GREMLIN Database
PCP2 - Pyrrolidone-carboxylate peptidase 2
UniProt: P58202 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (193)
Sequences: 1454 (1111)
Seq/√Len: 79.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_A146_M3.9741.00
146_M150_I3.4101.00
75_K132_E3.2121.00
49_E148_I3.1121.00
86_K144_N3.0951.00
45_Y88_S3.0691.00
44_E94_A2.9801.00
20_Q40_I2.8031.00
21_L24_E2.7101.00
47_K94_A2.5771.00
78_P121_V2.5101.00
22_I67_I2.4891.00
9_E43_V2.4491.00
23_V67_I2.3441.00
73_R77_T2.3441.00
2_T35_E2.2911.00
107_G147_Y2.2491.00
44_E47_K2.2351.00
66_G149_I2.1551.00
85_Y135_L2.1521.00
39_V55_K2.0681.00
37_K59_M2.0011.00
104_D151_R1.9861.00
5_L26_L1.9851.00
29_S192_R1.9831.00
65_L163_I1.9181.00
25_A188_I1.8261.00
14_Y69_V1.8001.00
71_P167_L1.7761.00
80_K135_L1.7591.00
153_A160_G1.7561.00
163_I194_S1.7541.00
70_A73_R1.7531.00
52_I149_I1.7471.00
41_L145_A1.7211.00
67_I191_I1.6761.00
69_V171_Y1.6741.00
150_I160_G1.6721.00
111_I151_R1.6571.00
76_I190_G1.6071.00
22_I191_I1.5971.00
63_L159_L1.5931.00
120_L124_L1.5821.00
120_L194_S1.5691.00
53_V152_E1.5400.99
153_A158_S1.5300.99
27_N30_T1.5300.99
124_L194_S1.5120.99
123_L193_L1.5090.99
169_E181_S1.4910.99
45_Y141_L1.4600.99
149_I160_G1.4030.99
100_G118_E1.3930.99
39_V59_M1.3850.99
129_I186_T1.3690.99
146_M161_G1.3330.98
54_T58_E1.3280.98
108_Q151_R1.3250.98
22_I165_V1.3130.98
28_G38_G1.2920.98
48_I144_N1.2830.98
39_V58_E1.2760.98
117_V133_L1.2650.98
66_G160_G1.2600.98
165_V187_M1.2360.97
124_L193_L1.2180.97
76_I163_I1.2100.97
50_D54_T1.1920.97
16_E21_L1.1920.97
186_T189_R1.1760.97
48_I141_L1.1710.96
56_I152_E1.1360.96
42_P51_L1.1290.96
56_I61_P1.1100.95
83_I139_S1.1070.95
56_I158_S1.1030.95
84_N143_N1.1000.95
103_I144_N1.0980.95
117_V135_L1.0910.95
56_I64_T1.0880.95
127_N193_L1.0870.95
27_N38_G1.0810.94
48_I145_A1.0790.94
122_D126_E1.0780.94
41_L52_I1.0740.94
151_R155_K1.0560.94
3_V63_L1.0440.93
7_G23_V1.0430.93
66_G145_A1.0420.93
57_R156_Y1.0370.93
9_E41_L1.0360.93
23_V38_G1.0290.93
135_L139_S1.0240.93
53_V156_Y1.0190.92
9_E93_N1.0150.92
37_K55_K1.0130.92
55_K59_M1.0110.92
68_G142_C1.0010.92
19_S41_L0.9900.91
47_K50_D0.9820.91
137_A143_N0.9640.90
103_I106_L0.9560.90
144_N148_I0.9560.90
87_Y100_G0.9510.90
20_Q24_E0.9460.89
113_T161_G0.9430.89
5_L27_N0.9300.89
109_D112_F0.9130.88
49_E145_A0.9040.87
113_T146_M0.9000.87
18_P69_V0.8970.87
102_K109_D0.8950.87
52_I66_G0.8920.86
49_E144_N0.8790.86
189_R192_R0.8780.86
81_I110_G0.8680.85
7_G20_Q0.8680.85
78_P117_V0.8660.85
123_L126_E0.8620.84
22_I187_M0.8510.84
127_N189_R0.8500.84
149_I153_A0.8480.83
83_I143_N0.8390.83
28_G31_I0.8390.83
2_T37_K0.8370.83
78_P113_T0.8370.83
57_R60_K0.8360.83
118_E133_L0.8280.82
75_K78_P0.8260.82
57_R152_E0.8230.82
124_L129_I0.8150.81
8_F141_L0.8110.81
172_A181_S0.8080.80
55_K58_E0.8060.80
139_S143_N0.8050.80
136_S139_S0.8040.80
106_L151_R0.8010.80
115_I161_G0.8000.80
51_L54_T0.7930.79
90_E97_K0.7920.79
80_K85_Y0.7920.79
117_V121_V0.7920.79
68_G162_F0.7870.79
120_L193_L0.7670.77
66_G88_S0.7650.77
129_I190_G0.7630.76
163_I191_I0.7590.76
6_F66_G0.7580.76
10_P20_Q0.7490.75
77_T132_E0.7490.75
87_Y118_E0.7480.75
152_E155_K0.7470.75
86_K103_I0.7320.73
184_L187_M0.7310.73
139_S161_G0.7300.73
104_D148_I0.7290.73
20_Q165_V0.7220.72
121_V133_L0.7190.72
37_K61_P0.7160.72
67_I165_V0.7140.72
3_V34_E0.7140.72
112_F146_M0.7000.70
2_T59_M0.6980.70
70_A77_T0.6960.70
66_G150_I0.6960.70
78_P131_A0.6950.70
142_C162_F0.6920.69
87_Y143_N0.6910.69
124_L190_G0.6900.69
21_L25_A0.6900.69
45_Y98_Y0.6850.68
190_G194_S0.6840.68
89_R97_K0.6830.68
8_F145_A0.6800.68
81_I112_F0.6780.68
44_E96_K0.6770.68
30_T33_K0.6770.68
88_S98_Y0.6760.67
129_I193_L0.6760.67
80_K100_G0.6730.67
27_N192_R0.6660.66
68_G164_H0.6660.66
19_S67_I0.6650.66
52_I145_A0.6640.66
167_L171_Y0.6620.66
80_K118_E0.6570.65
168_H184_L0.6560.65
54_T57_R0.6550.65
115_I120_L0.6530.65
83_I137_A0.6520.65
46_E96_K0.6510.65
48_I86_K0.6500.64
87_Y103_I0.6500.64
102_K105_P0.6490.64
108_Q154_R0.6460.64
116_P161_G0.6390.63
169_E182_M0.6360.63
52_I152_E0.6350.63
152_E156_Y0.6340.63
26_L31_I0.6340.63
142_C164_H0.6330.62
47_K51_L0.6330.62
9_E140_Y0.6330.62
7_G18_P0.6300.62
99_K118_E0.6300.62
184_L188_I0.6260.62
19_S165_V0.6250.61
83_I136_S0.6240.61
69_V167_L0.6190.61
80_K117_V0.6170.60
148_I153_A0.6160.60
65_L149_I0.6140.60
8_F140_Y0.6100.60
109_D154_R0.6090.59
73_R136_S0.6050.59
3_V65_L0.6050.59
112_F139_S0.5960.58
43_V141_L0.5960.58
168_H171_Y0.5960.58
11_F71_P0.5960.58
83_I112_F0.5940.58
77_T121_V0.5940.58
30_T34_E0.5940.58
85_Y117_V0.5880.57
20_Q23_V0.5870.57
25_A185_D0.5850.56
86_K101_E0.5850.56
66_G153_A0.5820.56
43_V140_Y0.5770.55
111_I154_R0.5760.55
27_N31_I0.5750.55
74_A78_P0.5740.55
11_F93_N0.5740.55
49_E53_V0.5690.54
124_L131_A0.5690.54
24_E40_I0.5680.54
14_Y167_L0.5680.54
86_K140_Y0.5660.54
114_N153_A0.5650.54
85_Y136_S0.5650.54
113_T150_I0.5640.54
22_I145_A0.5640.54
39_V51_L0.5550.53
180_P183_S0.5530.52
9_E40_I0.5530.52
15_K170_S0.5520.52
114_N154_R0.5520.52
19_S23_V0.5500.52
182_M190_G0.5490.52
75_K189_R0.5490.52
53_V148_I0.5430.51
54_T156_Y0.5420.51
63_L173_A0.5420.51
163_I193_L0.5420.51
23_V191_I0.5410.51
53_V57_R0.5410.51
140_Y144_N0.5380.50
28_G35_E0.5350.50
4_L73_R0.5350.50
117_V168_H0.5350.50
169_E187_M0.5350.50
46_E113_T0.5330.50
32_L157_N0.5260.49
20_Q38_G0.5260.49
72_G167_L0.5260.49
46_E144_N0.5240.49
134_S137_A0.5240.49
16_E168_H0.5240.49
50_D106_L0.5210.48
103_I143_N0.5200.48
168_H188_I0.5200.48
114_N160_G0.5180.48
123_L127_N0.5150.47
87_Y116_P0.5150.47
45_Y87_Y0.5140.47
185_D189_R0.5130.47
130_P137_A0.5130.47
174_R179_I0.5120.47
30_T38_G0.5100.47
17_N68_G0.5100.47
45_Y86_K0.5090.47
78_P182_M0.5060.46
51_L55_K0.5050.46
126_E192_R0.5030.46
43_V69_V0.5030.46
26_L30_T0.5020.46
180_P190_G0.5020.46
85_Y139_S0.5010.46
82_A145_A0.5000.45
29_S35_E0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a2zA 4 1 100 0.126 Contact Map
3ro0A 3 0.9809 100 0.128 Contact Map
3giuA 2 0.9856 100 0.129 Contact Map
1x10A 4 0.9713 100 0.131 Contact Map
3lacA 3 0.9617 100 0.133 Contact Map
1iu8A 3 0.9761 100 0.134 Contact Map
4hpsA 3 0.9713 100 0.134 Contact Map
2ebjA 3 0.9187 100 0.153 Contact Map
2is8A 3 0.7464 30.3 0.946 Contact Map
3mnfA 4 0.9187 23.3 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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