GREMLIN Database
Y2105 - Uncharacterized protein SSO2105
UniProt: P95879 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (306)
Sequences: 4126 (3200)
Seq/√Len: 183.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
257_A261_N5.2951.00
337_E352_A4.1851.00
317_S324_V3.6151.00
284_F291_F3.2301.00
70_Y74_P3.0071.00
280_F313_G2.9501.00
310_L326_L2.8381.00
223_L309_L2.7551.00
308_Q312_H2.7271.00
264_S268_E2.6821.00
279_V361_G2.5601.00
239_T243_S2.4971.00
70_Y73_L2.4771.00
314_V326_L2.4191.00
136_V140_V2.3541.00
308_Q311_I2.3061.00
179_A191_L2.2601.00
278_V317_S2.2491.00
57_F60_K2.2391.00
239_T242_Y2.2271.00
331_G334_N2.1861.00
71_N74_P2.1701.00
267_L317_S2.1371.00
62_V66_T2.0651.00
332_T357_I2.0611.00
232_G235_I2.0501.00
335_S342_M2.0411.00
327_V357_I1.9781.00
260_L315_I1.8661.00
223_L258_L1.8541.00
309_L313_G1.8491.00
295_K298_N1.8381.00
280_F324_V1.7901.00
260_L312_H1.7721.00
164_K167_E1.7701.00
63_D66_T1.7341.00
216_F224_N1.7341.00
256_R308_Q1.7201.00
238_R242_Y1.7101.00
260_L316_K1.6821.00
136_V141_R1.6711.00
39_V189_I1.6601.00
28_G31_I1.6571.00
104_I108_I1.6561.00
263_L312_H1.6391.00
280_F326_L1.6251.00
340_R343_R1.6101.00
69_F73_L1.6041.00
103_I106_A1.5921.00
61_S66_T1.5781.00
281_E329_P1.5761.00
259_R308_Q1.5691.00
54_K58_D1.5591.00
260_L263_L1.5371.00
177_Y196_W1.5351.00
294_S298_N1.5331.00
106_A109_R1.5291.00
108_I111_F1.5161.00
294_S297_G1.5121.00
61_S64_E1.4921.00
259_R312_H1.4881.00
292_I298_N1.4801.00
69_F74_P1.4611.00
149_I152_K1.4571.00
28_G32_F1.4541.00
81_T84_K1.4441.00
80_E84_K1.4411.00
25_T30_V1.4391.00
338_H345_K1.4331.00
25_T28_G1.4321.00
280_F310_L1.4051.00
314_V318_L1.4011.00
149_I154_Y1.3951.00
232_G239_T1.3911.00
38_V189_I1.3851.00
63_D67_K1.3821.00
87_K91_E1.3821.00
214_A226_V1.3701.00
42_A189_I1.3661.00
27_N30_V1.3491.00
36_D40_R1.3491.00
130_R133_E1.3391.00
235_I239_T1.3371.00
25_T31_I1.3361.00
284_F329_P1.3291.00
222_R225_V1.3251.00
69_F72_V1.3111.00
50_K53_I1.3031.00
151_G154_Y1.2871.00
263_L315_I1.2851.00
150_F153_A1.2821.00
27_N31_I1.2751.00
232_G237_T1.2731.00
106_A110_K1.2661.00
80_E93_L1.2481.00
163_L167_E1.2441.00
35_K39_V1.2411.00
234_V238_R1.2411.00
282_D326_L1.2401.00
105_H108_I1.2361.00
236_T239_T1.2331.00
101_G106_A1.2251.00
225_V351_T1.2231.00
301_I306_K1.2191.00
232_G243_S1.2151.00
242_Y246_T1.2111.00
339_D343_R1.1971.00
31_I34_E1.1941.00
83_L87_K1.1941.00
292_I295_K1.1921.00
43_R46_S1.1901.00
355_Y359_L1.1851.00
103_I108_I1.1851.00
81_T85_Q1.1831.00
239_T245_V1.1821.00
47_Q51_S1.1771.00
263_L309_L1.1761.00
75_N78_Y1.1621.00
62_V65_L1.1561.00
188_M249_G1.1531.00
123_G126_N1.1531.00
263_L316_K1.1461.00
90_V93_L1.1441.00
213_I277_Y1.1341.00
231_D234_V1.1301.00
46_S50_K1.1291.00
101_G104_I1.1261.00
118_N121_D1.1181.00
248_P255_A1.1171.00
249_G253_V1.1141.00
87_K90_V1.1121.00
292_I302_S1.1081.00
65_L68_E1.1041.00
329_P332_T1.0961.00
241_W246_T1.0921.00
215_G358_A1.0871.00
77_V81_T1.0831.00
140_V143_P1.0801.00
332_T360_K1.0741.00
238_R245_V1.0661.00
64_E68_E1.0651.00
92_G95_E1.0601.00
274_G322_F1.0561.00
136_V139_K1.0551.00
77_V80_E1.0401.00
231_D235_I1.0381.00
213_I358_A1.0381.00
77_V83_L1.0371.00
186_K249_G1.0180.99
79_L83_L1.0160.99
85_Q89_I1.0150.99
106_A111_F1.0150.99
64_E67_K1.0120.99
122_R126_N1.0100.99
76_Y80_E1.0100.99
50_K54_K1.0080.99
61_S68_E1.0050.99
312_H315_I1.0020.99
232_G240_F1.0010.99
106_A112_W0.9870.99
252_K256_R0.9840.99
51_S55_P0.9830.99
114_G118_N0.9820.99
238_R241_W0.9810.99
220_S304_F0.9730.99
336_G339_D0.9700.99
61_S65_L0.9700.99
49_V53_I0.9680.99
108_I113_F0.9680.99
259_R263_L0.9620.99
164_K168_D0.9580.99
88_T92_G0.9550.99
314_V324_V0.9540.99
29_K32_F0.9540.99
161_P164_K0.9520.99
351_T355_Y0.9510.99
66_T70_Y0.9510.99
122_R125_R0.9500.99
90_V94_L0.9500.99
45_Y49_V0.9450.99
89_I93_L0.9430.99
52_A83_L0.9410.99
25_T29_K0.9390.99
235_I238_R0.9380.99
78_Y81_T0.9360.99
293_K297_G0.9350.99
337_E347_F0.9310.99
242_Y245_V0.9240.99
53_I86_A0.9220.99
80_E83_L0.9220.99
75_N84_K0.9210.99
351_T354_A0.9200.99
234_V243_S0.9110.99
46_S53_I0.9100.99
78_Y89_I0.9060.99
111_F114_G0.9060.99
267_L322_F0.9010.99
267_L320_F0.8990.99
347_F351_T0.8990.99
218_L306_K0.8920.99
264_S320_F0.8900.99
237_T242_Y0.8810.99
138_I141_R0.8810.99
259_R309_L0.8760.98
96_R101_G0.8760.98
138_I142_D0.8730.98
62_V68_E0.8720.98
43_R47_Q0.8700.98
239_T246_T0.8680.98
122_R127_M0.8590.98
256_R312_H0.8560.98
285_L307_K0.8560.98
206_K209_G0.8540.98
61_S67_K0.8500.98
279_V357_I0.8490.98
105_H109_R0.8480.98
80_E86_A0.8430.98
227_V354_A0.8410.98
86_A90_V0.8380.98
317_S322_F0.8360.98
353_S356_L0.8360.98
39_V184_K0.8330.98
232_G238_R0.8310.98
137_L141_R0.8300.98
80_E89_I0.8280.98
234_V239_T0.8260.98
75_N79_L0.8230.98
32_F35_K0.8220.98
291_F294_S0.8220.98
163_L168_D0.8200.98
162_L167_E0.8170.98
283_L329_P0.8160.98
126_N130_R0.8140.98
124_N127_M0.8120.97
277_Y323_N0.8100.97
76_Y79_L0.8060.97
232_G236_T0.8050.97
155_F158_E0.8030.97
337_E355_Y0.8020.97
352_A356_L0.7970.97
268_E320_F0.7950.97
66_T69_F0.7950.97
104_I109_R0.7940.97
117_G120_S0.7930.97
233_K236_T0.7930.97
263_L313_G0.7900.97
163_L166_L0.7860.97
104_I107_R0.7850.97
79_L82_A0.7830.97
88_T91_E0.7780.97
218_L310_L0.7780.97
282_D310_L0.7760.97
184_K187_S0.7750.97
230_K235_I0.7750.97
126_N129_F0.7730.97
101_G108_I0.7700.97
81_T87_K0.7680.96
35_K189_I0.7680.96
127_M130_R0.7650.96
285_L306_K0.7650.96
130_R134_D0.7640.96
68_E72_V0.7600.96
180_L192_Q0.7560.96
282_D329_P0.7540.96
89_I94_L0.7530.96
45_Y50_K0.7530.96
230_K237_T0.7530.96
77_V84_K0.7520.96
78_Y83_L0.7490.96
337_E353_S0.7480.96
26_I30_V0.7480.96
238_R243_S0.7460.96
219_N225_V0.7440.96
107_R111_F0.7440.96
137_L140_V0.7420.96
307_K311_I0.7410.96
337_E345_K0.7400.96
235_I243_S0.7380.96
152_K156_G0.7380.96
236_T242_Y0.7360.96
85_Q88_T0.7360.96
235_I242_Y0.7360.96
267_L278_V0.7330.95
77_V82_A0.7320.95
84_K87_K0.7320.95
136_V143_P0.7300.95
250_F254_K0.7300.95
335_S360_K0.7300.95
237_T241_W0.7290.95
52_A86_A0.7280.95
107_R110_K0.7280.95
75_N85_Q0.7280.95
266_S278_V0.7260.95
327_V361_G0.7260.95
67_K70_Y0.7250.95
161_P165_E0.7190.95
46_S49_V0.7180.95
231_D239_T0.7170.95
79_L86_A0.7170.95
251_P303_K0.7160.95
293_K296_S0.7160.95
232_G299_R0.7140.95
232_G245_V0.7130.95
339_D342_M0.7110.95
100_R103_I0.7100.95
216_F226_V0.7050.94
103_I107_R0.7050.94
138_I143_P0.7030.94
334_N342_M0.7010.94
44_V47_Q0.7000.94
148_W152_K0.6990.94
86_A93_L0.6980.94
117_G121_D0.6970.94
153_A156_G0.6950.94
258_L262_A0.6950.94
82_A86_A0.6930.94
105_H110_K0.6900.94
57_F90_V0.6900.94
80_E90_V0.6850.93
109_R112_W0.6810.93
75_N80_E0.6800.93
297_G300_K0.6800.93
45_Y82_A0.6790.93
313_G324_V0.6750.93
91_E95_E0.6750.93
234_V245_V0.6710.93
243_S246_T0.6710.93
343_R349_K0.6690.93
104_I111_F0.6690.93
125_R128_K0.6660.93
48_V52_A0.6660.93
85_Q180_L0.6640.92
220_S300_K0.6620.92
227_V351_T0.6610.92
114_G117_G0.6580.92
45_Y48_V0.6540.92
75_N83_L0.6510.92
27_N188_M0.6470.91
232_G242_Y0.6450.91
81_T88_T0.6420.91
81_T90_V0.6420.91
82_A85_Q0.6420.91
143_P149_I0.6420.91
154_Y157_K0.6400.91
311_I314_V0.6400.91
78_Y93_L0.6390.91
291_F298_N0.6380.91
238_R246_T0.6380.91
40_R44_V0.6380.91
327_V360_K0.6370.91
292_I297_G0.6370.91
54_K57_F0.6350.91
218_L224_N0.6340.91
151_G155_F0.6340.91
230_K242_Y0.6340.91
150_F154_Y0.6330.91
41_I45_Y0.6310.90
347_F355_Y0.6310.90
236_T243_S0.6250.90
109_R113_F0.6250.90
214_A227_V0.6220.90
268_E277_Y0.6220.90
343_R347_F0.6210.90
105_H111_F0.6200.90
119_K122_R0.6200.90
259_R305_A0.6190.90
100_R105_H0.6190.90
96_R102_E0.6180.89
230_K243_S0.6140.89
298_N302_S0.6110.89
100_R104_I0.6100.89
279_V325_V0.6070.89
101_G105_H0.6060.89
39_V42_A0.6050.88
62_V67_K0.6040.88
240_F243_S0.6040.88
124_N128_K0.6040.88
122_R128_K0.6030.88
55_P59_G0.5980.88
76_Y93_L0.5960.88
78_Y84_K0.5960.88
110_K113_F0.5950.88
139_K143_P0.5940.88
315_I319_R0.5900.87
234_V237_T0.5900.87
77_V89_I0.5870.87
122_R129_F0.5820.86
162_L166_L0.5820.86
335_S356_L0.5810.86
274_G277_Y0.5800.86
216_F266_S0.5800.86
92_G96_R0.5790.86
120_S125_R0.5770.86
87_K93_L0.5740.86
66_T72_V0.5730.86
256_R260_L0.5730.86
63_D68_E0.5720.86
252_K255_A0.5710.85
285_L301_I0.5710.85
125_R129_F0.5700.85
292_I296_S0.5690.85
51_S54_K0.5660.85
162_L168_D0.5650.85
79_L93_L0.5650.85
108_I112_W0.5640.85
133_E137_L0.5640.85
226_V229_N0.5630.85
214_A278_V0.5620.85
135_R140_V0.5620.85
130_R137_L0.5610.84
345_K352_A0.5590.84
44_V48_V0.5580.84
345_K351_T0.5540.84
231_D236_T0.5540.84
66_T84_K0.5530.84
95_E102_E0.5530.84
178_G194_P0.5500.83
41_I44_V0.5500.83
102_E106_A0.5480.83
224_N262_A0.5480.83
37_K41_I0.5470.83
253_V261_N0.5440.83
213_I279_V0.5420.82
310_L314_V0.5420.82
316_K319_R0.5410.82
76_Y82_A0.5410.82
102_E108_I0.5410.82
84_K93_L0.5400.82
123_G129_F0.5380.82
174_E195_L0.5370.82
133_E136_V0.5360.82
253_V257_A0.5340.81
107_R112_W0.5340.81
109_R114_G0.5330.81
223_L304_F0.5320.81
82_A93_L0.5320.81
235_I245_V0.5310.81
230_K236_T0.5310.81
82_A92_G0.5300.81
355_Y358_A0.5250.80
27_N190_H0.5250.80
139_K142_D0.5240.80
255_A303_K0.5240.80
221_D225_V0.5230.80
231_D238_R0.5220.80
228_I358_A0.5200.80
294_S301_I0.5190.80
188_M253_V0.5190.80
247_R251_P0.5180.79
251_P255_A0.5170.79
221_D349_K0.5090.78
68_E71_N0.5070.78
75_N82_A0.5060.78
42_A45_Y0.5060.78
48_V54_K0.5050.78
81_T93_L0.5020.77
56_L87_K0.5000.77
79_L89_I0.5000.77
209_G212_L0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.3659 98 0.89 Contact Map
1nu0A 1 0.3523 97.8 0.893 Contact Map
1iv0A 1 0.2656 97 0.908 Contact Map
4ep4A 2 0.3604 93.5 0.929 Contact Map
1hjrA 2 0.3577 92.7 0.93 Contact Map
1kcfA 2 0.4743 55 0.953 Contact Map
3bzcA 1 0.8266 41 0.956 Contact Map
3htvA 2 0.3821 29.5 0.96 Contact Map
4wyqB 1 0.168 28.6 0.96 Contact Map
2aa4A 2 0.3902 28.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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