GREMLIN Database
SYL1 - Leucine--tRNA ligase 1
UniProt: P58176 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 934 (843)
Sequences: 757 (458)
Seq/√Len: 15.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_F155_F10.3891.00
68_K706_N7.5351.00
460_A588_I7.2101.00
15_A19_K6.0291.00
65_L70_Y6.0051.00
18_E136_K5.2571.00
462_K597_E5.1901.00
21_K24_E4.9431.00
241_N273_T4.7861.00
246_E269_K4.6671.00
241_N275_T4.4501.00
397_I412_L4.4151.00
348_E352_L4.2471.00
208_I215_S4.0971.00
256_E273_T3.7831.00
570_V587_Y3.7761.00
14_Q761_H3.7571.00
67_M756_A3.7261.00
692_E789_Y3.6451.00
164_G533_K3.6051.00
830_V834_M3.5120.99
62_A72_V3.4260.99
587_Y604_I3.3480.99
830_V833_L3.2290.99
349_S353_Q3.2030.99
181_Y186_G3.1360.99
411_E415_S3.1320.99
645_S718_V2.9860.98
550_E554_G2.9620.98
400_K408_N2.8300.97
464_I482_V2.8030.97
550_E553_Y2.7830.97
547_K550_E2.7740.97
16_E768_H2.7740.97
709_I758_F2.7080.97
20_S774_F2.7080.97
820_V823_Y2.7080.97
10_A636_V2.7010.96
724_E729_L2.6960.96
526_K560_L2.6490.96
470_I603_R2.6180.96
860_E865_V2.6140.96
703_E785_E2.5940.96
548_E551_R2.5670.95
727_E730_R2.5530.95
821_I825_N2.5350.95
755_L763_A2.5250.95
460_A463_A2.5120.95
523_V536_F2.5080.95
724_E731_D2.4830.94
132_K136_K2.4580.94
822_I825_N2.4500.94
396_N412_L2.4340.94
554_G558_I2.4120.93
163_L508_V2.4120.93
157_K536_F2.4050.93
63_R141_S2.3790.93
561_R565_L2.3630.93
860_E863_Y2.3540.92
724_E727_E2.3520.92
542_G561_R2.3310.92
724_E730_R2.3280.92
547_K551_R2.3210.92
244_V251_N2.2920.91
208_I285_I2.2540.91
570_V604_I2.2540.91
467_I588_I2.2310.90
37_T570_V2.2200.90
462_K465_N2.2180.90
16_E20_S2.2070.90
288_I413_L2.1880.89
819_K823_Y2.1780.89
749_S772_S2.1730.89
183_P439_V2.1670.89
100_I103_F2.1610.89
725_I730_R2.1540.89
838_I841_V2.1430.88
237_N240_A2.1360.88
698_V750_I2.0830.87
280_V297_K2.0640.86
684_I687_L2.0610.86
706_N710_T2.0350.85
8_S12_K2.0160.85
423_Y430_I2.0000.84
100_I104_K1.9980.84
478_L482_V1.9760.84
564_F568_Y1.9740.84
726_Y730_R1.9720.84
64_Y710_T1.9700.84
706_N780_Y1.9700.84
425_I430_I1.9530.83
363_F366_S1.9450.83
467_I586_F1.9370.82
165_K168_E1.9320.82
326_E358_Y1.9130.82
842_N845_I1.9120.82
458_A462_K1.9100.82
173_V450_A1.9050.81
548_E552_K1.8930.81
283_Y292_K1.8840.81
350_A371_E1.8690.80
60_I644_T1.8680.80
539_I542_G1.8540.80
552_K557_L1.8480.79
174_T445_D1.8270.78
813_V817_A1.8240.78
163_L590_N1.8030.78
413_L416_L1.8030.78
101_E105_N1.7990.77
841_V845_I1.7900.77
488_E586_F1.7890.77
104_K108_E1.7840.77
696_S793_I1.7800.77
537_D541_L1.7750.76
725_I729_L1.7740.76
423_Y427_N1.7620.76
237_N301_V1.7560.76
546_A550_E1.7550.76
547_K553_Y1.7530.75
464_I479_E1.7480.75
258_A261_K1.7410.75
863_Y866_V1.7340.75
493_S506_Q1.7250.74
423_Y426_S1.7240.74
820_V824_I1.7150.74
228_I311_M1.7110.74
685_K688_R1.7100.74
531_I539_I1.7080.74
819_K825_N1.7060.73
367_I372_Y1.7060.73
753_R778_E1.7050.73
11_F632_K1.6970.73
47_M131_M1.6890.73
356_N359_A1.6870.73
358_Y361_K1.6860.73
820_V825_N1.6850.72
39_P570_V1.6770.72
703_E707_N1.6730.72
547_K552_K1.6650.72
463_A592_L1.6600.71
551_R554_G1.6440.71
854_T857_K1.6430.70
821_I824_I1.6330.70
461_L483_F1.6320.70
705_V721_L1.6280.70
63_R72_V1.6260.70
23_F63_R1.6180.69
235_M312_S1.6130.69
64_Y68_K1.6130.69
702_I750_I1.5950.68
749_S753_R1.5950.68
827_S834_M1.5920.68
138_I639_V1.5920.68
288_I412_L1.5910.68
64_Y706_N1.5870.68
804_E808_E1.5870.68
219_M311_M1.5840.68
576_G621_L1.5750.67
65_L68_K1.5670.67
726_Y731_D1.5650.67
535_I539_I1.5620.66
463_A467_I1.5500.66
39_P722_L1.5450.66
381_I402_V1.5440.66
697_K728_I1.5420.65
206_N250_K1.5340.65
67_M780_Y1.5290.65
376_Y379_D1.5280.65
192_H579_L1.5220.64
517_Y521_Y1.5210.64
824_I833_L1.5040.63
707_N711_S1.4830.62
674_I766_L1.4820.62
301_V595_F1.4800.62
847_L850_F1.4800.62
817_A823_Y1.4800.62
137_S632_K1.4770.62
631_I636_V1.4740.62
831_K834_M1.4740.62
863_Y870_D1.4700.62
427_N430_I1.4670.61
548_E554_G1.4660.61
819_K824_I1.4620.61
400_K404_E1.4560.61
67_M753_R1.4540.61
865_V870_D1.4510.61
575_T579_L1.4510.61
531_I536_F1.4480.60
5_F8_S1.4420.60
572_Q603_R1.4420.60
338_E344_E1.4310.59
575_T578_D1.4230.59
357_P360_L1.4210.59
264_F439_V1.4180.59
727_E731_D1.4150.59
34_F788_L1.4110.58
630_A639_V1.4050.58
837_A841_V1.4000.58
127_F166_L1.4000.58
841_V855_E1.3980.58
272_K278_D1.3960.57
696_S699_R1.3940.57
565_L599_Y1.3910.57
750_I754_A1.3900.57
548_E553_Y1.3840.57
141_S776_S1.3830.57
20_S334_I1.3800.57
64_Y172_L1.3790.57
558_I562_E1.3770.56
698_V725_I1.3740.56
841_V846_P1.3730.56
356_N363_F1.3720.56
863_Y867_S1.3710.56
735_L796_I1.3650.56
703_E783_P1.3580.55
63_R621_L1.3550.55
851_T857_K1.3520.55
522_T525_Y1.3510.55
207_V210_F1.3450.55
574_H607_N1.3440.55
843_E855_E1.3360.54
465_N479_E1.3310.54
180_G440_P1.3300.54
51_H492_R1.3290.54
860_E866_V1.3200.53
368_Y372_Y1.3090.53
426_S430_I1.3080.52
684_I688_R1.3070.52
851_T855_E1.3030.52
814_H817_A1.2990.52
240_A303_P1.2990.52
364_M368_Y1.2980.52
482_V589_Y1.2950.52
345_I348_E1.2870.51
377_M381_I1.2850.51
17_W41_P1.2840.51
8_S11_F1.2830.51
702_I754_A1.2820.51
767_W771_S1.2810.51
546_A552_K1.2710.50
615_R621_L1.2680.50
14_Q17_W1.2610.50
12_K765_E1.2610.50
238_H300_Y1.2580.50
284_A295_I1.2550.49
39_P233_A1.2520.49
180_G194_T1.2500.49
20_S778_E1.2470.49
633_E657_E1.2450.49
44_N610_V1.2450.49
190_G610_V1.2430.49
354_T367_I1.2390.48
426_S432_C1.2390.48
842_N856_D1.2380.48
232_V314_P1.2380.48
325_T581_Q1.2370.48
841_V857_K1.2370.48
360_L365_E1.2350.48
42_Y48_H1.2350.48
824_I828_E1.2350.48
841_V844_E1.2290.48
72_V602_K1.2280.48
844_E848_R1.2280.48
100_I108_E1.2280.48
48_H51_H1.2240.48
459_S462_K1.2180.47
777_L799_I1.2160.47
393_V398_V1.2140.47
23_F776_S1.2100.47
380_I401_Q1.2060.47
756_A775_V1.1950.46
284_A293_L1.1900.46
726_Y729_L1.1860.45
408_N824_I1.1850.45
520_L524_I1.1830.45
848_R851_T1.1830.45
231_V311_M1.1820.45
864_V869_L1.1800.45
463_A588_I1.1780.45
731_D735_L1.1680.44
360_L369_K1.1660.44
350_A354_T1.1650.44
819_K822_I1.1570.44
399_G402_V1.1570.44
425_I432_C1.1540.44
192_H578_D1.1520.44
321_Y325_T1.1500.43
860_E870_D1.1490.43
182_C434_C1.1490.43
323_A326_E1.1470.43
77_A531_I1.1450.43
417_N539_I1.1440.43
42_Y50_G1.1430.43
531_I535_I1.1410.43
635_G638_P1.1380.43
563_E568_Y1.1380.43
546_A551_R1.1370.43
132_K147_T1.1340.43
752_I763_A1.1320.42
817_A825_N1.1310.42
473_P476_T1.1310.42
731_D796_I1.1270.42
103_F108_E1.1260.42
80_F576_G1.1220.42
864_V870_D1.1210.42
702_I783_P1.1200.42
251_N271_V1.1200.42
405_A409_T1.1200.42
243_V270_L1.1180.42
337_V402_V1.1170.42
823_Y833_L1.1170.42
704_K720_L1.1150.41
493_S505_S1.1140.41
669_K676_R1.1130.41
853_N856_D1.1100.41
356_N361_K1.1070.41
746_K749_S1.1060.41
192_H575_T1.1060.41
846_P851_T1.1030.41
105_N111_Q1.1020.41
241_N545_D1.1000.41
128_K151_T1.1000.41
218_F253_I1.0980.40
553_Y558_I1.0970.40
860_E864_V1.0920.40
245_V254_I1.0920.40
586_F595_F1.0900.40
867_S870_D1.0880.40
557_L560_L1.0880.40
88_I120_P1.0850.40
546_A553_Y1.0840.40
401_Q404_E1.0800.39
862_V872_A1.0750.39
137_S631_I1.0730.39
674_I748_L1.0710.39
184_N715_R1.0670.39
191_M577_R1.0670.39
148_F573_R1.0650.39
372_Y376_Y1.0640.39
516_L594_I1.0580.38
36_I58_A1.0560.38
706_N754_A1.0550.38
364_M367_I1.0530.38
612_V621_L1.0510.38
20_S768_H1.0500.38
202_I206_N1.0490.38
278_D862_V1.0470.38
634_F664_A1.0460.38
838_I842_N1.0460.38
560_L563_E1.0420.37
457_K483_F1.0420.37
634_F702_I1.0410.37
44_N619_K1.0390.37
247_Y252_F1.0360.37
607_N619_K1.0360.37
33_K571_D1.0350.37
641_I759_V1.0330.37
828_E833_L1.0330.37
366_S369_K1.0310.37
43_T131_M1.0280.37
35_F39_P1.0260.37
208_I217_N1.0260.37
833_L845_I1.0240.36
757_P781_P1.0220.36
138_I631_I1.0190.36
827_S833_L1.0170.36
23_F445_D1.0100.36
102_F106_V1.0100.36
431_Y641_I1.0090.36
822_I832_E1.0070.36
229_F395_E1.0040.35
547_K554_G1.0030.35
202_I205_M1.0030.35
824_I834_M1.0020.35
834_M847_L1.0000.35
844_E856_D0.9990.35
813_V818_E0.9950.35
518_T573_R0.9930.35
700_D790_P0.9930.35
372_Y379_D0.9890.35
457_K461_L0.9890.35
850_F856_D0.9850.34
109_V804_E0.9840.34
271_V783_P0.9800.34
467_I604_I0.9780.34
842_N846_P0.9780.34
359_A362_D0.9770.34
166_L569_P0.9760.34
450_A487_K0.9750.34
190_G494_R0.9690.34
58_A78_F0.9670.33
779_K782_E0.9670.33
808_E811_D0.9650.33
273_T775_V0.9640.33
865_V872_A0.9620.33
404_E408_N0.9610.33
233_A312_S0.9570.33
132_K704_K0.9550.33
844_E855_E0.9550.33
466_N597_E0.9540.33
822_I833_L0.9540.33
749_S773_T0.9510.33
103_F107_Y0.9500.33
817_A820_V0.9500.33
520_L594_I0.9480.33
846_P849_E0.9450.32
514_S518_T0.9450.32
279_I295_I0.9440.32
209_M216_Y0.9440.32
489_P502_W0.9400.32
43_T47_M0.9360.32
858_I867_S0.9350.32
838_I845_I0.9320.32
89_A761_H0.9310.32
861_K867_S0.9310.32
833_L838_I0.9300.32
629_K633_E0.9290.32
43_T589_Y0.9280.32
253_I279_I0.9280.32
847_L855_E0.9270.31
842_N852_A0.9270.31
651_Q658_N0.9260.31
149_T471_P0.9260.31
837_A840_A0.9250.31
332_E594_I0.9250.31
459_S596_G0.9240.31
160_H164_G0.9220.31
19_K791_D0.9210.31
374_K401_Q0.9200.31
474_T606_I0.9180.31
677_L744_I0.9160.31
845_I850_F0.9150.31
839_K852_A0.9140.31
316_H375_G0.9140.31
15_A684_I0.9120.31
805_N809_L0.9100.31
180_G606_I0.9100.31
37_T573_R0.9080.31
834_M840_A0.9040.30
862_V871_K0.9040.30
178_V255_S0.9030.30
43_T53_R0.9020.30
837_A845_I0.9000.30
542_G565_L0.9000.30
22_V67_M0.8990.30
22_V728_I0.8980.30
357_P361_K0.8970.30
522_T527_M0.8970.30
465_N475_K0.8960.30
63_R424_E0.8950.30
514_S517_Y0.8930.30
692_E806_V0.8930.30
28_D31_K0.8920.30
843_E851_T0.8920.30
333_V345_I0.8920.30
867_S871_K0.8920.30
191_M438_I0.8900.30
862_V873_I0.8890.30
170_G417_N0.8880.30
244_V658_N0.8860.29
840_A844_E0.8830.29
237_N303_P0.8820.29
785_E790_P0.8820.29
833_L841_V0.8820.29
63_R831_K0.8800.29
325_T565_L0.8800.29
586_F605_V0.8790.29
380_I539_I0.8790.29
841_V851_T0.8770.29
846_P850_F0.8750.29
157_K523_V0.8750.29
633_E794_L0.8740.29
841_V856_D0.8700.29
185_D432_C0.8690.29
101_E104_K0.8680.29
168_E269_K0.8670.29
819_K833_L0.8650.28
365_E369_K0.8640.28
358_Y362_D0.8640.28
826_E833_L0.8640.28
852_A856_D0.8630.28
52_G138_I0.8630.28
146_R517_Y0.8610.28
610_V619_K0.8610.28
15_A18_E0.8610.28
485_A585_P0.8610.28
214_D246_E0.8600.28
546_A554_G0.8580.28
232_V334_I0.8580.28
698_V746_K0.8560.28
197_D488_E0.8560.28
866_V872_A0.8540.28
19_K22_V0.8540.28
47_M619_K0.8530.28
864_V867_S0.8510.28
634_F739_P0.8500.28
866_V870_D0.8480.28
181_Y609_F0.8470.28
165_K533_K0.8400.27
685_K770_I0.8390.27
675_D769_K0.8380.27
784_N787_N0.8370.27
491_G506_Q0.8360.27
80_F574_H0.8360.27
848_R853_N0.8340.27
828_E832_E0.8320.27
86_L605_V0.8320.27
409_T843_E0.8320.27
220_V588_I0.8310.27
758_F839_K0.8300.27
374_K378_K0.8290.27
41_P44_N0.8280.27
191_M197_D0.8260.27
829_K833_L0.8240.27
57_T194_T0.8240.27
363_F368_Y0.8240.27
503_D510_S0.8240.27
36_I62_A0.8220.26
157_K160_H0.8210.26
44_N510_S0.8200.26
840_A848_R0.8200.26
368_Y375_G0.8200.26
83_T124_A0.8200.26
218_F279_I0.8160.26
819_K826_E0.8160.26
467_I775_V0.8150.26
735_L799_I0.8150.26
67_M274_I0.8140.26
205_M208_I0.8140.26
775_V779_K0.8130.26
395_E398_V0.8130.26
67_M779_K0.8110.26
172_L592_L0.8100.26
78_F147_T0.8090.26
182_C432_C0.8090.26
837_A857_K0.8080.26
20_S24_E0.8080.26
559_Q562_E0.8080.26
191_M488_E0.8080.26
199_E202_I0.8070.26
244_V253_I0.8070.26
820_V830_V0.8060.26
529_I534_E0.8060.26
373_Y377_M0.8060.26
852_A855_E0.8040.26
551_R558_I0.8040.26
718_V758_F0.8030.26
55_Y59_D0.8020.26
194_T197_D0.8000.26
199_E207_V0.8000.26
356_N362_D0.7990.25
191_M194_T0.7980.25
150_T276_T0.7970.25
273_T632_K0.7970.25
213_S216_Y0.7970.25
829_K834_M0.7960.25
127_F607_N0.7960.25
400_K474_T0.7940.25
484_N490_I0.7940.25
236_V775_V0.7910.25
693_W796_I0.7910.25
822_I826_E0.7900.25
63_R471_P0.7900.25
819_K832_E0.7890.25
852_A857_K0.7890.25
44_N653_L0.7870.25
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325_T328_N0.5390.16
829_K835_K0.5380.16
38_V43_T0.5380.16
575_T584_I0.5370.16
254_I270_L0.5370.16
138_I644_T0.5370.16
220_V450_A0.5370.16
576_G619_K0.5360.16
231_V286_N0.5360.16
843_E846_P0.5360.16
177_D368_Y0.5360.16
217_N220_V0.5350.16
22_V723_Y0.5350.16
455_K523_V0.5350.16
736_V739_P0.5340.16
846_P854_T0.5330.16
342_L347_G0.5320.16
336_V375_G0.5320.16
52_G627_L0.5310.16
321_Y348_E0.5310.16
560_L565_L0.5310.16
632_K794_L0.5300.16
57_T642_A0.5300.16
678_L745_R0.5300.16
378_K381_I0.5290.15
641_I722_L0.5290.15
274_I279_I0.5290.15
522_T563_E0.5290.15
231_V316_H0.5290.15
324_M333_V0.5290.15
295_I450_A0.5290.15
323_A358_Y0.5290.15
612_V651_Q0.5280.15
836_N848_R0.5280.15
782_E785_E0.5280.15
265_Q515_T0.5280.15
261_K300_Y0.5270.15
825_N828_E0.5270.15
850_F854_T0.5270.15
362_D366_S0.5260.15
202_I221_A0.5260.15
286_N724_E0.5260.15
511_L566_Y0.5260.15
185_D589_Y0.5250.15
136_K740_N0.5250.15
433_R440_P0.5250.15
114_I117_L0.5250.15
578_D608_G0.5250.15
18_E775_V0.5250.15
8_S215_S0.5250.15
797_S802_I0.5240.15
477_E480_K0.5240.15
194_T605_V0.5240.15
586_F612_V0.5230.15
180_G612_V0.5230.15
200_P205_M0.5230.15
8_S19_K0.5230.15
534_E678_L0.5230.15
291_R602_K0.5220.15
241_N256_E0.5220.15
271_V580_I0.5210.15
611_R638_P0.5210.15
138_I405_A0.5200.15
79_Q484_N0.5200.15
19_K68_K0.5190.15
68_K779_K0.5190.15
76_F140_M0.5190.15
844_E850_F0.5180.15
681_N745_R0.5180.15
53_R59_D0.5170.15
18_E64_Y0.5170.15
169_L241_N0.5170.15
161_W517_Y0.5170.15
331_F731_D0.5170.15
111_Q114_I0.5160.15
746_K779_K0.5160.15
142_I165_K0.5150.15
178_V440_P0.5150.15
456_W496_I0.5150.15
358_Y641_I0.5140.15
491_G623_N0.5140.15
256_E337_V0.5140.15
243_V638_P0.5130.15
717_A754_A0.5120.15
213_S256_E0.5120.15
222_T617_M0.5120.15
52_G88_I0.5120.15
398_V788_L0.5120.15
472_N475_K0.5120.15
840_A843_E0.5120.15
448_F659_L0.5110.15
519_L560_L0.5110.15
354_T363_F0.5100.15
545_D560_L0.5090.15
580_I755_L0.5090.15
107_Y531_I0.5090.15
236_V756_A0.5090.15
554_G559_Q0.5080.15
247_Y250_K0.5080.15
491_G812_I0.5070.15
868_K873_I0.5070.15
76_F144_W0.5070.15
220_V311_M0.5070.15
279_I750_I0.5070.15
252_F331_F0.5060.15
399_G404_E0.5060.15
253_I536_F0.5060.15
155_F571_D0.5060.15
142_I592_L0.5060.15
338_E782_E0.5060.15
838_I848_R0.5060.15
15_A22_V0.5050.15
400_K403_Q0.5050.15
93_R698_V0.5050.15
604_I749_S0.5030.15
858_I871_K0.5020.15
343_D347_G0.5020.15
687_L745_R0.5010.15
840_A845_I0.5010.15
7_N10_A0.5010.15
76_F671_Y0.5000.15
131_M612_V0.5000.15
248_E658_N0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wz2A 1 0.954 100 0.336 Contact Map
1wkbA 1 0.7934 100 0.443 Contact Map
1ffyA 1 0.8747 100 0.466 Contact Map
1gaxA 1 0.8801 100 0.477 Contact Map
1ileA 1 0.8009 100 0.494 Contact Map
2v0cA 1 0.7099 100 0.541 Contact Map
4arcA 1 0.742 100 0.56 Contact Map
3ziuA 1 0.6092 100 0.656 Contact Map
1rqgA 2 0.5749 100 0.729 Contact Map
4qreA 1 0.5236 100 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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