RIB7 - SULSO - GREMLIN Contacts

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RIB7 - 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

UniProt:	P95872	Sequences: MVMKPYVIIFSTVSIDGRLATKTGYSELSCPYDKQRQHEIRSEVDAVMVGANTVRVDNPSLTVKYGKNRRNPIRVVVTRSFNLDPSYKIFTTPPSTVIYTSNYESEKVEEFIRKGVIVRKFLHLDDLLEDLYDNFNVRRLMVEGGGHLIWWFIKDNLYDEIRITISPRIFGNGVSFTQGEGFIGEDSPRLELIDAKICECGNEVHLTYKKYMT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	213 (203)
Sequences:	4530 (3588)
Seq/√Len:	251.8

ECOLI - RIBD
BACSU - RIBD
HALSA - Q9HQA1
SULSO - RIB7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
99_Y	127_L	3.607	1.00
8_I	44_V	3.359	1.00
142_V	152_F	2.751	1.00
117_I	135_F	2.631	1.00
99_Y	130_D	2.565	1.00
36_R	164_T	2.462	1.00
46_A	75_V	2.416	1.00
130_D	133_D	2.372	1.00
130_D	135_F	2.338	1.00
58_N	88_K	2.313	1.00
52_N	56_V	2.295	1.00
51_A	55_R	2.247	1.00
9_I	149_I	2.218	1.00
73_I	97_V	2.117	1.00
7_V	128_L	2.094	1.00
60_S	88_K	2.064	1.00
162_R	205_H	2.008	1.00
77_V	148_L	1.968	1.00
19_L	146_G	1.963	1.00
30_C	202_N	1.929	1.00
49_V	144_G	1.925	1.00
49_V	54_V	1.914	1.00
194_D	208_Y	1.902	1.00
55_R	82_N	1.859	1.00
124_L	157_L	1.852	1.00
168_R	191_E	1.846	1.00
73_I	137_V	1.828	1.00
40_I	141_M	1.801	1.00
13_V	165_I	1.762	1.00
152_F	157_L	1.741	1.00
6_Y	160_E	1.737	1.00
54_V	89_I	1.729	1.00
160_E	207_T	1.686	1.00
9_I	158_Y	1.669	1.00
164_T	205_H	1.661	1.00
14_S	170_F	1.656	1.00
36_R	205_H	1.640	1.00
48_M	148_L	1.635	1.00
128_L	152_F	1.613	1.00
168_R	189_R	1.606	1.00
55_R	84_D	1.600	1.00
81_F	100_T	1.591	1.00
40_I	162_R	1.587	1.00
108_V	112_I	1.583	1.00
78_T	82_N	1.583	1.00
11_S	149_I	1.565	1.00
32_Y	201_G	1.537	1.00
48_M	152_F	1.496	1.00
4_K	129_E	1.482	1.00
18_R	175_S	1.481	1.00
42_S	63_V	1.473	1.00
51_A	83_L	1.461	1.00
30_C	203_E	1.452	1.00
13_V	176_F	1.416	1.00
16_D	171_G	1.399	1.00
51_A	82_N	1.393	1.00
11_S	163_I	1.389	1.00
165_I	206_L	1.380	1.00
30_C	33_D	1.355	1.00
124_L	152_F	1.353	1.00
8_I	162_R	1.350	1.00
25_Y	185_E	1.345	1.00
46_A	140_L	1.329	1.00
77_V	127_L	1.329	1.00
89_I	96_T	1.312	1.00
76_V	89_I	1.310	1.00
126_D	130_D	1.309	1.00
170_F	186_D	1.302	1.00
100_T	118_V	1.300	1.00
45_D	138_R	1.275	1.00
14_S	168_R	1.275	1.00
79_R	101_S	1.270	1.00
25_Y	186_D	1.253	1.00
44_V	139_R	1.210	1.00
83_L	98_I	1.202	1.00
192_L	208_Y	1.199	1.00
14_S	28_L	1.187	1.00
29_S	33_D	1.170	1.00
48_M	77_V	1.159	1.00
4_K	159_D	1.158	1.00
83_L	90_F	1.156	1.00
9_I	153_I	1.138	1.00
46_A	137_V	1.138	1.00
11_S	176_F	1.121	1.00
51_A	90_F	1.116	1.00
13_V	163_I	1.106	1.00
62_T	94_P	1.100	1.00
95_S	117_I	1.097	1.00
109_E	112_I	1.094	1.00
15_I	208_Y	1.086	1.00
3_M	132_Y	1.084	1.00
75_V	131_L	1.083	1.00
28_L	166_S	1.080	1.00
85_P	110_E	1.076	1.00
9_I	142_V	1.065	1.00
33_D	164_T	1.062	1.00
137_V	140_L	1.061	1.00
74_R	96_T	1.054	1.00
129_E	133_D	1.052	1.00
199_E	202_N	1.050	1.00
142_V	148_L	1.043	1.00
108_V	111_F	1.042	1.00
76_V	83_L	1.032	1.00
25_Y	187_S	1.031	1.00
55_R	78_T	1.031	1.00
97_V	135_F	1.027	1.00
36_R	198_C	1.026	1.00
51_A	79_R	1.014	1.00
101_S	122_L	1.013	1.00
197_I	204_V	1.011	1.00
111_F	115_G	0.992	1.00
124_L	155_D	0.987	1.00
125_D	155_D	0.973	1.00
124_L	128_L	0.960	1.00
33_D	203_E	0.958	1.00
150_W	154_K	0.953	1.00
54_V	87_Y	0.934	1.00
63_V	71_N	0.927	1.00
36_R	162_R	0.917	1.00
149_I	158_Y	0.915	1.00
51_A	78_T	0.897	1.00
132_Y	138_R	0.896	1.00
109_E	113_R	0.894	1.00
44_V	141_M	0.894	1.00
199_E	204_V	0.892	1.00
49_V	76_V	0.892	1.00
79_R	122_L	0.892	1.00
123_H	126_D	0.888	1.00
124_L	127_L	0.886	1.00
74_R	94_P	0.885	1.00
88_K	91_T	0.881	1.00
48_M	137_V	0.880	1.00
54_V	83_L	0.873	1.00
36_R	39_E	0.871	1.00
190_L	194_D	0.869	1.00
153_I	177_T	0.866	0.99
84_D	87_Y	0.862	0.99
198_C	207_T	0.861	0.99
194_D	197_I	0.861	0.99
194_D	206_L	0.860	0.99
39_E	43_E	0.858	0.99
4_K	125_D	0.855	0.99
7_V	142_V	0.851	0.99
14_S	21_T	0.850	0.99
126_D	129_E	0.847	0.99
154_K	180_E	0.846	0.99
48_M	140_L	0.845	0.99
104_E	107_K	0.840	0.99
46_A	73_I	0.840	0.99
195_A	207_T	0.838	0.99
26_S	34_K	0.838	0.99
8_I	139_R	0.837	0.99
185_E	188_P	0.836	0.99
41_R	143_E	0.827	0.99
10_F	33_D	0.822	0.99
175_S	179_G	0.817	0.99
172_N	181_G	0.816	0.99
79_R	121_F	0.810	0.99
10_F	37_Q	0.808	0.99
87_Y	90_F	0.804	0.99
112_I	115_G	0.804	0.99
124_L	148_L	0.804	0.99
90_F	116_V	0.795	0.99
64_K	68_N	0.792	0.99
31_P	35_Q	0.788	0.99
191_E	202_N	0.788	0.99
125_D	129_E	0.781	0.99
36_R	40_I	0.780	0.99
52_N	82_N	0.779	0.99
200_C	205_H	0.776	0.99
144_G	149_I	0.773	0.99
122_L	127_L	0.771	0.99
28_L	186_D	0.770	0.99
45_D	139_R	0.769	0.99
147_H	151_W	0.769	0.99
162_R	207_T	0.765	0.99
8_I	160_E	0.761	0.99
29_S	34_K	0.756	0.99
10_F	164_T	0.754	0.99
8_I	40_I	0.753	0.99
112_I	117_I	0.747	0.99
36_R	200_C	0.742	0.98
58_N	87_Y	0.741	0.98
163_I	176_F	0.737	0.98
38_H	63_V	0.729	0.98
128_L	140_L	0.725	0.98
105_S	108_V	0.725	0.98
107_K	111_F	0.720	0.98
34_K	164_T	0.713	0.98
10_F	29_S	0.710	0.98
68_N	71_N	0.709	0.98
95_S	135_F	0.708	0.98
119_R	122_L	0.705	0.98
21_T	170_F	0.703	0.98
148_L	152_F	0.699	0.98
18_R	173_G	0.698	0.98
29_S	37_Q	0.696	0.98
32_Y	202_N	0.696	0.98
98_I	111_F	0.692	0.98
12_T	29_S	0.689	0.97
91_T	94_P	0.689	0.97
197_I	206_L	0.685	0.97
33_D	200_C	0.677	0.97
21_T	25_Y	0.671	0.97
75_V	99_Y	0.670	0.97
186_D	189_R	0.667	0.97
153_I	158_Y	0.662	0.97
18_R	172_N	0.659	0.97
48_M	75_V	0.658	0.97
77_V	152_F	0.657	0.97
78_T	81_F	0.656	0.97
194_D	204_V	0.655	0.97
40_I	164_T	0.653	0.97
121_F	147_H	0.649	0.96
173_G	176_F	0.649	0.96
151_W	155_D	0.646	0.96
148_L	151_W	0.643	0.96
53_T	61_L	0.640	0.96
37_Q	141_M	0.640	0.96
83_L	89_I	0.639	0.96
107_K	110_E	0.638	0.96
123_H	155_D	0.636	0.96
65_Y	68_N	0.635	0.96
43_E	139_R	0.635	0.96
50_G	144_G	0.635	0.96
150_W	180_E	0.633	0.96
153_I	161_I	0.632	0.96
110_E	113_R	0.631	0.96
183_I	188_P	0.631	0.96
30_C	201_G	0.630	0.96
81_F	107_K	0.629	0.96
146_G	178_Q	0.628	0.96
7_V	140_L	0.627	0.96
108_V	118_V	0.627	0.96
25_Y	28_L	0.616	0.95
90_F	96_T	0.613	0.95
8_I	141_M	0.608	0.95
40_I	44_V	0.605	0.95
3_M	129_E	0.604	0.95
20_A	26_S	0.602	0.95
156_N	188_P	0.594	0.94
174_V	178_Q	0.594	0.94
97_V	117_I	0.593	0.94
49_V	61_L	0.589	0.94
29_S	164_T	0.588	0.94
21_T	26_S	0.587	0.94
40_I	43_E	0.586	0.94
114_K	118_V	0.585	0.94
32_Y	35_Q	0.585	0.94
37_Q	186_D	0.584	0.94
63_V	66_G	0.583	0.94
83_L	87_Y	0.583	0.94
11_S	161_I	0.582	0.94
142_V	158_Y	0.581	0.93
77_V	99_Y	0.581	0.93
174_V	177_T	0.579	0.93
35_Q	39_E	0.578	0.93
163_I	208_Y	0.575	0.93
33_D	36_R	0.567	0.93
172_N	179_G	0.565	0.93
169_I	192_L	0.565	0.93
47_V	71_N	0.564	0.92
125_D	157_L	0.561	0.92
175_S	178_Q	0.556	0.92
111_F	116_V	0.555	0.92
166_S	203_E	0.554	0.92
106_E	110_E	0.549	0.91
83_L	111_F	0.549	0.91
124_L	151_W	0.547	0.91
129_E	132_Y	0.546	0.91
92_T	96_T	0.546	0.91
48_M	142_V	0.544	0.91
10_F	141_M	0.542	0.91
91_T	114_K	0.541	0.91
90_F	111_F	0.541	0.91
65_Y	69_R	0.541	0.91
152_F	158_Y	0.540	0.91
62_T	74_R	0.540	0.91
60_S	92_T	0.536	0.90
192_L	206_L	0.536	0.90
71_N	92_T	0.535	0.90
53_T	59_P	0.534	0.90
198_C	205_H	0.531	0.90
58_N	86_S	0.530	0.90
96_T	99_Y	0.530	0.90
73_I	95_S	0.526	0.90
52_N	147_H	0.526	0.90
63_V	67_K	0.526	0.90
115_G	118_V	0.525	0.90
165_I	204_V	0.523	0.89
53_T	144_G	0.518	0.89
110_E	114_K	0.518	0.89
142_V	149_I	0.515	0.89
158_Y	161_I	0.513	0.88
15_I	165_I	0.512	0.88
77_V	124_L	0.512	0.88
164_T	200_C	0.512	0.88
63_V	68_N	0.511	0.88
11_S	19_L	0.510	0.88
44_V	162_R	0.507	0.88
20_A	34_K	0.507	0.88
45_D	137_V	0.507	0.88
48_M	128_L	0.501	0.87
111_F	114_K	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2b3zA	3	0.9812	100	0.234	Contact Map
2aznA	2	0.9812	100	0.235	Contact Map
2g6vA	2	0.9624	100	0.241	Contact Map
2p4gA	2	0.9812	100	0.284	Contact Map
3zpgA	2	0.9484	100	0.304	Contact Map
4ha7A	2	0.8779	100	0.305	Contact Map
2hxvA	2	0.9343	100	0.31	Contact Map
2gd9A	2	0.7793	100	0.488	Contact Map
1cz3A	2	0.77	100	0.504	Contact Map
3jtwA	2	0.8028	100	0.505	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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