GREMLIN Database
PCNA3 - DNA polymerase sliding clamp 3
UniProt: P57765 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 244 (239)
Sequences: 643 (449)
Seq/√Len: 29.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_I157_G4.8231.00
216_I224_L3.7911.00
129_D190_K3.7371.00
11_L87_I3.0461.00
69_F97_V2.9251.00
74_L99_I2.6711.00
132_A162_I2.5460.99
227_F237_T2.4960.99
196_Y218_F2.4150.99
29_F59_Y2.4080.99
155_V162_I2.4080.99
230_M234_G2.3750.99
51_L234_G2.3520.99
154_V193_K2.3180.99
30_K53_R2.3120.99
27_L36_L2.2620.99
208_T228_F2.2410.98
8_V87_I2.2330.98
155_V164_I2.1740.98
42_A239_L2.1550.98
50_N235_K2.1140.98
49_V236_V2.1140.98
89_I99_I2.0820.97
32_D143_I2.0570.97
40_D200_Y2.0550.97
223_P242_P2.0260.97
42_A200_Y2.0170.97
150_T166_A1.9760.96
43_H124_I1.9510.96
43_H46_L1.9200.96
132_A184_Q1.9130.96
129_D219_G1.8430.95
196_Y201_L1.8410.95
15_I27_L1.8300.95
132_A157_G1.8040.94
39_L43_H1.7550.93
30_K59_Y1.7470.93
157_G188_F1.7370.93
51_L143_I1.7310.93
40_D68_G1.7190.92
215_K227_F1.6920.92
89_I97_V1.6800.92
40_D44_I1.6670.91
108_E173_E1.6100.90
181_G212_D1.6010.89
14_I125_N1.5980.89
28_K120_E1.5630.88
216_I226_L1.5500.88
127_Q189_S1.5480.88
225_Q228_F1.5370.87
80_V145_E1.5190.87
29_F61_V1.4870.86
34_V97_V1.4800.85
111_V205_L1.4740.85
44_I200_Y1.4650.85
26_V116_V1.4600.85
73_Y172_V1.4550.84
24_E70_N1.4540.84
205_L208_T1.4530.84
105_T138_G1.4530.84
156_E167_E1.4530.84
109_F166_A1.4140.83
27_L67_F1.3940.82
39_L44_I1.3860.81
78_L155_V1.3780.81
150_T205_L1.3720.81
181_G228_F1.3560.80
45_S200_Y1.3520.80
30_K35_E1.3460.79
46_L124_I1.3350.79
134_I139_F1.3330.79
32_D54_E1.3280.78
113_N206_S1.3150.78
108_E228_F1.3120.78
43_H197_S1.2930.76
69_F111_V1.2810.76
77_I198_A1.2800.76
122_P222_K1.2730.75
11_L36_L1.2630.75
189_S192_S1.2590.75
79_K85_E1.2400.73
166_A196_Y1.2370.73
140_K198_A1.2340.73
136_S210_L1.2190.72
45_S240_L1.2180.72
229_N235_K1.2060.71
204_V240_L1.2060.71
18_L29_F1.1900.70
109_F133_T1.1840.70
62_N93_S1.1580.68
25_A36_L1.1480.67
125_N169_E1.1400.67
14_I96_S1.1370.67
78_L133_T1.1370.67
235_K239_L1.1260.66
137_D153_V1.1160.65
225_Q237_T1.1150.65
80_V107_R1.1130.65
24_E151_D1.1120.65
71_T85_E1.1110.65
160_D178_K1.1070.65
12_K240_L1.1060.64
89_I193_K1.1000.64
134_I142_A1.0970.64
124_I204_V1.0920.63
153_V164_I1.0720.62
18_L36_L1.0540.61
155_V168_G1.0490.60
21_L48_S1.0460.60
143_I202_D1.0440.60
212_D233_G1.0320.59
98_I149_V1.0220.58
61_V64_E1.0070.57
131_S215_K1.0040.57
68_G168_G0.9970.56
11_L81_A0.9930.56
92_E98_I0.9820.55
37_V243_K0.9790.55
43_H240_L0.9770.55
14_I211_S0.9750.55
231_E238_Y0.9740.55
183_L190_K0.9730.54
146_V164_I0.9720.54
55_M194_N0.9710.54
128_F219_G0.9710.54
83_R207_L0.9690.54
100_N108_E0.9640.54
22_V25_A0.9600.53
15_I25_A0.9590.53
58_E109_F0.9580.53
122_P125_N0.9580.53
87_I179_D0.9580.53
156_E216_I0.9470.52
140_K144_S0.9410.52
47_I201_L0.9390.52
40_D43_H0.9370.52
101_I196_Y0.9330.51
148_T171_E0.9290.51
55_M234_G0.9260.51
230_M233_G0.9250.51
49_V163_L0.9230.51
31_Q41_R0.9210.50
12_K56_F0.9190.50
41_R219_G0.9110.50
53_R59_Y0.9040.49
23_D72_Q0.9040.49
25_A71_T0.9020.49
106_N160_D0.9000.49
24_E238_Y0.8920.48
155_V159_E0.8890.48
143_I233_G0.8870.48
45_S63_D0.8860.48
14_I27_L0.8840.48
39_L119_Q0.8820.47
149_V198_A0.8700.46
39_L42_A0.8700.46
132_A186_L0.8660.46
46_L109_F0.8660.46
9_R75_M0.8630.46
20_R203_D0.8600.46
76_K121_I0.8590.46
74_L185_D0.8540.45
191_E208_T0.8530.45
201_L224_L0.8510.45
161_R175_E0.8510.45
86_A125_N0.8500.45
168_G172_V0.8470.45
89_I105_T0.8470.45
140_K208_T0.8450.44
154_V226_L0.8400.44
57_K87_I0.8390.44
42_A170_S0.8370.44
77_I176_F0.8370.44
26_V66_K0.8320.43
215_K234_G0.8320.43
16_Q230_M0.8270.43
47_I148_T0.8230.43
55_M78_L0.8220.43
64_E209_K0.8210.43
66_K141_S0.8210.43
207_L238_Y0.8160.42
131_S212_D0.8130.42
133_T213_Y0.8070.42
107_R112_R0.8070.42
44_I241_A0.8060.42
112_R155_V0.8050.41
111_V151_D0.8030.41
156_E191_E0.8020.41
130_I186_L0.7990.41
59_Y202_D0.7970.41
87_I183_L0.7970.41
163_L173_E0.7950.41
17_A27_L0.7900.40
158_H191_E0.7880.40
24_E198_A0.7840.40
15_I238_Y0.7740.39
59_Y99_I0.7690.39
22_V198_A0.7530.38
47_I69_F0.7500.37
123_E206_S0.7480.37
43_H243_K0.7450.37
127_Q187_E0.7440.37
136_S230_M0.7390.37
117_S139_F0.7230.35
81_A227_F0.7230.35
22_V26_V0.7220.35
76_K114_L0.7220.35
7_D149_V0.7190.35
46_L126_L0.7190.35
10_V149_V0.7160.35
63_D151_D0.7090.34
76_K113_N0.7020.34
94_P151_D0.7020.34
38_A160_D0.6990.34
89_I192_S0.6980.34
166_A199_E0.6970.34
21_L195_S0.6960.33
127_Q173_E0.6930.33
201_L207_L0.6920.33
36_L186_L0.6920.33
77_I93_S0.6860.33
150_T203_D0.6830.33
59_Y214_V0.6810.32
135_S179_D0.6780.32
208_T211_S0.6770.32
44_I71_T0.6770.32
85_E198_A0.6750.32
46_L121_I0.6740.32
224_L231_E0.6740.32
51_L233_G0.6700.32
149_V172_V0.6670.31
127_Q213_Y0.6660.31
16_Q32_D0.6650.31
47_I196_Y0.6640.31
53_R161_R0.6630.31
11_L76_K0.6620.31
19_A138_G0.6590.31
129_D220_N0.6580.31
217_S227_F0.6570.31
89_I131_S0.6570.31
14_I231_E0.6570.31
71_T89_I0.6550.31
26_V130_I0.6490.30
6_D57_K0.6480.30
60_D93_S0.6480.30
73_Y145_E0.6460.30
151_D238_Y0.6460.30
130_I188_F0.6450.30
16_Q155_V0.6420.30
11_L167_E0.6400.30
14_I189_S0.6370.29
154_V165_K0.6360.29
40_D168_G0.6360.29
122_P234_G0.6340.29
143_I218_F0.6330.29
163_L191_E0.6320.29
90_A99_I0.6300.29
194_N198_A0.6300.29
18_L72_Q0.6290.29
21_L198_A0.6280.29
42_A132_A0.6270.29
153_V162_I0.6230.29
139_F217_S0.6210.28
43_H200_Y0.6200.28
87_I233_G0.6190.28
129_D210_L0.6160.28
23_D204_V0.6150.28
89_I134_I0.6150.28
24_E149_V0.6130.28
127_Q232_G0.6100.28
200_Y239_L0.6090.28
36_L47_I0.6060.28
37_V46_L0.6040.27
73_Y95_D0.6030.27
76_K145_E0.6030.27
160_D188_F0.6020.27
141_S150_T0.6000.27
94_P235_K0.5990.27
92_E99_I0.5950.27
52_P57_K0.5950.27
95_D114_L0.5930.27
69_F94_P0.5920.27
78_L107_R0.5920.27
72_Q148_T0.5910.27
10_V151_D0.5910.27
66_K99_I0.5850.26
231_E236_V0.5820.26
174_V228_F0.5810.26
59_Y201_L0.5800.26
72_Q216_I0.5770.26
29_F67_F0.5760.26
176_F184_Q0.5750.26
126_L129_D0.5740.26
81_A101_I0.5730.26
87_I175_E0.5730.26
128_F132_A0.5730.26
18_L185_D0.5700.25
156_E215_K0.5690.25
165_K205_L0.5680.25
44_I223_P0.5680.25
15_I36_L0.5670.25
220_N238_Y0.5650.25
13_D37_V0.5650.25
97_V171_E0.5640.25
78_L187_E0.5620.25
43_H239_L0.5610.25
22_V44_I0.5590.25
57_K221_Q0.5580.25
27_L152_N0.5560.25
106_N218_F0.5560.25
177_S180_T0.5550.24
130_I151_D0.5530.24
124_I151_D0.5530.24
114_L121_I0.5520.24
90_A100_N0.5500.24
128_F136_S0.5490.24
135_S218_F0.5490.24
144_S176_F0.5470.24
74_L111_V0.5470.24
201_L208_T0.5460.24
167_E171_E0.5420.24
228_F240_L0.5410.24
234_G238_Y0.5380.23
17_A236_V0.5370.23
89_I125_N0.5370.23
194_N197_S0.5360.23
131_S224_L0.5340.23
177_S190_K0.5330.23
182_G239_L0.5330.23
32_D134_I0.5310.23
193_K212_D0.5300.23
115_E225_Q0.5270.23
57_K153_V0.5260.23
34_V77_I0.5230.23
162_I168_G0.5230.23
18_L229_N0.5200.22
43_H113_N0.5170.22
42_A240_L0.5170.22
141_S145_E0.5160.22
151_D242_P0.5150.22
146_V150_T0.5130.22
149_V233_G0.5130.22
62_N216_I0.5130.22
110_N168_G0.5130.22
23_D126_L0.5130.22
95_D243_K0.5120.22
126_L226_L0.5120.22
14_I89_I0.5110.22
202_D232_G0.5100.22
88_E135_S0.5100.22
138_G141_S0.5080.22
81_A117_S0.5080.22
83_R155_V0.5080.22
109_F238_Y0.5070.22
49_V150_T0.5050.22
81_A91_S0.5010.21
161_R193_K0.5010.21
215_K229_N0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a1jC 1 0.9877 100 0.276 Contact Map
3g65A 1 0.9631 100 0.292 Contact Map
3k4xA 1 0.9918 100 0.31 Contact Map
3a1jA 1 0.9918 100 0.324 Contact Map
3a1jB 1 0.959 100 0.327 Contact Map
3fdsC 1 0.9918 100 0.379 Contact Map
2ijxA 3 1 100 0.407 Contact Map
1ud9A 2 0.9877 100 0.407 Contact Map
3aizA 1 0.9918 100 0.413 Contact Map
3aizC 1 0.9959 100 0.418 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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