GREMLIN Database
KTHY2 - Probable thymidylate kinase 2
UniProt: P58157 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (191)
Sequences: 4666 (3540)
Seq/√Len: 256.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_R200_D3.6511.00
26_W202_R3.1361.00
32_D86_F3.1221.00
127_I190_G2.9101.00
22_L198_Q2.7301.00
102_V174_I2.7131.00
128_R172_V2.4001.00
24_K28_E2.3561.00
192_R196_D2.3181.00
133_I136_E2.1441.00
193_P196_D2.0871.00
172_V176_D2.0461.00
72_D76_R2.0421.00
34_Y86_F2.0031.00
36_T73_R1.9721.00
188_I197_V1.9711.00
20_A35_L1.8621.00
4_L87_V1.8501.00
20_A89_I1.8491.00
19_Q201_I1.8081.00
30_R206_G1.8031.00
19_Q198_Q1.8031.00
75_E79_L1.7921.00
128_R176_D1.7451.00
24_K35_L1.6821.00
79_L83_K1.6801.00
186_I204_I1.6471.00
14_S129_V1.6351.00
176_D187_T1.6341.00
95_Y184_N1.6251.00
26_W30_R1.6101.00
198_Q202_R1.5961.00
130_T191_N1.5871.00
125_F204_I1.5831.00
126_Y185_F1.5441.00
24_K89_I1.5371.00
5_L90_C1.5041.00
129_V133_I1.4811.00
113_R116_S1.4791.00
104_R163_G1.4771.00
19_Q22_L1.4461.00
186_I208_Y1.3801.00
126_Y187_T1.3671.00
177_K181_E1.3371.00
46_D69_D1.3371.00
79_L119_I1.3171.00
173_E177_K1.3151.00
179_A187_T1.3091.00
112_K181_E1.3081.00
169_S173_E1.3021.00
58_T75_E1.2941.00
47_I50_E1.2841.00
26_W206_G1.2781.00
7_A90_C1.2731.00
127_I201_I1.2621.00
125_F201_I1.2591.00
44_I57_L1.2581.00
26_W198_Q1.2511.00
95_Y124_T1.2431.00
23_L205_L1.2291.00
25_D29_M1.2271.00
7_A95_Y1.2251.00
12_D134_A1.2161.00
81_M86_F1.2071.00
11_I168_Q1.2061.00
131_P165_L1.2031.00
133_I191_N1.1951.00
8_F23_L1.1941.00
22_L195_K1.1921.00
71_S75_E1.1791.00
165_L169_S1.1761.00
34_Y81_M1.1731.00
134_A138_I1.1711.00
22_L194_L1.1671.00
202_R206_G1.1631.00
67_A115_Y1.1631.00
177_K180_K1.1551.00
48_I65_I1.1361.00
42_E45_H1.1361.00
204_I208_Y1.1351.00
94_V115_Y1.1211.00
146_K149_E1.1201.00
21_V25_D1.1091.00
166_K169_S1.1071.00
132_E169_S1.1061.00
63_S67_A1.1011.00
120_K182_E1.0901.00
126_Y179_A1.0891.00
198_Q201_I1.0841.00
30_R202_R1.0731.00
24_K33_V1.0711.00
9_E96_T1.0651.00
18_S194_L1.0641.00
110_W117_F1.0641.00
126_Y176_D1.0601.00
188_I204_I1.0601.00
60_I110_W1.0591.00
35_L89_I1.0541.00
109_D113_R1.0481.00
74_Y119_I1.0471.00
129_V134_A1.0421.00
130_T133_I1.0391.00
178_I185_F1.0351.00
126_Y172_V1.0281.00
200_D203_K1.0201.00
166_K170_R1.0181.00
45_H69_D1.0121.00
123_F186_I1.0101.00
36_T90_C1.0061.00
138_I141_A1.0041.00
204_I207_E1.0031.00
112_K116_S0.9891.00
28_E33_V0.9881.00
125_F186_I0.9861.00
67_A97_A0.9831.00
34_Y77_Y0.9811.00
194_L198_Q0.9761.00
25_D28_E0.9741.00
58_T71_S0.9661.00
131_P172_V0.9641.00
196_D200_D0.9611.00
115_Y118_A0.9601.00
69_D73_R0.9601.00
135_L138_I0.9601.00
199_I203_K0.9581.00
19_Q194_L0.9531.00
52_K55_N0.9521.00
135_L165_L0.9461.00
60_I75_E0.9451.00
67_A94_V0.9451.00
189_D192_R0.9411.00
200_D204_I0.9411.00
107_D111_V0.9401.00
99_A102_V0.9331.00
99_A103_V0.9261.00
26_W199_I0.9251.00
123_F208_Y0.9231.00
33_V87_V0.9071.00
103_V170_R0.9061.00
95_Y185_F0.8881.00
123_F204_I0.8871.00
78_I88_V0.8811.00
94_V120_K0.8751.00
128_R187_T0.8741.00
176_D179_A0.8721.00
42_E77_Y0.8641.00
203_K206_G0.8621.00
32_D84_S0.8611.00
125_F188_I0.8550.99
67_A111_V0.8520.99
182_E185_F0.8470.99
60_I117_F0.8430.99
26_W29_M0.8430.99
38_W73_R0.8410.99
5_L93_Y0.8390.99
7_A184_N0.8290.99
39_N70_F0.8240.99
63_S111_V0.8060.99
17_S21_V0.8050.99
135_L139_R0.8030.99
11_I134_A0.7970.99
22_L25_D0.7910.99
203_K207_E0.7890.99
98_Y178_I0.7850.99
188_I201_I0.7830.99
146_K150_A0.7810.99
136_E140_K0.7790.99
77_Y81_M0.7700.99
124_T184_N0.7690.99
103_V171_I0.7640.99
21_V35_L0.7640.99
28_E32_D0.7600.99
104_R167_Y0.7560.99
129_V190_G0.7530.99
58_T61_T0.7510.99
99_A174_I0.7470.99
45_H72_D0.7470.99
196_D199_I0.7460.99
12_D168_Q0.7420.99
64_L114_L0.7380.98
54_K57_L0.7370.98
107_D110_W0.7330.98
66_H148_Q0.7330.98
112_K120_K0.7300.98
63_S114_L0.7250.98
33_V86_F0.7250.98
11_I126_Y0.7240.98
73_R90_C0.7190.98
108_F177_K0.7160.98
98_Y108_F0.7130.98
8_F201_I0.7130.98
62_F104_R0.7080.98
125_F205_L0.7080.98
19_Q23_L0.7060.98
103_V167_Y0.7060.98
170_R173_E0.7040.98
70_F97_A0.7030.98
132_E165_L0.7030.98
21_V24_K0.7010.98
112_K182_E0.6950.98
179_A185_F0.6890.98
174_I177_K0.6880.98
37_E46_D0.6870.98
100_R167_Y0.6780.97
7_A185_F0.6760.97
45_H48_I0.6700.97
80_P84_S0.6620.97
4_L122_N0.6590.97
52_K57_L0.6570.97
116_S120_K0.6550.97
197_V200_D0.6540.97
13_G138_I0.6510.97
109_D112_K0.6500.97
98_Y112_K0.6460.96
8_F20_A0.6450.96
19_Q197_V0.6450.96
61_T71_S0.6440.96
39_N66_H0.6420.96
40_S49_K0.6350.96
17_S37_E0.6340.96
19_Q190_G0.6310.96
81_M84_S0.6280.96
67_A118_A0.6260.96
66_H69_D0.6250.96
74_Y78_I0.6210.96
164_F168_Q0.6150.95
93_Y119_I0.6140.95
8_F125_F0.6060.95
8_F19_Q0.6060.95
9_E100_R0.6040.95
28_E35_L0.6040.95
114_L117_F0.6030.95
47_I54_K0.6030.95
61_T68_T0.5830.94
70_F115_Y0.5830.94
132_E136_E0.5790.94
167_Y171_I0.5780.94
113_R117_F0.5770.94
97_A115_Y0.5770.94
8_F127_I0.5760.93
97_A101_D0.5750.93
81_M88_V0.5740.93
64_L117_F0.5740.93
33_V89_I0.5730.93
99_A171_I0.5730.93
47_I53_K0.5710.93
163_G167_Y0.5710.93
194_L197_V0.5700.93
124_T185_F0.5690.93
108_F112_K0.5680.93
5_L82_L0.5650.93
9_E126_Y0.5630.93
13_G141_A0.5630.93
38_W70_F0.5610.93
66_H98_Y0.5600.93
98_Y115_Y0.5550.92
105_N170_R0.5530.92
131_P169_S0.5470.92
14_S134_A0.5460.92
63_S94_V0.5450.92
173_E176_D0.5450.92
97_A111_V0.5390.91
6_I122_N0.5390.91
39_N96_T0.5370.91
131_P134_A0.5330.91
19_Q127_I0.5300.90
52_K66_H0.5280.90
43_W56_M0.5250.90
44_I47_I0.5220.90
51_A57_L0.5220.90
58_T72_D0.5200.90
109_D181_E0.5180.89
4_L208_Y0.5160.89
108_F174_I0.5160.89
142_K146_K0.5150.89
23_L198_Q0.5150.89
70_F96_T0.5150.89
110_W113_R0.5110.89
74_Y79_L0.5090.89
168_Q171_I0.5090.89
37_E91_D0.5040.88
63_S97_A0.5030.88
19_Q26_W0.5030.88
74_Y118_A0.5020.88
37_E41_S0.5020.88
36_T88_V0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2plrA 2 0.9906 100 0.373 Contact Map
3czpA 2 0.784 100 0.406 Contact Map
2yogA 1 0.8638 100 0.442 Contact Map
4edhA 2 0.9343 100 0.447 Contact Map
1nn5A 2 0.892 100 0.454 Contact Map
1p6xA 3 0.9202 100 0.455 Contact Map
4tmkA 3 0.9296 100 0.462 Contact Map
1osnA 4 0.8967 100 0.469 Contact Map
3czqA 3 0.8451 100 0.472 Contact Map
1gtvA 2 0.892 100 0.473 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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