GREMLIN Database
AMID - Amidase
UniProt: P95896 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 504 (443)
Sequences: 14129 (9875)
Seq/√Len: 469.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_E73_A4.4641.00
121_D129_L4.0911.00
45_D69_N3.5721.00
307_K310_E3.2771.00
422_A495_L2.9801.00
163_N166_Y2.9591.00
466_M496_A2.9031.00
286_K318_D2.8991.00
150_S173_S2.8971.00
121_D126_S2.8151.00
75_V89_K2.7941.00
186_M243_L2.7381.00
41_Y76_W2.7121.00
234_A240_V2.7001.00
33_L39_E2.6951.00
485_R488_E2.6811.00
175_S187_A2.6201.00
488_E491_K2.5311.00
126_S130_D2.5111.00
205_I233_M2.4621.00
33_L38_L2.3971.00
458_F483_I2.3641.00
317_E420_Y2.3151.00
196_I207_G2.2631.00
484_G488_E2.2481.00
283_G420_Y2.2151.00
128_I133_G2.2041.00
63_P105_P2.1881.00
206_Y240_V2.1271.00
281_K315_K2.0771.00
93_I186_M2.0671.00
497_N501_R2.0451.00
282_V422_A2.0391.00
95_I125_V2.0391.00
78_T89_K2.0211.00
42_E45_D2.0081.00
65_M104_I2.0011.00
299_D303_L2.0001.00
482_I492_V1.9771.00
32_Q36_L1.9761.00
161_P203_V1.9671.00
484_G492_V1.9561.00
238_K497_N1.9461.00
245_E268_P1.9461.00
86_G89_K1.9451.00
26_E29_S1.9431.00
150_S158_V1.9291.00
61_G94_C1.8751.00
48_P64_P1.8571.00
284_I306_A1.8401.00
208_L489_E1.8321.00
241_A497_N1.8161.00
127_R249_G1.8091.00
94_C139_T1.8011.00
431_K473_S1.7991.00
44_L68_E1.7731.00
395_N398_Y1.7401.00
105_P115_G1.7351.00
465_A483_I1.7221.00
54_V183_Y1.7161.00
87_K131_E1.6841.00
206_Y237_V1.6721.00
306_A316_V1.6661.00
51_T183_Y1.6651.00
166_Y476_L1.6551.00
179_V233_M1.6511.00
434_R437_S1.6381.00
424_I482_I1.6211.00
166_Y434_R1.6091.00
31_L35_K1.6051.00
165_E434_R1.6021.00
78_T85_E1.5911.00
58_R181_S1.5881.00
206_Y466_M1.5821.00
308_K311_D1.5771.00
28_K238_K1.5661.00
71_Y129_L1.5531.00
287_E320_S1.5421.00
100_M106_M1.5411.00
94_C184_C1.5381.00
27_L186_M1.5291.00
59_T156_W1.5251.00
301_L478_V1.5171.00
236_T239_D1.5161.00
31_L91_K1.5021.00
58_R177_V1.4881.00
306_A424_I1.4881.00
215_V247_I1.4861.00
93_I135_I1.4811.00
106_M138_K1.4781.00
220_A230_L1.4721.00
208_L493_L1.4651.00
97_D138_K1.4651.00
214_L244_L1.4561.00
108_N221_F1.4521.00
42_E69_N1.4391.00
99_V230_L1.4381.00
70_P73_A1.4381.00
73_A77_I1.4361.00
30_F185_D1.4301.00
44_L69_N1.4211.00
189_G233_M1.4201.00
99_V188_V1.4191.00
65_M71_Y1.4181.00
45_D49_D1.4121.00
209_K459_D1.4091.00
427_T467_N1.4051.00
162_R472_Y1.4041.00
176_A203_V1.4041.00
98_N145_C1.4021.00
44_L134_E1.4021.00
206_Y500_E1.3801.00
425_M483_I1.3771.00
131_E246_V1.3731.00
71_Y74_L1.3721.00
303_L307_K1.3721.00
98_N141_C1.3681.00
123_T126_S1.3641.00
307_K311_D1.3621.00
25_E29_S1.3491.00
25_E33_L1.3421.00
317_E419_K1.3381.00
85_E89_K1.3361.00
63_P104_I1.3311.00
70_P74_L1.3301.00
159_L435_Y1.3281.00
26_E238_K1.3221.00
94_C178_A1.3161.00
129_L135_I1.3161.00
51_T64_P1.3161.00
279_D315_K1.3061.00
49_D53_R1.3011.00
277_V314_I1.2991.00
151_H436_K1.2961.00
286_K303_L1.2961.00
463_H483_I1.2911.00
301_L471_G1.2891.00
202_W428_T1.2881.00
41_Y44_L1.2871.00
111_K114_E1.2861.00
51_T136_V1.2841.00
34_L79_S1.2761.00
67_E104_I1.2741.00
140_T152_T1.2721.00
27_L91_K1.2711.00
177_V181_S1.2711.00
297_D473_S1.2571.00
240_V493_L1.2551.00
44_L136_V1.2531.00
74_L77_I1.2531.00
415_S418_R1.2461.00
301_L470_V1.2461.00
381_K385_M1.2441.00
268_P271_K1.2421.00
101_I106_M1.2391.00
169_G198_I1.2371.00
74_L78_T1.2351.00
294_S454_N1.2351.00
281_K317_E1.2281.00
67_E71_Y1.2191.00
159_L164_P1.2191.00
305_S480_L1.2181.00
26_E236_T1.2101.00
124_V188_V1.2081.00
31_L34_L1.2071.00
443_E446_I1.2041.00
200_S233_M1.1991.00
50_Y54_V1.1951.00
101_I118_P1.1951.00
47_L136_V1.1921.00
188_V247_I1.1891.00
300_E304_D1.1861.00
279_D314_I1.1851.00
40_S43_R1.1801.00
61_G137_A1.1741.00
100_M116_F1.1721.00
196_I232_P1.1691.00
204_G472_Y1.1691.00
123_T127_R1.1681.00
28_K242_L1.1671.00
92_R185_D1.1641.00
172_S175_S1.1631.00
305_S499_F1.1611.00
372_R375_D1.1601.00
466_M492_V1.1541.00
157_P435_Y1.1531.00
37_Q79_S1.1411.00
42_E76_W1.1411.00
62_R109_G1.1401.00
232_P243_L1.1381.00
55_K183_Y1.1361.00
161_P177_V1.1301.00
100_M118_P1.1291.00
258_P487_F1.1281.00
94_C175_S1.1251.00
211_T486_H1.1211.00
126_S129_L1.1191.00
62_R140_T1.1191.00
411_E415_S1.1141.00
191_D197_R1.1051.00
77_I81_K1.1031.00
414_D486_H1.1021.00
182_G235_N1.0951.00
282_V314_I1.0911.00
465_A481_M1.0911.00
67_E129_L1.0891.00
88_L133_G1.0891.00
55_K60_L1.0841.00
25_E30_F1.0831.00
208_L244_L1.0811.00
104_I118_P1.0761.00
110_S144_L1.0751.00
34_L41_Y1.0731.00
127_R130_D1.0671.00
298_V478_V1.0661.00
78_T83_K1.0641.00
48_P52_P1.0641.00
47_L183_Y1.0621.00
68_E134_E1.0621.00
94_C187_A1.0601.00
101_I138_K1.0591.00
458_F465_A1.0571.00
75_V78_T1.0561.00
24_D182_G1.0561.00
330_I405_L1.0521.00
280_M495_L1.0521.00
319_T416_A1.0511.00
323_L412_A1.0501.00
302_V306_A1.0481.00
280_M491_K1.0481.00
282_V424_I1.0461.00
35_K84_E1.0401.00
214_L248_A1.0371.00
306_A310_E1.0351.00
296_K300_E1.0321.00
286_K320_S1.0271.00
467_N479_G1.0241.00
179_V187_A1.0231.00
101_I104_I1.0211.00
237_V500_E1.0141.00
283_G319_T1.0111.00
105_P117_V1.0081.00
308_K312_Y1.0071.00
473_S478_V1.0061.00
283_G416_A1.0051.00
124_V230_L1.0011.00
47_L185_D0.9981.00
48_P69_N0.9971.00
309_L499_F0.9941.00
140_T155_P0.9921.00
189_G196_I0.9891.00
41_Y75_V0.9871.00
310_E315_K0.9811.00
326_M405_L0.9741.00
190_G230_L0.9721.00
102_A121_D0.9711.00
202_W432_A0.9711.00
280_M314_I0.9681.00
277_V280_M0.9671.00
485_R491_K0.9651.00
412_A415_S0.9621.00
41_Y89_K0.9571.00
304_D307_K0.9541.00
408_V412_A0.9511.00
141_C145_C0.9511.00
208_L466_M0.9501.00
468_I482_I0.9481.00
47_L184_C0.9481.00
158_V177_V0.9481.00
120_M126_S0.9461.00
482_I495_L0.9461.00
211_T489_E0.9461.00
158_V168_A0.9461.00
184_C187_A0.9431.00
122_A125_V0.9431.00
126_S253_L0.9401.00
206_Y468_I0.9391.00
294_S299_D0.9371.00
50_Y53_R0.9371.00
301_L304_D0.9361.00
304_D308_K0.9351.00
285_V288_G0.9341.00
58_R164_P0.9271.00
208_L240_V0.9271.00
284_I302_V0.9261.00
79_S85_E0.9201.00
245_E270_S0.9151.00
201_S428_T0.9141.00
226_T338_G0.9141.00
211_T487_F0.9131.00
95_I135_I0.9121.00
237_V496_A0.9031.00
57_Q164_P0.9011.00
215_V244_L0.8961.00
399_Y403_R0.8951.00
407_I411_E0.8951.00
410_K414_D0.8951.00
470_V478_V0.8911.00
61_G139_T0.8911.00
34_L91_K0.8901.00
51_T55_K0.8901.00
84_E89_K0.8891.00
27_L242_L0.8881.00
272_L490_D0.8881.00
405_L408_V0.8881.00
272_L494_K0.8871.00
490_D494_K0.8861.00
123_T218_T0.8861.00
178_A183_Y0.8831.00
93_I133_G0.8801.00
209_K229_H0.8801.00
30_F34_L0.8791.00
52_P64_P0.8741.00
93_I243_L0.8721.00
280_M422_A0.8711.00
107_L115_G0.8681.00
482_I499_F0.8671.00
167_M202_W0.8651.00
101_I121_D0.8641.00
188_V230_L0.8601.00
238_K500_E0.8591.00
470_V480_L0.8591.00
308_K499_F0.8571.00
99_V122_A0.8531.00
79_S89_K0.8521.00
214_L489_E0.8511.00
139_T175_S0.8501.00
382_G385_M0.8501.00
40_S76_W0.8491.00
218_T253_L0.8481.00
166_Y432_A0.8461.00
377_P380_V0.8401.00
243_L247_I0.8401.00
200_S207_G0.8391.00
76_W80_I0.8361.00
55_K59_T0.8321.00
67_E70_P0.8311.00
206_Y496_A0.8301.00
148_G198_I0.8281.00
244_L489_E0.8231.00
27_L31_L0.8231.00
71_Y75_V0.8211.00
101_I135_I0.8191.00
44_L48_P0.8191.00
104_I138_K0.8181.00
98_N190_G0.8181.00
99_V190_G0.8131.00
94_C137_A0.8111.00
29_S33_L0.8101.00
41_Y79_S0.8101.00
110_S143_D0.8091.00
254_D257_Q0.8091.00
250_R257_Q0.8081.00
418_R485_R0.8061.00
124_V215_V0.8061.00
406_S410_K0.8051.00
69_N73_A0.8051.00
77_I80_I0.8041.00
491_K494_K0.8031.00
95_I101_I0.8031.00
422_A491_K0.8031.00
34_L39_E0.8031.00
159_L165_E0.8001.00
179_V205_I0.8001.00
51_T61_G0.7981.00
49_D52_P0.7971.00
297_D474_N0.7961.00
400_A404_N0.7941.00
251_D254_D0.7941.00
34_L89_K0.7941.00
75_V79_S0.7911.00
403_R406_S0.7891.00
333_P402_A0.7881.00
411_E414_D0.7881.00
61_G184_C0.7861.00
295_E431_K0.7831.00
282_V309_L0.7811.00
99_V220_A0.7801.00
82_G86_G0.7791.00
120_M218_T0.7761.00
214_L266_V0.7731.00
31_L79_S0.7711.00
127_R216_P0.7711.00
140_T156_W0.7701.00
302_V470_V0.7681.00
344_I348_G0.7661.00
125_V135_I0.7661.00
37_Q80_I0.7651.00
44_L47_L0.7641.00
238_K242_L0.7631.00
176_A233_M0.7611.00
489_E492_V0.7601.00
303_L310_E0.7601.00
123_T216_P0.7601.00
168_A177_V0.7561.00
168_A203_V0.7541.00
100_M120_M0.7531.00
139_T187_A0.7431.00
166_Y474_N0.7431.00
300_E303_L0.7411.00
417_L485_R0.7391.00
95_I188_V0.7391.00
295_E473_S0.7391.00
296_K299_D0.7391.00
166_Y433_M0.7311.00
139_T178_A0.7301.00
78_T81_K0.7291.00
309_L495_L0.7281.00
88_L242_L0.7251.00
303_L318_D0.7241.00
413_Y461_T0.7241.00
46_S49_D0.7221.00
208_L492_V0.7211.00
312_Y498_V0.7151.00
289_F302_V0.7141.00
201_S479_G0.7141.00
29_S32_Q0.7141.00
33_L36_L0.7141.00
31_L242_L0.7131.00
198_I428_T0.7101.00
193_G331_W0.7101.00
466_M493_L0.7101.00
432_A476_L0.7091.00
281_K420_Y0.7011.00
414_D485_R0.6961.00
35_K79_S0.6951.00
175_S178_A0.6951.00
180_A205_I0.6941.00
87_K246_V0.6941.00
104_I135_I0.6931.00
58_R183_Y0.6921.00
202_W451_M0.6881.00
192_Q228_D0.6871.00
215_V232_P0.6851.00
398_Y401_K0.6811.00
114_E154_Y0.6791.00
25_E39_E0.6791.00
408_V411_E0.6781.00
225_P342_T0.6761.00
45_D73_A0.6761.00
414_D463_H0.6751.00
27_L185_D0.6751.00
99_V124_V0.6741.00
417_L463_H0.6741.00
136_V184_C0.6731.00
167_M435_Y0.6701.00
396_N399_Y0.6701.00
236_T240_V0.6701.00
60_L183_Y0.6691.00
60_L178_A0.6691.00
196_I231_G0.6681.00
422_A482_I0.6681.00
102_A120_M0.6631.00
190_G220_A0.6621.00
244_L269_Y0.6611.00
186_M234_A0.6591.00
284_I318_D0.6581.00
288_G324_H0.6581.00
309_L314_I0.6551.00
276_D494_K0.6551.00
463_H486_H0.6531.00
39_E43_R0.6531.00
61_G183_Y0.6521.00
321_I416_A0.6511.00
410_K486_H0.6501.00
78_T132_A0.6491.00
223_I335_A0.6481.00
297_D301_L0.6451.00
101_I129_L0.6451.00
27_L34_L0.6451.00
373_A377_P0.6441.00
48_P51_T0.6411.00
30_F33_L0.6411.00
312_Y499_F0.6401.00
319_T420_Y0.6391.00
67_E102_A0.6391.00
425_M465_A0.6371.00
150_S168_A0.6361.00
470_V499_F0.6351.00
484_G491_K0.6351.00
497_N500_E0.6341.00
407_I410_K0.6331.00
458_F463_H0.6311.00
55_K158_V0.6300.99
297_D431_K0.6300.99
73_A76_W0.6290.99
54_V181_S0.6280.99
373_A381_K0.6260.99
404_N408_V0.6260.99
79_S84_E0.6240.99
269_Y273_I0.6230.99
427_T479_G0.6230.99
28_K236_T0.6230.99
42_E72_G0.6210.99
297_D478_V0.6200.99
105_P114_E0.6200.99
314_I498_V0.6180.99
122_A219_G0.6180.99
241_A245_E0.6170.99
108_N113_L0.6150.99
280_M494_K0.6150.99
396_N400_A0.6130.99
162_R204_G0.6120.99
54_V57_Q0.6100.99
279_D498_V0.6090.99
142_E147_S0.6090.99
284_I316_V0.6090.99
142_E150_S0.6070.99
310_E316_V0.6060.99
32_Q35_K0.6060.99
103_G117_V0.6050.99
283_G318_D0.6040.99
309_L424_I0.6040.99
424_I480_L0.6040.99
489_E493_L0.6030.99
86_G131_E0.6030.99
305_S470_V0.6010.99
176_A180_A0.6000.99
334_I338_G0.5990.99
488_E492_V0.5990.99
72_G76_W0.5970.99
149_G167_M0.5970.99
277_V498_V0.5960.99
100_M138_K0.5940.99
28_K270_S0.5940.99
273_I497_N0.5940.99
431_K474_N0.5940.99
237_V497_N0.5930.99
232_P247_I0.5880.99
427_T455_T0.5880.99
68_E136_V0.5880.99
123_T253_L0.5870.99
55_K64_P0.5860.99
242_L245_E0.5860.99
331_W335_A0.5850.99
162_R180_A0.5850.99
89_K132_A0.5850.99
242_L270_S0.5840.99
188_V243_L0.5830.99
326_M329_D0.5810.99
250_R259_D0.5800.99
75_V85_E0.5790.99
244_L493_L0.5780.99
62_R107_L0.5770.99
111_K154_Y0.5760.99
214_L490_D0.5760.99
298_V431_K0.5760.99
162_R477_P0.5750.99
310_E318_D0.5740.99
380_V383_V0.5730.99
242_L246_V0.5720.99
491_K495_L0.5690.99
413_Y463_H0.5690.99
63_P138_K0.5680.99
98_N108_N0.5670.99
123_T251_D0.5660.99
175_S188_V0.5650.99
373_A385_M0.5640.99
140_T158_V0.5640.99
423_L483_I0.5640.99
28_K32_Q0.5610.99
102_A119_H0.5590.99
142_E173_S0.5590.99
189_G232_P0.5580.99
111_K375_D0.5580.99
319_T423_L0.5580.99
297_D300_E0.5570.99
248_A269_Y0.5560.99
295_E298_V0.5550.99
348_G392_K0.5510.99
275_G494_K0.5500.99
59_T158_V0.5500.99
267_K272_L0.5490.99
71_Y135_I0.5490.99
56_Y59_T0.5480.99
113_L116_F0.5430.99
218_T251_D0.5430.99
266_V269_Y0.5420.98
149_G433_M0.5420.98
212_H462_G0.5410.98
202_W433_M0.5400.98
106_M118_P0.5390.98
241_A494_K0.5390.98
65_M68_E0.5390.98
345_L348_G0.5380.98
160_N168_A0.5370.98
178_A184_C0.5360.98
101_I125_V0.5360.98
283_G417_L0.5350.98
121_D125_V0.5350.98
343_M346_G0.5350.98
68_E72_G0.5350.98
69_N72_G0.5340.98
217_Y230_L0.5330.98
201_S427_T0.5310.98
177_V203_V0.5310.98
282_V316_V0.5310.98
137_A178_A0.5310.98
128_I243_L0.5290.98
61_G64_P0.5290.98
52_P56_Y0.5290.98
145_C192_Q0.5290.98
394_Y398_Y0.5280.98
58_R158_V0.5280.98
468_I480_L0.5280.98
422_A484_G0.5280.98
283_G421_D0.5280.98
107_L114_E0.5280.98
212_H229_H0.5270.98
138_K141_C0.5260.98
151_H157_P0.5260.98
91_K185_D0.5250.98
185_D239_D0.5240.98
159_L163_N0.5230.98
55_K61_G0.5220.98
30_F39_E0.5210.98
413_Y423_L0.5210.98
380_V387_G0.5200.98
302_V424_I0.5200.98
446_I450_G0.5190.98
78_T84_E0.5190.98
394_Y399_Y0.5190.98
113_L346_G0.5180.98
208_L234_A0.5180.98
274_D497_N0.5170.98
47_L182_G0.5170.98
321_I324_H0.5160.98
83_K86_G0.5150.98
285_V321_I0.5150.98
285_V289_F0.5140.98
196_I200_S0.5140.98
281_K419_K0.5140.98
163_N476_L0.5130.98
309_L312_Y0.5130.98
196_I233_M0.5120.98
87_K245_E0.5120.98
334_I402_A0.5120.98
403_R407_I0.5110.98
303_L306_A0.5110.98
87_K132_A0.5100.98
37_Q43_R0.5100.98
217_Y254_D0.5080.98
431_K476_L0.5080.98
235_N239_D0.5070.98
232_P240_V0.5070.98
335_A338_G0.5070.98
145_C228_D0.5060.98
492_V495_L0.5050.98
302_V480_L0.5050.98
96_K171_S0.5040.98
98_N220_A0.5040.98
66_K70_P0.5040.98
281_K421_D0.5040.98
62_R154_Y0.5030.98
149_G438_E0.5030.98
96_K195_S0.5030.98
268_P272_L0.5030.98
272_L275_G0.5020.98
310_E313_G0.5020.98
211_T464_P0.5020.98
380_V384_L0.5010.97
283_G317_E0.5010.97
82_G89_K0.5000.97
161_P164_P0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ip4A 1 0.9385 100 0.107 Contact Map
4wj3A 1 0.9365 100 0.11 Contact Map
3h0lA 1 0.9266 100 0.117 Contact Map
3kfuE 1 0.9048 100 0.124 Contact Map
2gi3A 2 0.8631 100 0.14 Contact Map
1m22A 1 0.9147 100 0.14 Contact Map
2dc0A 2 0.8532 100 0.143 Contact Map
3a2qA 2 0.8929 100 0.144 Contact Map
4cp8A 2 0.879 100 0.161 Contact Map
3ppmA 2 0.9405 100 0.166 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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