GREMLIN Database
CISY - Citrate synthase
UniProt: P80148 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (360)
Sequences: 4072 (2008)
Seq/√Len: 105.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_A208_A7.4401.00
37_D370_E4.2061.00
192_A209_A3.9991.00
55_K61_E3.4921.00
59_K63_N3.3751.00
246_V251_N3.3181.00
294_K297_E3.2221.00
154_K170_I3.1621.00
42_G371_Y3.0931.00
34_N37_D3.0491.00
166_T281_R2.9011.00
40_N273_K2.8811.00
58_T61_E2.7761.00
151_S154_K2.7121.00
195_A212_A2.7021.00
200_S214_K2.6601.00
237_R240_N2.6571.00
239_Q294_K2.5231.00
276_L293_Q2.5181.00
233_G237_R2.5111.00
46_E62_L2.4751.00
169_E323_L2.4131.00
230_I321_Y2.3581.00
55_K369_Q2.3491.00
194_V357_I2.3371.00
100_T210_L2.3041.00
191_A212_A2.2111.00
155_S159_A2.1721.00
273_K277_T2.1221.00
9_E355_R2.0991.00
120_A343_L2.0731.00
131_V336_L2.0361.00
153_A174_D2.0221.00
198_T212_A2.0191.00
48_I340_L1.9911.00
245_K249_Q1.9561.00
187_A198_T1.9401.00
43_S62_L1.9291.00
196_A205_S1.9121.00
168_D281_R1.9101.00
49_Y55_K1.8611.00
150_D154_K1.8311.00
77_Q81_D1.8221.00
81_D84_Y1.8131.00
230_I327_V1.8061.00
112_W115_N1.7991.00
239_Q298_L1.7891.00
294_K298_L1.7831.00
171_N174_D1.7641.00
325_F333_L1.7391.00
196_A346_I1.7331.00
276_L280_E1.7041.00
33_Y369_Q1.7031.00
36_E269_K1.6931.00
98_V101_A1.6931.00
176_A320_F1.6911.00
223_E227_K1.6821.00
151_S170_I1.6781.00
63_N67_A1.6631.00
136_R141_N1.6271.00
175_K274_L1.6261.00
243_N248_N1.5971.00
60_K64_D1.5941.00
19_T182_D1.5811.00
132_A156_F1.5721.00
166_T169_E1.5711.00
97_E211_A1.5671.00
292_A318_I1.5591.00
144_R159_A1.5581.00
127_M339_T1.5521.00
160_S325_F1.5471.00
240_N245_K1.5461.00
97_E101_A1.5421.00
138_K328_Y1.5401.00
95_L134_V1.5321.00
167_T171_N1.5251.00
99_G130_L1.5141.00
245_K250_K1.5001.00
52_L124_I1.5001.00
147_E164_E1.4891.00
27_I34_N1.4721.00
176_A271_F1.4711.00
72_E122_S1.4571.00
45_E69_L1.4421.00
208_A212_A1.4371.00
82_T102_A1.4301.00
147_E158_L1.4291.00
273_K276_L1.4221.00
67_A71_E1.4151.00
49_Y61_E1.4151.00
68_K121_I1.4131.00
47_T178_I1.4081.00
246_V250_K1.4041.00
100_T127_M1.3981.00
171_N175_K1.3891.00
253_L299_G1.3521.00
146_P155_S1.3511.00
80_L133_N1.3410.99
191_A208_A1.3300.99
9_E259_R1.3250.99
147_E150_D1.3220.99
234_D287_R1.3170.99
146_P159_A1.3010.99
280_E286_R1.2880.99
275_A318_I1.2720.99
73_Y148_P1.2700.99
184_E360_R1.2680.99
81_D85_L1.2630.99
200_S204_S1.2580.99
286_R321_Y1.2540.99
191_A195_A1.2480.99
213_L335_A1.2460.99
264_Y269_K1.2450.99
51_M340_L1.2390.99
73_Y152_F1.2370.99
15_V362_L1.2340.99
247_V250_K1.2290.99
181_T340_L1.2270.99
218_H221_A1.2230.99
272_K296_E1.2210.99
20_F23_G1.2200.99
46_E371_Y1.2150.99
192_A346_I1.2130.99
204_S214_K1.2110.99
115_N119_K1.2040.99
33_Y56_L1.1960.99
283_A286_R1.1950.99
31_R54_G1.1840.99
50_L56_L1.1780.99
123_I206_L1.1710.99
64_D68_K1.1630.99
63_N66_K1.1570.98
36_E270_I1.1560.98
30_Y181_T1.1500.98
93_I222_A1.1480.98
49_Y53_Y1.1480.98
22_D25_K1.1450.98
256_F299_G1.1380.98
16_T19_T1.1380.98
191_A194_V1.1370.98
72_E121_I1.1340.98
119_K202_M1.1320.98
168_D277_T1.1240.98
113_K351_E1.1200.98
274_L277_T1.1130.98
84_Y142_K1.1130.98
202_M343_L1.1110.98
271_F319_V1.1100.98
246_V249_Q1.1100.98
272_K276_L1.1090.98
52_L343_L1.1040.98
235_P294_K1.1000.98
43_S174_D1.0990.98
290_E293_Q1.0950.98
33_Y50_L1.0910.98
35_I270_I1.0870.98
217_L252_R1.0860.98
174_D178_I1.0800.98
234_D237_R1.0660.97
154_K167_T1.0650.97
68_K118_E1.0600.97
206_L339_T1.0480.97
235_P291_I1.0400.97
321_Y327_V1.0390.97
286_R290_E1.0320.97
44_Y340_L1.0280.97
37_D41_Y1.0220.97
96_L131_V1.0220.97
347_I351_E1.0210.97
42_G46_E1.0200.97
129_T146_P1.0130.96
30_Y47_T1.0110.96
233_G287_R1.0090.96
206_L343_L1.0070.96
131_V332_A1.0070.96
91_D223_E1.0030.96
202_M346_I1.0030.96
6_K353_Q1.0020.96
60_K63_N0.9960.96
144_R162_A0.9950.96
15_V364_V0.9930.96
232_I241_W0.9920.96
293_Q297_E0.9910.96
238_V294_K0.9870.96
241_W246_V0.9840.96
23_G26_G0.9830.96
144_R158_L0.9810.96
29_R368_Y0.9790.96
200_S205_S0.9770.96
161_F169_E0.9770.96
53_Y117_K0.9740.96
117_K347_I0.9740.96
118_E122_S0.9690.95
221_A311_N0.9620.95
55_K58_T0.9610.95
83_I99_G0.9600.95
337_S340_L0.9560.95
193_L349_Y0.9500.95
140_G144_R0.9490.95
304_S307_G0.9470.95
66_K70_N0.9460.95
228_Q246_V0.9450.95
74_E145_I0.9410.95
227_K327_V0.9350.94
37_D40_N0.9320.94
155_S158_L0.9270.94
97_E207_T0.9260.94
51_M181_T0.9230.94
187_A212_A0.9200.94
235_P290_E0.9170.94
61_E64_D0.9150.94
233_G236_N0.9140.94
232_I238_V0.9130.94
239_Q243_N0.9110.94
292_A314_F0.9020.93
45_E153_A0.8980.93
142_K145_I0.8980.93
75_V133_N0.8980.93
180_Y312_T0.8940.93
33_Y38_L0.8910.93
14_K185_V0.8900.93
198_T356_L0.8900.93
150_D155_S0.8880.93
272_K293_Q0.8870.93
80_L84_Y0.8860.93
75_V130_L0.8810.92
83_I137_R0.8790.92
49_Y65_L0.8780.92
224_E227_K0.8780.92
68_K72_E0.8760.92
17_N364_V0.8750.92
171_N277_T0.8730.92
225_A291_I0.8670.92
232_I295_L0.8670.92
236_N240_N0.8620.92
188_S218_H0.8610.92
264_Y272_K0.8600.92
84_Y137_R0.8570.91
19_T184_E0.8530.91
256_F310_P0.8530.91
199_L217_L0.8450.91
38_L47_T0.8410.91
219_G334_F0.8410.91
83_I134_V0.8380.90
183_H261_Y0.8360.90
115_N118_E0.8300.90
210_L335_A0.8300.90
177_L336_L0.8300.90
213_L334_F0.8280.90
190_T357_I0.8240.90
292_A317_G0.8220.90
72_E118_E0.8190.89
129_T159_A0.8190.89
225_A229_F0.8120.89
150_D165_P0.8080.89
52_L340_L0.8070.89
169_E278_L0.8060.89
171_N274_L0.8050.89
153_A170_I0.8030.88
185_V360_R0.8030.88
101_A211_A0.8030.88
213_L219_G0.7990.88
238_V298_L0.7990.88
240_N243_N0.7970.88
222_A313_D0.7970.88
19_T23_G0.7950.88
109_N118_E0.7920.88
109_N122_S0.7890.88
231_E251_N0.7870.87
151_S174_D0.7840.87
82_T86_M0.7820.87
190_T194_V0.7800.87
69_L121_I0.7790.87
120_A347_I0.7780.87
153_A173_M0.7760.87
30_Y50_L0.7750.87
218_H313_D0.7740.87
228_Q241_W0.7740.87
62_L66_K0.7700.86
78_E106_I0.7680.86
296_E299_G0.7660.86
218_H334_F0.7660.86
82_T85_L0.7610.86
20_F25_K0.7580.85
136_R144_R0.7570.85
116_D119_K0.7560.85
38_L56_L0.7540.85
43_S46_E0.7510.85
86_M102_A0.7500.85
47_T181_T0.7480.85
232_I246_V0.7470.85
205_S346_I0.7440.84
86_M105_S0.7430.84
180_Y222_A0.7420.84
125_A128_A0.7400.84
39_V178_I0.7390.84
135_Y139_E0.7380.84
169_E282_N0.7370.84
96_L210_L0.7370.84
221_A257_G0.7350.84
13_I190_T0.7350.84
114_E118_E0.7340.84
230_I288_Y0.7340.84
74_E118_E0.7330.83
119_K203_Y0.7310.83
124_I152_F0.7270.83
235_P239_Q0.7260.83
222_A331_T0.7260.83
227_K230_I0.7250.83
74_E148_P0.7240.83
150_D170_I0.7230.83
122_S126_K0.7200.82
335_A342_W0.7190.82
275_A319_V0.7190.82
366_P369_Q0.7190.82
8_L11_V0.7180.82
226_F330_F0.7180.82
153_A157_L0.7180.82
168_D172_A0.7100.82
183_H219_G0.7080.81
78_E81_D0.7080.81
291_I295_L0.7070.81
79_V102_A0.7060.81
229_F295_L0.7060.81
46_E56_L0.7040.81
153_A177_L0.7040.81
233_G238_V0.7030.81
288_Y321_Y0.7020.81
79_V99_G0.7020.81
271_F316_S0.6980.80
29_R34_N0.6970.80
184_E361_A0.6970.80
48_I65_L0.6960.80
83_I143_P0.6940.80
42_G178_I0.6850.79
48_I124_I0.6850.79
116_D350_V0.6840.79
180_Y316_S0.6840.79
84_Y133_N0.6840.79
274_L319_V0.6830.79
44_Y48_I0.6810.79
188_S219_G0.6780.78
225_A312_T0.6780.78
64_D67_A0.6740.78
231_E246_V0.6730.78
275_A292_A0.6710.78
213_L222_A0.6700.78
132_A136_R0.6680.77
195_A205_S0.6670.77
135_Y138_K0.6670.77
242_F299_G0.6660.77
19_T29_R0.6660.77
101_A207_T0.6640.77
8_L12_I0.6640.77
199_L350_V0.6630.77
199_L216_P0.6620.77
163_R169_E0.6600.77
79_V82_T0.6600.77
72_E126_K0.6600.77
175_K178_I0.6600.77
257_G311_N0.6600.77
165_P170_I0.6600.77
124_I340_L0.6590.76
183_H334_F0.6580.76
276_L289_F0.6560.76
235_P238_V0.6560.76
243_N305_S0.6530.76
245_K251_N0.6510.76
132_A159_A0.6510.76
20_F363_Y0.6490.75
147_E155_S0.6490.75
237_R245_K0.6480.75
33_Y55_K0.6470.75
176_A180_Y0.6470.75
8_L190_T0.6460.75
291_I294_K0.6430.75
177_L337_S0.6400.74
239_Q304_S0.6380.74
240_N248_N0.6380.74
239_Q242_F0.6360.74
201_D204_S0.6360.74
303_F308_I0.6350.74
11_V14_K0.6350.74
107_D122_S0.6320.73
140_G143_P0.6290.73
75_V80_L0.6280.73
252_R356_L0.6240.73
150_D158_L0.6230.72
193_L229_F0.6230.72
224_E254_M0.6220.72
43_S66_K0.6220.72
261_Y342_W0.6200.72
71_E148_P0.6190.72
171_N178_I0.6190.72
327_V330_F0.6140.71
77_Q145_I0.6090.71
34_N370_E0.6060.70
235_P297_E0.6020.70
184_E308_I0.6020.70
35_I179_L0.6020.70
8_L13_I0.6010.70
18_L31_R0.6010.70
247_V303_F0.6010.70
242_F298_L0.6000.70
174_D355_R0.6000.70
129_T155_S0.5980.69
120_A202_M0.5980.69
189_T331_T0.5960.69
312_T316_S0.5950.69
8_L357_I0.5950.69
157_L170_I0.5950.69
104_A201_D0.5940.69
345_H354_H0.5930.69
139_E326_P0.5920.69
44_Y174_D0.5920.69
243_N247_V0.5920.69
186_P261_Y0.5920.69
259_R262_K0.5910.68
189_T193_L0.5910.68
27_I368_Y0.5900.68
243_N304_S0.5890.68
339_T343_L0.5890.68
10_N21_I0.5890.68
86_M98_V0.5890.68
79_V83_I0.5890.68
189_T345_H0.5880.68
253_L306_K0.5850.68
123_I202_M0.5840.68
81_D138_K0.5830.67
133_N137_R0.5830.67
303_F307_G0.5810.67
79_V144_R0.5810.67
129_T132_A0.5810.67
176_A333_L0.5800.67
272_K315_Y0.5800.67
218_H257_G0.5800.67
68_K71_E0.5790.67
325_F329_M0.5790.67
119_K123_I0.5780.67
79_V87_P0.5770.67
14_K21_I0.5760.66
172_A274_L0.5750.66
72_E209_A0.5730.66
201_D214_K0.5730.66
182_D343_L0.5730.66
75_V79_V0.5710.66
124_I343_L0.5710.66
42_G174_D0.5700.66
33_Y37_D0.5700.66
188_S334_F0.5700.66
133_N143_P0.5690.66
28_L35_I0.5670.65
179_L270_I0.5660.65
180_Y313_D0.5660.65
126_K129_T0.5660.65
76_P79_V0.5650.65
236_N239_Q0.5650.65
278_L319_V0.5630.65
188_S213_L0.5630.65
70_N148_P0.5630.65
100_T123_I0.5620.65
133_N159_A0.5620.65
188_S313_D0.5620.65
137_R143_P0.5610.64
23_G263_T0.5600.64
312_T319_V0.5600.64
82_T99_G0.5580.64
226_F321_Y0.5570.64
123_I339_T0.5550.64
31_R48_I0.5550.64
31_R364_V0.5550.64
232_I242_F0.5550.64
242_F295_L0.5540.63
14_K19_T0.5530.63
289_F293_Q0.5530.63
227_K231_E0.5520.63
42_G62_L0.5510.63
33_Y47_T0.5510.63
28_L32_G0.5510.63
69_L125_A0.5500.63
146_P150_D0.5480.63
239_Q276_L0.5480.63
311_N317_G0.5470.62
264_Y309_Y0.5470.62
245_K248_N0.5440.62
172_A319_V0.5440.62
43_S48_I0.5440.62
303_F309_Y0.5420.62
299_G314_F0.5410.62
48_I52_L0.5400.62
76_P103_L0.5400.62
229_F292_A0.5390.61
78_E88_K0.5390.61
226_F327_V0.5390.61
12_I362_L0.5380.61
120_A123_I0.5350.61
15_V19_T0.5350.61
116_D347_I0.5350.61
101_A104_A0.5350.61
262_K307_G0.5340.61
113_K347_I0.5340.61
104_A200_S0.5320.60
45_E152_F0.5320.60
107_D119_K0.5320.60
191_A306_K0.5320.60
290_E294_K0.5320.60
196_A350_V0.5320.60
317_G334_F0.5310.60
258_H334_F0.5300.60
278_L326_P0.5260.60
65_L121_I0.5260.60
22_D27_I0.5240.59
175_K277_T0.5240.59
183_H188_S0.5230.59
110_F119_K0.5230.59
43_S171_N0.5230.59
48_I193_L0.5230.59
22_D29_R0.5210.59
257_G313_D0.5210.59
238_V291_I0.5190.58
225_A288_Y0.5190.58
127_M130_L0.5190.58
222_A330_F0.5180.58
346_I361_A0.5170.58
94_G104_A0.5160.58
287_R290_E0.5140.58
38_L50_L0.5140.58
80_L145_I0.5120.57
116_D120_A0.5110.57
93_I213_L0.5110.57
199_L354_H0.5100.57
271_F312_T0.5090.57
230_I330_F0.5090.57
246_V306_K0.5080.57
160_S329_M0.5080.57
16_T345_H0.5060.57
321_Y356_L0.5040.56
129_T142_K0.5020.56
117_K121_I0.5000.56
185_V193_L0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h12A 4 0.9973 100 0.037 Contact Map
4xghA 5 0.9125 100 0.038 Contact Map
1o7xA 2 0.9788 100 0.04 Contact Map
4jadA 5 0.9973 100 0.049 Contact Map
1vgmA 2 0.9894 100 0.05 Contact Map
2ibpA 2 0.992 100 0.052 Contact Map
4tvmA 2 0.8886 100 0.053 Contact Map
1iomA 2 0.9867 100 0.053 Contact Map
1vgpA 2 0.9867 100 0.053 Contact Map
2ifcA 2 0.9894 100 0.054 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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