GREMLIN Database
PCNA1 - DNA polymerase sliding clamp 1
UniProt: P57766 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (244)
Sequences: 647 (442)
Seq/√Len: 28.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_V161_T4.8031.00
235_A239_G4.1551.00
221_V229_M3.9241.00
133_A194_T3.3991.00
136_F166_I3.1231.00
9_A87_A3.1181.00
12_F87_A2.9201.00
30_F60_Y2.7451.00
154_G170_A2.5190.99
159_I166_I2.5180.99
200_Y223_F2.5170.99
232_D242_I2.4890.99
213_R233_V2.4270.99
158_R197_S2.3700.99
159_I168_I2.3680.99
70_L98_L2.3450.99
235_A238_G2.3350.99
31_T54_K2.3250.99
28_L37_S2.2470.98
50_M241_M2.2290.98
75_V100_I2.1780.98
52_I239_G2.1390.98
43_D244_W2.0550.97
33_D147_A2.0020.96
89_I100_I1.9750.96
44_K47_M1.9260.96
228_P247_P1.9200.96
41_T204_M1.9070.95
161_T192_I1.9060.95
89_I98_L1.9050.95
43_D204_M1.8760.95
16_I28_L1.8440.94
72_V86_K1.7720.93
230_K233_V1.7590.93
220_M232_D1.7560.93
52_I147_A1.7300.92
44_K128_P1.7130.92
136_F161_T1.7070.92
51_R240_H1.6950.91
133_A224_G1.6930.91
3_K90_E1.6810.91
40_L44_K1.6560.90
29_N124_Q1.6470.90
136_F188_K1.6000.89
200_Y205_F1.5960.89
41_T69_K1.5950.89
173_E229_M1.5900.88
28_L68_V1.5860.88
70_L237_S1.5620.88
41_T45_V1.5590.87
221_V231_I1.5580.87
81_K149_D1.5490.87
74_S177_Y1.5220.86
30_F62_I1.5010.85
15_F97_G1.4870.85
112_T178_V1.4680.84
15_F129_K1.4670.84
209_V213_R1.4630.84
31_T60_Y1.4490.83
31_T36_F1.4440.83
45_V204_M1.4360.83
138_T143_L1.4320.83
12_F37_S1.4220.82
113_I170_A1.4020.81
25_S71_D1.3950.81
81_K111_S1.3800.80
40_L45_V1.3520.79
102_I200_Y1.3490.78
126_T227_L1.3120.77
89_I176_R1.3100.76
89_I197_S1.3070.76
113_I137_T1.3050.76
47_M128_P1.3020.76
117_A210_K1.3020.76
131_N193_D1.2990.76
46_L204_M1.2960.76
154_G209_V1.2880.75
115_I209_V1.2810.75
19_I30_F1.2770.75
33_D55_D1.2590.73
136_F190_L1.2530.73
185_K217_A1.2490.73
15_F236_V1.2380.72
112_T233_V1.2080.70
69_K172_E1.2010.70
2_F30_F1.1990.70
27_I120_G1.1970.70
80_S86_K1.1890.69
170_A200_Y1.1890.69
2_F211_G1.1870.69
140_E215_F1.1850.69
147_A206_K1.1820.69
109_A142_V1.1460.66
101_I112_T1.1460.66
240_H244_W1.1410.66
26_I37_S1.1230.65
44_K201_S1.1140.64
22_V49_I1.1100.64
59_E113_I1.1080.63
128_P208_A1.1030.63
46_L245_I1.0960.63
79_L159_I1.0870.62
160_S171_G1.0860.62
157_M168_I1.0800.61
226_N249_L1.0770.61
176_R180_F1.0760.61
155_E243_F1.0750.61
164_D192_I1.0670.60
230_K242_I1.0640.60
141_S157_M1.0420.59
2_F46_L1.0390.58
16_I26_I1.0380.58
153_V177_Y1.0370.58
66_T91_L1.0260.57
138_T146_I1.0200.57
208_A245_I0.9990.55
150_V170_A0.9980.55
54_K60_Y0.9910.55
126_T129_K0.9900.55
174_G177_Y0.9850.54
131_N237_S0.9840.54
84_S211_G0.9750.54
79_L137_T0.9640.53
38_R248_R0.9630.53
23_T26_I0.9610.52
160_S221_V0.9590.52
46_L64_S0.9590.52
26_I72_V0.9560.52
211_G243_F0.9510.52
167_K195_S0.9480.51
234_E238_G0.9420.51
16_I243_F0.9370.51
13_F245_I0.9350.50
137_T218_P0.9340.50
58_S87_A0.9280.50
15_F28_L0.9250.50
32_E42_E0.9240.50
134_V190_L0.9140.49
127_E210_K0.9140.49
5_V146_I0.9140.49
78_I202_A0.9130.49
165_K180_F0.9120.49
161_T184_D0.9120.49
150_V168_I0.9070.48
144_N202_A0.9000.48
10_K76_K0.8810.46
79_L94_T0.8790.46
56_V198_S0.8780.46
5_V144_N0.8770.46
135_N220_M0.8760.46
243_F249_L0.8740.46
77_K118_E0.8710.46
35_I98_L0.8700.45
56_V79_L0.8670.45
19_I37_S0.8650.45
24_D73_S0.8610.45
12_F82_A0.8530.44
190_L193_D0.8480.44
50_M167_K0.8460.44
234_E240_H0.8450.44
40_L123_E0.8440.43
146_I181_L0.8350.43
48_A205_F0.8350.43
48_A152_L0.8300.42
47_M125_L0.8270.42
60_Y219_T0.8250.42
200_Y249_L0.8210.42
47_M130_V0.8200.42
33_D238_G0.8180.42
148_A181_L0.8180.42
111_S116_K0.8170.41
168_I179_A0.8160.41
132_L224_G0.8160.41
15_F216_S0.8130.41
41_T44_K0.7980.40
27_I67_S0.7930.40
144_N148_A0.7910.40
43_D136_F0.7880.39
94_T155_E0.7850.39
8_N153_V0.7820.39
205_F229_M0.7810.39
45_V246_A0.7800.39
82_A86_K0.7730.38
116_K159_I0.7730.38
44_K117_A0.7710.38
23_T202_A0.7690.38
62_I65_P0.7670.38
101_I110_K0.7620.37
164_D186_P0.7610.37
21_N207_D0.7600.37
17_N235_A0.7590.37
160_S195_S0.7580.37
92_T95_D0.7530.37
56_V236_V0.7500.37
131_N218_P0.7490.36
144_N213_R0.7470.36
158_R231_I0.7450.36
17_N159_I0.7440.36
131_N191_S0.7420.36
7_P58_S0.7410.36
151_T170_A0.7410.36
79_L191_S0.7390.36
11_D153_V0.7390.36
157_M166_I0.7370.36
170_A203_E0.7350.35
86_K202_A0.7350.35
140_E235_A0.7350.35
25_S202_A0.7340.35
64_S155_E0.7310.35
25_S155_E0.7280.35
5_V112_T0.7240.35
139_D223_F0.7200.34
44_K245_I0.7180.34
133_A215_F0.7140.34
47_M113_I0.7140.34
18_S241_M0.7130.34
164_D183_K0.7120.34
129_K173_E0.7100.34
143_L222_S0.7070.34
60_Y206_K0.7050.33
22_V199_S0.7030.33
104_D235_A0.7010.33
207_D238_G0.7000.33
131_N141_S0.6990.33
225_E243_F0.6990.33
56_V239_G0.6990.33
50_M193_D0.6980.33
43_D175_K0.6980.33
77_K117_A0.6910.32
48_A70_L0.6900.32
229_M249_L0.6870.32
169_E209_V0.6860.32
159_I163_E0.6800.32
165_K197_S0.6790.32
135_N217_A0.6770.31
25_S243_F0.6770.31
89_I129_K0.6760.31
152_L176_R0.6760.31
144_N209_V0.6740.31
71_D94_T0.6730.31
37_S48_A0.6720.31
132_L136_F0.6720.31
198_S202_A0.6710.31
13_F57_L0.6690.31
197_S217_A0.6640.31
12_F171_G0.6630.31
31_T157_M0.6610.30
44_K248_R0.6600.30
162_E195_S0.6580.30
63_D93_E0.6570.30
45_V72_V0.6570.30
60_Y100_I0.6540.30
74_S149_D0.6540.30
185_K233_V0.6520.30
18_S28_L0.6510.30
134_V155_E0.6480.30
40_L43_D0.6470.30
136_F237_S0.6470.30
102_I168_I0.6470.30
153_V202_A0.6470.30
9_A183_K0.6460.29
115_I225_E0.6460.29
204_M244_W0.6450.29
77_K125_L0.6400.29
90_E100_I0.6400.29
16_I37_S0.6400.29
12_F63_D0.6400.29
87_A170_A0.6390.29
172_E249_L0.6380.29
31_T66_T0.6360.29
77_K149_D0.6360.29
75_V176_R0.6340.29
60_Y186_P0.6320.29
23_T27_I0.6290.28
90_E99_K0.6240.28
12_F213_R0.6230.28
195_S213_R0.6200.28
198_S224_G0.6200.28
19_I73_S0.6170.28
78_I161_T0.6170.28
147_A223_F0.6170.28
73_S221_V0.6130.27
17_N33_D0.6120.27
84_S224_G0.6120.27
42_E224_G0.6090.27
85_K184_D0.6080.27
128_P249_L0.6080.27
153_V238_G0.6060.27
25_S182_M0.6060.27
89_I135_N0.6050.27
82_A121_Q0.6050.27
73_S152_L0.6040.27
166_I190_L0.6000.27
24_D130_V0.5980.26
82_A102_I0.5960.26
187_L223_F0.5930.26
94_T209_V0.5930.26
27_I134_V0.5920.26
99_K153_V0.5910.26
44_K116_K0.5880.26
72_V89_I0.5870.26
5_V153_V0.5870.26
137_T187_L0.5860.26
12_F77_K0.5820.26
8_N13_F0.5810.25
6_Y102_I0.5810.25
133_A225_E0.5780.25
61_S143_L0.5740.25
35_I78_I0.5730.25
155_E246_A0.5670.25
96_S118_E0.5660.25
99_K184_D0.5660.25
30_F35_I0.5650.25
114_Y223_F0.5630.24
15_F185_K0.5620.24
5_V63_D0.5610.24
35_I185_K0.5610.24
82_A232_D0.5600.24
179_A233_V0.5580.24
104_D145_V0.5570.24
114_Y154_G0.5560.24
186_P218_P0.5560.24
130_V133_A0.5530.24
48_A200_Y0.5530.24
41_T172_E0.5520.24
18_S129_K0.5490.24
217_A237_S0.5480.24
14_S34_G0.5430.23
64_S148_A0.5420.23
128_P155_E0.5420.23
35_I61_S0.5410.23
27_I113_I0.5410.23
231_I237_S0.5410.23
88_T188_K0.5410.23
25_S42_E0.5390.23
159_I223_F0.5380.23
3_K61_S0.5380.23
205_F213_R0.5380.23
3_K30_F0.5370.23
73_S241_M0.5370.23
33_D138_T0.5310.23
28_L156_E0.5300.23
56_V170_A0.5260.22
65_P189_E0.5250.22
19_I234_E0.5250.22
139_D176_R0.5210.22
79_L111_S0.5200.22
65_P194_T0.5190.22
26_I100_I0.5170.22
63_D231_I0.5150.22
20_T142_V0.5150.22
22_V51_R0.5140.22
2_F144_N0.5110.22
44_K244_W0.5100.22
220_M234_E0.5100.22
150_V154_G0.5080.21
113_I155_E0.5060.21
110_K164_D0.5060.21
233_V245_I0.5050.21
30_F68_V0.5030.21
101_I220_M0.5020.21
139_D213_R0.5020.21
222_S242_I0.5010.21
186_P191_S0.5010.21
24_D208_A0.5010.21
44_K204_M0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a1jC 1 0.9759 100 0.267 Contact Map
3k4xA 1 0.9839 100 0.283 Contact Map
3g65A 1 0.9518 100 0.287 Contact Map
3a1jB 1 0.9598 100 0.3 Contact Map
3a1jA 1 0.9839 100 0.314 Contact Map
3fdsC 1 0.992 100 0.348 Contact Map
3aizA 1 0.988 100 0.396 Contact Map
2zvvA 3 0.992 100 0.396 Contact Map
1u7bA 3 0.996 100 0.398 Contact Map
1plqA 3 0.992 100 0.4 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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