CISY - SULSO - GREMLIN Contacts

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CISY - Citrate synthase

UniProt:	P80148	Sequences: MSVVSKGLENVIIKVTNLTFIDGEKGILRYRGYNIEDLVNYGSYEETIYLMLYGKLPTKKELNDLKAKLNEEYEVPQEVLDTIYLMPKEADAIGLLEVGTAALASIDKNFKWKENDKEKAISIIAKMATLVANVYRRKEGNKPRIPEPSDSFAKSFLLASFAREPTTDEINAMDKALILYTDHEVPASTTAALVAASTLSDMYSSLTAALAALKGPLHGGAAEEAFKQFIEIGDPNRVQNWFNDKVVNQKNRLMGFGHRVYKTYDPRAKIFKKLALTLIERNADARRYFEIAQKLEELGIKQFSSKGIYPNTDFYSGIVFYALGFPVYMFTALFALSRTLGWLAHIIEYVEEQHRLIRPRALYVGPEYQEYVSIDKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	377 (360)
Sequences:	4072 (2008)
Seq/√Len:	105.8

ECOLI - CISY PRPC
BACSU - CISY3 CISY2 CISY
HALSA - Q9HNH4
SULSO - CISY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
195_A	208_A	7.440	1.00
37_D	370_E	4.206	1.00
192_A	209_A	3.999	1.00
55_K	61_E	3.492	1.00
59_K	63_N	3.375	1.00
246_V	251_N	3.318	1.00
294_K	297_E	3.222	1.00
154_K	170_I	3.162	1.00
42_G	371_Y	3.093	1.00
34_N	37_D	3.049	1.00
166_T	281_R	2.901	1.00
40_N	273_K	2.881	1.00
58_T	61_E	2.776	1.00
151_S	154_K	2.712	1.00
195_A	212_A	2.702	1.00
200_S	214_K	2.660	1.00
237_R	240_N	2.657	1.00
239_Q	294_K	2.523	1.00
276_L	293_Q	2.518	1.00
233_G	237_R	2.511	1.00
46_E	62_L	2.475	1.00
169_E	323_L	2.413	1.00
230_I	321_Y	2.358	1.00
55_K	369_Q	2.349	1.00
194_V	357_I	2.337	1.00
100_T	210_L	2.304	1.00
191_A	212_A	2.211	1.00
155_S	159_A	2.172	1.00
273_K	277_T	2.122	1.00
9_E	355_R	2.099	1.00
120_A	343_L	2.073	1.00
131_V	336_L	2.036	1.00
153_A	174_D	2.022	1.00
198_T	212_A	2.019	1.00
48_I	340_L	1.991	1.00
245_K	249_Q	1.956	1.00
187_A	198_T	1.940	1.00
43_S	62_L	1.929	1.00
196_A	205_S	1.912	1.00
168_D	281_R	1.910	1.00
49_Y	55_K	1.861	1.00
150_D	154_K	1.831	1.00
77_Q	81_D	1.822	1.00
81_D	84_Y	1.813	1.00
230_I	327_V	1.806	1.00
112_W	115_N	1.799	1.00
239_Q	298_L	1.789	1.00
294_K	298_L	1.783	1.00
171_N	174_D	1.764	1.00
325_F	333_L	1.739	1.00
196_A	346_I	1.733	1.00
276_L	280_E	1.704	1.00
33_Y	369_Q	1.703	1.00
36_E	269_K	1.693	1.00
98_V	101_A	1.693	1.00
176_A	320_F	1.691	1.00
223_E	227_K	1.682	1.00
151_S	170_I	1.678	1.00
63_N	67_A	1.663	1.00
136_R	141_N	1.627	1.00
175_K	274_L	1.626	1.00
243_N	248_N	1.597	1.00
60_K	64_D	1.594	1.00
19_T	182_D	1.581	1.00
132_A	156_F	1.572	1.00
166_T	169_E	1.571	1.00
97_E	211_A	1.567	1.00
292_A	318_I	1.559	1.00
144_R	159_A	1.558	1.00
127_M	339_T	1.552	1.00
160_S	325_F	1.547	1.00
240_N	245_K	1.546	1.00
97_E	101_A	1.542	1.00
138_K	328_Y	1.540	1.00
95_L	134_V	1.532	1.00
167_T	171_N	1.525	1.00
99_G	130_L	1.514	1.00
245_K	250_K	1.500	1.00
52_L	124_I	1.500	1.00
147_E	164_E	1.489	1.00
27_I	34_N	1.472	1.00
176_A	271_F	1.471	1.00
72_E	122_S	1.457	1.00
45_E	69_L	1.442	1.00
208_A	212_A	1.437	1.00
82_T	102_A	1.430	1.00
147_E	158_L	1.429	1.00
273_K	276_L	1.422	1.00
67_A	71_E	1.415	1.00
49_Y	61_E	1.415	1.00
68_K	121_I	1.413	1.00
47_T	178_I	1.408	1.00
246_V	250_K	1.404	1.00
100_T	127_M	1.398	1.00
171_N	175_K	1.389	1.00
253_L	299_G	1.352	1.00
146_P	155_S	1.351	1.00
80_L	133_N	1.341	0.99
191_A	208_A	1.330	0.99
9_E	259_R	1.325	0.99
147_E	150_D	1.322	0.99
234_D	287_R	1.317	0.99
146_P	159_A	1.301	0.99
280_E	286_R	1.288	0.99
275_A	318_I	1.272	0.99
73_Y	148_P	1.270	0.99
184_E	360_R	1.268	0.99
81_D	85_L	1.263	0.99
200_S	204_S	1.258	0.99
286_R	321_Y	1.254	0.99
191_A	195_A	1.248	0.99
213_L	335_A	1.246	0.99
264_Y	269_K	1.245	0.99
51_M	340_L	1.239	0.99
73_Y	152_F	1.237	0.99
15_V	362_L	1.234	0.99
247_V	250_K	1.229	0.99
181_T	340_L	1.227	0.99
218_H	221_A	1.223	0.99
272_K	296_E	1.221	0.99
20_F	23_G	1.220	0.99
46_E	371_Y	1.215	0.99
192_A	346_I	1.213	0.99
204_S	214_K	1.211	0.99
115_N	119_K	1.204	0.99
33_Y	56_L	1.196	0.99
283_A	286_R	1.195	0.99
31_R	54_G	1.184	0.99
50_L	56_L	1.178	0.99
123_I	206_L	1.171	0.99
64_D	68_K	1.163	0.99
63_N	66_K	1.157	0.98
36_E	270_I	1.156	0.98
30_Y	181_T	1.150	0.98
93_I	222_A	1.148	0.98
49_Y	53_Y	1.148	0.98
22_D	25_K	1.145	0.98
256_F	299_G	1.138	0.98
16_T	19_T	1.138	0.98
191_A	194_V	1.137	0.98
72_E	121_I	1.134	0.98
119_K	202_M	1.132	0.98
168_D	277_T	1.124	0.98
113_K	351_E	1.120	0.98
274_L	277_T	1.113	0.98
84_Y	142_K	1.113	0.98
202_M	343_L	1.111	0.98
271_F	319_V	1.110	0.98
246_V	249_Q	1.110	0.98
272_K	276_L	1.109	0.98
52_L	343_L	1.104	0.98
235_P	294_K	1.100	0.98
43_S	174_D	1.099	0.98
290_E	293_Q	1.095	0.98
33_Y	50_L	1.091	0.98
35_I	270_I	1.087	0.98
217_L	252_R	1.086	0.98
174_D	178_I	1.080	0.98
234_D	237_R	1.066	0.97
154_K	167_T	1.065	0.97
68_K	118_E	1.060	0.97
206_L	339_T	1.048	0.97
235_P	291_I	1.040	0.97
321_Y	327_V	1.039	0.97
286_R	290_E	1.032	0.97
44_Y	340_L	1.028	0.97
37_D	41_Y	1.022	0.97
96_L	131_V	1.022	0.97
347_I	351_E	1.021	0.97
42_G	46_E	1.020	0.97
129_T	146_P	1.013	0.96
30_Y	47_T	1.011	0.96
233_G	287_R	1.009	0.96
206_L	343_L	1.007	0.96
131_V	332_A	1.007	0.96
91_D	223_E	1.003	0.96
202_M	346_I	1.003	0.96
6_K	353_Q	1.002	0.96
60_K	63_N	0.996	0.96
144_R	162_A	0.995	0.96
15_V	364_V	0.993	0.96
232_I	241_W	0.992	0.96
293_Q	297_E	0.991	0.96
238_V	294_K	0.987	0.96
241_W	246_V	0.984	0.96
23_G	26_G	0.983	0.96
144_R	158_L	0.981	0.96
29_R	368_Y	0.979	0.96
200_S	205_S	0.977	0.96
161_F	169_E	0.977	0.96
53_Y	117_K	0.974	0.96
117_K	347_I	0.974	0.96
118_E	122_S	0.969	0.95
221_A	311_N	0.962	0.95
55_K	58_T	0.961	0.95
83_I	99_G	0.960	0.95
337_S	340_L	0.956	0.95
193_L	349_Y	0.950	0.95
140_G	144_R	0.949	0.95
304_S	307_G	0.947	0.95
66_K	70_N	0.946	0.95
228_Q	246_V	0.945	0.95
74_E	145_I	0.941	0.95
227_K	327_V	0.935	0.94
37_D	40_N	0.932	0.94
155_S	158_L	0.927	0.94
97_E	207_T	0.926	0.94
51_M	181_T	0.923	0.94
187_A	212_A	0.920	0.94
235_P	290_E	0.917	0.94
61_E	64_D	0.915	0.94
233_G	236_N	0.914	0.94
232_I	238_V	0.913	0.94
239_Q	243_N	0.911	0.94
292_A	314_F	0.902	0.93
45_E	153_A	0.898	0.93
142_K	145_I	0.898	0.93
75_V	133_N	0.898	0.93
180_Y	312_T	0.894	0.93
33_Y	38_L	0.891	0.93
14_K	185_V	0.890	0.93
198_T	356_L	0.890	0.93
150_D	155_S	0.888	0.93
272_K	293_Q	0.887	0.93
80_L	84_Y	0.886	0.93
75_V	130_L	0.881	0.92
83_I	137_R	0.879	0.92
49_Y	65_L	0.878	0.92
224_E	227_K	0.878	0.92
68_K	72_E	0.876	0.92
17_N	364_V	0.875	0.92
171_N	277_T	0.873	0.92
225_A	291_I	0.867	0.92
232_I	295_L	0.867	0.92
236_N	240_N	0.862	0.92
188_S	218_H	0.861	0.92
264_Y	272_K	0.860	0.92
84_Y	137_R	0.857	0.91
19_T	184_E	0.853	0.91
256_F	310_P	0.853	0.91
199_L	217_L	0.845	0.91
38_L	47_T	0.841	0.91
219_G	334_F	0.841	0.91
83_I	134_V	0.838	0.90
183_H	261_Y	0.836	0.90
115_N	118_E	0.830	0.90
210_L	335_A	0.830	0.90
177_L	336_L	0.830	0.90
213_L	334_F	0.828	0.90
190_T	357_I	0.824	0.90
292_A	317_G	0.822	0.90
72_E	118_E	0.819	0.89
129_T	159_A	0.819	0.89
225_A	229_F	0.812	0.89
150_D	165_P	0.808	0.89
52_L	340_L	0.807	0.89
169_E	278_L	0.806	0.89
171_N	274_L	0.805	0.89
153_A	170_I	0.803	0.88
185_V	360_R	0.803	0.88
101_A	211_A	0.803	0.88
213_L	219_G	0.799	0.88
238_V	298_L	0.799	0.88
240_N	243_N	0.797	0.88
222_A	313_D	0.797	0.88
19_T	23_G	0.795	0.88
109_N	118_E	0.792	0.88
109_N	122_S	0.789	0.88
231_E	251_N	0.787	0.87
151_S	174_D	0.784	0.87
82_T	86_M	0.782	0.87
190_T	194_V	0.780	0.87
69_L	121_I	0.779	0.87
120_A	347_I	0.778	0.87
153_A	173_M	0.776	0.87
30_Y	50_L	0.775	0.87
218_H	313_D	0.774	0.87
228_Q	241_W	0.774	0.87
62_L	66_K	0.770	0.86
78_E	106_I	0.768	0.86
296_E	299_G	0.766	0.86
218_H	334_F	0.766	0.86
82_T	85_L	0.761	0.86
20_F	25_K	0.758	0.85
136_R	144_R	0.757	0.85
116_D	119_K	0.756	0.85
38_L	56_L	0.754	0.85
43_S	46_E	0.751	0.85
86_M	102_A	0.750	0.85
47_T	181_T	0.748	0.85
232_I	246_V	0.747	0.85
205_S	346_I	0.744	0.84
86_M	105_S	0.743	0.84
180_Y	222_A	0.742	0.84
125_A	128_A	0.740	0.84
39_V	178_I	0.739	0.84
135_Y	139_E	0.738	0.84
169_E	282_N	0.737	0.84
96_L	210_L	0.737	0.84
221_A	257_G	0.735	0.84
13_I	190_T	0.735	0.84
114_E	118_E	0.734	0.84
230_I	288_Y	0.734	0.84
74_E	118_E	0.733	0.83
119_K	203_Y	0.731	0.83
124_I	152_F	0.727	0.83
235_P	239_Q	0.726	0.83
222_A	331_T	0.726	0.83
227_K	230_I	0.725	0.83
74_E	148_P	0.724	0.83
150_D	170_I	0.723	0.83
122_S	126_K	0.720	0.82
335_A	342_W	0.719	0.82
275_A	319_V	0.719	0.82
366_P	369_Q	0.719	0.82
8_L	11_V	0.718	0.82
226_F	330_F	0.718	0.82
153_A	157_L	0.718	0.82
168_D	172_A	0.710	0.82
183_H	219_G	0.708	0.81
78_E	81_D	0.708	0.81
291_I	295_L	0.707	0.81
79_V	102_A	0.706	0.81
229_F	295_L	0.706	0.81
46_E	56_L	0.704	0.81
153_A	177_L	0.704	0.81
233_G	238_V	0.703	0.81
288_Y	321_Y	0.702	0.81
79_V	99_G	0.702	0.81
271_F	316_S	0.698	0.80
29_R	34_N	0.697	0.80
184_E	361_A	0.697	0.80
48_I	65_L	0.696	0.80
83_I	143_P	0.694	0.80
42_G	178_I	0.685	0.79
48_I	124_I	0.685	0.79
116_D	350_V	0.684	0.79
180_Y	316_S	0.684	0.79
84_Y	133_N	0.684	0.79
274_L	319_V	0.683	0.79
44_Y	48_I	0.681	0.79
188_S	219_G	0.678	0.78
225_A	312_T	0.678	0.78
64_D	67_A	0.674	0.78
231_E	246_V	0.673	0.78
275_A	292_A	0.671	0.78
213_L	222_A	0.670	0.78
132_A	136_R	0.668	0.77
195_A	205_S	0.667	0.77
135_Y	138_K	0.667	0.77
242_F	299_G	0.666	0.77
19_T	29_R	0.666	0.77
101_A	207_T	0.664	0.77
8_L	12_I	0.664	0.77
199_L	350_V	0.663	0.77
199_L	216_P	0.662	0.77
163_R	169_E	0.660	0.77
79_V	82_T	0.660	0.77
72_E	126_K	0.660	0.77
175_K	178_I	0.660	0.77
257_G	311_N	0.660	0.77
165_P	170_I	0.660	0.77
124_I	340_L	0.659	0.76
183_H	334_F	0.658	0.76
276_L	289_F	0.656	0.76
235_P	238_V	0.656	0.76
243_N	305_S	0.653	0.76
245_K	251_N	0.651	0.76
132_A	159_A	0.651	0.76
20_F	363_Y	0.649	0.75
147_E	155_S	0.649	0.75
237_R	245_K	0.648	0.75
33_Y	55_K	0.647	0.75
176_A	180_Y	0.647	0.75
8_L	190_T	0.646	0.75
291_I	294_K	0.643	0.75
177_L	337_S	0.640	0.74
239_Q	304_S	0.638	0.74
240_N	248_N	0.638	0.74
239_Q	242_F	0.636	0.74
201_D	204_S	0.636	0.74
303_F	308_I	0.635	0.74
11_V	14_K	0.635	0.74
107_D	122_S	0.632	0.73
140_G	143_P	0.629	0.73
75_V	80_L	0.628	0.73
252_R	356_L	0.624	0.73
150_D	158_L	0.623	0.72
193_L	229_F	0.623	0.72
224_E	254_M	0.622	0.72
43_S	66_K	0.622	0.72
261_Y	342_W	0.620	0.72
71_E	148_P	0.619	0.72
171_N	178_I	0.619	0.72
327_V	330_F	0.614	0.71
77_Q	145_I	0.609	0.71
34_N	370_E	0.606	0.70
235_P	297_E	0.602	0.70
184_E	308_I	0.602	0.70
35_I	179_L	0.602	0.70
8_L	13_I	0.601	0.70
18_L	31_R	0.601	0.70
247_V	303_F	0.601	0.70
242_F	298_L	0.600	0.70
174_D	355_R	0.600	0.70
129_T	155_S	0.598	0.69
120_A	202_M	0.598	0.69
189_T	331_T	0.596	0.69
312_T	316_S	0.595	0.69
8_L	357_I	0.595	0.69
157_L	170_I	0.595	0.69
104_A	201_D	0.594	0.69
345_H	354_H	0.593	0.69
139_E	326_P	0.592	0.69
44_Y	174_D	0.592	0.69
243_N	247_V	0.592	0.69
186_P	261_Y	0.592	0.69
259_R	262_K	0.591	0.68
189_T	193_L	0.591	0.68
27_I	368_Y	0.590	0.68
243_N	304_S	0.589	0.68
339_T	343_L	0.589	0.68
10_N	21_I	0.589	0.68
86_M	98_V	0.589	0.68
79_V	83_I	0.589	0.68
189_T	345_H	0.588	0.68
253_L	306_K	0.585	0.68
123_I	202_M	0.584	0.68
81_D	138_K	0.583	0.67
133_N	137_R	0.583	0.67
303_F	307_G	0.581	0.67
79_V	144_R	0.581	0.67
129_T	132_A	0.581	0.67
176_A	333_L	0.580	0.67
272_K	315_Y	0.580	0.67
218_H	257_G	0.580	0.67
68_K	71_E	0.579	0.67
325_F	329_M	0.579	0.67
119_K	123_I	0.578	0.67
79_V	87_P	0.577	0.67
14_K	21_I	0.576	0.66
172_A	274_L	0.575	0.66
72_E	209_A	0.573	0.66
201_D	214_K	0.573	0.66
182_D	343_L	0.573	0.66
75_V	79_V	0.571	0.66
124_I	343_L	0.571	0.66
42_G	174_D	0.570	0.66
33_Y	37_D	0.570	0.66
188_S	334_F	0.570	0.66
133_N	143_P	0.569	0.66
28_L	35_I	0.567	0.65
179_L	270_I	0.566	0.65
180_Y	313_D	0.566	0.65
126_K	129_T	0.566	0.65
76_P	79_V	0.565	0.65
236_N	239_Q	0.565	0.65
278_L	319_V	0.563	0.65
188_S	213_L	0.563	0.65
70_N	148_P	0.563	0.65
100_T	123_I	0.562	0.65
133_N	159_A	0.562	0.65
188_S	313_D	0.562	0.65
137_R	143_P	0.561	0.64
23_G	263_T	0.560	0.64
312_T	319_V	0.560	0.64
82_T	99_G	0.558	0.64
226_F	321_Y	0.557	0.64
123_I	339_T	0.555	0.64
31_R	48_I	0.555	0.64
31_R	364_V	0.555	0.64
232_I	242_F	0.555	0.64
242_F	295_L	0.554	0.63
14_K	19_T	0.553	0.63
289_F	293_Q	0.553	0.63
227_K	231_E	0.552	0.63
42_G	62_L	0.551	0.63
33_Y	47_T	0.551	0.63
28_L	32_G	0.551	0.63
69_L	125_A	0.550	0.63
146_P	150_D	0.548	0.63
239_Q	276_L	0.548	0.63
311_N	317_G	0.547	0.62
264_Y	309_Y	0.547	0.62
245_K	248_N	0.544	0.62
172_A	319_V	0.544	0.62
43_S	48_I	0.544	0.62
303_F	309_Y	0.542	0.62
299_G	314_F	0.541	0.62
48_I	52_L	0.540	0.62
76_P	103_L	0.540	0.62
229_F	292_A	0.539	0.61
78_E	88_K	0.539	0.61
226_F	327_V	0.539	0.61
12_I	362_L	0.538	0.61
120_A	123_I	0.535	0.61
15_V	19_T	0.535	0.61
116_D	347_I	0.535	0.61
101_A	104_A	0.535	0.61
262_K	307_G	0.534	0.61
113_K	347_I	0.534	0.61
104_A	200_S	0.532	0.60
45_E	152_F	0.532	0.60
107_D	119_K	0.532	0.60
191_A	306_K	0.532	0.60
290_E	294_K	0.532	0.60
196_A	350_V	0.532	0.60
317_G	334_F	0.531	0.60
258_H	334_F	0.530	0.60
278_L	326_P	0.526	0.60
65_L	121_I	0.526	0.60
22_D	27_I	0.524	0.59
175_K	277_T	0.524	0.59
183_H	188_S	0.523	0.59
110_F	119_K	0.523	0.59
43_S	171_N	0.523	0.59
48_I	193_L	0.523	0.59
22_D	29_R	0.521	0.59
257_G	313_D	0.521	0.59
238_V	291_I	0.519	0.58
225_A	288_Y	0.519	0.58
127_M	130_L	0.519	0.58
222_A	330_F	0.518	0.58
346_I	361_A	0.517	0.58
94_G	104_A	0.516	0.58
287_R	290_E	0.514	0.58
38_L	50_L	0.514	0.58
80_L	145_I	0.512	0.57
116_D	120_A	0.511	0.57
93_I	213_L	0.511	0.57
199_L	354_H	0.510	0.57
271_F	312_T	0.509	0.57
230_I	330_F	0.509	0.57
246_V	306_K	0.508	0.57
160_S	329_M	0.508	0.57
16_T	345_H	0.506	0.57
321_Y	356_L	0.504	0.56
129_T	142_K	0.502	0.56
117_K	121_I	0.500	0.56
185_V	193_L	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2h12A	4	0.9973	100	0.037	Contact Map
4xghA	5	0.9125	100	0.038	Contact Map
1o7xA	2	0.9788	100	0.04	Contact Map
4jadA	5	0.9973	100	0.049	Contact Map
1vgmA	2	0.9894	100	0.05	Contact Map
2ibpA	2	0.992	100	0.052	Contact Map
4tvmA	2	0.8886	100	0.053	Contact Map
1iomA	2	0.9867	100	0.053	Contact Map
1vgpA	2	0.9867	100	0.053	Contact Map
2ifcA	2	0.9894	100	0.054	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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