GREMLIN Database
DLHH - Putative carboxymethylenebutenolidase
UniProt: P95862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (228)
Sequences: 284 (241)
Seq/√Len: 15.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_L42_K4.6401.00
217_E247_R4.4261.00
154_A166_T4.3851.00
188_L247_R3.4990.99
169_F229_F3.3730.99
119_T122_Q3.2850.99
158_A166_T3.2640.99
207_S211_K3.0650.98
238_K242_E2.5810.96
32_H57_A2.3580.93
167_I248_V2.2860.92
17_F46_R2.2200.90
56_L130_A2.2040.90
151_G168_V2.1860.90
143_V252_L2.1780.89
33_E231_D2.1460.89
18_L54_M2.1220.88
145_M248_V2.1020.88
246_E250_S2.0960.87
165_G255_V2.0790.87
40_N251_F2.0540.86
143_V164_D1.9760.84
48_L147_F1.9360.83
144_S154_A1.9290.83
101_L224_A1.9150.82
149_M172_R1.8460.80
114_L118_K1.8250.79
145_M167_I1.8000.78
203_P207_S1.7750.77
149_M153_L1.7390.75
170_Y227_A1.7010.74
206_I210_I1.6600.72
33_E170_Y1.6510.71
171_G231_D1.6000.69
208_A252_L1.5690.67
86_E134_V1.5320.65
43_D171_G1.5140.64
203_P206_I1.5110.64
31_I144_S1.4890.63
239_E243_D1.4810.63
208_A212_Y1.4780.62
61_Y167_I1.4490.61
190_L247_R1.4440.61
202_L206_I1.4350.60
35_W141_K1.4280.60
183_I187_I1.4270.60
133_Y223_G1.4200.59
157_L244_A1.3990.58
152_G180_I1.3870.57
166_T192_A1.3840.57
219_K243_D1.3810.57
49_A162_P1.3800.57
219_K222_P1.3750.57
18_L179_A1.3500.55
167_I188_L1.3310.54
191_Y202_L1.2910.52
146_G151_G1.2860.52
28_V187_I1.2400.49
21_P162_P1.2320.48
13_K136_S1.2240.48
30_V45_S1.2200.48
131_Y134_V1.2150.47
193_G222_P1.2120.47
240_A253_R1.2090.47
31_I198_I1.2020.47
19_A134_V1.1940.46
229_F232_R1.1790.45
34_I120_E1.1760.45
22_E253_R1.1650.45
79_K84_P1.1570.44
177_L188_L1.1570.44
169_F190_L1.1540.44
136_S151_G1.1510.44
146_G150_G1.1440.43
46_R63_R1.1420.43
164_D252_L1.1380.43
85_P211_K1.1330.43
151_G213_K1.1320.43
123_M206_I1.1240.42
61_Y168_V1.1180.42
192_A224_A1.1170.42
168_V183_I1.1170.42
56_L106_K1.1170.42
230_N251_F1.1060.41
98_M135_S1.1030.41
227_A231_D1.1000.41
40_N43_D1.0860.40
12_A209_I1.0840.40
188_L217_E1.0830.40
219_K250_S1.0820.40
179_A183_I1.0800.40
209_I216_L1.0790.40
120_E211_K1.0780.40
204_D207_S1.0780.40
59_Q126_D1.0760.40
194_E254_R1.0760.40
64_N114_L1.0700.39
24_P255_V1.0700.39
29_I119_T1.0690.39
54_M249_K1.0670.39
155_F189_G1.0650.39
133_Y136_S1.0540.38
106_K253_R1.0520.38
55_A150_G1.0510.38
41_I57_A1.0480.38
115_N125_K1.0420.38
31_I53_Y1.0420.38
37_L65_E1.0400.38
35_W231_D1.0400.38
98_M105_G1.0320.37
141_K164_D1.0220.37
120_E153_L1.0190.36
35_W148_C1.0150.36
198_I223_G1.0100.36
106_K184_K1.0050.36
49_A146_G1.0040.36
40_N217_E1.0020.36
117_Q234_R0.9990.35
59_Q186_P0.9840.35
40_N231_D0.9830.35
32_H152_G0.9810.34
170_Y230_N0.9760.34
19_A27_A0.9710.34
187_I225_Y0.9700.34
114_L167_I0.9700.34
102_D232_R0.9680.34
60_L218_L0.9640.34
201_G204_D0.9610.33
232_R241_A0.9570.33
170_Y191_Y0.9530.33
30_V57_A0.9460.33
106_K117_Q0.9450.33
238_K250_S0.9440.33
221_Y243_D0.9430.32
56_L151_G0.9310.32
46_R59_Q0.9290.32
170_Y229_F0.9290.32
52_G195_D0.9280.32
181_Q217_E0.9250.32
28_V112_L0.9240.32
163_L244_A0.9220.31
98_M175_Q0.9150.31
247_R251_F0.9130.31
178_E181_Q0.9100.31
33_E227_A0.9090.31
56_L165_G0.9080.31
39_D169_F0.9020.30
44_I147_F0.8960.30
201_G215_D0.8950.30
83_I236_Y0.8940.30
58_P146_G0.8880.30
38_N189_G0.8870.30
40_N170_Y0.8850.30
171_G186_P0.8830.30
163_L166_T0.8800.29
184_K223_G0.8760.29
210_I246_E0.8750.29
13_K171_G0.8740.29
59_Q63_R0.8730.29
63_R154_A0.8700.29
86_E213_K0.8680.29
165_G185_G0.8650.29
143_V148_C0.8650.29
40_N46_R0.8610.28
37_L138_G0.8610.28
19_A29_I0.8580.28
80_V151_G0.8570.28
198_I205_L0.8560.28
16_A43_D0.8530.28
111_L202_L0.8520.28
34_I41_I0.8500.28
29_I149_M0.8480.28
21_P255_V0.8440.28
230_N241_A0.8410.28
56_L65_E0.8390.27
40_N125_K0.8350.27
169_F248_V0.8350.27
122_Q126_D0.8340.27
115_N119_T0.8330.27
158_A194_E0.8280.27
156_Q192_A0.8230.27
41_I151_G0.8180.26
40_N63_R0.8160.26
60_L208_A0.8150.26
167_I190_L0.8130.26
162_P249_K0.8040.26
79_K82_S0.7930.25
28_V177_L0.7930.25
44_I227_A0.7900.25
32_H190_L0.7890.25
132_E135_S0.7860.25
58_P63_R0.7840.25
135_S253_R0.7800.25
32_H232_R0.7790.25
82_S159_T0.7790.25
62_T126_D0.7760.25
13_K62_T0.7760.25
211_K246_E0.7750.25
12_A158_A0.7750.25
209_I252_L0.7750.25
34_I145_M0.7740.25
69_N250_S0.7700.24
121_E129_K0.7700.24
46_R58_P0.7650.24
195_D226_H0.7620.24
207_S246_E0.7580.24
29_I64_N0.7570.24
211_K235_S0.7570.24
192_A198_I0.7500.24
146_G195_D0.7490.23
37_L149_M0.7490.23
238_K243_D0.7480.23
171_G191_Y0.7430.23
32_H45_S0.7420.23
57_A232_R0.7370.23
64_N118_K0.7350.23
22_E209_I0.7330.23
108_V112_L0.7310.23
37_L172_R0.7260.23
36_G226_H0.7240.22
175_Q178_E0.7200.22
145_M208_A0.7200.22
17_F63_R0.7170.22
14_I140_K0.7170.22
192_A202_L0.7160.22
129_K238_K0.7120.22
149_M177_L0.7110.22
17_F40_N0.7110.22
58_P221_Y0.7090.22
33_E171_G0.7070.22
47_R229_F0.7060.22
49_A145_M0.7010.22
37_L54_M0.7000.22
146_G226_H0.7000.22
128_I138_G0.6940.21
140_K160_E0.6910.21
69_N200_A0.6880.21
33_E130_A0.6850.21
80_V85_P0.6820.21
194_E250_S0.6780.21
37_L177_L0.6770.21
81_W85_P0.6770.21
23_N193_G0.6720.20
144_S198_I0.6640.20
171_G174_P0.6620.20
136_S204_D0.6590.20
52_G185_G0.6560.20
107_K113_V0.6550.20
147_F191_Y0.6530.20
155_F174_P0.6530.20
100_A254_R0.6480.20
137_Q172_R0.6460.19
25_K207_S0.6450.19
134_V143_V0.6450.19
166_T187_I0.6440.19
155_F187_I0.6440.19
135_S177_L0.6430.19
219_K242_E0.6420.19
163_L185_G0.6410.19
165_G179_A0.6410.19
198_I237_N0.6410.19
84_P87_K0.6300.19
20_T109_A0.6260.19
234_R237_N0.6250.19
141_K220_I0.6230.19
193_G248_V0.6230.19
69_N104_K0.6200.19
175_Q236_Y0.6160.18
121_E252_L0.6150.18
47_R158_A0.6150.18
34_I167_I0.6150.18
154_A199_D0.6110.18
32_H114_L0.6060.18
28_V100_A0.6060.18
129_K239_E0.6060.18
224_A240_A0.6050.18
18_L188_L0.6030.18
56_L235_S0.6020.18
207_S250_S0.5980.18
53_Y98_M0.5970.18
237_N241_A0.5940.18
80_V98_M0.5940.18
35_W63_R0.5940.18
188_L251_F0.5920.18
186_P228_F0.5920.18
244_A248_V0.5910.18
135_S161_V0.5900.18
82_S111_L0.5900.18
42_K138_G0.5880.17
81_W84_P0.5880.17
95_Q99_S0.5860.17
157_L228_F0.5850.17
46_R61_Y0.5830.17
54_M95_Q0.5810.17
112_L143_V0.5790.17
102_D114_L0.5790.17
206_I218_L0.5760.17
107_K137_Q0.5730.17
191_Y240_A0.5730.17
68_L153_L0.5720.17
158_A187_I0.5710.17
115_N126_D0.5640.17
132_E161_V0.5640.17
16_A97_I0.5600.17
67_V174_P0.5600.17
159_T184_K0.5540.16
187_I196_P0.5490.16
46_R148_C0.5490.16
18_L22_E0.5490.16
86_E239_E0.5490.16
155_F163_L0.5480.16
37_L61_Y0.5480.16
53_Y249_K0.5480.16
46_R170_Y0.5470.16
224_A237_N0.5460.16
60_L101_L0.5420.16
80_V255_V0.5390.16
173_N207_S0.5380.16
96_Q223_G0.5380.16
250_S253_R0.5350.16
105_G194_E0.5350.16
31_I228_F0.5320.16
163_L193_G0.5310.16
152_G166_T0.5310.16
199_D204_D0.5230.15
49_A213_K0.5170.15
129_K173_N0.5160.15
213_K255_V0.5150.15
151_G240_A0.5140.15
37_L218_L0.5130.15
63_R149_M0.5130.15
61_Y65_E0.5120.15
18_L163_L0.5110.15
118_K153_L0.5100.15
21_P125_K0.5090.15
58_P61_Y0.5080.15
148_C226_H0.5070.15
63_R66_D0.5060.15
41_I230_N0.5040.15
158_A163_L0.5010.15
152_G218_L0.5010.15
31_I241_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zi8A 1 0.8794 100 0.622 Contact Map
4zv9A 1 0.8482 100 0.627 Contact Map
3f67A 1 0.8599 100 0.635 Contact Map
1xfdA 2 0.8132 99.9 0.688 Contact Map
2o2gA 1 0.8016 99.9 0.691 Contact Map
4wjlA 2 0.8093 99.9 0.698 Contact Map
2ecfA 2 0.8093 99.9 0.698 Contact Map
3bxpA 2 0.7899 99.9 0.698 Contact Map
3o4hA 2 0.8132 99.9 0.701 Contact Map
4q3kA 3 0.7977 99.9 0.701 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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