GREMLIN Database
SODF - Superoxide dismutase [Fe]
UniProt: P80857 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (195)
Sequences: 4186 (2399)
Seq/√Len: 171.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_K44_N4.0101.00
184_K187_D2.9481.00
119_R122_Q2.5241.00
107_A111_N2.5051.00
200_A203_K2.4531.00
142_D149_Q2.3891.00
29_D182_K2.3711.00
128_A137_A2.3291.00
45_G48_S2.2771.00
106_L202_E2.2371.00
28_K32_D2.2291.00
200_A204_K2.1841.00
170_L189_V2.1691.00
25_Y194_N2.1111.00
122_Q126_E2.1051.00
142_D145_S2.0121.00
108_D111_N1.9821.00
92_M192_W1.9381.00
113_Q147_N1.9061.00
125_T190_N1.8591.00
131_L152_T1.8561.00
119_R123_V1.8511.00
27_S180_Q1.8201.00
90_E200_A1.8021.00
19_I36_N1.8021.00
187_D190_N1.7901.00
128_A170_L1.7711.00
43_V82_H1.7601.00
109_L112_K1.7421.00
26_I88_Y1.7411.00
109_L205_L1.7411.00
168_L201_A1.6991.00
128_A189_V1.6971.00
140_Y151_M1.6201.00
126_E130_S1.6171.00
48_S51_E1.6081.00
46_A79_I1.5921.00
20_D28_K1.5811.00
105_A206_Q1.5611.00
202_E206_Q1.5561.00
123_V126_E1.5521.00
11_E14_P1.5391.00
120_F124_F1.5331.00
44_N48_S1.5171.00
109_L113_Q1.5091.00
93_A98_G1.4661.00
13_P86_A1.4651.00
69_Q72_I1.4541.00
60_D63_T1.4511.00
179_L182_K1.4151.00
170_L192_W1.4141.00
91_N201_A1.4031.00
125_T129_N1.3951.00
39_H89_W1.3841.00
82_H86_A1.3791.00
129_N186_A1.3781.00
129_N189_V1.3631.00
31_I88_Y1.3371.00
181_Y191_A1.3281.00
138_V153_F1.3231.00
105_A108_D1.2961.00
125_T189_V1.2661.00
140_Y149_Q1.2631.00
29_D32_D1.2541.00
141_Y205_L1.2511.00
53_L56_V1.2391.00
91_N200_A1.2111.00
18_K21_A1.2061.00
203_K207_K1.2011.00
19_I32_D1.1921.00
45_G78_N1.1871.00
196_V201_A1.1871.00
90_E204_K1.1841.00
137_A152_T1.1811.00
46_A75_L1.1781.00
125_T193_W1.1751.00
193_W196_V1.1601.00
33_V182_K1.1601.00
80_N156_H1.1591.00
12_L35_Y1.1581.00
32_D36_N1.1571.00
101_K118_D1.1491.00
50_L53_L1.1411.00
149_Q164_I1.1361.00
199_D202_E1.1321.00
172_E185_R1.1311.00
167_I201_A1.1291.00
131_L137_A1.1241.00
127_T137_A1.1111.00
116_S119_R1.1041.00
127_T150_I1.1031.00
19_I35_Y1.1031.00
122_Q190_N1.0791.00
197_N200_A1.0761.00
16_P90_E1.0741.00
117_F120_F1.0741.00
124_F170_L1.0721.00
83_K158_Q1.0711.00
88_Y188_Y1.0711.00
177_Y185_R1.0631.00
10_Y46_A1.0611.00
10_Y50_L1.0541.00
101_K107_A1.0541.00
83_K87_L1.0440.99
142_D164_I1.0370.99
105_A202_E1.0240.99
76_T157_F1.0240.99
91_N204_K1.0210.99
86_A90_E1.0120.99
103_G202_E1.0100.99
192_W196_V1.0090.99
38_H178_Y1.0060.99
108_D112_K0.9980.99
41_G45_G0.9980.99
93_A99_G0.9900.99
120_F150_I0.9780.99
52_R56_V0.9720.99
87_L200_A0.9710.99
151_M164_I0.9690.99
126_E129_N0.9670.99
118_D121_K0.9660.99
191_A194_N0.9590.99
168_L196_V0.9490.99
124_F192_W0.9430.99
19_I28_K0.9340.99
110_I120_F0.9340.99
127_T152_T0.9340.99
187_D191_A0.9300.99
30_I180_Q0.9290.99
101_K111_N0.9250.99
27_S30_I0.9180.99
55_K59_G0.9180.99
92_M195_V0.9040.98
9_K51_E0.9010.98
39_H86_A0.8980.98
81_G156_H0.8910.98
109_L141_Y0.8780.98
199_D203_K0.8760.98
110_I117_F0.8750.98
88_Y170_L0.8720.98
43_V47_N0.8660.98
56_V59_G0.8630.98
141_Y146_G0.8600.98
106_L205_L0.8500.98
123_V127_T0.8490.98
140_Y164_I0.8470.98
142_D147_N0.8360.97
29_D180_Q0.8310.97
36_N40_K0.8300.97
77_F132_P0.8240.97
102_P107_A0.8200.97
106_L110_I0.8130.97
117_F121_K0.8130.97
106_L201_A0.8130.97
37_G184_K0.8040.97
104_G108_D0.8040.97
131_L154_E0.8010.97
113_Q148_L0.8010.97
93_A199_D0.7980.97
19_I31_I0.7960.97
20_D23_E0.7930.96
13_P39_H0.7920.96
41_G44_N0.7890.96
55_K58_K0.7880.96
137_A170_L0.7730.96
29_D33_V0.7680.96
17_Y92_M0.7670.96
93_A197_N0.7630.96
95_S100_G0.7600.96
83_K160_H0.7600.96
102_P117_F0.7580.95
12_L39_H0.7560.95
51_E56_V0.7520.95
39_H82_H0.7490.95
82_H89_W0.7380.95
53_L57_V0.7320.95
141_Y167_I0.7230.94
112_K147_N0.7220.94
23_E28_K0.7210.94
121_K125_T0.7190.94
37_G183_N0.7160.94
95_S99_G0.7150.94
118_D122_Q0.7150.94
73_R76_T0.7150.94
85_H171_D0.7110.94
121_K190_N0.7060.93
141_Y165_P0.7020.93
26_I188_Y0.7000.93
41_G129_N0.7000.93
25_Y191_A0.6980.93
52_R55_K0.6890.93
111_N116_S0.6850.92
114_Y123_V0.6820.92
158_Q161_I0.6810.92
84_L138_V0.6810.92
37_G40_K0.6810.92
134_T155_N0.6800.92
138_V169_I0.6800.92
87_L204_K0.6610.91
63_T67_D0.6610.91
65_Q68_I0.6590.91
34_H85_H0.6590.91
121_K194_N0.6580.91
45_G74_G0.6530.90
61_L83_K0.6500.90
121_K193_W0.6440.90
42_Y81_G0.6430.90
101_K121_K0.6420.90
31_I188_Y0.6380.89
139_L148_L0.6370.89
103_G199_D0.6350.89
26_I31_I0.6330.89
12_L43_V0.6270.89
53_L58_K0.6260.89
26_I92_M0.6250.88
43_V86_A0.6250.88
104_G107_A0.6240.88
198_W201_A0.6210.88
76_T156_H0.6210.88
169_I188_Y0.6210.88
135_G172_E0.6160.88
40_K43_V0.6160.88
131_L150_I0.6160.88
151_M161_I0.6150.88
107_A117_F0.6140.88
181_Y187_D0.6130.88
76_T81_G0.6120.87
25_Y195_V0.6030.87
130_S152_T0.6020.87
114_Y148_L0.6020.87
186_A190_N0.6000.86
34_H171_D0.6000.86
12_L40_K0.5920.86
14_P18_K0.5850.85
127_T131_L0.5840.85
25_Y192_W0.5810.85
16_P197_N0.5790.84
137_A172_E0.5790.84
27_S33_V0.5780.84
85_H175_H0.5770.84
123_V150_I0.5760.84
203_K206_Q0.5740.84
171_D175_H0.5740.84
84_L156_H0.5730.84
33_V36_N0.5710.84
33_V179_L0.5700.83
156_H169_I0.5680.83
25_Y180_Q0.5680.83
91_N167_I0.5680.83
48_S52_R0.5670.83
80_N84_L0.5670.83
103_G107_A0.5650.83
52_R67_D0.5620.83
38_H183_N0.5580.82
49_L74_G0.5510.81
34_H175_H0.5480.81
113_Q149_Q0.5470.81
82_H88_Y0.5470.81
189_V193_W0.5450.81
49_L75_L0.5410.80
46_A50_L0.5370.80
23_E29_D0.5350.79
131_L177_Y0.5320.79
128_A172_E0.5260.78
141_Y147_N0.5260.78
88_Y169_I0.5230.78
54_E58_K0.5230.78
104_G202_E0.5210.78
86_A89_W0.5200.78
58_K63_T0.5200.78
178_Y183_N0.5190.77
104_G117_F0.5170.77
160_H166_I0.5170.77
157_F162_A0.5160.77
10_Y83_K0.5140.77
117_F193_W0.5130.77
180_Q195_V0.5120.76
68_I161_I0.5120.76
29_D179_L0.5110.76
37_G187_D0.5100.76
33_V184_K0.5100.76
204_K207_K0.5100.76
161_I164_I0.5090.76
46_A82_H0.5060.76
105_A205_L0.5050.75
124_F150_I0.5040.75
14_P36_N0.5030.75
100_G202_E0.5030.75
87_L169_I0.5020.75
103_G106_L0.5010.75
76_T80_N0.5000.75
10_Y47_N0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gv3A 2 0.9716 100 0.032 Contact Map
3tjtA 2 0.9384 100 0.037 Contact Map
1b06A 4 0.9858 100 0.039 Contact Map
3ak2A 4 0.9716 100 0.046 Contact Map
1mngA 3 0.9194 100 0.048 Contact Map
5a9gA 2 0.9431 100 0.049 Contact Map
2rcvA 2 0.9289 100 0.049 Contact Map
1xreA 2 0.9336 100 0.053 Contact Map
1ma1A 4 0.9526 100 0.055 Contact Map
3kkyA 2 0.9194 100 0.056 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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