GREMLIN Database
RIB7 - 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
UniProt: P95872 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (203)
Sequences: 4530 (3588)
Seq/√Len: 251.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_Y127_L3.6071.00
8_I44_V3.3591.00
142_V152_F2.7511.00
117_I135_F2.6311.00
99_Y130_D2.5651.00
36_R164_T2.4621.00
46_A75_V2.4161.00
130_D133_D2.3721.00
130_D135_F2.3381.00
58_N88_K2.3131.00
52_N56_V2.2951.00
51_A55_R2.2471.00
9_I149_I2.2181.00
73_I97_V2.1171.00
7_V128_L2.0941.00
60_S88_K2.0641.00
162_R205_H2.0081.00
77_V148_L1.9681.00
19_L146_G1.9631.00
30_C202_N1.9291.00
49_V144_G1.9251.00
49_V54_V1.9141.00
194_D208_Y1.9021.00
55_R82_N1.8591.00
124_L157_L1.8521.00
168_R191_E1.8461.00
73_I137_V1.8281.00
40_I141_M1.8011.00
13_V165_I1.7621.00
152_F157_L1.7411.00
6_Y160_E1.7371.00
54_V89_I1.7291.00
160_E207_T1.6861.00
9_I158_Y1.6691.00
164_T205_H1.6611.00
14_S170_F1.6561.00
36_R205_H1.6401.00
48_M148_L1.6351.00
128_L152_F1.6131.00
168_R189_R1.6061.00
55_R84_D1.6001.00
81_F100_T1.5911.00
40_I162_R1.5871.00
108_V112_I1.5831.00
78_T82_N1.5831.00
11_S149_I1.5651.00
32_Y201_G1.5371.00
48_M152_F1.4961.00
4_K129_E1.4821.00
18_R175_S1.4811.00
42_S63_V1.4731.00
51_A83_L1.4611.00
30_C203_E1.4521.00
13_V176_F1.4161.00
16_D171_G1.3991.00
51_A82_N1.3931.00
11_S163_I1.3891.00
165_I206_L1.3801.00
30_C33_D1.3551.00
124_L152_F1.3531.00
8_I162_R1.3501.00
25_Y185_E1.3451.00
46_A140_L1.3291.00
77_V127_L1.3291.00
89_I96_T1.3121.00
76_V89_I1.3101.00
126_D130_D1.3091.00
170_F186_D1.3021.00
100_T118_V1.3001.00
45_D138_R1.2751.00
14_S168_R1.2751.00
79_R101_S1.2701.00
25_Y186_D1.2531.00
44_V139_R1.2101.00
83_L98_I1.2021.00
192_L208_Y1.1991.00
14_S28_L1.1871.00
29_S33_D1.1701.00
48_M77_V1.1591.00
4_K159_D1.1581.00
83_L90_F1.1561.00
9_I153_I1.1381.00
46_A137_V1.1381.00
11_S176_F1.1211.00
51_A90_F1.1161.00
13_V163_I1.1061.00
62_T94_P1.1001.00
95_S117_I1.0971.00
109_E112_I1.0941.00
15_I208_Y1.0861.00
3_M132_Y1.0841.00
75_V131_L1.0831.00
28_L166_S1.0801.00
85_P110_E1.0761.00
9_I142_V1.0651.00
33_D164_T1.0621.00
137_V140_L1.0611.00
74_R96_T1.0541.00
129_E133_D1.0521.00
199_E202_N1.0501.00
142_V148_L1.0431.00
108_V111_F1.0421.00
76_V83_L1.0321.00
25_Y187_S1.0311.00
55_R78_T1.0311.00
97_V135_F1.0271.00
36_R198_C1.0261.00
51_A79_R1.0141.00
101_S122_L1.0131.00
197_I204_V1.0111.00
111_F115_G0.9921.00
124_L155_D0.9871.00
125_D155_D0.9731.00
124_L128_L0.9601.00
33_D203_E0.9581.00
150_W154_K0.9531.00
54_V87_Y0.9341.00
63_V71_N0.9271.00
36_R162_R0.9171.00
149_I158_Y0.9151.00
51_A78_T0.8971.00
132_Y138_R0.8961.00
109_E113_R0.8941.00
44_V141_M0.8941.00
199_E204_V0.8921.00
49_V76_V0.8921.00
79_R122_L0.8921.00
123_H126_D0.8881.00
124_L127_L0.8861.00
74_R94_P0.8851.00
88_K91_T0.8811.00
48_M137_V0.8801.00
54_V83_L0.8731.00
36_R39_E0.8711.00
190_L194_D0.8691.00
153_I177_T0.8660.99
84_D87_Y0.8620.99
198_C207_T0.8610.99
194_D197_I0.8610.99
194_D206_L0.8600.99
39_E43_E0.8580.99
4_K125_D0.8550.99
7_V142_V0.8510.99
14_S21_T0.8500.99
126_D129_E0.8470.99
154_K180_E0.8460.99
48_M140_L0.8450.99
104_E107_K0.8400.99
46_A73_I0.8400.99
195_A207_T0.8380.99
26_S34_K0.8380.99
8_I139_R0.8370.99
185_E188_P0.8360.99
41_R143_E0.8270.99
10_F33_D0.8220.99
175_S179_G0.8170.99
172_N181_G0.8160.99
79_R121_F0.8100.99
10_F37_Q0.8080.99
87_Y90_F0.8040.99
112_I115_G0.8040.99
124_L148_L0.8040.99
90_F116_V0.7950.99
64_K68_N0.7920.99
31_P35_Q0.7880.99
191_E202_N0.7880.99
125_D129_E0.7810.99
36_R40_I0.7800.99
52_N82_N0.7790.99
200_C205_H0.7760.99
144_G149_I0.7730.99
122_L127_L0.7710.99
28_L186_D0.7700.99
45_D139_R0.7690.99
147_H151_W0.7690.99
162_R207_T0.7650.99
8_I160_E0.7610.99
29_S34_K0.7560.99
10_F164_T0.7540.99
8_I40_I0.7530.99
112_I117_I0.7470.99
36_R200_C0.7420.98
58_N87_Y0.7410.98
163_I176_F0.7370.98
38_H63_V0.7290.98
128_L140_L0.7250.98
105_S108_V0.7250.98
107_K111_F0.7200.98
34_K164_T0.7130.98
10_F29_S0.7100.98
68_N71_N0.7090.98
95_S135_F0.7080.98
119_R122_L0.7050.98
21_T170_F0.7030.98
148_L152_F0.6990.98
18_R173_G0.6980.98
29_S37_Q0.6960.98
32_Y202_N0.6960.98
98_I111_F0.6920.98
12_T29_S0.6890.97
91_T94_P0.6890.97
197_I206_L0.6850.97
33_D200_C0.6770.97
21_T25_Y0.6710.97
75_V99_Y0.6700.97
186_D189_R0.6670.97
153_I158_Y0.6620.97
18_R172_N0.6590.97
48_M75_V0.6580.97
77_V152_F0.6570.97
78_T81_F0.6560.97
194_D204_V0.6550.97
40_I164_T0.6530.97
121_F147_H0.6490.96
173_G176_F0.6490.96
151_W155_D0.6460.96
148_L151_W0.6430.96
53_T61_L0.6400.96
37_Q141_M0.6400.96
83_L89_I0.6390.96
107_K110_E0.6380.96
123_H155_D0.6360.96
65_Y68_N0.6350.96
43_E139_R0.6350.96
50_G144_G0.6350.96
150_W180_E0.6330.96
153_I161_I0.6320.96
110_E113_R0.6310.96
183_I188_P0.6310.96
30_C201_G0.6300.96
81_F107_K0.6290.96
146_G178_Q0.6280.96
7_V140_L0.6270.96
108_V118_V0.6270.96
25_Y28_L0.6160.95
90_F96_T0.6130.95
8_I141_M0.6080.95
40_I44_V0.6050.95
3_M129_E0.6040.95
20_A26_S0.6020.95
156_N188_P0.5940.94
174_V178_Q0.5940.94
97_V117_I0.5930.94
49_V61_L0.5890.94
29_S164_T0.5880.94
21_T26_S0.5870.94
40_I43_E0.5860.94
114_K118_V0.5850.94
32_Y35_Q0.5850.94
37_Q186_D0.5840.94
63_V66_G0.5830.94
83_L87_Y0.5830.94
11_S161_I0.5820.94
142_V158_Y0.5810.93
77_V99_Y0.5810.93
174_V177_T0.5790.93
35_Q39_E0.5780.93
163_I208_Y0.5750.93
33_D36_R0.5670.93
172_N179_G0.5650.93
169_I192_L0.5650.93
47_V71_N0.5640.92
125_D157_L0.5610.92
175_S178_Q0.5560.92
111_F116_V0.5550.92
166_S203_E0.5540.92
106_E110_E0.5490.91
83_L111_F0.5490.91
124_L151_W0.5470.91
129_E132_Y0.5460.91
92_T96_T0.5460.91
48_M142_V0.5440.91
10_F141_M0.5420.91
91_T114_K0.5410.91
90_F111_F0.5410.91
65_Y69_R0.5410.91
152_F158_Y0.5400.91
62_T74_R0.5400.91
60_S92_T0.5360.90
192_L206_L0.5360.90
71_N92_T0.5350.90
53_T59_P0.5340.90
198_C205_H0.5310.90
58_N86_S0.5300.90
96_T99_Y0.5300.90
73_I95_S0.5260.90
52_N147_H0.5260.90
63_V67_K0.5260.90
115_G118_V0.5250.90
165_I204_V0.5230.89
53_T144_G0.5180.89
110_E114_K0.5180.89
142_V149_I0.5150.89
158_Y161_I0.5130.88
15_I165_I0.5120.88
77_V124_L0.5120.88
164_T200_C0.5120.88
63_V68_N0.5110.88
11_S19_L0.5100.88
44_V162_R0.5070.88
20_A34_K0.5070.88
45_D137_V0.5070.88
48_M128_L0.5010.87
111_F114_K0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3zA 3 0.9812 100 0.234 Contact Map
2aznA 2 0.9812 100 0.235 Contact Map
2g6vA 2 0.9624 100 0.241 Contact Map
2p4gA 2 0.9812 100 0.284 Contact Map
3zpgA 2 0.9484 100 0.304 Contact Map
4ha7A 2 0.8779 100 0.305 Contact Map
2hxvA 2 0.9343 100 0.31 Contact Map
2gd9A 2 0.7793 100 0.488 Contact Map
1cz3A 2 0.77 100 0.504 Contact Map
3jtwA 2 0.8028 100 0.505 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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