GREMLIN Database
FLPA - Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
UniProt: P58032 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (215)
Sequences: 402 (210)
Seq/√Len: 14.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_I106_G4.3041.00
163_A177_M3.8651.00
150_L167_A3.8361.00
80_V94_V3.3020.99
94_V104_A3.2460.99
135_R158_D3.2230.98
199_E202_K2.9840.97
158_D161_D2.9070.97
64_A225_I2.4680.92
171_L175_G2.4230.92
132_A139_S2.4220.92
120_V127_I2.3960.91
152_V163_A2.3750.91
200_V213_I2.3740.91
112_R115_R2.3490.90
177_M228_S2.2780.89
62_A151_Y2.2520.88
74_I149_V2.2490.88
178_L227_L2.2460.88
181_I199_E2.2380.88
184_R222_D2.2130.87
64_A69_L2.2010.87
136_F139_S2.1540.86
151_Y180_V2.1470.86
181_I226_V2.1060.85
200_V226_V2.0990.84
85_A106_G2.0920.84
95_S127_I2.0840.84
31_N43_L1.9070.78
183_A196_Y1.9020.78
18_C28_C1.8830.77
35_N50_E1.8530.76
163_A228_S1.7570.72
30_R49_V1.7510.72
187_D192_P1.7410.71
31_N50_E1.7150.70
87_S186_I1.6820.68
74_I78_T1.6530.67
201_E204_E1.6440.67
97_I186_I1.6400.66
28_C53_E1.6300.66
18_C44_I1.6140.65
132_A216_L1.5990.64
34_P43_L1.5930.64
211_I229_K1.5730.63
190_K194_E1.5240.60
196_Y213_I1.5030.59
19_E23_G1.4990.59
110_S113_V1.4930.59
186_I199_E1.4910.59
64_A163_A1.4630.57
106_G127_I1.4550.57
110_S114_V1.4370.56
85_A91_I1.4220.55
161_D165_Y1.4170.55
98_I104_A1.4010.54
28_C44_I1.3990.54
168_K206_S1.3920.53
208_F228_S1.3900.53
201_E205_N1.3740.52
94_V149_V1.3540.51
31_N35_N1.3510.51
91_I127_I1.3500.51
56_A219_Y1.3320.50
43_L50_E1.3100.49
72_N178_L1.3000.48
177_M226_V1.2940.48
218_P222_D1.2850.47
22_D215_N1.2730.47
85_A117_L1.2670.46
156_Q162_I1.2440.45
186_I202_K1.2430.45
86_A155_A1.2400.45
171_L174_N1.2240.44
160_T181_I1.2060.43
158_D162_I1.1920.42
192_P222_D1.1900.42
112_R116_E1.1780.42
52_R88_G1.1720.41
130_L162_I1.1670.41
33_V104_A1.1550.40
38_V41_E1.1460.40
196_Y224_A1.1290.39
86_A160_T1.1100.38
57_F99_E1.0980.37
110_S120_V1.0940.37
216_L222_D1.0780.36
86_A167_A1.0700.36
14_N99_E1.0690.36
77_G99_E1.0620.36
63_G116_E1.0550.35
105_Y145_E1.0490.35
160_T164_I1.0450.35
112_R181_I1.0440.35
112_R160_T1.0390.34
155_A226_V1.0130.33
110_S213_I1.0040.33
64_A97_I1.0030.33
13_E17_E1.0010.33
106_G117_L0.9920.32
37_N43_L0.9920.32
112_R223_H0.9900.32
114_V131_L0.9820.32
64_A95_S0.9810.32
191_D222_D0.9690.31
57_F67_K0.9680.31
147_V175_G0.9600.31
58_R92_S0.9550.30
33_V127_I0.9550.30
15_I65_I0.9540.30
28_C63_G0.9500.30
87_S102_G0.9450.30
33_V123_R0.9380.30
164_I167_A0.9290.29
182_K223_H0.9240.29
82_Y124_R0.9170.29
64_A177_M0.9110.28
216_L226_V0.9100.28
122_Q139_S0.9050.28
84_G88_G0.9040.28
17_E20_F0.8840.27
58_R89_T0.8820.27
32_L157_P0.8810.27
106_G121_A0.8780.27
137_P175_G0.8740.27
205_N208_F0.8730.27
117_L125_P0.8680.27
97_I214_I0.8680.27
168_K208_F0.8670.27
147_V171_L0.8660.26
91_I190_K0.8650.26
37_N110_S0.8550.26
154_I195_I0.8540.26
185_S223_H0.8530.26
15_I211_I0.8510.26
80_V210_T0.8480.26
43_L117_L0.8420.25
59_S88_G0.8390.25
120_V123_R0.8380.25
213_I226_V0.8360.25
80_V98_I0.8350.25
73_P176_D0.8330.25
154_I220_D0.8320.25
81_L223_H0.8300.25
20_F23_G0.8300.25
208_F229_K0.8290.25
74_I80_V0.8280.25
65_I161_D0.8260.25
205_N229_K0.8260.25
150_L180_V0.8250.25
177_M208_F0.8230.25
106_G217_D0.8190.25
96_D102_G0.8180.24
40_G190_K0.8160.24
99_E152_V0.8160.24
118_L214_I0.8090.24
198_T214_I0.8070.24
217_D226_V0.8060.24
15_I197_K0.8040.24
184_R208_F0.8020.24
212_Q217_D0.8000.24
74_I94_V0.7990.24
74_I225_I0.7980.24
40_G131_L0.7900.23
90_T95_S0.7880.23
138_Q174_N0.7880.23
97_I208_F0.7840.23
113_V220_D0.7820.23
129_P156_Q0.7690.23
64_A220_D0.7660.22
61_L118_L0.7640.22
130_L145_E0.7570.22
66_L219_Y0.7520.22
91_I217_D0.7510.22
51_Y126_N0.7500.22
59_S82_Y0.7430.22
150_L202_K0.7410.21
43_L113_V0.7400.21
73_P78_T0.7400.21
80_V149_V0.7380.21
16_Y100_L0.7240.21
52_R84_G0.7240.21
62_A216_L0.7210.21
164_I206_S0.7190.21
62_A218_P0.7160.21
16_Y46_Y0.7090.20
19_E145_E0.6980.20
71_T108_E0.6980.20
208_F221_K0.6870.20
164_I204_E0.6860.20
119_L191_D0.6850.19
84_G89_T0.6800.19
13_E75_R0.6780.19
67_K218_P0.6740.19
195_I221_K0.6720.19
191_D205_N0.6700.19
103_K128_F0.6700.19
19_E176_D0.6640.19
203_L227_L0.6620.19
79_K120_V0.6610.19
77_G127_I0.6580.19
94_V180_V0.6560.18
35_N135_R0.6540.18
85_A108_E0.6530.18
150_L160_T0.6520.18
52_R59_S0.6520.18
114_V180_V0.6500.18
154_I180_V0.6490.18
23_G26_R0.6480.18
183_A226_V0.6480.18
81_L129_P0.6470.18
180_V225_I0.6450.18
121_A206_S0.6440.18
87_S220_D0.6430.18
184_R192_P0.6430.18
169_F226_V0.6410.18
37_N123_R0.6380.18
118_L132_A0.6380.18
144_V170_F0.6330.18
66_L97_I0.6320.18
187_D195_I0.6290.18
89_T93_H0.6290.18
38_V118_L0.6280.18
108_E170_F0.6270.18
156_Q186_I0.6240.17
106_G161_D0.6210.17
65_I150_L0.6190.17
126_N162_I0.6180.17
121_A219_Y0.6150.17
120_V180_V0.6150.17
67_K214_I0.6150.17
20_F194_E0.6150.17
110_S188_V0.6080.17
23_G139_S0.6080.17
51_Y130_L0.6060.17
117_L142_S0.6050.17
82_Y88_G0.6000.17
128_F138_Q0.5990.17
31_N219_Y0.5990.17
204_E213_I0.5980.17
65_I87_S0.5970.17
62_A201_E0.5960.17
126_N156_Q0.5950.17
89_T155_A0.5910.16
139_S209_E0.5910.16
53_E128_F0.5900.16
196_Y218_P0.5900.16
122_Q155_A0.5890.16
110_S162_I0.5890.16
147_V151_Y0.5870.16
116_E212_Q0.5870.16
150_L201_E0.5850.16
212_Q220_D0.5840.16
193_K206_S0.5840.16
90_T165_Y0.5840.16
21_N205_N0.5800.16
87_S180_V0.5780.16
90_T131_L0.5780.16
34_P50_E0.5770.16
34_P164_I0.5760.16
94_V106_G0.5730.16
114_V142_S0.5730.16
143_V190_K0.5730.16
46_Y144_V0.5720.16
180_V191_D0.5700.16
200_V204_E0.5680.16
129_P166_N0.5670.16
103_K121_A0.5670.16
59_S84_G0.5660.16
132_A142_S0.5650.16
122_Q219_Y0.5640.16
40_G123_R0.5620.16
84_G90_T0.5600.16
15_I170_F0.5580.15
51_Y186_I0.5550.15
147_V172_K0.5530.15
31_N115_R0.5510.15
109_F154_I0.5510.15
75_R197_K0.5500.15
64_A120_V0.5500.15
57_F229_K0.5460.15
62_A208_F0.5450.15
36_F53_E0.5430.15
195_I222_D0.5400.15
168_K204_E0.5400.15
95_S197_K0.5390.15
109_F112_R0.5380.15
207_N217_D0.5380.15
217_D220_D0.5370.15
112_R157_P0.5370.15
82_Y89_T0.5360.15
209_E229_K0.5360.15
66_L110_S0.5360.15
72_N131_L0.5350.15
39_Y166_N0.5340.15
203_L223_H0.5340.15
127_I198_T0.5310.15
176_D211_I0.5300.15
176_D208_F0.5300.15
29_T41_E0.5280.15
17_E66_L0.5260.15
202_K206_S0.5260.15
80_V127_I0.5260.15
79_K139_S0.5250.15
146_N179_L0.5240.15
116_E224_A0.5220.14
145_E197_K0.5220.14
21_N165_Y0.5210.14
89_T182_K0.5190.14
119_L193_K0.5150.14
50_E57_F0.5140.14
85_A121_A0.5130.14
41_E63_G0.5130.14
28_C191_D0.5120.14
21_N117_L0.5110.14
23_G131_L0.5100.14
127_I205_N0.5080.14
60_K63_G0.5060.14
30_R56_A0.5030.14
14_N164_I0.5030.14
34_P38_V0.5020.14
121_A127_I0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3id6C 1 0.9483 100 0.645 Contact Map
2ipxA 1 0.9483 100 0.657 Contact Map
4df3A 1 0.9871 100 0.659 Contact Map
1g8aA 1 0.9784 100 0.676 Contact Map
1fbnA 1 0.9871 100 0.687 Contact Map
1nt2A 2 0.9009 100 0.743 Contact Map
1o54A 4 0.8793 99.2 0.872 Contact Map
1i9gA 3 0.9009 99.1 0.876 Contact Map
2pwyA 3 0.9009 99.1 0.878 Contact Map
4k6mA 2 0.8276 99.1 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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