GREMLIN Database
TF2B2 - Transcription initiation factor IIB 2
UniProt: P58110 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (276)
Sequences: 1059 (709)
Seq/√Len: 42.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_L249_V6.4871.00
113_S152_L4.7461.00
23_C26_C3.9741.00
262_Q277_R3.5201.00
279_R282_D3.4421.00
222_K256_M3.3861.00
216_P258_I3.3381.00
15_D18_K3.1301.00
105_L130_I3.1151.00
112_E152_L2.8741.00
3_C26_C2.7681.00
106_L127_S2.6031.00
113_S123_K2.5411.00
3_C6_C2.5301.00
108_I111_D2.5001.00
246_A269_L2.4971.00
152_L168_F2.4181.00
12_I30_I2.4091.00
263_K273_E2.4021.00
118_L152_L2.3891.00
141_R241_Y2.3791.00
126_A155_S2.2671.00
176_S180_W2.2121.00
43_A46_A2.2111.00
122_V155_S2.1781.00
6_C23_C2.1140.99
40_D54_R2.0960.99
273_E281_K2.0010.99
222_K225_E1.8730.99
130_I139_T1.8700.99
12_I21_Y1.8070.98
263_K276_I1.7920.98
3_C7_K1.7910.98
22_V268_S1.7780.98
226_L252_I1.7710.98
223_A252_I1.7640.98
209_I213_L1.7490.98
223_A245_S1.7440.98
15_D19_G1.7380.98
23_C27_A1.7210.98
227_V248_S1.7080.97
128_L131_R1.7050.97
209_I249_V1.7010.97
227_V244_L1.6940.97
3_C23_C1.6880.97
112_E171_R1.6860.97
125_T159_N1.6650.97
43_A48_D1.6220.97
163_R167_E1.5950.96
261_T264_E1.5500.95
243_S275_T1.5310.95
105_L109_L1.5010.95
226_L248_S1.4960.94
215_L260_K1.4890.94
125_T158_V1.4890.94
40_D52_K1.4830.94
54_R70_T1.4590.94
109_L148_I1.4450.93
41_W52_K1.4430.93
141_R275_T1.4390.93
6_C26_C1.4280.93
203_A228_D1.4270.93
38_G41_W1.4270.93
253_S268_S1.4120.93
262_Q274_V1.4050.92
190_A193_I1.3850.92
116_L232_K1.3710.91
83_T86_M1.3670.91
5_Y28_S1.3670.91
219_I256_M1.3670.91
109_L127_S1.3560.91
105_L134_V1.3430.91
260_K264_E1.3420.91
157_Q180_W1.3360.90
3_C8_T1.3260.90
154_Y157_Q1.3150.90
180_W209_I1.3100.89
105_L181_S1.3040.89
245_S269_L1.3040.89
201_K204_E1.2980.89
41_W44_Y1.2980.89
220_G224_S1.2890.89
168_F171_R1.2760.88
154_Y195_G1.2570.87
248_S252_I1.2510.87
249_V265_V1.2500.87
60_T64_H1.2450.87
125_T128_L1.2430.87
40_D44_Y1.2380.87
165_L180_W1.2370.87
127_S131_R1.2270.86
64_H67_G1.2170.86
8_T25_N1.2050.85
56_G60_T1.1970.85
271_I276_I1.1920.84
153_Y200_I1.1900.84
127_S134_V1.1830.84
135_E263_K1.1710.83
167_E208_K1.1690.83
247_A275_T1.1650.83
246_A251_L1.1610.83
5_Y8_T1.1130.80
69_H112_E1.1110.80
102_L127_S1.1100.80
130_I144_Q1.1050.80
174_I212_K1.1040.79
217_P221_T1.0890.79
227_V245_S1.0860.78
219_I258_I1.0850.78
132_K136_T1.0840.78
12_I19_G1.0820.78
21_Y24_T1.0770.78
246_A276_I1.0760.78
25_N113_S1.0720.77
264_E268_S1.0710.77
165_L176_S1.0690.77
243_S247_A1.0550.76
169_K174_I1.0500.76
101_K154_Y1.0480.76
43_A51_E1.0400.75
54_R72_I1.0370.75
250_Y254_A1.0290.74
89_M130_I1.0200.74
122_V161_I1.0200.74
95_V109_L1.0180.74
41_W58_P1.0160.74
259_K264_E1.0130.73
147_L182_A1.0060.73
136_T264_E1.0000.72
13_T21_Y0.9980.72
154_Y253_S0.9970.72
21_Y226_L0.9910.72
22_V281_K0.9860.71
31_E37_P0.9790.71
12_I17_E0.9730.70
105_L113_S0.9720.70
192_S227_V0.9690.70
177_S281_K0.9670.70
22_V194_P0.9660.70
266_A269_L0.9660.70
149_V156_C0.9640.70
103_V107_S0.9640.70
126_A151_A0.9620.69
175_S178_E0.9610.69
90_Q113_S0.9540.69
164_H168_F0.9530.69
251_L265_V0.9490.68
235_L253_S0.9460.68
60_T63_V0.9380.67
229_L233_Q0.9340.67
61_P64_H0.9190.66
42_R54_R0.9190.66
257_D261_T0.9130.65
178_E206_I0.9110.65
201_K227_V0.9060.65
59_S62_K0.9060.65
105_L133_M0.9020.64
203_A270_D0.9010.64
116_L230_M0.9000.64
102_L162_P0.8980.64
235_L246_A0.8970.64
274_V277_R0.8900.63
13_T24_T0.8810.62
243_S279_R0.8720.62
109_L130_I0.8700.61
253_S258_I0.8700.61
80_R84_L0.8670.61
168_F234_G0.8610.61
246_A266_A0.8610.61
140_K244_L0.8500.60
76_R132_K0.8490.60
249_V269_L0.8490.60
85_K89_M0.8480.59
9_D189_V0.8450.59
100_K108_I0.8440.59
260_K273_E0.8410.59
94_R244_L0.8400.59
261_T273_E0.8400.59
162_P248_S0.8390.59
146_T150_A0.8380.59
72_I86_M0.8380.59
14_Y21_Y0.8370.58
44_Y209_I0.8360.58
36_D39_P0.8350.58
45_N164_H0.8330.58
189_V193_I0.8310.58
89_M92_K0.8290.58
226_L238_G0.8280.58
83_T107_S0.8230.57
180_W183_L0.8200.57
14_Y17_E0.8180.57
27_A238_G0.8110.56
172_Y280_Y0.8110.56
153_Y197_R0.8100.56
175_S179_F0.8080.56
32_D37_P0.8070.56
81_L84_L0.8050.56
108_I181_S0.8030.55
218_I256_M0.8030.55
153_Y156_C0.8020.55
71_I90_Q0.8020.55
47_K54_R0.8010.55
181_S188_Y0.7960.55
129_I155_S0.7930.54
49_R52_K0.7930.54
183_L243_S0.7890.54
180_W240_G0.7870.54
208_K240_G0.7850.54
109_L115_K0.7840.54
104_T231_H0.7830.53
123_K152_L0.7830.53
168_F207_P0.7830.53
112_E158_V0.7800.53
222_K255_L0.7800.53
235_L282_D0.7770.53
255_L280_Y0.7750.53
7_K13_T0.7620.51
239_K252_I0.7600.51
92_K238_G0.7600.51
129_I151_A0.7570.51
35_V41_W0.7560.51
210_L213_L0.7540.51
166_Q176_S0.7520.51
30_I174_I0.7520.51
203_A231_H0.7510.50
163_R208_K0.7510.50
122_V163_R0.7490.50
198_P201_K0.7490.50
182_A195_G0.7420.50
29_V61_P0.7410.49
36_D40_D0.7400.49
98_K214_N0.7400.49
105_L247_A0.7370.49
183_L271_I0.7350.49
164_H167_E0.7340.49
108_I112_E0.7330.49
140_K273_E0.7320.49
143_D192_S0.7300.48
32_D251_L0.7270.48
42_R52_K0.7250.48
240_G250_Y0.7240.48
85_K90_Q0.7240.48
105_L272_T0.7230.48
131_R155_S0.7230.48
263_K278_N0.7220.48
124_E137_G0.7200.47
268_S276_I0.7190.47
162_P204_E0.7180.47
30_I178_E0.7140.47
167_E275_T0.7140.47
60_T66_W0.7140.47
133_M183_L0.7120.47
62_K66_W0.7110.47
280_Y284_V0.7110.47
99_D136_T0.7110.47
122_V140_K0.7100.47
101_K143_D0.7090.46
132_K178_E0.7080.46
170_V286_N0.7080.46
263_K271_I0.7070.46
68_F71_I0.6990.46
60_T65_D0.6980.45
7_K26_C0.6960.45
117_E154_Y0.6950.45
19_G118_L0.6940.45
234_G239_K0.6930.45
27_A153_Y0.6930.45
4_P30_I0.6900.45
127_S181_S0.6890.45
87_Q131_R0.6880.44
211_Y246_A0.6880.44
59_S66_W0.6830.44
271_I275_T0.6820.44
205_Y210_L0.6810.44
9_D148_I0.6800.44
201_K231_H0.6800.44
213_L249_V0.6760.43
248_S267_D0.6760.43
46_A51_E0.6670.43
131_R221_T0.6650.42
168_F197_R0.6600.42
122_V159_N0.6590.42
149_V168_F0.6580.42
69_H81_L0.6580.42
152_L234_G0.6560.42
4_P249_V0.6530.41
239_K244_L0.6500.41
150_A206_I0.6490.41
30_I240_G0.6420.40
228_D232_K0.6410.40
113_S244_L0.6390.40
171_R246_A0.6390.40
240_G276_I0.6370.40
101_K130_I0.6370.40
215_L238_G0.6370.40
183_L238_G0.6340.39
56_G70_T0.6340.39
58_P64_H0.6330.39
97_P282_D0.6320.39
55_V206_I0.6320.39
133_M269_L0.6320.39
215_L219_I0.6290.39
44_Y56_G0.6260.39
31_E268_S0.6240.39
49_R203_A0.6200.38
13_T17_E0.6190.38
99_D123_K0.6180.38
106_L124_E0.6180.38
162_P191_N0.6150.38
173_S246_A0.6140.38
172_Y200_I0.6130.38
190_A197_R0.6130.38
151_A257_D0.6130.38
59_S63_V0.6120.38
59_S96_S0.6100.37
38_G276_I0.6100.37
130_I279_R0.6090.37
239_K259_K0.6090.37
118_L156_C0.6080.37
12_I15_D0.6080.37
18_K34_A0.6070.37
105_L276_I0.6070.37
14_Y109_L0.6050.37
263_K267_D0.6040.37
38_G43_A0.6030.37
209_I239_K0.5980.36
178_E181_S0.5980.36
39_P250_Y0.5950.36
175_S263_K0.5950.36
170_V270_D0.5950.36
90_Q94_R0.5930.36
105_L142_I0.5900.36
110_N127_S0.5890.35
76_R219_I0.5890.35
253_S259_K0.5880.35
190_A195_G0.5850.35
225_E237_S0.5840.35
83_T232_K0.5820.35
90_Q199_K0.5820.35
7_K198_P0.5820.35
108_I118_L0.5800.35
209_I268_S0.5800.35
97_P190_A0.5760.34
13_T246_A0.5710.34
215_L258_I0.5710.34
244_L279_R0.5700.34
122_V231_H0.5680.34
109_L126_A0.5680.34
194_P214_N0.5670.34
33_S39_P0.5650.33
58_P65_D0.5620.33
46_A254_A0.5620.33
219_I248_S0.5610.33
16_V31_E0.5590.33
120_E124_E0.5580.33
87_Q130_I0.5570.33
168_F265_V0.5560.33
246_A250_Y0.5560.33
19_G34_A0.5550.33
67_G116_L0.5540.33
130_I134_V0.5530.32
61_P118_L0.5530.32
156_C159_N0.5500.32
170_V225_E0.5480.32
43_A52_K0.5470.32
148_I196_F0.5450.32
22_V120_E0.5440.32
25_N112_E0.5430.32
93_I107_S0.5430.32
45_N244_L0.5430.32
29_V221_T0.5420.32
25_N119_P0.5420.32
147_L173_S0.5410.31
17_E20_M0.5400.31
240_G243_S0.5400.31
97_P104_T0.5380.31
156_C200_I0.5370.31
106_L250_Y0.5370.31
143_D241_Y0.5350.31
67_G277_R0.5310.31
167_E246_A0.5290.30
15_D28_S0.5280.30
115_K198_P0.5280.30
41_W202_P0.5270.30
124_E127_S0.5260.30
8_T33_S0.5250.30
91_N94_R0.5240.30
118_L285_D0.5230.30
7_K47_K0.5230.30
220_G264_E0.5220.30
69_H260_K0.5220.30
147_L213_L0.5210.30
139_T279_R0.5210.30
20_M277_R0.5210.30
111_D220_G0.5180.30
167_E178_E0.5160.29
6_C24_T0.5160.29
14_Y20_M0.5160.29
49_R57_S0.5150.29
156_C227_V0.5150.29
182_A199_K0.5150.29
69_H72_I0.5140.29
180_W268_S0.5140.29
55_V70_T0.5140.29
29_V151_A0.5120.29
121_H160_N0.5100.29
230_M233_Q0.5070.29
243_S271_I0.5070.29
199_K206_I0.5070.29
125_T199_K0.5040.29
29_V161_I0.5030.28
176_S263_K0.5020.28
151_A234_G0.5000.28
179_F228_D0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bbrM 1 0.6485 100 0.208 Contact Map
1aisB 1 0.6485 100 0.569 Contact Map
1c9bA 1 0.6587 100 0.58 Contact Map
2pk2A 3 0.744 99.9 0.694 Contact Map
2w96A 1 0.7816 99.9 0.695 Contact Map
4f6uB 1 0.7816 99.9 0.705 Contact Map
3g33B 2 0.7372 99.9 0.711 Contact Map
2i53A 1 0.7645 99.9 0.717 Contact Map
2b9rA 1 0.7509 99.9 0.718 Contact Map
4eojB 1 0.7645 99.9 0.72 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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