PCNA1 - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

PCNA1 - DNA polymerase sliding clamp 1

UniProt:	P57766	Sequences: MFKIVYPNAKDFFSFINSITNVTDSIILNFTEDGIFSRHLTEDKVLMAIMRIPKDVLSEYSIDSPTSVKLDVSSVKKILSKASSKKATIELTETDSGLKIIIRDEKSGAKSTIYIKAEKGQVEQLTEPKVNLAVNFTTDESVLNVIAADVTLVGEEMRISTEEDKIKIEAGEEGKRYVAFLMKDKPLKELSIDTSASSSYSAEMFKDAVKGLRGFSAPTMVSFGENLPMKIDVEAVSGGHMIFWIAPRL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	249 (244)
Sequences:	647 (442)
Seq/√Len:	28.3

HALSA - PCNA
SULSO - PCNA1 PCNA2 PCNA3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
134_V	161_T	4.803	1.00
235_A	239_G	4.155	1.00
221_V	229_M	3.924	1.00
133_A	194_T	3.399	1.00
136_F	166_I	3.123	1.00
9_A	87_A	3.118	1.00
12_F	87_A	2.920	1.00
30_F	60_Y	2.745	1.00
154_G	170_A	2.519	0.99
159_I	166_I	2.518	0.99
200_Y	223_F	2.517	0.99
232_D	242_I	2.489	0.99
213_R	233_V	2.427	0.99
158_R	197_S	2.370	0.99
159_I	168_I	2.368	0.99
70_L	98_L	2.345	0.99
235_A	238_G	2.335	0.99
31_T	54_K	2.325	0.99
28_L	37_S	2.247	0.98
50_M	241_M	2.229	0.98
75_V	100_I	2.178	0.98
52_I	239_G	2.139	0.98
43_D	244_W	2.055	0.97
33_D	147_A	2.002	0.96
89_I	100_I	1.975	0.96
44_K	47_M	1.926	0.96
228_P	247_P	1.920	0.96
41_T	204_M	1.907	0.95
161_T	192_I	1.906	0.95
89_I	98_L	1.905	0.95
43_D	204_M	1.876	0.95
16_I	28_L	1.844	0.94
72_V	86_K	1.772	0.93
230_K	233_V	1.759	0.93
220_M	232_D	1.756	0.93
52_I	147_A	1.730	0.92
44_K	128_P	1.713	0.92
136_F	161_T	1.707	0.92
51_R	240_H	1.695	0.91
133_A	224_G	1.693	0.91
3_K	90_E	1.681	0.91
40_L	44_K	1.656	0.90
29_N	124_Q	1.647	0.90
136_F	188_K	1.600	0.89
200_Y	205_F	1.596	0.89
41_T	69_K	1.595	0.89
173_E	229_M	1.590	0.88
28_L	68_V	1.586	0.88
70_L	237_S	1.562	0.88
41_T	45_V	1.559	0.87
221_V	231_I	1.558	0.87
81_K	149_D	1.549	0.87
74_S	177_Y	1.522	0.86
30_F	62_I	1.501	0.85
15_F	97_G	1.487	0.85
112_T	178_V	1.468	0.84
15_F	129_K	1.467	0.84
209_V	213_R	1.463	0.84
31_T	60_Y	1.449	0.83
31_T	36_F	1.444	0.83
45_V	204_M	1.436	0.83
138_T	143_L	1.432	0.83
12_F	37_S	1.422	0.82
113_I	170_A	1.402	0.81
25_S	71_D	1.395	0.81
81_K	111_S	1.380	0.80
40_L	45_V	1.352	0.79
102_I	200_Y	1.349	0.78
126_T	227_L	1.312	0.77
89_I	176_R	1.310	0.76
89_I	197_S	1.307	0.76
113_I	137_T	1.305	0.76
47_M	128_P	1.302	0.76
117_A	210_K	1.302	0.76
131_N	193_D	1.299	0.76
46_L	204_M	1.296	0.76
154_G	209_V	1.288	0.75
115_I	209_V	1.281	0.75
19_I	30_F	1.277	0.75
33_D	55_D	1.259	0.73
136_F	190_L	1.253	0.73
185_K	217_A	1.249	0.73
15_F	236_V	1.238	0.72
112_T	233_V	1.208	0.70
69_K	172_E	1.201	0.70
2_F	30_F	1.199	0.70
27_I	120_G	1.197	0.70
80_S	86_K	1.189	0.69
170_A	200_Y	1.189	0.69
2_F	211_G	1.187	0.69
140_E	215_F	1.185	0.69
147_A	206_K	1.182	0.69
109_A	142_V	1.146	0.66
101_I	112_T	1.146	0.66
240_H	244_W	1.141	0.66
26_I	37_S	1.123	0.65
44_K	201_S	1.114	0.64
22_V	49_I	1.110	0.64
59_E	113_I	1.108	0.63
128_P	208_A	1.103	0.63
46_L	245_I	1.096	0.63
79_L	159_I	1.087	0.62
160_S	171_G	1.086	0.62
157_M	168_I	1.080	0.61
226_N	249_L	1.077	0.61
176_R	180_F	1.076	0.61
155_E	243_F	1.075	0.61
164_D	192_I	1.067	0.60
230_K	242_I	1.064	0.60
141_S	157_M	1.042	0.59
2_F	46_L	1.039	0.58
16_I	26_I	1.038	0.58
153_V	177_Y	1.037	0.58
66_T	91_L	1.026	0.57
138_T	146_I	1.020	0.57
208_A	245_I	0.999	0.55
150_V	170_A	0.998	0.55
54_K	60_Y	0.991	0.55
126_T	129_K	0.990	0.55
174_G	177_Y	0.985	0.54
131_N	237_S	0.984	0.54
84_S	211_G	0.975	0.54
79_L	137_T	0.964	0.53
38_R	248_R	0.963	0.53
23_T	26_I	0.961	0.52
160_S	221_V	0.959	0.52
46_L	64_S	0.959	0.52
26_I	72_V	0.956	0.52
211_G	243_F	0.951	0.52
167_K	195_S	0.948	0.51
234_E	238_G	0.942	0.51
16_I	243_F	0.937	0.51
13_F	245_I	0.935	0.50
137_T	218_P	0.934	0.50
58_S	87_A	0.928	0.50
15_F	28_L	0.925	0.50
32_E	42_E	0.924	0.50
134_V	190_L	0.914	0.49
127_E	210_K	0.914	0.49
5_V	146_I	0.914	0.49
78_I	202_A	0.913	0.49
165_K	180_F	0.912	0.49
161_T	184_D	0.912	0.49
150_V	168_I	0.907	0.48
144_N	202_A	0.900	0.48
10_K	76_K	0.881	0.46
79_L	94_T	0.879	0.46
56_V	198_S	0.878	0.46
5_V	144_N	0.877	0.46
135_N	220_M	0.876	0.46
243_F	249_L	0.874	0.46
77_K	118_E	0.871	0.46
35_I	98_L	0.870	0.45
56_V	79_L	0.867	0.45
19_I	37_S	0.865	0.45
24_D	73_S	0.861	0.45
12_F	82_A	0.853	0.44
190_L	193_D	0.848	0.44
50_M	167_K	0.846	0.44
234_E	240_H	0.845	0.44
40_L	123_E	0.844	0.43
146_I	181_L	0.835	0.43
48_A	205_F	0.835	0.43
48_A	152_L	0.830	0.42
47_M	125_L	0.827	0.42
60_Y	219_T	0.825	0.42
200_Y	249_L	0.821	0.42
47_M	130_V	0.820	0.42
33_D	238_G	0.818	0.42
148_A	181_L	0.818	0.42
111_S	116_K	0.817	0.41
168_I	179_A	0.816	0.41
132_L	224_G	0.816	0.41
15_F	216_S	0.813	0.41
41_T	44_K	0.798	0.40
27_I	67_S	0.793	0.40
144_N	148_A	0.791	0.40
43_D	136_F	0.788	0.39
94_T	155_E	0.785	0.39
8_N	153_V	0.782	0.39
205_F	229_M	0.781	0.39
45_V	246_A	0.780	0.39
82_A	86_K	0.773	0.38
116_K	159_I	0.773	0.38
44_K	117_A	0.771	0.38
23_T	202_A	0.769	0.38
62_I	65_P	0.767	0.38
101_I	110_K	0.762	0.37
164_D	186_P	0.761	0.37
21_N	207_D	0.760	0.37
17_N	235_A	0.759	0.37
160_S	195_S	0.758	0.37
92_T	95_D	0.753	0.37
56_V	236_V	0.750	0.37
131_N	218_P	0.749	0.36
144_N	213_R	0.747	0.36
158_R	231_I	0.745	0.36
17_N	159_I	0.744	0.36
131_N	191_S	0.742	0.36
7_P	58_S	0.741	0.36
151_T	170_A	0.741	0.36
79_L	191_S	0.739	0.36
11_D	153_V	0.739	0.36
157_M	166_I	0.737	0.36
170_A	203_E	0.735	0.35
86_K	202_A	0.735	0.35
140_E	235_A	0.735	0.35
25_S	202_A	0.734	0.35
64_S	155_E	0.731	0.35
25_S	155_E	0.728	0.35
5_V	112_T	0.724	0.35
139_D	223_F	0.720	0.34
44_K	245_I	0.718	0.34
133_A	215_F	0.714	0.34
47_M	113_I	0.714	0.34
18_S	241_M	0.713	0.34
164_D	183_K	0.712	0.34
129_K	173_E	0.710	0.34
143_L	222_S	0.707	0.34
60_Y	206_K	0.705	0.33
22_V	199_S	0.703	0.33
104_D	235_A	0.701	0.33
207_D	238_G	0.700	0.33
131_N	141_S	0.699	0.33
225_E	243_F	0.699	0.33
56_V	239_G	0.699	0.33
50_M	193_D	0.698	0.33
43_D	175_K	0.698	0.33
77_K	117_A	0.691	0.32
48_A	70_L	0.690	0.32
229_M	249_L	0.687	0.32
169_E	209_V	0.686	0.32
159_I	163_E	0.680	0.32
165_K	197_S	0.679	0.32
135_N	217_A	0.677	0.31
25_S	243_F	0.677	0.31
89_I	129_K	0.676	0.31
152_L	176_R	0.676	0.31
144_N	209_V	0.674	0.31
71_D	94_T	0.673	0.31
37_S	48_A	0.672	0.31
132_L	136_F	0.672	0.31
198_S	202_A	0.671	0.31
13_F	57_L	0.669	0.31
197_S	217_A	0.664	0.31
12_F	171_G	0.663	0.31
31_T	157_M	0.661	0.30
44_K	248_R	0.660	0.30
162_E	195_S	0.658	0.30
63_D	93_E	0.657	0.30
45_V	72_V	0.657	0.30
60_Y	100_I	0.654	0.30
74_S	149_D	0.654	0.30
185_K	233_V	0.652	0.30
18_S	28_L	0.651	0.30
134_V	155_E	0.648	0.30
40_L	43_D	0.647	0.30
136_F	237_S	0.647	0.30
102_I	168_I	0.647	0.30
153_V	202_A	0.647	0.30
9_A	183_K	0.646	0.29
115_I	225_E	0.646	0.29
204_M	244_W	0.645	0.29
77_K	125_L	0.640	0.29
90_E	100_I	0.640	0.29
16_I	37_S	0.640	0.29
12_F	63_D	0.640	0.29
87_A	170_A	0.639	0.29
172_E	249_L	0.638	0.29
31_T	66_T	0.636	0.29
77_K	149_D	0.636	0.29
75_V	176_R	0.634	0.29
60_Y	186_P	0.632	0.29
23_T	27_I	0.629	0.28
90_E	99_K	0.624	0.28
12_F	213_R	0.623	0.28
195_S	213_R	0.620	0.28
198_S	224_G	0.620	0.28
19_I	73_S	0.617	0.28
78_I	161_T	0.617	0.28
147_A	223_F	0.617	0.28
73_S	221_V	0.613	0.27
17_N	33_D	0.612	0.27
84_S	224_G	0.612	0.27
42_E	224_G	0.609	0.27
85_K	184_D	0.608	0.27
128_P	249_L	0.608	0.27
153_V	238_G	0.606	0.27
25_S	182_M	0.606	0.27
89_I	135_N	0.605	0.27
82_A	121_Q	0.605	0.27
73_S	152_L	0.604	0.27
166_I	190_L	0.600	0.27
24_D	130_V	0.598	0.26
82_A	102_I	0.596	0.26
187_L	223_F	0.593	0.26
94_T	209_V	0.593	0.26
27_I	134_V	0.592	0.26
99_K	153_V	0.591	0.26
44_K	116_K	0.588	0.26
72_V	89_I	0.587	0.26
5_V	153_V	0.587	0.26
137_T	187_L	0.586	0.26
12_F	77_K	0.582	0.26
8_N	13_F	0.581	0.25
6_Y	102_I	0.581	0.25
133_A	225_E	0.578	0.25
61_S	143_L	0.574	0.25
35_I	78_I	0.573	0.25
155_E	246_A	0.567	0.25
96_S	118_E	0.566	0.25
99_K	184_D	0.566	0.25
30_F	35_I	0.565	0.25
114_Y	223_F	0.563	0.24
15_F	185_K	0.562	0.24
5_V	63_D	0.561	0.24
35_I	185_K	0.561	0.24
82_A	232_D	0.560	0.24
179_A	233_V	0.558	0.24
104_D	145_V	0.557	0.24
114_Y	154_G	0.556	0.24
186_P	218_P	0.556	0.24
130_V	133_A	0.553	0.24
48_A	200_Y	0.553	0.24
41_T	172_E	0.552	0.24
18_S	129_K	0.549	0.24
217_A	237_S	0.548	0.24
14_S	34_G	0.543	0.23
64_S	148_A	0.542	0.23
128_P	155_E	0.542	0.23
35_I	61_S	0.541	0.23
27_I	113_I	0.541	0.23
231_I	237_S	0.541	0.23
88_T	188_K	0.541	0.23
25_S	42_E	0.539	0.23
159_I	223_F	0.538	0.23
3_K	61_S	0.538	0.23
205_F	213_R	0.538	0.23
3_K	30_F	0.537	0.23
73_S	241_M	0.537	0.23
33_D	138_T	0.531	0.23
28_L	156_E	0.530	0.23
56_V	170_A	0.526	0.22
65_P	189_E	0.525	0.22
19_I	234_E	0.525	0.22
139_D	176_R	0.521	0.22
79_L	111_S	0.520	0.22
65_P	194_T	0.519	0.22
26_I	100_I	0.517	0.22
63_D	231_I	0.515	0.22
20_T	142_V	0.515	0.22
22_V	51_R	0.514	0.22
2_F	144_N	0.511	0.22
44_K	244_W	0.510	0.22
220_M	234_E	0.510	0.22
150_V	154_G	0.508	0.21
113_I	155_E	0.506	0.21
110_K	164_D	0.506	0.21
233_V	245_I	0.505	0.21
30_F	68_V	0.503	0.21
101_I	220_M	0.502	0.21
139_D	213_R	0.502	0.21
222_S	242_I	0.501	0.21
186_P	191_S	0.501	0.21
24_D	208_A	0.501	0.21
44_K	204_M	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a1jC	1	0.9759	100	0.267	Contact Map
3k4xA	1	0.9839	100	0.283	Contact Map
3g65A	1	0.9518	100	0.287	Contact Map
3a1jB	1	0.9598	100	0.3	Contact Map
3a1jA	1	0.9839	100	0.314	Contact Map
3fdsC	1	0.992	100	0.348	Contact Map
3aizA	1	0.988	100	0.396	Contact Map
2zvvA	3	0.992	100	0.396	Contact Map
1u7bA	3	0.996	100	0.398	Contact Map
1plqA	3	0.992	100	0.4	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.