A1.6181.00
305_K370_E1.6171.00
650_D654_E1.6061.00
570_P576_I1.6001.00
6_R160_E1.5971.00
726_M729_A1.5931.00
488_K517_D1.5891.00
387_K390_S1.5871.00
255_A259_S1.5841.00
753_R757_Q1.5771.00
192_T200_G1.5751.00
383_V387_K1.5531.00
384_N406_V1.5521.00
6_R127_K1.5481.00
381_G403_I1.5411.00
725_F728_E1.5291.00
21_K77_E1.5261.00
416_A420_T1.5261.00
10_F23_Y1.5251.00
256_D259_S1.5251.00
265_F319_Y1.5241.00
121_A287_K1.5231.00
573_Y577_A1.5141.00
5_N27_E1.5051.00
305_K313_S1.4991.00
694_K697_D1.4981.00
5_N29_E1.4971.00
573_Y576_I1.4961.00
40_V61_S1.4951.00
473_K476_D1.4941.00
188_I207_S1.4871.00
217_Y375_E1.4791.00
613_E617_G1.4751.00
230_I245_A1.4661.00
577_A580_F1.4661.00
138_V156_Y1.4631.00
377_N380_R1.4631.00
693_I696_Q1.4581.00
172_G176_F1.4581.00
722_H725_F1.4551.00
454_Y458_L1.4551.00
337_T422_P1.4541.00
696_Q705_A1.4531.00
695_K705_A1.4521.00
649_V653_L1.4511.00
190_V204_M1.4491.00
619_S622_F1.4421.00
135_G175_N1.4391.00
207_S229_L1.4371.00
544_S547_F1.4371.00
675_F680_L1.4371.00
721_M758_F1.4301.00
572_K576_I1.4251.00
220_I390_S1.4231.00
583_I586_K1.4201.00
569_N572_K1.4201.00
551_D554_P1.4201.00
621_L624_F1.4201.00
338_H355_D1.4091.00
129_T155_V1.4091.00
569_N580_F1.4091.00
203_S271_V1.4061.00
454_Y457_P1.4001.00
178_E191_A1.3981.00
429_V489_V1.3971.00
638_V674_F1.3941.00
228_H244_G1.3941.00
172_G230_I1.3931.00
426_M498_R1.3921.00
438_L471_L1.3891.00
46_K53_E1.3851.00
113_F171_L1.3851.00
608_A615_S1.3831.00
177_E195_G1.3811.00
65_V68_G1.3801.00
34_T66_K1.3791.00
677_K680_L1.3791.00
143_P159_D1.3741.00
500_F506_D1.3661.00
426_M500_F1.3651.00
241_E274_E1.3611.00
201_R205_Q1.3571.00
274_E277_H1.3561.00
273_H277_H1.3551.00
327_R356_D1.3551.00
652_L668_Y1.3521.00
401_N404_S1.3491.00
381_G402_S1.3481.00
241_E277_H1.3471.00
277_H359_Y1.3381.00
435_R477_T1.3371.00
110_A116_C1.3361.00
59_D64_N1.3341.00
286_L393_N1.3341.00
63_V67_S1.3311.00
427_V490_N1.3291.00
701_T705_A1.3251.00
430_S437_S1.3231.00
388_K402_S1.3191.00
59_D62_R1.3141.00
8_E129_T1.3131.00
541_R544_S1.3131.00
570_P577_A1.3121.00
190_V203_S1.3111.00
239_A270_V1.3111.00
196_K199_K1.3081.00
749_I752_E1.3081.00
192_T197_V1.3051.00
617_G620_E1.3041.00
241_E273_H1.3021.00
273_H359_Y1.3021.00
94_S99_Y1.3001.00
202_F206_I1.3001.00
234_E694_K1.2991.00
573_Y580_F1.2971.00
454_Y459_T1.2951.00
123_K165_S1.2911.00
45_V77_E1.2881.00
104_Q107_A1.2831.00
631_D655_R1.2811.00
435_R479_V1.2791.00
653_L657_R1.2761.00
193_I196_K1.2741.00
592_K597_R1.2721.00
220_I387_K1.2721.00
198_Q256_D1.2711.00
19_D79_E1.2711.00
269_E303_S1.2681.00
653_L663_E1.2671.00
202_F311_F1.2551.00
397_S412_S1.2531.00
212_E215_E1.2521.00
457_P461_E1.2481.00
220_I383_V1.2431.00
48_K53_E1.2431.00
90_I101_I1.2411.00
128_L140_S1.2381.00
402_S406_V1.2361.00
490_N499_V1.2361.00
573_Y581_H1.2361.00
401_N405_E1.2351.00
181_D204_M1.2331.00
717_N721_M1.2321.00
502_Y505_S1.2301.00
170_Y245_A1.2281.00
404_S410_D1.2251.00
428_R441_E1.2241.00
417_D452_L1.2241.00
469_H478_M1.2231.00
8_E157_E1.2181.00
277_H296_E1.2151.00
102_S232_I1.2141.00
428_R439_E1.2131.00
748_G752_E1.2131.00
57_S66_K1.2131.00
455_K470_L1.2101.00
22_G115_P1.2091.00
320_F363_A1.2091.00
49_V54_I1.2081.00
227_V275_L1.2071.00
46_K75_E1.2000.99
316_F320_F1.1980.99
297_S362_G1.1960.99
427_V471_L1.1930.99
757_Q761_N1.1910.99
86_K112_D1.1880.99
241_E359_Y1.1860.99
42_L80_G1.1860.99
514_S517_D1.1760.99
184_K221_P1.1750.99
93_A234_E1.1740.99
127_K157_E1.1740.99
62_R65_V1.1700.99
104_Q237_Y1.1700.99
578_K582_R1.1690.99
284_V386_L1.1690.99
432_S435_R1.1660.99
757_Q760_S1.1660.99
682_G718_W1.1640.99
8_E25_K1.1630.99
280_F298_F1.1630.99
694_K705_A1.1630.99
298_F382_V1.1600.99
127_K145_V1.1570.99
28_M74_L1.1550.99
237_Y295_N1.1510.99
341_E420_T1.1500.99
59_D63_V1.1500.99
427_V497_Y1.1430.99
109_H112_D1.1410.99
573_Y579_E1.1400.99
372_Y470_L1.1390.99
83_T86_K1.1380.99
622_F625_Y1.1350.99
146_R155_V1.1340.99
569_N579_E1.1320.99
744_I755_T1.1300.99
587_N600_Y1.1300.99
214_Y306_A1.1270.99
641_A652_L1.1260.99
456_I462_V1.1250.99
612_D615_S1.1230.99
188_I208_R1.1190.99
525_Y534_I1.1170.99
576_I580_F1.1170.99
274_E359_Y1.1170.99
458_L489_V1.1150.99
47_A76_V1.1150.99
60_E63_V1.1140.99
21_K79_E1.1130.99
431_V484_V1.1120.99
701_T704_T1.1070.99
503_N507_L1.1070.99
696_Q701_T1.1050.99
456_I461_E1.1050.99
36_V64_N1.1020.99
561_E564_T1.0970.99
369_I400_W1.0970.99
127_K159_D1.0910.99
10_F155_V1.0890.99
133_D153_K1.0890.99
772_G776_E1.0880.99
64_N67_S1.0830.99
436_V440_Q1.0810.99
445_L448_N1.0800.99
454_Y462_V1.0800.99
680_L683_N1.0760.99
11_L171_L1.0710.99
137_K178_E1.0640.99
246_I275_L1.0610.99
695_K704_T1.0600.99
398_D401_N1.0590.99
473_K478_M1.0560.99
431_V502_Y1.0550.99
235_F238_G1.0540.99
144_V189_I1.0530.99
525_Y542_V1.0520.99
592_K600_Y1.0510.99
445_L451_N1.0500.99
554_P562_L1.0490.99
356_D360_G1.0470.99
196_K250_E1.0430.99
697_D701_T1.0410.99
213_F305_K1.0410.99
224_L243_W1.0390.99
206_I268_A1.0370.98
513_L517_D1.0350.98
252_A270_V1.0340.98
309_Q375_E1.0310.98
297_S366_L1.0310.98
43_K81_K1.0300.98
577_A581_H1.0280.98
433_G483_D1.0270.98
417_D454_Y1.0250.98
569_N574_Q1.0250.98
104_Q109_H1.0240.98
148_K157_E1.0230.98
213_F306_A1.0220.98
380_R384_N1.0210.98
653_L687_L1.0200.98
381_G406_V1.0190.98
254_L259_S1.0150.98
82_V101_I1.0150.98
631_D656_F1.0130.98
402_S405_E1.0120.98
213_F309_Q1.0100.98
52_K55_E1.0080.98
384_N402_S1.0080.98
448_N451_N1.0080.98
235_F249_R1.0040.98
280_F284_V1.0010.98
92_K101_I1.0010.98
504_N507_L1.0010.98
654_E657_R1.0000.98
608_A618_L1.0000.98
9_I128_L1.0000.98
700_L705_A0.9990.98
253_L256_D0.9990.98
40_V112_D0.9980.98
646_D680_L0.9960.98
728_E762_L0.9950.98
651_E655_R0.9940.98
554_P558_L0.9930.98
708_N711_A0.9930.98
456_I460_M0.9920.98
377_N406_V0.9920.98
139_I230_I0.9900.98
654_E658_K0.9890.98
296_E359_Y0.9880.98
506_D525_Y0.9860.98
618_L621_L0.9840.98
487_L503_N0.9820.98
681_V705_A0.9810.98
251_T266_R0.9810.98
644_Y648_S0.9790.98
39_A42_L0.9780.98
458_L471_L0.9770.98
380_R406_V0.9740.98
562_L565_L0.9730.98
273_H296_E0.9720.98
717_N720_K0.9700.98
751_A754_E0.9700.98
11_L22_G0.9670.98
574_Q578_K0.9670.98
22_G80_G0.9650.98
451_N454_Y0.9620.98
240_M277_H0.9620.98
437_S475_R0.9550.97
633_R637_A0.9520.97
300_T303_S0.9510.97
753_R756_E0.9500.97
554_P557_E0.9490.97
38_D62_R0.9490.97
404_S408_G0.9480.97
371_A494_T0.9470.97
747_I752_E0.9470.97
135_G154_V0.9450.97
728_E761_N0.9440.97
700_L704_T0.9440.97
265_F594_E0.9440.97
104_Q242_N0.9430.97
569_N578_K0.9400.97
145_V157_E0.9390.97
668_Y704_T0.9390.97
117_F122_M0.9380.97
383_V386_L0.9370.97
164_M168_L0.9360.97
570_P574_Q0.9330.97
621_L625_Y0.9320.97
693_I705_A0.9300.97
13_F18_G0.9300.97
718_W722_H0.9290.97
673_L704_T0.9280.97
106_E295_N0.9280.97
241_E296_E0.9250.97
452_L461_E0.9250.97
131_R153_K0.9250.97
695_K701_T0.9250.97
461_E491_V0.9250.97
472_D476_D0.9250.97
400_W415_M0.9220.97
9_I24_E0.9220.97
193_I250_E0.9210.97
11_L20_Y0.9200.97
182_E187_T0.9190.97
455_K472_D0.9180.97
254_L257_D0.9180.97
266_R270_V0.9180.97
184_K215_E0.9170.97
91_Y234_E0.9160.97
724_N728_E0.9150.97
227_V246_I0.9140.97
649_V684_T0.9130.97
552_F556_N0.9120.97
551_D555_V0.9120.97
696_Q704_T0.9100.97
284_V402_S0.9100.97
452_L458_L0.9080.97
202_F268_A0.9080.97
13_F90_I0.9080.97
294_L385_Y0.9070.96
267_V270_V0.9060.96
342_A353_M0.9060.96
705_A711_A0.9050.96
696_Q699_P0.9050.96
325_T496_F0.9040.96
388_K401_N0.9040.96
438_L489_V0.9030.96
139_I191_A0.9030.96
91_Y235_F0.9030.96
639_A642_I0.9030.96
681_V711_A0.9020.96
20_Y78_F0.9020.96
331_K773_T0.8980.96
641_A675_F0.8930.96
646_D683_N0.8900.96
457_P462_V0.8880.96
587_N590_N0.8870.96
321_V367_R0.8870.96
386_L394_A0.8860.96
369_I414_I0.8850.96
373_V381_G0.8840.96
763_N775_L0.8810.96
461_E466_V0.8810.96
590_N593_D0.8790.96
123_K285_T0.8790.96
596_G600_Y0.8730.96
722_H726_M0.8720.96
240_M273_H0.8720.96
291_D341_E0.8720.96
593_D597_R0.8700.96
594_E597_R0.8690.96
12_D21_K0.8690.96
633_R655_R0.8680.95
13_F101_I0.8660.95
458_L490_N0.8640.95
276_A302_M0.8630.95
239_A359_Y0.8630.95
413_P472_D0.8620.95
61_S64_N0.8620.95
100_V232_I0.8610.95
63_V68_G0.8550.95
446_I451_N0.8520.95
436_V487_L0.8520.95
274_E296_E0.8510.95
39_A80_G0.8510.95
159_D225_P0.8510.95
616_L619_S0.8490.95
641_A644_Y0.8470.95
556_N560_N0.8460.95
62_R67_S0.8450.95
15_F18_G0.8450.95
231_A254_L0.8450.95
574_Q577_A0.8420.95
679_Y682_G0.8420.95
441_E533_K0.8420.95
33_E66_K0.8420.95
657_R692_E0.8400.95
47_A65_V0.8390.95
343_H420_T0.8390.95
529_L539_Y0.8370.95
240_M359_Y0.8360.94
693_I697_D0.8360.94
191_A228_H0.8360.94
240_M274_E0.8340.94
576_I579_E0.8340.94
431_V487_L0.8330.94
594_E603_I0.8330.94
194_P197_V0.8320.94
257_D264_K0.8320.94
286_L295_N0.8300.94
683_N686_S0.8290.94
602_N606_R0.8280.94
758_F761_N0.8280.94
167_Y359_Y0.8270.94
455_K458_L0.8260.94
217_Y305_K0.8250.94
26_I117_F0.8250.94
578_K581_H0.8240.94
404_S407_Y0.8240.94
174_G230_I0.8220.94
724_N762_L0.8210.94
5_N71_S0.8200.94
452_L456_I0.8200.94
604_L618_L0.8200.94
421_K452_L0.8190.94
41_G86_K0.8180.94
685_L718_W0.8160.94
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572_K581_H0.5000.65
698_I703_S0.5000.65
285_T296_E0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kx7A 1 0.9911 100 0.139 Contact Map
4fkeA 1 0.9962 100 0.139 Contact Map
2yd0A 1 0.9898 100 0.139 Contact Map
4jbsA 1 0.9924 100 0.144 Contact Map
4pj6A 2 0.9885 100 0.144 Contact Map
4wz9A 2 0.9924 100 0.153 Contact Map
1z5hA 3 0.9771 100 0.16 Contact Map
4x2uA 1 0.9796 100 0.384 Contact Map
4qhpA 1 0.9771 100 0.398 Contact Map
3b34A 1 0.9669 100 0.399 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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