GREMLIN Database
NADM - Nicotinamide-nucleotide adenylyltransferase
UniProt: P57084 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (165)
Sequences: 518 (414)
Seq/√Len: 32.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_S156_L6.2341.00
13_F57_I5.4701.00
13_F18_L4.7531.00
4_G28_V4.5991.00
25_L70_R3.3881.00
159_K162_Q3.1361.00
30_E72_Y2.9591.00
142_N145_E2.4761.00
55_E154_Y2.4530.99
135_R139_L2.4430.99
6_Y20_V2.2620.99
34_L76_M2.1660.99
37_S78_D2.0910.98
35_V73_I1.9830.98
37_S85_W1.9800.98
13_F21_I1.9420.97
107_V117_V1.9160.97
23_W26_E1.8670.96
36_G78_D1.8280.96
132_Y136_L1.8100.96
21_I31_L1.7820.95
48_F56_M1.6560.93
4_G104_P1.6480.93
3_R30_E1.6380.93
78_D85_W1.6180.92
149_K153_K1.5860.91
61_L71_I1.5840.91
23_W27_R1.5800.91
82_N106_V1.5770.91
42_H105_L1.5760.91
11_Q53_R1.5410.90
107_V111_K1.5310.90
103_N106_V1.5170.90
18_L61_L1.4900.89
3_R32_I1.4890.89
132_Y135_R1.4540.87
9_R17_H1.3780.84
28_V31_L1.3700.84
86_A105_L1.3160.81
54_V58_R1.3130.81
115_Y167_I1.2930.80
136_L146_L1.2910.80
63_D150_P1.2900.80
9_R14_H1.2620.79
60_S150_P1.2590.78
48_F160_G1.2470.78
60_S151_V1.2390.77
55_E59_N1.2330.77
14_H17_H1.2000.75
80_L129_N1.1870.74
20_V129_N1.1750.73
38_S50_A1.1630.73
143_W152_Y1.1210.70
155_I160_G1.1170.70
10_F14_H1.1130.69
78_D105_L1.1100.69
42_H52_E1.1090.69
51_G94_P1.0950.68
44_V167_I1.0890.68
111_K114_G1.0890.68
137_I164_L1.0820.67
86_A90_S1.0730.66
162_Q165_R1.0680.66
143_W165_R1.0630.66
77_P88_Y1.0620.66
31_L113_A1.0450.64
15_L31_L1.0440.64
42_H112_E1.0410.64
152_Y156_L1.0390.64
153_K157_E1.0330.63
29_D74_I1.0160.62
12_P16_G1.0120.62
21_I33_I1.0010.61
49_T52_E0.9740.59
7_P78_D0.9740.59
8_G14_H0.9670.58
107_V167_I0.9610.58
4_G31_L0.9580.58
59_N153_K0.9570.57
56_M151_V0.9560.57
65_G68_L0.9550.57
139_L142_N0.9540.57
50_A76_M0.9500.57
8_G17_H0.9440.56
79_I88_Y0.9380.56
141_D145_E0.9370.56
33_I57_I0.9280.55
138_I168_V0.9270.55
22_K26_E0.9200.54
12_P17_H0.9200.54
3_R94_P0.9140.54
152_Y159_K0.9110.54
56_M155_I0.9050.53
56_M154_Y0.8960.52
124_N149_K0.8950.52
41_S78_D0.8910.52
160_G163_R0.8890.52
110_F114_G0.8860.52
166_E169_G0.8860.52
64_V73_I0.8670.50
22_K64_V0.8670.50
94_P97_E0.8660.50
124_N127_K0.8640.50
6_Y21_I0.8620.50
80_L130_S0.8580.49
84_I131_T0.8580.49
86_A115_Y0.8480.49
32_I158_I0.8470.48
57_I87_H0.8460.48
137_I161_D0.8400.48
5_L34_L0.8370.48
34_L74_I0.8340.47
27_R118_E0.8330.47
143_W147_V0.8290.47
48_F60_S0.8240.47
18_L22_K0.8230.46
6_Y120_P0.8210.46
4_G106_V0.8100.45
102_R106_V0.8000.45
25_L81_M0.7900.44
10_F17_H0.7830.43
155_I161_D0.7800.43
90_S122_A0.7730.42
39_Q77_P0.7680.42
50_A75_P0.7670.42
124_N130_S0.7650.42
71_I98_V0.7640.42
76_M92_Y0.7630.42
72_Y82_N0.7620.42
42_H110_F0.7580.41
34_L80_L0.7570.41
7_P36_G0.7550.41
52_E148_P0.7550.41
162_Q168_V0.7540.41
24_S93_T0.7520.41
7_P85_W0.7450.40
116_K138_I0.7420.40
70_R111_K0.7420.40
22_K63_D0.7410.40
64_V124_N0.7370.40
43_T59_N0.7350.39
99_V110_F0.7320.39
136_L141_D0.7260.39
71_I133_I0.7220.38
40_E46_N0.7200.38
16_G36_G0.7190.38
165_R169_G0.7180.38
19_N169_G0.7180.38
22_K70_R0.7140.38
27_R165_R0.7120.38
43_T78_D0.7100.37
35_V50_A0.7090.37
29_D143_W0.7090.37
108_R166_E0.6950.36
42_H78_D0.6900.36
139_L156_L0.6890.36
147_V151_V0.6820.35
60_S148_P0.6790.35
128_Y146_L0.6760.35
63_D153_K0.6760.35
90_S113_A0.6750.35
25_L85_W0.6710.34
86_A110_F0.6710.34
73_I111_K0.6700.34
30_E51_G0.6690.34
94_P163_R0.6660.34
90_S115_Y0.6640.34
76_M126_E0.6640.34
105_L122_A0.6620.34
157_E160_G0.6610.34
65_G145_E0.6600.34
20_V120_P0.6530.33
49_T133_I0.6520.33
15_L148_P0.6510.33
13_F60_S0.6450.33
93_T166_E0.6450.33
10_F46_N0.6450.33
22_K31_L0.6400.32
129_N135_R0.6400.32
46_N152_Y0.6390.32
122_A130_S0.6360.32
9_R16_G0.6330.32
48_F151_V0.6310.32
93_T123_F0.6280.31
60_S76_M0.6270.31
138_I164_L0.6210.31
11_Q82_N0.6200.31
117_V123_F0.6160.30
40_E43_T0.6150.30
45_T90_S0.6130.30
25_L107_V0.6080.30
11_Q17_H0.6070.30
13_F22_K0.6030.30
107_V123_F0.6010.29
32_I167_I0.6000.29
107_V116_K0.5980.29
10_F13_F0.5920.29
131_T165_R0.5860.28
140_N161_D0.5860.28
46_N134_R0.5820.28
107_V114_G0.5810.28
4_G44_V0.5810.28
111_K131_T0.5760.28
103_N120_P0.5750.28
111_K135_R0.5740.28
97_E103_N0.5740.28
45_T131_T0.5670.27
36_G43_T0.5660.27
41_S81_M0.5650.27
23_W118_E0.5630.27
145_E165_R0.5620.27
111_K116_K0.5590.27
102_R120_P0.5590.27
137_I158_I0.5580.27
11_Q14_H0.5570.27
25_L73_I0.5570.27
144_S149_K0.5560.26
65_G119_I0.5550.26
85_W130_S0.5500.26
60_S156_L0.5490.26
32_I115_Y0.5490.26
90_S119_I0.5470.26
159_K164_L0.5420.26
33_I71_I0.5370.25
83_N133_I0.5360.25
79_I90_S0.5350.25
39_Q90_S0.5350.25
70_R73_I0.5300.25
79_I84_I0.5300.25
30_E54_V0.5280.25
49_T148_P0.5250.25
81_M84_I0.5230.24
69_S76_M0.5210.24
4_G100_F0.5200.24
91_T95_K0.5190.24
124_N169_G0.5190.24
151_V154_Y0.5170.24
3_R106_V0.5150.24
107_V110_F0.5140.24
16_G73_I0.5140.24
113_A116_K0.5130.24
21_I167_I0.5100.24
129_N132_Y0.5050.23
99_V149_K0.5050.23
104_P108_R0.5040.23
32_I119_I0.5020.23
42_H94_P0.5000.23
9_R12_P0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ej2A 5 0.9651 100 0.501 Contact Map
1f9aA 5 0.9535 100 0.519 Contact Map
2qjtB 2 1 100 0.536 Contact Map
2qjoA 3 0.9767 99.9 0.556 Contact Map
3nv7A 4 0.843 99.9 0.636 Contact Map
4natA 5 0.843 99.9 0.638 Contact Map
3nd5A 5 0.814 99.9 0.64 Contact Map
1o6bA 5 0.8895 99.8 0.642 Contact Map
3nbkA 5 0.8605 99.8 0.643 Contact Map
1qjcA 4 0.8488 99.8 0.643 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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