GREMLIN Database
TDXH - Peroxiredoxin
UniProt: P95895 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (180)
Sequences: 3859 (1759)
Seq/√Len: 131.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_L158_R3.7121.00
68_T157_I3.4511.00
137_R143_P3.2111.00
31_Y36_F3.0891.00
34_R69_E2.9511.00
17_E24_R2.8771.00
131_D137_R2.7881.00
17_E26_K2.6641.00
62_E65_K2.6171.00
13_F112_L2.5361.00
60_Y64_K2.4711.00
19_I24_R2.4631.00
64_K69_E2.4461.00
45_F83_E2.4281.00
18_V101_I2.2861.00
59_K151_D2.2781.00
72_G100_I2.2641.00
158_R176_N2.2581.00
61_E65_K2.1671.00
137_R164_D2.1641.00
138_L156_A2.0531.00
57_A97_P1.9431.00
12_R135_V1.8861.00
107_N111_R1.8821.00
18_V108_V1.8491.00
175_P178_E1.8181.00
146_I159_A1.8041.00
59_K62_E1.7781.00
53_F98_F1.7211.00
35_W132_D1.6761.00
19_I78_N1.6701.00
116_H124_V1.6671.00
133_K164_D1.6531.00
89_E95_E1.6301.00
44_D81_H1.6091.00
61_E64_K1.6081.00
7_P136_V1.6021.00
15_E26_K1.5831.00
55_S173_N1.5531.00
106_G115_I1.5361.00
26_K29_D1.5091.00
36_F71_I1.4821.00
29_D32_K1.4701.00
126_A141_Y1.4671.00
75_V109_A1.4441.00
63_F154_L1.4331.00
122_A144_M1.4131.00
56_F70_L1.4021.00
75_V104_P1.3771.00
83_E86_M1.3291.00
20_T101_I1.2881.00
114_M128_F1.2851.00
151_D175_P1.2731.00
110_K117_A1.2641.00
109_A115_I1.2561.00
127_V153_I1.2171.00
13_F136_V1.2111.00
146_I160_L1.2070.99
55_S172_A1.2070.99
54_Y92_L1.2000.99
55_S58_K1.1920.99
60_Y97_P1.1870.99
129_V138_L1.1850.99
116_H119_S1.1690.99
106_G110_K1.1680.99
129_V157_I1.1580.99
136_V139_I1.1550.99
188_A191_T1.1370.99
140_L156_A1.1360.99
37_V153_I1.1320.99
152_E155_R1.1040.99
37_V157_I1.0890.99
88_I91_N1.0870.99
37_V129_V1.0850.99
56_F153_I1.0650.99
22_Q99_P1.0550.99
25_I71_I1.0530.99
15_E29_D1.0510.99
75_V123_T1.0310.98
30_D33_G1.0270.98
67_N161_Q1.0220.98
131_D164_D1.0010.98
8_L113_G1.0000.98
56_F150_I0.9960.98
82_I86_M0.9940.98
66_L157_I0.9740.98
108_V112_L0.9710.98
168_V184_V0.9620.97
35_W161_Q0.9620.97
66_L154_L0.9570.97
61_E97_P0.9530.97
77_S104_P0.9490.97
60_Y98_F0.9470.97
124_V144_M0.9460.97
7_P11_E0.9410.97
8_L11_E0.9390.97
38_L101_I0.9370.97
36_F69_E0.9320.97
78_N102_A0.9260.97
149_N153_I0.9140.97
16_M112_L0.9130.97
161_Q165_K0.9070.96
124_V142_Y0.9020.96
31_Y71_I0.8960.96
127_V140_L0.8950.96
186_N192_I0.8950.96
63_F70_L0.8920.96
37_V127_V0.8890.96
50_T88_I0.8850.96
129_V140_L0.8780.96
41_H44_D0.8720.95
54_Y58_K0.8720.95
14_P111_R0.8680.95
85_I100_I0.8570.95
110_K115_I0.8540.95
62_E158_R0.8500.95
21_T85_I0.8390.94
77_S80_S0.8320.94
162_L168_V0.8310.94
40_S73_L0.8270.94
60_Y70_L0.8270.94
62_E154_L0.8260.94
11_E118_Q0.8250.94
10_G124_V0.8240.94
62_E66_L0.8210.94
13_F108_V0.8180.94
140_L153_I0.8170.94
59_K150_I0.8170.94
59_K63_F0.8150.94
41_H72_G0.8090.93
73_L101_I0.8070.93
64_K97_P0.8050.93
163_V168_V0.8030.93
57_A60_Y0.8020.93
116_H144_M0.8000.93
55_S59_K0.8000.93
37_V68_T0.7960.93
86_M89_E0.7960.93
127_V173_N0.7930.93
39_F72_G0.7840.92
32_K134_G0.7820.92
31_Y38_L0.7800.92
158_R175_P0.7740.92
21_T78_N0.7740.92
162_L184_V0.7700.92
146_I170_T0.7680.91
38_L130_V0.7670.91
72_G96_I0.7650.91
48_V185_I0.7640.91
12_R136_V0.7610.91
78_N104_P0.7600.91
133_K137_R0.7570.91
138_L142_Y0.7560.91
146_I156_A0.7470.90
25_I31_Y0.7460.90
43_G77_S0.7380.90
112_L130_V0.7370.90
38_L112_L0.7330.89
13_F16_M0.7320.89
149_N173_N0.7310.89
189_P192_I0.7300.89
20_T23_G0.7300.89
59_K154_L0.7270.89
89_E94_V0.7270.89
79_I83_E0.7240.89
36_F130_V0.7210.89
132_D157_I0.7200.89
12_R32_K0.7190.88
107_N110_K0.7060.88
60_Y69_E0.7030.87
9_I124_V0.6980.87
47_P50_T0.6930.87
85_I95_E0.6890.86
27_L30_D0.6880.86
43_G76_D0.6870.86
154_L158_R0.6820.86
9_I136_V0.6780.85
129_V153_I0.6750.85
54_Y57_A0.6730.85
43_G122_A0.6730.85
49_C125_R0.6690.85
109_A123_T0.6650.84
162_L166_A0.6610.84
36_F134_G0.6570.84
131_D135_V0.6550.83
82_I85_I0.6540.83
26_K30_D0.6520.83
19_I102_A0.6480.83
30_D36_F0.6470.83
53_F72_G0.6410.82
126_A139_I0.6370.82
116_H120_S0.6320.81
56_F98_F0.6310.81
119_S144_M0.6300.81
43_G79_I0.6300.81
77_S83_E0.6290.81
119_S122_A0.6260.81
117_A120_S0.6250.80
77_S122_A0.6190.80
185_I191_T0.6110.79
48_V147_G0.6070.78
159_A170_T0.6060.78
145_E163_V0.6060.78
169_V187_P0.6040.78
9_I138_L0.6040.78
167_G187_P0.6040.78
10_G116_H0.6020.78
40_S114_M0.5940.77
105_M110_K0.5930.77
59_K173_N0.5920.77
146_I163_V0.5890.76
43_G80_S0.5880.76
142_Y156_A0.5870.76
56_F63_F0.5860.76
165_K176_N0.5850.76
148_R155_R0.5820.76
162_L165_K0.5800.75
11_E117_A0.5780.75
21_T82_I0.5740.75
127_V150_I0.5690.74
55_S151_D0.5660.74
67_N91_N0.5650.73
85_I89_E0.5640.73
16_M27_L0.5640.73
13_F27_L0.5630.73
43_G78_N0.5620.73
35_W160_L0.5610.73
187_P190_R0.5610.73
110_K118_Q0.5600.73
158_R177_N0.5590.73
25_I101_I0.5570.72
65_K176_N0.5570.72
127_V156_A0.5560.72
66_L161_Q0.5510.72
32_K133_K0.5460.71
55_S150_I0.5450.71
18_V25_I0.5410.70
186_N191_T0.5410.70
113_G126_A0.5400.70
43_G104_P0.5390.70
120_S144_M0.5390.70
185_I192_I0.5380.70
82_I192_I0.5380.70
27_L36_F0.5350.69
157_I161_Q0.5340.69
20_T25_I0.5330.69
75_V119_S0.5320.69
16_M130_V0.5310.69
16_M108_V0.5310.69
33_G134_G0.5290.69
75_V106_G0.5290.69
132_D164_D0.5270.68
80_S100_I0.5240.68
35_W164_D0.5190.67
58_K89_E0.5180.67
149_N172_A0.5180.67
127_V138_L0.5120.66
57_A85_I0.5110.66
57_A96_I0.5110.66
85_I93_K0.5100.66
25_I30_D0.5090.66
59_K149_N0.5080.65
168_V186_N0.5080.65
147_G177_N0.5060.65
184_V187_P0.5050.65
31_Y134_G0.5030.65
37_V56_F0.5020.65
38_L73_L0.5020.65
12_R133_K0.5010.64
149_N152_E0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a2vA 5 0.9721 100 0.317 Contact Map
2v2gA 2 0.9581 100 0.326 Contact Map
1prxA 2 0.9581 100 0.326 Contact Map
1xccA 2 0.9442 100 0.326 Contact Map
3w6gA 6 0.9349 100 0.331 Contact Map
3tjjA 3 0.7535 100 0.542 Contact Map
2c0dA 2 0.7814 100 0.564 Contact Map
3sbcA 3 0.8884 100 0.566 Contact Map
4rqxA 3 0.7488 100 0.566 Contact Map
2pn8A 4 0.8651 100 0.569 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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