GREMLIN Database
RL7A - 50S ribosomal protein L7Ae
UniProt: P55858 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (115)
Sequences: 647 (348)
Seq/√Len: 32.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_I63_V4.6611.00
43_V75_I3.1811.00
19_V114_I2.8701.00
53_I66_L2.7021.00
23_V52_I2.6311.00
108_K112_D2.3770.99
16_A81_S2.2560.99
51_V70_C2.2500.99
32_I56_D2.1590.99
51_V100_A2.1110.98
50_L101_I2.1030.98
48_A100_A2.0270.98
46_G83_K2.0120.98
70_C79_Y2.0040.98
40_T65_H1.9900.98
14_D21_E1.9410.97
19_V52_I1.9140.97
24_R28_E1.8710.97
80_V86_L1.8360.96
61_E64_A1.7970.96
18_K117_R1.7420.95
84_K99_A1.7350.95
34_K38_E1.5690.91
56_D84_K1.5450.90
56_D82_S1.5380.90
105_G111_V1.5310.90
20_L81_S1.5260.90
27_K30_G1.4580.88
40_T69_L1.4370.87
11_V55_E1.4230.86
21_E25_K1.3900.85
42_A100_A1.3630.84
37_N61_E1.3100.81
36_T97_A1.2880.80
39_T51_V1.2810.80
107_A111_V1.2590.79
92_L97_A1.2380.78
20_L90_C1.2290.77
114_I118_V1.2160.76
115_I118_V1.2050.76
83_K98_S1.1960.75
23_V86_L1.1930.75
90_C96_T1.1750.74
7_V10_E1.1690.73
36_T41_K1.1640.73
22_A114_I1.1280.71
43_V73_K1.1250.70
71_D93_Q1.1020.69
13_Q17_D1.0760.67
38_E61_E1.0550.65
54_A83_K1.0460.65
32_I74_K1.0320.64
18_K113_E1.0310.63
56_D87_G1.0280.63
112_D116_K1.0140.62
16_A19_V0.9990.61
53_I64_A0.9940.61
38_E41_K0.9750.59
10_E43_V0.9670.58
51_V72_E0.9640.58
46_G85_A0.9620.58
58_Q110_L0.9340.56
107_A110_L0.9320.56
8_K79_Y0.9250.55
18_K21_E0.9220.55
81_S113_E0.9210.55
62_I90_C0.9140.54
50_L118_V0.9080.54
64_A68_L0.9060.54
77_Y83_K0.8930.52
116_K119_N0.8660.50
50_L89_A0.8590.50
42_A79_Y0.8490.49
34_K98_S0.8480.49
99_A106_E0.8460.49
48_A73_K0.8310.47
101_I113_E0.8240.47
88_E120_E0.8220.47
55_E85_A0.8190.46
36_T65_H0.8190.46
26_A81_S0.8150.46
92_L99_A0.8120.46
50_L104_P0.8070.45
51_V79_Y0.8050.45
19_V28_E0.7980.45
23_V50_L0.7890.44
84_K88_E0.7870.44
115_I119_N0.7860.44
14_D18_K0.7800.43
20_L82_S0.7780.43
18_K68_L0.7660.42
72_E118_V0.7640.42
87_G97_A0.7530.41
34_K96_T0.7520.41
33_K38_E0.7510.41
11_V15_L0.7450.40
20_L66_L0.7380.40
66_L72_E0.7270.39
31_K72_E0.7190.38
51_V102_L0.7180.38
68_L116_K0.7110.38
30_G105_G0.7090.38
113_E120_E0.7010.37
36_T69_L0.6990.37
118_V121_I0.6950.36
15_L101_I0.6930.36
32_I90_C0.6900.36
25_K99_A0.6870.36
66_L73_K0.6860.36
23_V99_A0.6850.36
33_K87_G0.6750.35
37_N40_T0.6720.35
17_D85_A0.6690.34
19_V115_I0.6570.34
36_T43_V0.6500.33
74_K116_K0.6470.33
10_E41_K0.6410.32
12_P46_G0.6410.32
17_D21_E0.6380.32
75_I92_L0.6340.32
9_F55_E0.6320.32
12_P101_I0.6240.31
58_Q61_E0.6190.31
40_T64_A0.6150.31
58_Q117_R0.6070.30
58_Q66_L0.6070.30
86_L96_T0.6060.30
39_T93_Q0.6050.30
66_L86_L0.5990.29
8_K13_Q0.5970.29
14_D77_Y0.5940.29
80_V112_D0.5940.29
16_A78_V0.5890.29
71_D119_N0.5890.29
99_A113_E0.5880.29
40_T91_G0.5820.28
110_L114_I0.5810.28
32_I57_V0.5810.28
82_S108_K0.5800.28
19_V23_V0.5750.28
50_L79_Y0.5740.28
24_R88_E0.5740.28
14_D17_D0.5740.28
45_R69_L0.5690.27
20_L89_A0.5670.27
64_A72_E0.5630.27
111_V115_I0.5620.27
111_V119_N0.5570.27
31_K101_I0.5520.26
30_G85_A0.5520.26
90_C98_S0.5510.26
32_I35_G0.5510.26
17_D24_R0.5480.26
56_D104_P0.5430.26
14_D44_E0.5390.26
65_H77_Y0.5350.25
74_K105_G0.5350.25
29_S43_V0.5330.25
28_E75_I0.5300.25
37_N100_A0.5290.25
19_V78_V0.5280.25
33_K47_Q0.5210.24
62_I70_C0.5210.24
75_I82_S0.5140.24
24_R83_K0.5080.24
45_R87_G0.5070.24
58_Q92_L0.5070.24
33_K102_L0.5050.23
61_E70_C0.5030.23
8_K85_A0.5030.23
111_V118_V0.5020.23
79_Y88_E0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o85A 1 0.9528 100 0.41 Contact Map
4nutA 1 0.9449 100 0.422 Contact Map
2aifA 1 0.8898 100 0.426 Contact Map
2jnbA 1 0.9685 100 0.426 Contact Map
2fc3A 1 0.9764 99.9 0.429 Contact Map
1vq8F 1 0.937 99.9 0.432 Contact Map
1xbiA 1 0.9291 99.9 0.442 Contact Map
4bw0B 1 0.9213 99.9 0.445 Contact Map
3j60M 1 0.8819 99.9 0.458 Contact Map
2lbwA 1 0.8661 99.9 0.463 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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