GREMLIN Database
GLPK2 - Glycerol kinase 2
UniProt: P95907 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 499 (471)
Sequences: 12542 (8464)
Seq/√Len: 390.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_I145_D3.8141.00
200_R210_E3.7401.00
22_N26_E3.4201.00
114_W145_D3.2821.00
18_A59_A3.2581.00
192_N195_K2.8521.00
385_R479_Y2.8501.00
392_E424_I2.7941.00
126_K199_D2.7881.00
385_R389_E2.7391.00
97_I150_V2.7191.00
425_R467_I2.7141.00
416_Q420_D2.6621.00
38_H99_N2.6361.00
33_Y58_L2.6331.00
360_I372_I2.5821.00
191_F216_V2.5481.00
451_N455_E2.5401.00
412_N464_K2.5271.00
452_S455_E2.5221.00
31_G62_E2.5181.00
33_Y62_E2.5081.00
332_V371_H2.5061.00
401_I427_V2.4921.00
218_P221_D2.4831.00
98_Y147_L2.4831.00
53_W171_K2.4551.00
90_D153_K2.4241.00
91_A155_E2.4141.00
50_D171_K2.3611.00
20_I63_A2.2921.00
90_D93_S2.2851.00
385_R476_E2.2771.00
203_L210_E2.1591.00
192_N199_D2.1321.00
239_A244_A2.1301.00
200_R204_E2.1231.00
175_G215_E2.1011.00
321_A324_D2.1001.00
9_I56_Q2.0761.00
19_I436_S2.0661.00
169_I238_D2.0531.00
336_G371_H2.0511.00
197_E210_E2.0281.00
15_S32_Q2.0021.00
308_A376_I1.9781.00
160_K178_H1.9541.00
469_S472_K1.9291.00
114_W118_N1.9121.00
122_M125_D1.9051.00
50_D95_K1.9001.00
155_E160_K1.8951.00
265_S305_T1.8901.00
324_D327_P1.8831.00
36_P51_E1.8801.00
173_T235_I1.8741.00
6_I444_G1.8661.00
41_S44_Y1.8641.00
392_E398_K1.8551.00
339_Y481_A1.8481.00
331_S370_A1.8451.00
368_T371_H1.8261.00
62_E66_K1.8251.00
430_K461_T1.8211.00
7_L60_I1.8201.00
423_G473_E1.8161.00
5_F28_L1.8061.00
404_V415_M1.8061.00
7_L18_A1.7851.00
11_E16_A1.7781.00
228_V231_S1.7631.00
479_Y483_K1.7611.00
340_F360_I1.7481.00
320_D324_D1.7051.00
141_K145_D1.6911.00
312_F376_I1.6891.00
94_G170_W1.6851.00
420_D472_K1.6681.00
217_R221_D1.6621.00
126_K201_E1.6621.00
113_D117_E1.6571.00
427_V465_E1.6531.00
122_M201_E1.6341.00
122_M126_K1.6211.00
88_L143_I1.6151.00
420_D469_S1.6091.00
5_F20_I1.6061.00
90_D95_K1.6041.00
256_E401_I1.5951.00
236_S446_A1.5881.00
179_V217_R1.5831.00
310_Q314_D1.5791.00
382_Y478_R1.5531.00
87_I164_I1.5421.00
222_I236_S1.5351.00
222_I225_Y1.5291.00
110_N114_W1.5241.00
149_N152_S1.5091.00
88_L212_I1.5051.00
6_I449_Y1.5021.00
116_K120_F1.5011.00
473_E476_E1.4991.00
326_E330_A1.4911.00
425_R465_E1.4891.00
328_L331_S1.4871.00
357_R364_T1.4691.00
38_H51_E1.4601.00
471_N474_E1.4431.00
389_E483_K1.4411.00
327_P331_S1.4381.00
48_N51_E1.4331.00
121_G125_D1.4321.00
31_G59_A1.4231.00
63_A67_A1.4031.00
169_I223_Y1.3911.00
29_G63_A1.3811.00
374_R378_E1.3801.00
64_M71_S1.3771.00
31_G63_A1.3701.00
389_E392_E1.3651.00
328_L370_A1.3641.00
142_W146_N1.3641.00
413_L417_F1.3621.00
340_F344_F1.3591.00
76_G443_A1.3581.00
412_N428_R1.3581.00
444_G450_W1.3581.00
53_W57_M1.3541.00
412_N466_F1.3481.00
50_D54_N1.3401.00
430_K463_D1.3391.00
83_R240_G1.3371.00
230_G233_I1.3341.00
29_G66_K1.3311.00
20_I67_A1.3181.00
91_A160_K1.3121.00
225_Y232_S1.3111.00
302_I383_Q1.3021.00
261_Y418_Q1.3021.00
209_P212_I1.3011.00
363_I367_T1.2981.00
167_Y171_K1.2961.00
257_V399_I1.2951.00
9_I60_I1.2851.00
381_A417_F1.2831.00
173_T224_G1.2791.00
401_I425_R1.2741.00
472_K475_R1.2711.00
70_E73_Q1.2691.00
328_L369_K1.2691.00
89_W162_G1.2661.00
325_I373_A1.2631.00
29_G67_A1.2581.00
109_S113_D1.2581.00
259_S418_Q1.2581.00
329_A413_L1.2511.00
122_M205_L1.2471.00
474_E477_R1.2451.00
182_Y196_L1.2431.00
428_R466_F1.2411.00
16_A56_Q1.2371.00
381_A418_Q1.2341.00
340_F376_I1.2341.00
217_R223_Y1.2301.00
137_G206_L1.2281.00
381_A421_I1.2271.00
23_Q449_Y1.2241.00
423_G475_R1.2131.00
194_N275_P1.1961.00
239_A442_L1.1911.00
169_I179_V1.1911.00
203_L213_L1.1891.00
415_M466_F1.1861.00
144_L151_R1.1831.00
222_I234_P1.1781.00
323_D326_E1.1751.00
123_I131_P1.1731.00
338_V367_T1.1701.00
21_Y27_V1.1691.00
254_M272_G1.1691.00
20_I69_I1.1681.00
111_I141_K1.1661.00
410_K432_M1.1621.00
327_P330_A1.1601.00
361_I485_A1.1551.00
16_A55_A1.1551.00
5_F73_Q1.1431.00
253_D457_K1.1411.00
147_L150_V1.1371.00
273_S293_R1.1341.00
94_G178_H1.1341.00
58_L62_E1.1331.00
322_S325_I1.1331.00
54_N58_L1.1281.00
201_E204_E1.1271.00
417_F421_I1.1241.00
175_G179_V1.1231.00
423_G476_E1.1211.00
118_N205_L1.1141.00
316_L372_I1.1131.00
46_E99_N1.1091.00
85_T100_A1.1081.00
324_D328_L1.1081.00
326_E412_N1.1051.00
48_N99_N1.1011.00
64_M67_A1.0971.00
110_N113_D1.0951.00
256_E403_K1.0941.00
386_D483_K1.0901.00
255_G400_N1.0891.00
9_I18_A1.0881.00
326_E329_A1.0871.00
112_T131_P1.0861.00
182_Y216_V1.0771.00
389_E479_Y1.0751.00
385_R422_L1.0751.00
222_I446_A1.0721.00
56_Q168_L1.0711.00
52_I164_I1.0651.00
304_I308_A1.0651.00
326_E411_D1.0631.00
253_D454_N1.0621.00
88_L154_A1.0621.00
191_F195_K1.0611.00
253_D256_E1.0601.00
149_N153_K1.0601.00
182_Y191_F1.0601.00
98_Y150_V1.0491.00
76_G447_I1.0491.00
88_L140_I1.0481.00
304_I307_A1.0471.00
476_E480_N1.0461.00
79_V169_I1.0441.00
154_A212_I1.0401.00
69_I73_Q1.0391.00
37_Q47_H1.0371.00
49_P87_I1.0321.00
403_K427_V1.0241.00
388_I422_L1.0221.00
21_Y440_A1.0221.00
6_I447_I1.0131.00
462_V465_E1.0131.00
107_R142_W1.0121.00
445_L456_L1.0121.00
469_S473_E1.0111.00
77_I233_I1.0091.00
203_L208_I1.0061.00
328_L373_A1.0051.00
308_A340_F1.0031.00
113_D116_K1.0011.00
380_I408_G0.9971.00
441_M456_L0.9911.00
111_I114_W0.9851.00
162_G178_H0.9831.00
257_V269_M0.9791.00
179_V223_Y0.9791.00
137_G189_M0.9781.00
35_F55_A0.9771.00
481_A484_E0.9741.00
51_E54_N0.9721.00
123_I189_M0.9701.00
111_I146_N0.9681.00
45_V104_Q0.9651.00
56_Q60_I0.9631.00
76_G236_S0.9601.00
353_D356_A0.9591.00
151_R154_A0.9581.00
57_M61_K0.9571.00
61_K65_K0.9541.00
382_Y421_I0.9521.00
470_I475_R0.9501.00
180_T185_A0.9501.00
347_L350_P0.9501.00
5_F69_I0.9491.00
62_E65_K0.9481.00
253_D400_N0.9471.00
367_T371_H0.9451.00
334_D337_G0.9451.00
31_G66_K0.9441.00
6_I76_G0.9421.00
18_A63_A0.9391.00
408_G414_L0.9391.00
258_K405_D0.9361.00
114_W117_E0.9331.00
340_F375_A0.9311.00
444_G449_Y0.9281.00
64_M74_V0.9261.00
225_Y234_P0.9221.00
80_T435_A0.9221.00
455_E458_Q0.9191.00
140_I161_F0.9171.00
88_L161_F0.9161.00
166_T180_T0.9111.00
22_N28_L0.9081.00
7_L20_I0.9041.00
253_D458_Q0.8981.00
470_I473_E0.8961.00
75_A447_I0.8951.00
150_V153_K0.8941.00
155_E211_S0.8941.00
79_V168_L0.8911.00
196_L294_V0.8911.00
374_R413_L0.8911.00
422_L425_R0.8901.00
125_D194_N0.8881.00
441_M460_W0.8871.00
358_G363_I0.8861.00
288_G294_V0.8851.00
401_I465_E0.8841.00
95_K171_K0.8841.00
196_L218_P0.8831.00
385_R421_I0.8811.00
21_Y437_M0.8761.00
402_L422_L0.8721.00
363_I372_I0.8671.00
450_W456_L0.8671.00
84_E187_R0.8651.00
330_A413_L0.8641.00
86_T161_F0.8601.00
267_I388_I0.8581.00
143_I150_V0.8581.00
226_T233_I0.8581.00
148_P152_S0.8571.00
290_E294_V0.8551.00
33_Y59_A0.8521.00
382_Y479_Y0.8521.00
265_S384_N0.8511.00
236_S447_I0.8511.00
182_Y218_P0.8511.00
20_I74_V0.8501.00
154_A161_F0.8471.00
98_Y143_I0.8471.00
7_L74_V0.8461.00
74_V233_I0.8421.00
114_W141_K0.8421.00
228_V232_S0.8391.00
11_E168_L0.8391.00
97_I153_K0.8371.00
141_K144_L0.8341.00
125_D277_F0.8331.00
332_V335_T0.8311.00
329_A332_V0.8281.00
78_G236_S0.8271.00
79_V172_L0.8251.00
245_A405_D0.8241.00
266_F301_S0.8231.00
83_R299_E0.8211.00
217_R237_G0.8201.00
72_R230_G0.8201.00
11_E56_Q0.8191.00
229_L232_S0.8181.00
470_I474_E0.8161.00
163_T188_T0.8111.00
356_A360_I0.8111.00
445_L452_S0.8111.00
182_Y288_G0.8061.00
242_Q266_F0.8011.00
91_A153_K0.8011.00
339_Y361_I0.8011.00
356_A359_L0.8001.00
225_Y231_S0.8001.00
40_P44_Y0.7991.00
174_N227_E0.7981.00
311_W314_D0.7971.00
89_W94_G0.7941.00
325_I329_A0.7931.00
137_G190_L0.7921.00
106_R132_D0.7921.00
197_E215_E0.7911.00
319_I325_I0.7891.00
60_I64_M0.7841.00
34_D310_Q0.7821.00
185_A198_W0.7811.00
112_T133_P0.7791.00
229_L233_I0.7771.00
116_K131_P0.7771.00
191_F196_L0.7761.00
377_L417_F0.7751.00
197_E200_R0.7741.00
269_M391_M0.7731.00
272_G295_T0.7701.00
360_I376_I0.7701.00
421_I475_R0.7691.00
290_E293_R0.7691.00
388_I392_E0.7691.00
110_N146_N0.7691.00
21_Y431_V0.7681.00
103_W264_G0.7671.00
377_L411_D0.7661.00
350_P353_D0.7651.00
445_L453_L0.7631.00
198_W213_L0.7611.00
34_D313_R0.7611.00
305_T380_I0.7611.00
179_V215_E0.7601.00
427_V462_V0.7601.00
455_E459_K0.7591.00
312_F372_I0.7581.00
110_N145_D0.7581.00
257_V402_L0.7581.00
249_Q405_D0.7571.00
83_R184_N0.7551.00
259_S265_S0.7541.00
409_A432_M0.7541.00
416_Q469_S0.7521.00
323_D327_P0.7511.00
89_W178_H0.7501.00
141_K207_K0.7501.00
404_V418_Q0.7481.00
112_T138_S0.7471.00
404_V428_R0.7441.00
49_P99_N0.7431.00
332_V336_G0.7431.00
165_D238_D0.7401.00
444_G448_N0.7401.00
113_D355_Y0.7391.00
94_G155_E0.7381.00
474_E478_R0.7371.00
89_W160_K0.7361.00
337_G478_R0.7351.00
46_E107_R0.7351.00
259_S384_N0.7341.00
170_W178_H0.7331.00
312_F373_A0.7321.00
386_D479_Y0.7311.00
183_S287_W0.7281.00
477_R481_A0.7281.00
75_A449_Y0.7271.00
382_Y475_R0.7241.00
226_T229_L0.7231.00
385_R483_K0.7231.00
90_D97_I0.7231.00
192_N197_E0.7221.00
13_T102_V0.7211.00
35_F47_H0.7201.00
51_E55_A0.7201.00
8_A78_G0.7201.00
50_D167_Y0.7191.00
330_A416_Q0.7191.00
201_E205_L0.7181.00
270_N295_T0.7181.00
477_R480_N0.7161.00
484_E487_K0.7151.00
126_K192_N0.7121.00
76_G234_P0.7121.00
409_A415_M0.7121.00
390_I394_E0.7091.00
33_Y55_A0.7071.00
381_A414_L0.7041.00
450_W459_K0.7021.00
183_S239_A0.7021.00
336_G367_T0.7001.00
77_I226_T0.6991.00
30_I433_E0.6991.00
249_Q258_K0.6981.00
199_D202_I0.6961.00
180_T214_P0.6961.00
160_K212_I0.6951.00
478_R481_A0.6951.00
11_E55_A0.6951.00
27_V30_I0.6941.00
300_G387_V0.6920.99
16_A35_F0.6920.99
462_V468_P0.6920.99
231_S234_P0.6910.99
223_Y237_G0.6870.99
180_T216_V0.6870.99
54_N57_M0.6870.99
322_S326_E0.6860.99
88_L97_I0.6860.99
57_M171_K0.6840.99
121_G124_K0.6820.99
141_K151_R0.6800.99
227_E232_S0.6780.99
225_Y228_V0.6770.99
335_T339_Y0.6770.99
64_M69_I0.6770.99
24_D459_K0.6760.99
245_A435_A0.6750.99
169_I173_T0.6720.99
404_V426_V0.6710.99
417_F475_R0.6700.99
56_Q59_A0.6690.99
317_R369_K0.6670.99
87_I100_A0.6670.99
312_F316_L0.6660.99
6_I75_A0.6650.99
140_I190_L0.6640.99
456_L460_W0.6640.99
219_S238_D0.6590.99
340_F379_S0.6590.99
317_R320_D0.6560.99
334_D374_R0.6540.99
483_K487_K0.6510.99
71_S74_V0.6510.99
241_D263_T0.6510.99
251_A256_E0.6500.99
123_I202_I0.6500.99
50_D96_P0.6500.99
127_T202_I0.6500.99
337_G374_R0.6500.99
183_S219_S0.6490.99
90_D155_E0.6470.99
329_A374_R0.6460.99
19_I27_V0.6440.99
23_Q75_A0.6440.99
425_R468_P0.6440.99
119_Y202_I0.6420.99
378_E417_F0.6400.99
400_N424_I0.6400.99
5_F67_A0.6390.99
89_W170_W0.6390.99
50_D99_N0.6360.99
89_W167_Y0.6360.99
101_I107_R0.6360.99
401_I424_I0.6360.99
476_E479_Y0.6350.99
167_Y170_W0.6340.99
265_S418_Q0.6340.99
60_I63_A0.6330.99
330_A412_N0.6320.99
302_I387_V0.6320.99
222_I447_I0.6310.99
81_N184_N0.6300.99
467_I470_I0.6290.99
472_K476_E0.6260.99
454_N457_K0.6260.99
160_K170_W0.6260.99
115_L206_L0.6240.99
441_M459_K0.6230.99
441_M445_L0.6220.99
141_K206_L0.6220.99
21_Y436_S0.6210.99
86_T136_S0.6190.99
259_S402_L0.6190.99
58_L61_K0.6190.99
402_L426_V0.6170.99
351_Y386_D0.6160.99
457_K460_W0.6130.99
87_I96_P0.6120.99
131_P189_M0.6100.99
309_V325_I0.6090.99
357_R360_I0.6070.99
240_G243_Q0.6060.99
268_L297_A0.6060.99
30_I66_K0.6050.99
402_L424_I0.6050.99
374_R417_F0.6050.99
428_R463_D0.6050.99
166_T178_H0.6040.99
82_Q103_W0.6040.99
196_L288_G0.6030.99
280_N298_L0.6020.99
57_M60_I0.6010.99
452_S458_Q0.5990.99
416_Q466_F0.5980.99
320_D369_K0.5960.98
204_E209_P0.5960.98
347_L353_D0.5960.98
336_G366_G0.5950.98
226_T230_G0.5940.98
337_G371_H0.5930.98
332_V370_A0.5930.98
411_D414_L0.5920.98
335_T371_H0.5910.98
275_P283_T0.5890.98
480_N483_K0.5860.98
313_R322_S0.5860.98
115_L138_S0.5840.98
353_D357_R0.5840.98
144_L207_K0.5830.98
202_I206_L0.5830.98
218_P288_G0.5820.98
46_E98_Y0.5820.98
109_S133_P0.5800.98
81_N164_I0.5800.98
27_V431_V0.5790.98
337_G378_E0.5780.98
261_Y404_V0.5780.98
96_P99_N0.5780.98
399_I424_I0.5770.98
94_G160_K0.5760.98
108_T138_S0.5750.98
346_G350_P0.5750.98
334_D371_H0.5750.98
61_K229_L0.5740.98
135_F187_R0.5740.98
39_Y45_V0.5740.98
445_L448_N0.5730.98
242_Q260_T0.5730.98
430_K462_V0.5730.98
341_V359_L0.5730.98
329_A373_A0.5720.98
271_I275_P0.5710.98
85_T102_V0.5710.98
335_T378_E0.5710.98
326_E413_L0.5690.98
50_D53_W0.5680.98
52_I100_A0.5670.98
107_R146_N0.5670.98
415_M428_R0.5670.98
271_I298_L0.5660.98
6_I450_W0.5660.98
431_V437_M0.5660.98
26_E430_K0.5650.98
83_R187_R0.5650.98
204_E207_K0.5630.98
342_P379_S0.5630.98
140_I212_I0.5630.98
101_I143_I0.5620.98
315_G368_T0.5620.98
129_L135_F0.5620.98
445_L450_W0.5620.98
248_G434_T0.5620.98
416_Q419_A0.5620.98
272_G275_P0.5610.98
475_R478_R0.5600.98
194_N197_E0.5590.98
175_G217_R0.5590.98
208_I213_L0.5580.98
246_L268_L0.5580.98
412_N416_Q0.5580.98
188_T198_W0.5570.98
423_G470_I0.5570.98
341_V486_V0.5540.98
338_V372_I0.5530.98
346_G349_A0.5530.98
234_P447_I0.5520.98
138_S189_M0.5520.98
378_E382_Y0.5510.97
48_N54_N0.5500.97
26_E461_T0.5500.97
409_A428_R0.5490.97
380_I414_L0.5490.97
123_I206_L0.5480.97
49_P100_A0.5470.97
265_S302_I0.5470.97
84_E103_W0.5450.97
250_V457_K0.5420.97
353_D360_I0.5410.97
333_P336_G0.5410.97
190_L198_W0.5400.97
343_A347_L0.5400.97
215_E221_D0.5390.97
190_L213_L0.5390.97
14_T17_R0.5370.97
436_S439_V0.5360.97
267_I387_V0.5350.97
13_T103_W0.5350.97
297_A301_S0.5350.97
84_E264_G0.5320.97
77_I235_I0.5310.97
286_A296_Y0.5300.97
151_R155_E0.5300.97
351_Y356_A0.5290.97
219_S239_A0.5290.97
417_F478_R0.5280.97
95_K153_K0.5280.97
334_D338_V0.5270.97
120_F124_K0.5270.97
162_G170_W0.5260.97
418_Q422_L0.5260.97
328_L332_V0.5250.97
220_S446_A0.5250.97
341_V485_A0.5240.97
86_T143_I0.5240.97
74_V229_L0.5230.97
335_T374_R0.5230.97
67_A71_S0.5230.97
230_G234_P0.5230.97
329_A377_L0.5220.97
310_Q322_S0.5220.97
419_A426_V0.5210.97
5_F72_R0.5200.96
456_L459_K0.5190.96
84_E240_G0.5190.96
88_L98_Y0.5180.96
89_W155_E0.5180.96
334_D378_E0.5160.96
80_T439_V0.5150.96
165_D180_T0.5150.96
306_G310_Q0.5140.96
250_V460_W0.5140.96
133_P354_P0.5140.96
325_I411_D0.5140.96
259_S267_I0.5130.96
351_Y483_K0.5120.96
325_I328_L0.5110.96
247_F441_M0.5090.96
345_V365_R0.5080.96
351_Y486_V0.5070.96
454_N458_Q0.5070.96
195_K198_W0.5060.96
337_G481_A0.5060.96
382_Y481_A0.5050.96
273_S295_T0.5050.96
334_D478_R0.5040.96
260_T266_F0.5040.96
339_Y382_Y0.5040.96
263_T307_A0.5030.96
305_T308_A0.5020.96
19_I437_M0.5020.96
151_R207_K0.5020.96
8_A436_S0.5020.96
83_R164_I0.5010.96
310_Q313_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9639 100 0.135 Contact Map
3ezwA 3 0.986 100 0.138 Contact Map
2zf5O 3 0.986 100 0.14 Contact Map
3h3nX 3 0.99 100 0.141 Contact Map
2d4wA 2 0.986 100 0.142 Contact Map
3g25A 3 0.986 100 0.145 Contact Map
3wxlA 2 0.984 100 0.152 Contact Map
2dpnA 2 0.976 100 0.156 Contact Map
2w40A 3 0.984 100 0.158 Contact Map
3ifrA 2 0.9519 100 0.158 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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