DLHH - SULSO - GREMLIN Contacts

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DLHH - Putative carboxymethylenebutenolidase

UniProt:	P95862	Sequences: MEKEIFYDSDGAKIRAFLATPENPKLAVIVIHEIWGLNDNIKDISRRLANEGYMALAPQLYTRNEDVLNEGNIQNVMMKVWSIPPEKRNDPNSYQQIMSALDEKGKKVAELLVLNRQKTEEQMIKDAIKAYEYVSSQGVKKIVSMGFCMGGGLAFQLATEVPLDGTIVFYGRNPQPLEAIQKIKGPILGLYAGEDPPIDAGLPDLISAIIKYKKDLELKIYPGAYHAFFNDRGRSYNKEAAEDAWERVKSFLRRVSK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	257 (228)
Sequences:	284 (241)
Seq/√Len:	15.9

BACSU - YCZH
SULSO - DLHH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
37_L	42_K	4.640	1.00
217_E	247_R	4.426	1.00
154_A	166_T	4.385	1.00
188_L	247_R	3.499	0.99
169_F	229_F	3.373	0.99
119_T	122_Q	3.285	0.99
158_A	166_T	3.264	0.99
207_S	211_K	3.065	0.98
238_K	242_E	2.581	0.96
32_H	57_A	2.358	0.93
167_I	248_V	2.286	0.92
17_F	46_R	2.220	0.90
56_L	130_A	2.204	0.90
151_G	168_V	2.186	0.90
143_V	252_L	2.178	0.89
33_E	231_D	2.146	0.89
18_L	54_M	2.122	0.88
145_M	248_V	2.102	0.88
246_E	250_S	2.096	0.87
165_G	255_V	2.079	0.87
40_N	251_F	2.054	0.86
143_V	164_D	1.976	0.84
48_L	147_F	1.936	0.83
144_S	154_A	1.929	0.83
101_L	224_A	1.915	0.82
149_M	172_R	1.846	0.80
114_L	118_K	1.825	0.79
145_M	167_I	1.800	0.78
203_P	207_S	1.775	0.77
149_M	153_L	1.739	0.75
170_Y	227_A	1.701	0.74
206_I	210_I	1.660	0.72
33_E	170_Y	1.651	0.71
171_G	231_D	1.600	0.69
208_A	252_L	1.569	0.67
86_E	134_V	1.532	0.65
43_D	171_G	1.514	0.64
203_P	206_I	1.511	0.64
31_I	144_S	1.489	0.63
239_E	243_D	1.481	0.63
208_A	212_Y	1.478	0.62
61_Y	167_I	1.449	0.61
190_L	247_R	1.444	0.61
202_L	206_I	1.435	0.60
35_W	141_K	1.428	0.60
183_I	187_I	1.427	0.60
133_Y	223_G	1.420	0.59
157_L	244_A	1.399	0.58
152_G	180_I	1.387	0.57
166_T	192_A	1.384	0.57
219_K	243_D	1.381	0.57
49_A	162_P	1.380	0.57
219_K	222_P	1.375	0.57
18_L	179_A	1.350	0.55
167_I	188_L	1.331	0.54
191_Y	202_L	1.291	0.52
146_G	151_G	1.286	0.52
28_V	187_I	1.240	0.49
21_P	162_P	1.232	0.48
13_K	136_S	1.224	0.48
30_V	45_S	1.220	0.48
131_Y	134_V	1.215	0.47
193_G	222_P	1.212	0.47
240_A	253_R	1.209	0.47
31_I	198_I	1.202	0.47
19_A	134_V	1.194	0.46
229_F	232_R	1.179	0.45
34_I	120_E	1.176	0.45
22_E	253_R	1.165	0.45
79_K	84_P	1.157	0.44
177_L	188_L	1.157	0.44
169_F	190_L	1.154	0.44
136_S	151_G	1.151	0.44
146_G	150_G	1.144	0.43
46_R	63_R	1.142	0.43
164_D	252_L	1.138	0.43
85_P	211_K	1.133	0.43
151_G	213_K	1.132	0.43
123_M	206_I	1.124	0.42
61_Y	168_V	1.118	0.42
192_A	224_A	1.117	0.42
168_V	183_I	1.117	0.42
56_L	106_K	1.117	0.42
230_N	251_F	1.106	0.41
98_M	135_S	1.103	0.41
227_A	231_D	1.100	0.41
40_N	43_D	1.086	0.40
12_A	209_I	1.084	0.40
188_L	217_E	1.083	0.40
219_K	250_S	1.082	0.40
179_A	183_I	1.080	0.40
209_I	216_L	1.079	0.40
120_E	211_K	1.078	0.40
204_D	207_S	1.078	0.40
59_Q	126_D	1.076	0.40
194_E	254_R	1.076	0.40
64_N	114_L	1.070	0.39
24_P	255_V	1.070	0.39
29_I	119_T	1.069	0.39
54_M	249_K	1.067	0.39
155_F	189_G	1.065	0.39
133_Y	136_S	1.054	0.38
106_K	253_R	1.052	0.38
55_A	150_G	1.051	0.38
41_I	57_A	1.048	0.38
115_N	125_K	1.042	0.38
31_I	53_Y	1.042	0.38
37_L	65_E	1.040	0.38
35_W	231_D	1.040	0.38
98_M	105_G	1.032	0.37
141_K	164_D	1.022	0.37
120_E	153_L	1.019	0.36
35_W	148_C	1.015	0.36
198_I	223_G	1.010	0.36
106_K	184_K	1.005	0.36
49_A	146_G	1.004	0.36
40_N	217_E	1.002	0.36
117_Q	234_R	0.999	0.35
59_Q	186_P	0.984	0.35
40_N	231_D	0.983	0.35
32_H	152_G	0.981	0.34
170_Y	230_N	0.976	0.34
19_A	27_A	0.971	0.34
187_I	225_Y	0.970	0.34
114_L	167_I	0.970	0.34
102_D	232_R	0.968	0.34
60_L	218_L	0.964	0.34
201_G	204_D	0.961	0.33
232_R	241_A	0.957	0.33
170_Y	191_Y	0.953	0.33
30_V	57_A	0.946	0.33
106_K	117_Q	0.945	0.33
238_K	250_S	0.944	0.33
221_Y	243_D	0.943	0.32
56_L	151_G	0.931	0.32
46_R	59_Q	0.929	0.32
170_Y	229_F	0.929	0.32
52_G	195_D	0.928	0.32
181_Q	217_E	0.925	0.32
28_V	112_L	0.924	0.32
163_L	244_A	0.922	0.31
98_M	175_Q	0.915	0.31
247_R	251_F	0.913	0.31
178_E	181_Q	0.910	0.31
33_E	227_A	0.909	0.31
56_L	165_G	0.908	0.31
39_D	169_F	0.902	0.30
44_I	147_F	0.896	0.30
201_G	215_D	0.895	0.30
83_I	236_Y	0.894	0.30
58_P	146_G	0.888	0.30
38_N	189_G	0.887	0.30
40_N	170_Y	0.885	0.30
171_G	186_P	0.883	0.30
163_L	166_T	0.880	0.29
184_K	223_G	0.876	0.29
210_I	246_E	0.875	0.29
13_K	171_G	0.874	0.29
59_Q	63_R	0.873	0.29
63_R	154_A	0.870	0.29
86_E	213_K	0.868	0.29
165_G	185_G	0.865	0.29
143_V	148_C	0.865	0.29
40_N	46_R	0.861	0.28
37_L	138_G	0.861	0.28
19_A	29_I	0.858	0.28
80_V	151_G	0.857	0.28
198_I	205_L	0.856	0.28
16_A	43_D	0.853	0.28
111_L	202_L	0.852	0.28
34_I	41_I	0.850	0.28
29_I	149_M	0.848	0.28
21_P	255_V	0.844	0.28
230_N	241_A	0.841	0.28
56_L	65_E	0.839	0.27
40_N	125_K	0.835	0.27
169_F	248_V	0.835	0.27
122_Q	126_D	0.834	0.27
115_N	119_T	0.833	0.27
158_A	194_E	0.828	0.27
156_Q	192_A	0.823	0.27
41_I	151_G	0.818	0.26
40_N	63_R	0.816	0.26
60_L	208_A	0.815	0.26
167_I	190_L	0.813	0.26
162_P	249_K	0.804	0.26
79_K	82_S	0.793	0.25
28_V	177_L	0.793	0.25
44_I	227_A	0.790	0.25
32_H	190_L	0.789	0.25
132_E	135_S	0.786	0.25
58_P	63_R	0.784	0.25
135_S	253_R	0.780	0.25
32_H	232_R	0.779	0.25
82_S	159_T	0.779	0.25
62_T	126_D	0.776	0.25
13_K	62_T	0.776	0.25
211_K	246_E	0.775	0.25
12_A	158_A	0.775	0.25
209_I	252_L	0.775	0.25
34_I	145_M	0.774	0.25
69_N	250_S	0.770	0.24
121_E	129_K	0.770	0.24
46_R	58_P	0.765	0.24
195_D	226_H	0.762	0.24
207_S	246_E	0.758	0.24
29_I	64_N	0.757	0.24
211_K	235_S	0.757	0.24
192_A	198_I	0.750	0.24
146_G	195_D	0.749	0.23
37_L	149_M	0.749	0.23
238_K	243_D	0.748	0.23
171_G	191_Y	0.743	0.23
32_H	45_S	0.742	0.23
57_A	232_R	0.737	0.23
64_N	118_K	0.735	0.23
22_E	209_I	0.733	0.23
108_V	112_L	0.731	0.23
37_L	172_R	0.726	0.23
36_G	226_H	0.724	0.22
175_Q	178_E	0.720	0.22
145_M	208_A	0.720	0.22
17_F	63_R	0.717	0.22
14_I	140_K	0.717	0.22
192_A	202_L	0.716	0.22
129_K	238_K	0.712	0.22
149_M	177_L	0.711	0.22
17_F	40_N	0.711	0.22
58_P	221_Y	0.709	0.22
33_E	171_G	0.707	0.22
47_R	229_F	0.706	0.22
49_A	145_M	0.701	0.22
37_L	54_M	0.700	0.22
146_G	226_H	0.700	0.22
128_I	138_G	0.694	0.21
140_K	160_E	0.691	0.21
69_N	200_A	0.688	0.21
33_E	130_A	0.685	0.21
80_V	85_P	0.682	0.21
194_E	250_S	0.678	0.21
37_L	177_L	0.677	0.21
81_W	85_P	0.677	0.21
23_N	193_G	0.672	0.20
144_S	198_I	0.664	0.20
171_G	174_P	0.662	0.20
136_S	204_D	0.659	0.20
52_G	185_G	0.656	0.20
107_K	113_V	0.655	0.20
147_F	191_Y	0.653	0.20
155_F	174_P	0.653	0.20
100_A	254_R	0.648	0.20
137_Q	172_R	0.646	0.19
25_K	207_S	0.645	0.19
134_V	143_V	0.645	0.19
166_T	187_I	0.644	0.19
155_F	187_I	0.644	0.19
135_S	177_L	0.643	0.19
219_K	242_E	0.642	0.19
163_L	185_G	0.641	0.19
165_G	179_A	0.641	0.19
198_I	237_N	0.641	0.19
84_P	87_K	0.630	0.19
20_T	109_A	0.626	0.19
234_R	237_N	0.625	0.19
141_K	220_I	0.623	0.19
193_G	248_V	0.623	0.19
69_N	104_K	0.620	0.19
175_Q	236_Y	0.616	0.18
121_E	252_L	0.615	0.18
47_R	158_A	0.615	0.18
34_I	167_I	0.615	0.18
154_A	199_D	0.611	0.18
32_H	114_L	0.606	0.18
28_V	100_A	0.606	0.18
129_K	239_E	0.606	0.18
224_A	240_A	0.605	0.18
18_L	188_L	0.603	0.18
56_L	235_S	0.602	0.18
207_S	250_S	0.598	0.18
53_Y	98_M	0.597	0.18
237_N	241_A	0.594	0.18
80_V	98_M	0.594	0.18
35_W	63_R	0.594	0.18
188_L	251_F	0.592	0.18
186_P	228_F	0.592	0.18
244_A	248_V	0.591	0.18
135_S	161_V	0.590	0.18
82_S	111_L	0.590	0.18
42_K	138_G	0.588	0.17
81_W	84_P	0.588	0.17
95_Q	99_S	0.586	0.17
157_L	228_F	0.585	0.17
46_R	61_Y	0.583	0.17
54_M	95_Q	0.581	0.17
112_L	143_V	0.579	0.17
102_D	114_L	0.579	0.17
206_I	218_L	0.576	0.17
107_K	137_Q	0.573	0.17
191_Y	240_A	0.573	0.17
68_L	153_L	0.572	0.17
158_A	187_I	0.571	0.17
115_N	126_D	0.564	0.17
132_E	161_V	0.564	0.17
16_A	97_I	0.560	0.17
67_V	174_P	0.560	0.17
159_T	184_K	0.554	0.16
187_I	196_P	0.549	0.16
46_R	148_C	0.549	0.16
18_L	22_E	0.549	0.16
86_E	239_E	0.549	0.16
155_F	163_L	0.548	0.16
37_L	61_Y	0.548	0.16
53_Y	249_K	0.548	0.16
46_R	170_Y	0.547	0.16
224_A	237_N	0.546	0.16
60_L	101_L	0.542	0.16
80_V	255_V	0.539	0.16
173_N	207_S	0.538	0.16
96_Q	223_G	0.538	0.16
250_S	253_R	0.535	0.16
105_G	194_E	0.535	0.16
31_I	228_F	0.532	0.16
163_L	193_G	0.531	0.16
152_G	166_T	0.531	0.16
199_D	204_D	0.523	0.15
49_A	213_K	0.517	0.15
129_K	173_N	0.516	0.15
213_K	255_V	0.515	0.15
151_G	240_A	0.514	0.15
37_L	218_L	0.513	0.15
63_R	149_M	0.513	0.15
61_Y	65_E	0.512	0.15
18_L	163_L	0.511	0.15
118_K	153_L	0.510	0.15
21_P	125_K	0.509	0.15
58_P	61_Y	0.508	0.15
148_C	226_H	0.507	0.15
63_R	66_D	0.506	0.15
41_I	230_N	0.504	0.15
158_A	163_L	0.501	0.15
152_G	218_L	0.501	0.15
31_I	241_A	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zi8A	1	0.8794	100	0.622	Contact Map
4zv9A	1	0.8482	100	0.627	Contact Map
3f67A	1	0.8599	100	0.635	Contact Map
1xfdA	2	0.8132	99.9	0.688	Contact Map
2o2gA	1	0.8016	99.9	0.691	Contact Map
4wjlA	2	0.8093	99.9	0.698	Contact Map
2ecfA	2	0.8093	99.9	0.698	Contact Map
3bxpA	2	0.7899	99.9	0.698	Contact Map
3o4hA	2	0.8132	99.9	0.701	Contact Map
4q3kA	3	0.7977	99.9	0.701	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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