GREMLIN Database
PCP1 - Pyrrolidone-carboxylate peptidase 1
UniProt: P58201 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (190)
Sequences: 1454 (1121)
Seq/√Len: 81.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_A146_M4.0311.00
146_M150_I3.4431.00
75_K132_E3.2221.00
86_R144_N3.1561.00
49_E148_I3.0901.00
44_E94_A3.0821.00
45_Y88_S3.0801.00
20_Q40_I2.7601.00
21_L24_E2.6841.00
78_P121_V2.6721.00
47_K94_A2.6151.00
22_I67_I2.5541.00
9_E43_V2.4601.00
23_V67_I2.4511.00
73_R77_T2.3921.00
44_E47_K2.3041.00
107_G147_Y2.2901.00
85_Y135_L2.2091.00
2_T35_E2.1571.00
66_G149_I2.1411.00
5_L26_L2.0731.00
39_V55_K2.0601.00
104_D151_R2.0521.00
29_S192_K1.9141.00
65_L163_I1.9141.00
37_K59_T1.8331.00
14_Y69_L1.8301.00
71_P167_L1.8151.00
80_K135_L1.7921.00
25_A188_I1.7911.00
70_A73_R1.7851.00
153_A160_G1.7751.00
67_I191_I1.7291.00
41_L145_A1.7001.00
52_I149_I1.7001.00
120_L124_L1.6831.00
69_L171_Y1.6791.00
150_I160_G1.6631.00
111_I151_R1.6371.00
53_V152_E1.5951.00
153_A158_S1.5481.00
63_L159_L1.5471.00
169_E181_S1.5451.00
39_V59_T1.5250.99
22_I191_I1.5240.99
76_I190_G1.5110.99
45_Y141_L1.4440.99
149_I160_G1.4420.99
100_G118_E1.3970.99
129_I186_T1.3730.99
22_I165_V1.3630.99
28_R38_G1.3610.99
146_M161_G1.3370.99
66_G160_G1.3110.98
39_V58_E1.3010.98
48_I144_N1.2960.98
108_Q151_R1.2900.98
54_T58_E1.2650.98
117_V133_L1.2600.98
50_D54_T1.2240.97
76_I163_I1.2090.97
27_N38_G1.1960.97
122_D126_E1.1830.97
16_E21_L1.1790.97
48_I141_L1.1750.97
165_V187_M1.1630.96
42_P51_V1.1340.96
56_I152_E1.1320.96
186_T189_R1.1250.96
48_I145_A1.1240.96
103_I144_N1.1160.96
83_I139_S1.1150.96
56_I64_T1.1060.95
84_N143_N1.1030.95
56_I61_P1.0980.95
56_I158_S1.0920.95
66_G145_A1.0880.95
151_R155_K1.0740.94
7_G23_V1.0670.94
9_E93_N1.0580.94
68_G142_C1.0540.94
117_V135_L1.0520.94
57_R156_Y1.0380.93
41_L52_I1.0290.93
55_K59_T1.0250.93
23_V38_G1.0160.93
135_L139_S1.0140.93
5_L27_N1.0120.93
37_K55_K1.0110.93
103_I106_L1.0030.92
3_V63_L0.9980.92
9_E41_L0.9950.92
19_S41_L0.9930.92
144_N148_I0.9850.92
53_V156_Y0.9660.91
109_D112_F0.9520.90
137_A143_N0.9460.90
87_Y100_G0.9340.89
18_P69_L0.9330.89
47_K50_D0.9190.88
78_P117_V0.9180.88
49_E144_N0.9090.88
189_R192_K0.9070.88
20_Q24_E0.9020.87
113_T161_G0.8970.87
102_K109_D0.8940.87
123_L126_E0.8940.87
113_T146_M0.8940.87
49_E145_A0.8920.87
149_I153_A0.8890.87
78_P113_T0.8870.87
22_I187_M0.8790.86
7_G20_Q0.8780.86
57_R152_E0.8680.85
57_R60_K0.8620.85
174_R177_R0.8580.85
75_K78_P0.8540.84
52_I66_G0.8460.84
2_T37_K0.8410.84
124_L129_I0.8410.84
80_K85_Y0.8370.83
106_L151_R0.8340.83
27_N30_T0.8330.83
66_G88_S0.8300.83
163_I191_I0.8280.83
68_G162_F0.8230.82
90_E97_K0.8190.82
26_L31_I0.8180.82
136_S139_S0.8160.82
81_I110_G0.8140.82
8_F141_L0.8080.81
83_I143_N0.8070.81
2_T59_T0.8040.81
77_T132_E0.8000.80
118_E133_L0.8000.80
139_S143_N0.7990.80
27_N192_K0.7980.80
169_E182_M0.7950.80
172_A181_S0.7890.79
184_L187_M0.7860.79
10_P20_Q0.7840.79
115_I161_G0.7830.79
51_V54_T0.7810.79
37_K61_P0.7780.78
86_R103_I0.7720.78
117_V121_V0.7540.76
20_Q165_V0.7530.76
121_V133_L0.7520.76
104_D148_I0.7470.76
55_K58_E0.7470.76
142_C162_F0.7460.76
139_S161_G0.7430.75
6_F66_G0.7380.75
45_Y98_Y0.7360.75
87_Y118_E0.7330.74
177_R180_P0.7240.73
67_I165_V0.7200.73
152_E155_K0.7200.73
68_G164_H0.7170.73
129_I190_G0.7160.73
43_V140_Y0.7160.73
70_A77_T0.7150.72
31_I34_E0.7110.72
142_C164_H0.7080.72
183_S186_T0.7070.72
80_K100_G0.7060.71
54_T57_R0.7010.71
9_E140_Y0.6990.71
102_K105_P0.6980.71
66_G150_I0.6960.70
52_I145_A0.6950.70
167_L171_Y0.6930.70
78_P131_A0.6920.70
112_F146_M0.6860.69
46_K96_K0.6810.69
152_E156_Y0.6790.68
127_N189_R0.6780.68
3_V65_L0.6750.68
48_I86_R0.6700.67
109_D154_R0.6700.67
87_Y143_N0.6690.67
108_Q154_R0.6680.67
89_R97_K0.6660.67
47_K51_V0.6650.67
80_K118_E0.6640.67
8_F145_A0.6610.66
19_S67_I0.6560.66
85_Y117_V0.6530.65
69_L167_L0.6520.65
8_F140_Y0.6510.65
7_G18_P0.6500.65
44_E96_K0.6480.65
83_I136_S0.6470.65
148_I153_A0.6450.65
83_I137_A0.6440.64
21_L25_A0.6440.64
88_S98_Y0.6430.64
80_K117_V0.6410.64
3_V34_E0.6410.64
19_S165_V0.6390.64
77_T121_V0.6380.64
43_V141_L0.6380.64
30_T34_E0.6380.64
140_Y144_N0.6360.63
87_Y103_I0.6320.63
22_I145_A0.6300.63
124_L131_A0.6290.63
30_T33_K0.6230.62
86_R140_Y0.6230.62
11_F71_P0.6220.62
123_L127_N0.6190.61
111_I154_R0.6180.61
66_G153_A0.6170.61
65_L149_I0.6130.61
180_P190_G0.6130.61
81_I112_F0.6120.60
176_Q179_I0.6070.60
168_H171_Y0.6050.60
74_A78_P0.6040.59
180_P183_S0.6040.59
99_R118_E0.6020.59
24_E40_I0.6010.59
52_I152_E0.5990.59
14_Y167_L0.5980.59
31_I36_V0.5970.59
15_K170_S0.5970.59
85_Y136_S0.5940.58
86_R101_E0.5940.58
130_P137_A0.5930.58
83_I112_F0.5900.58
122_D125_N0.5870.57
124_L190_G0.5840.57
9_E40_I0.5830.57
112_F139_S0.5820.57
75_K189_R0.5820.57
116_P161_G0.5820.57
49_E53_V0.5810.57
11_F93_N0.5800.56
181_S185_D0.5760.56
113_T150_I0.5750.56
20_Q23_V0.5670.55
39_V51_V0.5660.55
4_L73_R0.5650.54
53_V148_I0.5590.54
185_D188_I0.5570.53
61_P82_A0.5560.53
73_R136_S0.5560.53
19_S23_V0.5550.53
27_N35_E0.5540.53
185_D189_R0.5520.53
172_A176_Q0.5510.53
141_L145_A0.5500.53
114_N154_R0.5490.52
46_K144_N0.5460.52
34_E120_L0.5460.52
25_A185_D0.5440.52
181_S186_T0.5430.52
114_N160_G0.5390.51
16_E168_H0.5390.51
53_V57_R0.5360.51
103_I143_N0.5350.51
72_G167_L0.5320.50
177_R181_S0.5320.50
80_K87_Y0.5310.50
20_Q88_S0.5310.50
23_V191_I0.5310.50
77_T140_Y0.5290.50
182_M190_G0.5270.50
45_Y86_R0.5270.50
60_K185_D0.5250.49
117_V168_H0.5250.49
104_D128_G0.5210.49
54_T156_Y0.5190.48
80_K161_G0.5170.48
32_L157_N0.5150.48
78_P154_R0.5110.47
70_A137_A0.5100.47
17_N68_G0.5100.47
82_A143_N0.5090.47
63_L173_A0.5090.47
7_G146_M0.5070.47
156_Y173_A0.5040.47
5_L38_G0.5040.47
85_Y139_S0.5010.46
45_Y144_N0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a2zA 4 0.9905 100 0.109 Contact Map
3ro0A 3 0.9716 100 0.116 Contact Map
3giuA 2 0.9858 100 0.116 Contact Map
1x10A 4 0.9621 100 0.12 Contact Map
1iu8A 3 0.9668 100 0.122 Contact Map
3lacA 3 0.9479 100 0.124 Contact Map
4hpsA 3 0.9621 100 0.124 Contact Map
2ebjA 3 0.91 100 0.144 Contact Map
3mnfA 4 0.9242 49.7 0.94 Contact Map
1kz1A 5 0.6161 33.1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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