GREMLIN Database
Y2140 - Putative esterase SSO2140
UniProt: P95914 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 140 (120)
Sequences: 6241 (4290)
Seq/√Len: 391.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_E94_P3.4091.00
27_I37_E3.0311.00
80_Q108_V2.6181.00
35_V98_E2.4761.00
98_E116_K2.3031.00
28_N35_V2.2741.00
25_K37_E2.2471.00
28_N33_R2.2281.00
36_V63_T2.1651.00
57_M82_L2.0281.00
30_E33_R2.0101.00
64_G113_I1.9361.00
114_E122_L1.9281.00
63_T97_I1.8531.00
38_I55_I1.8141.00
88_E121_K1.8051.00
33_R98_E1.7821.00
68_A109_I1.7461.00
37_E96_T1.7461.00
33_R100_K1.7451.00
35_V96_T1.7291.00
112_E125_K1.6631.00
60_I126_A1.6331.00
102_L112_E1.6191.00
100_K112_E1.6061.00
39_P94_P1.5871.00
101_V104_K1.5781.00
117_D121_K1.5581.00
100_K114_E1.5421.00
60_I113_I1.5121.00
57_M84_I1.4501.00
64_G128_G1.4331.00
27_I35_V1.4261.00
18_I55_I1.4231.00
93_G118_A1.4031.00
81_E85_N1.3971.00
90_M123_G1.3661.00
21_F43_E1.3411.00
102_L125_K1.3141.00
114_E125_K1.3021.00
57_M86_F1.2671.00
18_I58_S1.2601.00
32_G70_T1.2461.00
68_A130_W1.2061.00
93_G117_D1.1891.00
60_I115_F1.1701.00
116_K120_G1.1611.00
56_I124_A1.1551.00
40_Y51_L1.1531.00
42_E45_T1.1511.00
103_R108_V1.1501.00
84_I124_A1.1471.00
41_K44_F1.1431.00
90_M95_F1.1371.00
71_V104_K1.1331.00
51_L95_F1.1211.00
97_I113_I1.1191.00
109_I132_I1.1011.00
112_E127_I1.0981.00
87_L125_K1.0871.00
116_K122_L1.0251.00
59_A97_I1.0231.00
108_V131_Y0.9901.00
56_I115_F0.9861.00
68_A111_V0.9731.00
25_K94_P0.9651.00
24_V36_V0.9631.00
50_V78_V0.9611.00
56_I123_G0.9551.00
85_N129_S0.9551.00
38_I59_A0.9451.00
61_D79_T0.9331.00
107_T131_Y0.9291.00
83_K127_I0.9231.00
94_P118_A0.9171.00
71_V101_V0.9151.00
72_N75_M0.8961.00
98_E114_E0.8901.00
67_A111_V0.8791.00
103_R110_V0.8741.00
54_G58_S0.8681.00
81_E127_I0.8531.00
78_V133_L0.8371.00
67_A101_V0.8221.00
19_F62_I0.8161.00
64_G130_W0.8111.00
110_V129_S0.8091.00
25_K39_P0.8091.00
51_L90_M0.8091.00
67_A99_G0.8021.00
96_T116_K0.8021.00
29_L70_T0.7931.00
87_L103_R0.7921.00
50_V89_P0.7851.00
44_F55_I0.7831.00
85_N110_V0.7771.00
82_L86_F0.7741.00
87_L122_L0.7721.00
88_E103_R0.7711.00
39_P44_F0.7701.00
101_V111_V0.7681.00
69_L77_Q0.7391.00
97_I115_F0.7391.00
56_I86_F0.7351.00
47_R65_G0.7241.00
22_L58_S0.7231.00
15_A20_K0.7231.00
61_D65_G0.7171.00
81_E129_S0.7141.00
69_L76_D0.7131.00
87_L110_V0.7101.00
95_F115_F0.7041.00
53_G86_F0.7021.00
26_V36_V0.6981.00
17_Q20_K0.6921.00
27_I94_P0.6921.00
52_H62_I0.6890.99
82_L126_A0.6870.99
31_K71_V0.6860.99
45_T92_K0.6840.99
64_G126_A0.6760.99
96_T120_G0.6750.99
95_F123_G0.6740.99
113_I128_G0.6710.99
40_Y45_T0.6700.99
40_Y44_F0.6670.99
62_I66_L0.6510.99
96_T118_A0.6490.99
14_K20_K0.6470.99
65_G130_W0.6460.99
60_I84_I0.6440.99
32_G101_V0.6430.99
122_L125_K0.6340.99
79_T82_L0.6330.99
19_F66_L0.6300.99
75_M132_I0.6280.99
96_T117_D0.6280.99
64_G111_V0.6210.99
24_V38_I0.6170.99
23_D43_E0.6160.99
99_G113_I0.6080.99
79_T130_W0.6010.99
98_E120_G0.5960.99
57_M126_A0.5950.98
77_Q132_I0.5830.98
79_T128_G0.5750.98
63_T99_G0.5680.98
88_E131_Y0.5660.98
110_V125_K0.5630.98
104_K109_I0.5630.98
34_A67_A0.5610.98
32_G71_V0.5530.98
24_V58_S0.5520.98
56_I90_M0.5510.98
76_D133_L0.5500.98
56_I61_D0.5500.98
99_G111_V0.5470.97
23_D41_K0.5420.97
80_Q131_Y0.5410.97
50_V91_Y0.5380.97
17_Q21_F0.5310.97
27_I36_V0.5310.97
16_D47_R0.5280.97
21_F55_I0.5270.97
77_Q130_W0.5270.97
85_N127_I0.5260.97
26_V66_L0.5260.97
51_L56_I0.5260.97
104_K132_I0.5240.97
113_I126_A0.5210.97
109_I130_W0.5200.97
18_I21_F0.5160.96
20_K43_E0.5150.96
17_Q42_E0.5150.96
46_R50_V0.5110.96
48_G78_V0.5080.96
32_G67_A0.5070.96
110_V127_I0.5050.96
78_V131_Y0.5010.96
84_I126_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t82A 2 0.95 99.9 0.273 Contact Map
3e8pA 3 0.95 99.9 0.278 Contact Map
3hduA 4 0.95 99.9 0.289 Contact Map
1sh8A 2 0.9857 99.9 0.291 Contact Map
4rmmA 2 0.9143 99.9 0.296 Contact Map
3f1tA 2 0.9286 99.9 0.303 Contact Map
3e29A 3 0.9429 99.9 0.304 Contact Map
3lmbA 2 0.95 99.9 0.304 Contact Map
1yocA 4 0.9571 99.9 0.309 Contact Map
3e1eA 3 0.9571 99.9 0.316 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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