GREMLIN Database
DHE2 - Glutamate dehydrogenase 2
UniProt: P80053 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (373)
Sequences: 4943 (2447)
Seq/√Len: 126.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_L238_A4.3711.00
287_I309_K3.7041.00
219_I230_G3.6981.00
218_I290_C3.4161.00
263_E267_K3.3711.00
290_C312_A3.0961.00
257_D260_K2.9771.00
289_D311_K2.9161.00
201_A316_V2.8481.00
329_E333_Q2.7901.00
122_E126_Q2.6361.00
105_Y353_Y2.5421.00
115_D118_K2.5321.00
203_E206_N2.4841.00
98_N349_V2.4401.00
332_R397_D2.4241.00
150_V298_L2.3891.00
216_R239_K2.3811.00
43_Q84_Q2.3461.00
50_G56_K2.3371.00
133_Q163_E2.3221.00
230_G243_V2.3171.00
203_E379_N2.2961.00
207_K390_Q2.2691.00
210_G215_A2.2081.00
65_H91_S2.1891.00
200_I344_A2.1761.00
217_V233_L2.1501.00
197_V318_G2.1321.00
382_F386_Y2.0641.00
397_D400_T2.0601.00
323_L331_M2.0521.00
304_K326_D2.0511.00
231_K235_E2.0411.00
47_Q130_K2.0371.00
153_D156_T2.0241.00
408_D412_R2.0211.00
388_Y408_D2.0031.00
207_K386_Y1.9571.00
217_V238_A1.9561.00
188_V367_D1.9481.00
316_V344_A1.9411.00
76_V160_F1.9341.00
203_E383_N1.9241.00
339_V344_A1.8991.00
307_A330_I1.8601.00
387_D391_K1.8541.00
369_E373_L1.8421.00
114_V119_L1.8261.00
303_N306_N1.8151.00
212_V238_A1.8111.00
198_A236_M1.8051.00
72_Y108_G1.7761.00
182_E412_R1.7561.00
63_S91_S1.7491.00
253_E278_R1.7421.00
243_V261_A1.7261.00
202_K375_V1.7211.00
204_A314_L1.7191.00
242_G285_L1.7171.00
207_K382_F1.7101.00
202_K236_M1.7011.00
330_I334_R1.7001.00
325_A328_D1.6991.00
132_I160_F1.6951.00
69_L102_L1.6841.00
342_I403_M1.6821.00
218_I242_G1.6721.00
133_Q166_K1.6561.00
100_L343_L1.6441.00
262_I266_E1.6401.00
302_I310_V1.6121.00
388_Y394_E1.6061.00
158_A180_P1.5881.00
136_Y168_T1.5871.00
242_G288_S1.5731.00
246_S265_K1.5651.00
390_Q395_D1.5471.00
396_H401_A1.5441.00
286_L293_L1.5431.00
41_I88_E1.5291.00
319_A322_P1.5241.00
83_T86_E1.5071.00
396_H404_A1.4931.00
199_T375_V1.4891.00
217_V294_I1.4801.00
249_G280_V1.4571.00
231_K262_I1.4491.00
367_D371_K1.4391.00
204_A339_V1.4321.00
163_E166_K1.4301.00
211_G214_E1.4171.00
281_T284_E1.4131.00
205_A292_I1.4031.00
60_G131_Y1.3981.00
65_H95_T1.3961.00
247_K270_S1.3841.00
383_N387_D1.3831.00
304_K330_I1.3701.00
316_V339_V1.3511.00
225_V318_G1.3431.00
229_A294_I1.3401.00
197_V316_V1.3341.00
154_S190_L1.3331.00
293_L310_V1.3311.00
199_T371_K1.3301.00
207_K383_N1.3251.00
67_S72_Y1.3231.00
331_M336_I1.3211.00
121_R155_Q1.3191.00
202_K206_N1.3131.00
264_I268_T1.3061.00
359_N364_I1.3051.00
49_R122_E1.2991.00
391_K408_D1.2951.00
229_A296_A1.2791.00
46_I130_K1.2791.00
302_I323_L1.2781.00
136_Y167_I1.2771.00
41_I84_Q1.2721.00
95_T410_V1.2651.00
382_F398_L1.2551.00
308_P330_I1.2471.00
234_S259_G1.2421.00
329_E332_R1.2371.00
260_K274_Y1.2361.00
79_H298_L1.2260.99
330_I333_Q1.2240.99
216_R253_E1.2190.99
210_G313_K1.2170.99
201_A292_I1.2150.99
216_R291_D1.2150.99
42_I138_Y1.2140.99
388_Y405_L1.2130.99
217_V292_I1.2130.99
182_E416_A1.2110.99
120_T123_E1.2060.99
96_W342_I1.1970.99
302_I331_M1.1970.99
205_A212_V1.1870.99
44_V135_I1.1850.99
233_L240_I1.1780.99
63_S84_Q1.1770.99
343_L385_L1.1740.99
201_A294_I1.1660.99
218_I288_S1.1650.99
152_T157_M1.1560.99
241_V290_C1.1530.99
368_E372_K1.1430.99
228_Y231_K1.1430.99
101_L350_V1.1380.99
216_R289_D1.1360.99
314_L337_A1.1340.99
61_W113_R1.1320.99
114_V127_L1.1280.99
218_I241_V1.1270.99
375_V379_N1.1220.99
249_G282_N1.1200.99
96_W410_V1.1190.99
241_V251_I1.1070.99
198_A233_L1.1070.99
217_V240_I1.0990.99
80_P115_D1.0910.99
229_A233_L1.0900.99
366_S376_D1.0880.99
59_M113_R1.0810.99
159_W162_D1.0800.99
328_D399_R1.0780.99
78_Y152_T1.0780.99
197_V294_I1.0770.99
47_Q57_T1.0770.99
195_L232_F1.0690.99
366_S369_E1.0690.99
252_N260_K1.0670.99
130_K163_E1.0650.99
143_L169_G1.0640.99
284_E287_I1.0610.99
394_E400_T1.0580.98
157_M160_F1.0490.98
197_V296_A1.0390.98
261_A265_K1.0370.98
304_K308_P1.0370.98
128_S132_I1.0370.98
130_K133_Q1.0330.98
388_Y404_A1.0310.98
258_V262_I1.0310.98
234_S258_V1.0310.98
195_L371_K1.0290.98
66_N414_M1.0270.98
261_A274_Y1.0250.98
227_Y262_I1.0200.98
315_I331_M1.0200.98
412_R415_K1.0190.98
43_Q59_M1.0120.98
190_L228_Y1.0110.98
125_E129_R1.0070.98
204_A316_V1.0060.98
230_G240_I1.0060.98
230_G261_A1.0060.98
101_L346_A1.0040.98
371_K375_V1.0000.98
282_N285_L1.0000.98
119_L127_L0.9910.98
197_V201_A0.9860.98
50_G58_F0.9780.97
251_I278_R0.9770.97
183_L416_A0.9740.97
137_K169_G0.9710.97
222_F243_V0.9700.97
68_A410_V0.9700.97
270_S273_N0.9660.97
302_I307_A0.9650.97
208_F313_K0.9620.97
294_I316_V0.9570.97
380_N384_T0.9490.97
79_H150_V0.9490.97
260_K263_E0.9480.97
208_F337_A0.9480.97
180_P183_L0.9430.97
227_Y266_E0.9390.97
289_D312_A0.9380.97
81_N86_E0.9350.97
293_L301_V0.9340.97
41_I63_S0.9330.97
269_G273_N0.9320.97
78_Y128_S0.9310.97
407_V410_V0.9310.97
44_V60_G0.9260.96
186_I365_I0.9240.96
41_I87_V0.9190.96
102_L377_R0.9180.96
49_R56_K0.9160.96
305_F308_P0.9120.96
250_V271_V0.9100.96
207_K387_D0.9100.96
199_T202_K0.9080.96
128_S131_Y0.9080.96
283_E287_I0.9010.96
234_S257_D0.9000.96
202_K212_V0.8910.96
201_A314_L0.8900.96
349_V352_S0.8850.95
396_H400_T0.8850.95
264_I274_Y0.8810.95
268_T273_N0.8750.95
200_I385_L0.8730.95
233_L294_I0.8720.95
263_E266_E0.8710.95
308_P334_R0.8670.95
169_G172_D0.8640.95
352_S355_E0.8560.95
310_V315_I0.8490.94
76_V146_P0.8480.94
250_V261_A0.8460.94
195_L375_V0.8450.94
85_D88_E0.8450.94
109_K320_N0.8430.94
40_R64_Q0.8380.94
130_K166_K0.8380.94
69_L99_S0.8330.94
78_Y112_V0.8310.94
379_N383_N0.8300.94
73_K349_V0.8260.93
372_K376_D0.8240.93
328_D332_R0.8220.93
135_I138_Y0.8220.93
160_F163_E0.8220.93
208_F314_L0.8180.93
161_L165_I0.8180.93
376_D380_N0.8170.93
245_D265_K0.8130.93
160_F176_F0.8130.93
109_K193_T0.8110.93
234_S240_I0.8110.93
252_N274_Y0.8110.93
228_Y232_F0.8100.93
261_A271_V0.8100.93
222_F261_A0.8060.93
76_V131_Y0.8040.92
117_K246_S0.8040.92
161_L171_V0.8040.92
248_G271_V0.8020.92
110_G128_S0.8010.92
389_H396_H0.8000.92
262_I265_K0.7980.92
158_A162_D0.7950.92
372_K375_V0.7920.92
56_K118_K0.7920.92
304_K328_D0.7900.92
168_T172_D0.7890.92
302_I341_D0.7890.92
197_V229_A0.7860.92
274_Y277_G0.7860.92
304_K327_A0.7850.92
155_Q158_A0.7840.92
252_N277_G0.7830.91
389_H398_L0.7830.91
312_A336_I0.7810.91
42_I135_I0.7770.91
261_A279_K0.7760.91
265_K279_K0.7710.91
394_E404_A0.7700.91
148_P189_R0.7690.91
264_I273_N0.7680.91
216_R241_V0.7650.91
251_I288_S0.7640.90
141_S172_D0.7610.90
157_M176_F0.7600.90
295_P319_A0.7550.90
157_M183_L0.7530.90
280_V288_S0.7510.90
388_Y401_A0.7510.90
50_G54_K0.7480.90
350_V378_M0.7480.90
245_D248_G0.7450.89
155_Q159_W0.7450.89
91_S95_T0.7440.89
357_A363_E0.7440.89
142_E360_K0.7420.89
315_I323_L0.7410.89
130_K134_A0.7410.89
287_I306_N0.7400.89
302_I315_I0.7390.89
186_I351_G0.7390.89
230_G258_V0.7390.89
110_G131_Y0.7340.89
249_G287_I0.7340.89
178_G352_S0.7300.88
194_G229_A0.7300.88
242_G249_G0.7290.88
139_L160_F0.7220.88
337_A398_L0.7210.88
232_F371_K0.7210.88
48_I58_F0.7190.88
43_Q61_W0.7180.88
117_K265_K0.7160.87
406_A410_V0.7150.87
310_V331_M0.7150.87
374_I378_M0.7120.87
212_V217_V0.7120.87
163_E167_I0.7110.87
102_L380_N0.7100.87
115_D120_T0.7070.87
294_I318_G0.7070.87
256_I261_A0.7050.87
252_N276_E0.7020.86
280_V284_E0.7000.86
61_W84_Q0.7000.86
412_R416_A0.6990.86
407_V411_V0.6960.86
193_T348_G0.6910.85
97_K320_N0.6880.85
386_Y390_Q0.6880.85
136_Y139_L0.6850.85
241_V288_S0.6830.85
291_D313_K0.6820.85
131_Y373_L0.6820.85
147_A178_G0.6810.85
350_V377_R0.6770.84
64_Q143_L0.6770.84
132_I176_F0.6770.84
200_I339_V0.6750.84
323_L338_V0.6740.84
303_N323_L0.6740.84
132_I139_L0.6740.84
151_N225_V0.6710.84
265_K268_T0.6710.84
64_Q72_Y0.6710.84
192_S374_I0.6680.84
292_I314_L0.6680.84
264_I275_P0.6680.84
219_I233_L0.6660.83
391_K394_E0.6650.83
315_I336_I0.6640.83
93_I321_G0.6600.83
168_T171_V0.6590.83
248_G279_K0.6570.82
249_G288_S0.6570.82
216_R237_G0.6570.82
205_A210_G0.6570.82
225_V246_S0.6520.82
157_M162_D0.6500.82
389_H394_E0.6500.82
73_K105_Y0.6500.82
399_R403_M0.6490.82
189_R352_S0.6490.82
191_Y228_Y0.6480.82
45_K57_T0.6470.82
338_V341_D0.6460.81
318_G344_A0.6450.81
328_D338_V0.6450.81
192_S224_N0.6440.81
386_Y398_L0.6440.81
197_V344_A0.6430.81
219_I243_V0.6430.81
156_T159_W0.6430.81
220_Q301_V0.6420.81
46_I127_L0.6390.81
377_R380_N0.6390.81
283_E305_F0.6390.81
141_S170_K0.6390.81
56_K119_L0.6370.81
204_A337_A0.6370.81
284_E306_N0.6370.81
388_Y396_H0.6350.80
222_F258_V0.6310.80
99_S406_A0.6260.79
232_F236_M0.6250.79
126_Q162_D0.6230.79
247_K272_I0.6220.79
268_T271_V0.6220.79
200_I316_V0.6210.79
100_L384_T0.6190.79
216_R251_I0.6190.79
147_A189_R0.6180.79
387_D390_Q0.6170.78
395_D400_T0.6160.78
233_L292_I0.6160.78
148_P224_N0.6150.78
312_A315_I0.6150.78
272_I276_E0.6130.78
339_V398_L0.6120.78
132_I163_E0.6110.78
405_L409_R0.6110.78
308_P333_Q0.6100.78
49_R55_L0.6100.78
82_V111_G0.6090.78
244_S286_L0.6070.77
58_F114_V0.6040.77
384_T387_D0.6040.77
78_Y114_V0.6030.77
88_E91_S0.6010.77
382_F385_L0.6010.77
128_S160_F0.6010.77
136_Y140_G0.6000.76
351_G365_I0.5990.76
218_I285_L0.5990.76
218_I312_A0.5980.76
302_I338_V0.5980.76
68_A414_M0.5970.76
193_T345_N0.5950.76
92_M96_W0.5950.76
193_T224_N0.5950.76
351_G370_A0.5950.76
357_A361_M0.5950.76
338_V399_R0.5940.76
299_E321_G0.5930.76
239_K254_K0.5930.76
346_A350_V0.5920.76
358_N365_I0.5910.75
192_S351_G0.5900.75
244_S282_N0.5880.75
218_I249_G0.5880.75
69_L409_R0.5870.75
202_K379_N0.5860.75
198_A232_F0.5860.75
303_N324_T0.5850.75
401_A404_A0.5840.75
307_A331_M0.5830.74
160_F164_Y0.5830.74
323_L328_D0.5830.74
54_K57_T0.5800.74
89_A321_G0.5790.74
97_K109_K0.5790.74
353_Y357_A0.5790.74
354_V369_E0.5790.74
189_R351_G0.5760.74
68_A413_A0.5730.73
386_Y389_H0.5710.73
388_Y391_K0.5710.73
204_A386_Y0.5690.73
389_H395_D0.5670.72
76_V128_S0.5670.72
302_I308_P0.5650.72
250_V275_P0.5650.72
213_E289_D0.5620.72
104_P357_A0.5620.72
328_D331_M0.5620.72
105_Y356_W0.5600.71
339_V382_F0.5590.71
286_L306_N0.5570.71
404_A407_V0.5570.71
189_R224_N0.5560.71
205_A209_I0.5540.71
121_R124_L0.5540.71
279_K282_N0.5540.71
125_E159_W0.5520.70
132_I135_I0.5520.70
205_A215_A0.5510.70
114_V120_T0.5510.70
198_A202_K0.5510.70
293_L315_I0.5500.70
76_V110_G0.5490.70
73_K356_W0.5490.70
128_S156_T0.5460.70
119_L123_E0.5460.70
87_V91_S0.5450.69
194_G318_G0.5440.69
218_I289_D0.5430.69
195_L231_K0.5430.69
373_L376_D0.5420.69
206_N379_N0.5410.69
205_A314_L0.5410.69
127_L135_I0.5400.69
152_T192_S0.5390.69
203_E207_K0.5360.68
142_E362_G0.5360.68
102_L384_T0.5360.68
305_F309_K0.5360.68
135_I139_L0.5350.68
83_T113_R0.5340.68
259_G262_I0.5330.68
129_R163_E0.5320.68
198_A201_A0.5310.67
200_I343_L0.5310.67
335_G395_D0.5300.67
323_L327_A0.5300.67
156_T160_F0.5300.67
156_T164_Y0.5270.67
324_T328_D0.5260.67
194_G225_V0.5260.67
177_T352_S0.5260.67
186_I358_N0.5250.67
147_A224_N0.5240.66
134_A137_K0.5240.66
331_M338_V0.5240.66
148_P352_S0.5240.66
133_Q165_I0.5200.66
272_I279_K0.5200.66
161_L164_Y0.5200.66
301_V307_A0.5190.66
178_G355_E0.5190.66
201_A318_G0.5180.66
198_A229_A0.5160.65
73_K352_S0.5160.65
177_T349_V0.5160.65
283_E306_N0.5160.65
207_K337_A0.5150.65
295_P302_I0.5140.65
247_K279_K0.5130.65
216_R290_C0.5130.65
229_A318_G0.5130.65
200_I382_F0.5120.65
129_R162_D0.5120.65
186_I370_A0.5110.65
159_W164_Y0.5110.65
155_Q162_D0.5110.65
222_F230_G0.5080.64
286_L301_V0.5080.64
177_T185_G0.5050.64
73_K98_N0.5050.64
157_M161_L0.5040.63
43_Q88_E0.5040.63
252_N256_I0.5030.63
384_T405_L0.5030.63
302_I306_N0.5030.63
242_G280_V0.5020.63
296_A318_G0.5010.63
408_D415_K0.5010.63
306_N330_I0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgiA 6 0.9738 100 0.073 Contact Map
2yfqA 5 0.931 100 0.074 Contact Map
2tmgA 5 0.969 100 0.088 Contact Map
1v9lA 4 0.9786 100 0.089 Contact Map
3r3jA 5 0.9976 100 0.089 Contact Map
4fccA 5 0.9929 100 0.092 Contact Map
3aogA 8 0.9881 100 0.093 Contact Map
2bmaA 5 0.9929 100 0.093 Contact Map
3k92A 5 0.9905 100 0.095 Contact Map
1bgvA 5 1 100 0.096 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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