Y2105 - SULSO - GREMLIN Contacts

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Y2105 - Uncharacterized protein SSO2105

UniProt:	P95879	Sequences: MLSYQMMRSKLIGSKEALDNFQFVTINGKVIFNEKDKVVRIARVYSQVVKSAIKPLFDGKSVDELTKEFYNVLPNYVYLETALKQAKTIVEGLLEREEERGEIIHARIRKFWFGSRGNKSDRGNRNMKFRVLEDRVLIKVRDPWNKEWIFGKAYFGKEYLPLLKELEDLAQRKEEGYGALVSFKEKSMIHLQIPLWLYLKHFSLPKPTGYGLIAGFDLNSDRLNVVVINKDGKVITTRTFWYSDVTRPGFPKVKARALRLNALSNSLEFLSRIGVDYVVFEDLFLVKRRKFIKSKSGNRKISKFAKKQLLIHGVIKSLRFGFNVVLVNPKGTTNSGEHDRVMREKGFDKHTASAYLIALKGLGMLNDIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	369 (306)
Sequences:	4126 (3200)
Seq/√Len:	183.0

ECOLI - INSQ
HALSA - Q9HSW9 Q9HHJ9 Q9HM87 Q9HHG8 Q9HSW7 Q9HSZ6 Q9HSD4 Q9HHU6 Q9HSY4 Q9HHX8
SULSO - Y2105 Q97WZ3 Q97X39 Q97WY6 Q97Z61 Q97YU1 Q97U68 Q97YI5 Q97UQ8 Q97XB6 Q97XQ0 Q97U51 Q97Y48 Q97YW9 Q97Y67 Q7LXD9 Q97XP1 Q97XQ8 Q7LXH2 Q97V47 Q97V25 Q97Y44 Q97YI2 Q97YW4 Q7LXH6 Q97XA4 Q97V53

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
257_A	261_N	5.295	1.00
337_E	352_A	4.185	1.00
317_S	324_V	3.615	1.00
284_F	291_F	3.230	1.00
70_Y	74_P	3.007	1.00
280_F	313_G	2.950	1.00
310_L	326_L	2.838	1.00
223_L	309_L	2.755	1.00
308_Q	312_H	2.727	1.00
264_S	268_E	2.682	1.00
279_V	361_G	2.560	1.00
239_T	243_S	2.497	1.00
70_Y	73_L	2.477	1.00
314_V	326_L	2.419	1.00
136_V	140_V	2.354	1.00
308_Q	311_I	2.306	1.00
179_A	191_L	2.260	1.00
278_V	317_S	2.249	1.00
57_F	60_K	2.239	1.00
239_T	242_Y	2.227	1.00
331_G	334_N	2.186	1.00
71_N	74_P	2.170	1.00
267_L	317_S	2.137	1.00
62_V	66_T	2.065	1.00
332_T	357_I	2.061	1.00
232_G	235_I	2.050	1.00
335_S	342_M	2.041	1.00
327_V	357_I	1.978	1.00
260_L	315_I	1.866	1.00
223_L	258_L	1.854	1.00
309_L	313_G	1.849	1.00
295_K	298_N	1.838	1.00
280_F	324_V	1.790	1.00
260_L	312_H	1.772	1.00
164_K	167_E	1.770	1.00
63_D	66_T	1.734	1.00
216_F	224_N	1.734	1.00
256_R	308_Q	1.720	1.00
238_R	242_Y	1.710	1.00
260_L	316_K	1.682	1.00
136_V	141_R	1.671	1.00
39_V	189_I	1.660	1.00
28_G	31_I	1.657	1.00
104_I	108_I	1.656	1.00
263_L	312_H	1.639	1.00
280_F	326_L	1.625	1.00
340_R	343_R	1.610	1.00
69_F	73_L	1.604	1.00
103_I	106_A	1.592	1.00
61_S	66_T	1.578	1.00
281_E	329_P	1.576	1.00
259_R	308_Q	1.569	1.00
54_K	58_D	1.559	1.00
260_L	263_L	1.537	1.00
177_Y	196_W	1.535	1.00
294_S	298_N	1.533	1.00
106_A	109_R	1.529	1.00
108_I	111_F	1.516	1.00
294_S	297_G	1.512	1.00
61_S	64_E	1.492	1.00
259_R	312_H	1.488	1.00
292_I	298_N	1.480	1.00
69_F	74_P	1.461	1.00
149_I	152_K	1.457	1.00
28_G	32_F	1.454	1.00
81_T	84_K	1.444	1.00
80_E	84_K	1.441	1.00
25_T	30_V	1.439	1.00
338_H	345_K	1.433	1.00
25_T	28_G	1.432	1.00
280_F	310_L	1.405	1.00
314_V	318_L	1.401	1.00
149_I	154_Y	1.395	1.00
232_G	239_T	1.391	1.00
38_V	189_I	1.385	1.00
63_D	67_K	1.382	1.00
87_K	91_E	1.382	1.00
214_A	226_V	1.370	1.00
42_A	189_I	1.366	1.00
27_N	30_V	1.349	1.00
36_D	40_R	1.349	1.00
130_R	133_E	1.339	1.00
235_I	239_T	1.337	1.00
25_T	31_I	1.336	1.00
284_F	329_P	1.329	1.00
222_R	225_V	1.325	1.00
69_F	72_V	1.311	1.00
50_K	53_I	1.303	1.00
151_G	154_Y	1.287	1.00
263_L	315_I	1.285	1.00
150_F	153_A	1.282	1.00
27_N	31_I	1.275	1.00
232_G	237_T	1.273	1.00
106_A	110_K	1.266	1.00
80_E	93_L	1.248	1.00
163_L	167_E	1.244	1.00
35_K	39_V	1.241	1.00
234_V	238_R	1.241	1.00
282_D	326_L	1.240	1.00
105_H	108_I	1.236	1.00
236_T	239_T	1.233	1.00
101_G	106_A	1.225	1.00
225_V	351_T	1.223	1.00
301_I	306_K	1.219	1.00
232_G	243_S	1.215	1.00
242_Y	246_T	1.211	1.00
339_D	343_R	1.197	1.00
31_I	34_E	1.194	1.00
83_L	87_K	1.194	1.00
292_I	295_K	1.192	1.00
43_R	46_S	1.190	1.00
355_Y	359_L	1.185	1.00
103_I	108_I	1.185	1.00
81_T	85_Q	1.183	1.00
239_T	245_V	1.182	1.00
47_Q	51_S	1.177	1.00
263_L	309_L	1.176	1.00
75_N	78_Y	1.162	1.00
62_V	65_L	1.156	1.00
188_M	249_G	1.153	1.00
123_G	126_N	1.153	1.00
263_L	316_K	1.146	1.00
90_V	93_L	1.144	1.00
213_I	277_Y	1.134	1.00
231_D	234_V	1.130	1.00
46_S	50_K	1.129	1.00
101_G	104_I	1.126	1.00
118_N	121_D	1.118	1.00
248_P	255_A	1.117	1.00
249_G	253_V	1.114	1.00
87_K	90_V	1.112	1.00
292_I	302_S	1.108	1.00
65_L	68_E	1.104	1.00
329_P	332_T	1.096	1.00
241_W	246_T	1.092	1.00
215_G	358_A	1.087	1.00
77_V	81_T	1.083	1.00
140_V	143_P	1.080	1.00
332_T	360_K	1.074	1.00
238_R	245_V	1.066	1.00
64_E	68_E	1.065	1.00
92_G	95_E	1.060	1.00
274_G	322_F	1.056	1.00
136_V	139_K	1.055	1.00
77_V	80_E	1.040	1.00
231_D	235_I	1.038	1.00
213_I	358_A	1.038	1.00
77_V	83_L	1.037	1.00
186_K	249_G	1.018	0.99
79_L	83_L	1.016	0.99
85_Q	89_I	1.015	0.99
106_A	111_F	1.015	0.99
64_E	67_K	1.012	0.99
122_R	126_N	1.010	0.99
76_Y	80_E	1.010	0.99
50_K	54_K	1.008	0.99
61_S	68_E	1.005	0.99
312_H	315_I	1.002	0.99
232_G	240_F	1.001	0.99
106_A	112_W	0.987	0.99
252_K	256_R	0.984	0.99
51_S	55_P	0.983	0.99
114_G	118_N	0.982	0.99
238_R	241_W	0.981	0.99
220_S	304_F	0.973	0.99
336_G	339_D	0.970	0.99
61_S	65_L	0.970	0.99
49_V	53_I	0.968	0.99
108_I	113_F	0.968	0.99
259_R	263_L	0.962	0.99
164_K	168_D	0.958	0.99
88_T	92_G	0.955	0.99
314_V	324_V	0.954	0.99
29_K	32_F	0.954	0.99
161_P	164_K	0.952	0.99
351_T	355_Y	0.951	0.99
66_T	70_Y	0.951	0.99
122_R	125_R	0.950	0.99
90_V	94_L	0.950	0.99
45_Y	49_V	0.945	0.99
89_I	93_L	0.943	0.99
52_A	83_L	0.941	0.99
25_T	29_K	0.939	0.99
235_I	238_R	0.938	0.99
78_Y	81_T	0.936	0.99
293_K	297_G	0.935	0.99
337_E	347_F	0.931	0.99
242_Y	245_V	0.924	0.99
53_I	86_A	0.922	0.99
80_E	83_L	0.922	0.99
75_N	84_K	0.921	0.99
351_T	354_A	0.920	0.99
234_V	243_S	0.911	0.99
46_S	53_I	0.910	0.99
78_Y	89_I	0.906	0.99
111_F	114_G	0.906	0.99
267_L	322_F	0.901	0.99
267_L	320_F	0.899	0.99
347_F	351_T	0.899	0.99
218_L	306_K	0.892	0.99
264_S	320_F	0.890	0.99
237_T	242_Y	0.881	0.99
138_I	141_R	0.881	0.99
259_R	309_L	0.876	0.98
96_R	101_G	0.876	0.98
138_I	142_D	0.873	0.98
62_V	68_E	0.872	0.98
43_R	47_Q	0.870	0.98
239_T	246_T	0.868	0.98
122_R	127_M	0.859	0.98
256_R	312_H	0.856	0.98
285_L	307_K	0.856	0.98
206_K	209_G	0.854	0.98
61_S	67_K	0.850	0.98
279_V	357_I	0.849	0.98
105_H	109_R	0.848	0.98
80_E	86_A	0.843	0.98
227_V	354_A	0.841	0.98
86_A	90_V	0.838	0.98
317_S	322_F	0.836	0.98
353_S	356_L	0.836	0.98
39_V	184_K	0.833	0.98
232_G	238_R	0.831	0.98
137_L	141_R	0.830	0.98
80_E	89_I	0.828	0.98
234_V	239_T	0.826	0.98
75_N	79_L	0.823	0.98
32_F	35_K	0.822	0.98
291_F	294_S	0.822	0.98
163_L	168_D	0.820	0.98
162_L	167_E	0.817	0.98
283_L	329_P	0.816	0.98
126_N	130_R	0.814	0.98
124_N	127_M	0.812	0.97
277_Y	323_N	0.810	0.97
76_Y	79_L	0.806	0.97
232_G	236_T	0.805	0.97
155_F	158_E	0.803	0.97
337_E	355_Y	0.802	0.97
352_A	356_L	0.797	0.97
268_E	320_F	0.795	0.97
66_T	69_F	0.795	0.97
104_I	109_R	0.794	0.97
117_G	120_S	0.793	0.97
233_K	236_T	0.793	0.97
263_L	313_G	0.790	0.97
163_L	166_L	0.786	0.97
104_I	107_R	0.785	0.97
79_L	82_A	0.783	0.97
88_T	91_E	0.778	0.97
218_L	310_L	0.778	0.97
282_D	310_L	0.776	0.97
184_K	187_S	0.775	0.97
230_K	235_I	0.775	0.97
126_N	129_F	0.773	0.97
101_G	108_I	0.770	0.97
81_T	87_K	0.768	0.96
35_K	189_I	0.768	0.96
127_M	130_R	0.765	0.96
285_L	306_K	0.765	0.96
130_R	134_D	0.764	0.96
68_E	72_V	0.760	0.96
180_L	192_Q	0.756	0.96
282_D	329_P	0.754	0.96
89_I	94_L	0.753	0.96
45_Y	50_K	0.753	0.96
230_K	237_T	0.753	0.96
77_V	84_K	0.752	0.96
78_Y	83_L	0.749	0.96
337_E	353_S	0.748	0.96
26_I	30_V	0.748	0.96
238_R	243_S	0.746	0.96
219_N	225_V	0.744	0.96
107_R	111_F	0.744	0.96
137_L	140_V	0.742	0.96
307_K	311_I	0.741	0.96
337_E	345_K	0.740	0.96
235_I	243_S	0.738	0.96
152_K	156_G	0.738	0.96
236_T	242_Y	0.736	0.96
85_Q	88_T	0.736	0.96
235_I	242_Y	0.736	0.96
267_L	278_V	0.733	0.95
77_V	82_A	0.732	0.95
84_K	87_K	0.732	0.95
136_V	143_P	0.730	0.95
250_F	254_K	0.730	0.95
335_S	360_K	0.730	0.95
237_T	241_W	0.729	0.95
52_A	86_A	0.728	0.95
107_R	110_K	0.728	0.95
75_N	85_Q	0.728	0.95
266_S	278_V	0.726	0.95
327_V	361_G	0.726	0.95
67_K	70_Y	0.725	0.95
161_P	165_E	0.719	0.95
46_S	49_V	0.718	0.95
231_D	239_T	0.717	0.95
79_L	86_A	0.717	0.95
251_P	303_K	0.716	0.95
293_K	296_S	0.716	0.95
232_G	299_R	0.714	0.95
232_G	245_V	0.713	0.95
339_D	342_M	0.711	0.95
100_R	103_I	0.710	0.95
216_F	226_V	0.705	0.94
103_I	107_R	0.705	0.94
138_I	143_P	0.703	0.94
334_N	342_M	0.701	0.94
44_V	47_Q	0.700	0.94
148_W	152_K	0.699	0.94
86_A	93_L	0.698	0.94
117_G	121_D	0.697	0.94
153_A	156_G	0.695	0.94
258_L	262_A	0.695	0.94
82_A	86_A	0.693	0.94
105_H	110_K	0.690	0.94
57_F	90_V	0.690	0.94
80_E	90_V	0.685	0.93
109_R	112_W	0.681	0.93
75_N	80_E	0.680	0.93
297_G	300_K	0.680	0.93
45_Y	82_A	0.679	0.93
313_G	324_V	0.675	0.93
91_E	95_E	0.675	0.93
234_V	245_V	0.671	0.93
243_S	246_T	0.671	0.93
343_R	349_K	0.669	0.93
104_I	111_F	0.669	0.93
125_R	128_K	0.666	0.93
48_V	52_A	0.666	0.93
85_Q	180_L	0.664	0.92
220_S	300_K	0.662	0.92
227_V	351_T	0.661	0.92
114_G	117_G	0.658	0.92
45_Y	48_V	0.654	0.92
75_N	83_L	0.651	0.92
27_N	188_M	0.647	0.91
232_G	242_Y	0.645	0.91
81_T	88_T	0.642	0.91
81_T	90_V	0.642	0.91
82_A	85_Q	0.642	0.91
143_P	149_I	0.642	0.91
154_Y	157_K	0.640	0.91
311_I	314_V	0.640	0.91
78_Y	93_L	0.639	0.91
291_F	298_N	0.638	0.91
238_R	246_T	0.638	0.91
40_R	44_V	0.638	0.91
327_V	360_K	0.637	0.91
292_I	297_G	0.637	0.91
54_K	57_F	0.635	0.91
218_L	224_N	0.634	0.91
151_G	155_F	0.634	0.91
230_K	242_Y	0.634	0.91
150_F	154_Y	0.633	0.91
41_I	45_Y	0.631	0.90
347_F	355_Y	0.631	0.90
236_T	243_S	0.625	0.90
109_R	113_F	0.625	0.90
214_A	227_V	0.622	0.90
268_E	277_Y	0.622	0.90
343_R	347_F	0.621	0.90
105_H	111_F	0.620	0.90
119_K	122_R	0.620	0.90
259_R	305_A	0.619	0.90
100_R	105_H	0.619	0.90
96_R	102_E	0.618	0.89
230_K	243_S	0.614	0.89
298_N	302_S	0.611	0.89
100_R	104_I	0.610	0.89
279_V	325_V	0.607	0.89
101_G	105_H	0.606	0.89
39_V	42_A	0.605	0.88
62_V	67_K	0.604	0.88
240_F	243_S	0.604	0.88
124_N	128_K	0.604	0.88
122_R	128_K	0.603	0.88
55_P	59_G	0.598	0.88
76_Y	93_L	0.596	0.88
78_Y	84_K	0.596	0.88
110_K	113_F	0.595	0.88
139_K	143_P	0.594	0.88
315_I	319_R	0.590	0.87
234_V	237_T	0.590	0.87
77_V	89_I	0.587	0.87
122_R	129_F	0.582	0.86
162_L	166_L	0.582	0.86
335_S	356_L	0.581	0.86
274_G	277_Y	0.580	0.86
216_F	266_S	0.580	0.86
92_G	96_R	0.579	0.86
120_S	125_R	0.577	0.86
87_K	93_L	0.574	0.86
66_T	72_V	0.573	0.86
256_R	260_L	0.573	0.86
63_D	68_E	0.572	0.86
252_K	255_A	0.571	0.85
285_L	301_I	0.571	0.85
125_R	129_F	0.570	0.85
292_I	296_S	0.569	0.85
51_S	54_K	0.566	0.85
162_L	168_D	0.565	0.85
79_L	93_L	0.565	0.85
108_I	112_W	0.564	0.85
133_E	137_L	0.564	0.85
226_V	229_N	0.563	0.85
214_A	278_V	0.562	0.85
135_R	140_V	0.562	0.85
130_R	137_L	0.561	0.84
345_K	352_A	0.559	0.84
44_V	48_V	0.558	0.84
345_K	351_T	0.554	0.84
231_D	236_T	0.554	0.84
66_T	84_K	0.553	0.84
95_E	102_E	0.553	0.84
178_G	194_P	0.550	0.83
41_I	44_V	0.550	0.83
102_E	106_A	0.548	0.83
224_N	262_A	0.548	0.83
37_K	41_I	0.547	0.83
253_V	261_N	0.544	0.83
213_I	279_V	0.542	0.82
310_L	314_V	0.542	0.82
316_K	319_R	0.541	0.82
76_Y	82_A	0.541	0.82
102_E	108_I	0.541	0.82
84_K	93_L	0.540	0.82
123_G	129_F	0.538	0.82
174_E	195_L	0.537	0.82
133_E	136_V	0.536	0.82
253_V	257_A	0.534	0.81
107_R	112_W	0.534	0.81
109_R	114_G	0.533	0.81
223_L	304_F	0.532	0.81
82_A	93_L	0.532	0.81
235_I	245_V	0.531	0.81
230_K	236_T	0.531	0.81
82_A	92_G	0.530	0.81
355_Y	358_A	0.525	0.80
27_N	190_H	0.525	0.80
139_K	142_D	0.524	0.80
255_A	303_K	0.524	0.80
221_D	225_V	0.523	0.80
231_D	238_R	0.522	0.80
228_I	358_A	0.520	0.80
294_S	301_I	0.519	0.80
188_M	253_V	0.519	0.80
247_R	251_P	0.518	0.79
251_P	255_A	0.517	0.79
221_D	349_K	0.509	0.78
68_E	71_N	0.507	0.78
75_N	82_A	0.506	0.78
42_A	45_Y	0.506	0.78
48_V	54_K	0.505	0.78
81_T	93_L	0.502	0.77
56_L	87_K	0.500	0.77
79_L	89_I	0.500	0.77
209_G	212_L	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vhxA	2	0.3659	98	0.89	Contact Map
1nu0A	1	0.3523	97.8	0.893	Contact Map
1iv0A	1	0.2656	97	0.908	Contact Map
4ep4A	2	0.3604	93.5	0.929	Contact Map
1hjrA	2	0.3577	92.7	0.93	Contact Map
1kcfA	2	0.4743	55	0.953	Contact Map
3bzcA	1	0.8266	41	0.956	Contact Map
3htvA	2	0.3821	29.5	0.96	Contact Map
4wyqB	1	0.168	28.6	0.96	Contact Map
2aa4A	2	0.3902	28.5	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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