PNPH - SULSO - GREMLIN Contacts

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PNPH - Purine nucleoside phosphorylase

UniProt:	P50389	Sequences: MNPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	236 (213)
Sequences:	5589 (3801)
Seq/√Len:	260.5

ECOLI - UDP DEOD MTNN
BACSU - DEOD MTNN
HALSA - Q9HP14 Q9HR25
SULSO - PNPH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
90_T	203_V	3.108	1.00
190_S	197_S	3.004	1.00
77_A	195_W	2.841	1.00
15_E	82_N	2.727	1.00
106_T	151_V	2.711	1.00
35_N	51_K	2.594	1.00
139_V	151_V	2.570	1.00
107_G	153_N	2.554	1.00
131_D	196_K	2.546	1.00
183_C	199_T	2.443	1.00
83_V	196_K	2.377	1.00
107_G	129_T	2.295	1.00
51_K	56_T	2.214	1.00
105_V	154_V	2.143	1.00
169_K	173_S	2.076	1.00
155_F	176_N	2.066	1.00
41_E	46_L	2.060	1.00
94_V	177_I	2.039	1.00
74_E	193_K	2.005	1.00
139_V	143_S	1.998	1.00
16_R	83_V	1.975	1.00
136_N	140_T	1.831	1.00
107_G	127_A	1.795	1.00
37_K	49_T	1.770	1.00
66_G	185_T	1.759	1.00
98_N	101_E	1.691	1.00
104_I	135_T	1.640	1.00
90_T	178_A	1.636	1.00
215_T	218_E	1.628	1.00
103_I	178_A	1.613	1.00
82_N	195_W	1.610	1.00
23_P	61_T	1.601	1.00
154_V	178_A	1.594	1.00
135_T	151_V	1.577	1.00
134_L	198_A	1.574	1.00
132_F	136_N	1.549	1.00
97_I	150_Y	1.542	1.00
138_L	198_A	1.541	1.00
166_E	169_K	1.536	1.00
20_V	26_A	1.535	1.00
180_E	183_C	1.486	1.00
114_G	118_Q	1.480	1.00
28_L	224_M	1.477	1.00
45_F	61_T	1.475	1.00
66_G	156_S	1.474	1.00
73_L	84_F	1.458	1.00
224_M	228_K	1.453	1.00
152_G	177_I	1.443	1.00
19_V	62_H	1.438	1.00
40_N	79_L	1.435	1.00
167_F	170_K	1.425	1.00
110_Y	188_T	1.409	1.00
27_R	31_T	1.400	1.00
73_L	189_L	1.380	1.00
142_F	149_Y	1.375	1.00
19_V	84_F	1.362	1.00
114_G	119_Y	1.349	1.00
111_N	157_S	1.349	1.00
169_K	172_S	1.325	1.00
135_T	198_A	1.322	1.00
115_L	120_L	1.308	1.00
96_Y	150_Y	1.307	1.00
154_V	201_L	1.294	1.00
116_F	119_Y	1.294	1.00
166_E	170_K	1.293	1.00
104_I	149_Y	1.284	1.00
34_Q	51_K	1.276	1.00
167_F	171_W	1.261	1.00
110_Y	184_A	1.241	1.00
47_V	60_A	1.240	1.00
178_A	203_V	1.233	1.00
170_K	173_S	1.226	1.00
52_Y	231_L	1.223	1.00
16_R	55_E	1.223	1.00
101_E	150_Y	1.222	1.00
214_I	218_E	1.220	1.00
221_K	225_D	1.219	1.00
115_L	119_Y	1.206	1.00
206_N	209_K	1.199	1.00
53_N	232_D	1.199	1.00
116_F	120_L	1.199	1.00
108_A	183_C	1.193	1.00
15_E	56_T	1.190	1.00
49_T	58_S	1.190	1.00
104_I	139_V	1.186	1.00
136_N	139_V	1.177	1.00
39_T	46_L	1.169	1.00
108_A	187_F	1.163	1.00
145_R	228_K	1.148	1.00
49_T	56_T	1.141	1.00
30_S	48_Y	1.131	1.00
168_V	172_S	1.130	1.00
141_S	145_R	1.130	1.00
103_I	177_I	1.129	1.00
140_T	143_S	1.125	1.00
92_A	203_V	1.122	1.00
141_S	144_K	1.104	1.00
84_F	190_S	1.085	1.00
28_L	31_T	1.085	1.00
37_K	56_T	1.085	1.00
145_R	232_D	1.084	1.00
40_N	49_T	1.078	1.00
17_V	81_A	1.077	1.00
133_E	196_K	1.077	1.00
187_F	197_S	1.076	1.00
92_A	97_I	1.069	1.00
26_A	59_I	1.067	1.00
130_P	135_T	1.063	1.00
168_V	171_W	1.063	1.00
37_K	40_N	1.062	1.00
60_A	72_V	1.061	1.00
47_V	58_S	1.058	1.00
135_T	138_L	1.056	1.00
108_A	199_T	1.050	1.00
39_T	60_A	1.047	1.00
69_I	186_L	1.042	1.00
150_Y	177_I	1.034	1.00
137_K	141_S	1.027	1.00
225_D	228_K	1.023	1.00
92_A	206_N	1.022	1.00
133_E	136_N	1.012	1.00
77_A	193_K	1.011	1.00
111_N	159_A	1.011	1.00
21_G	25_R	1.011	1.00
109_S	127_A	1.011	1.00
77_A	84_F	1.010	1.00
70_A	189_L	1.004	1.00
29_L	59_I	1.001	1.00
214_I	217_E	0.980	1.00
133_E	137_K	0.975	1.00
33_L	50_G	0.973	1.00
28_L	227_A	0.966	1.00
134_L	138_L	0.965	1.00
217_E	221_K	0.965	1.00
109_S	155_F	0.959	1.00
114_G	120_L	0.955	1.00
114_G	117_Y	0.953	1.00
139_V	149_Y	0.942	1.00
83_V	134_L	0.938	1.00
165_E	168_V	0.933	1.00
127_A	153_N	0.930	1.00
140_T	144_K	0.930	1.00
147_L	229_A	0.928	1.00
86_R	186_L	0.926	1.00
135_T	139_V	0.920	1.00
104_I	198_A	0.920	1.00
66_G	112_Q	0.918	1.00
52_Y	57_V	0.916	1.00
94_V	97_I	0.913	1.00
132_F	135_T	0.913	1.00
71_I	189_L	0.911	1.00
100_G	214_I	0.906	1.00
66_G	158_D	0.900	1.00
20_V	87_Y	0.900	1.00
51_K	54_G	0.898	1.00
156_S	183_C	0.897	1.00
105_V	201_L	0.896	1.00
228_K	232_D	0.896	1.00
98_N	209_K	0.886	1.00
115_L	118_Q	0.878	1.00
98_N	206_N	0.874	1.00
93_L	176_N	0.874	1.00
93_L	179_V	0.869	1.00
144_K	232_D	0.863	1.00
69_I	185_T	0.863	1.00
130_P	187_F	0.859	1.00
43_R	75_E	0.848	0.99
69_I	73_L	0.847	0.99
98_N	211_G	0.840	0.99
23_P	27_R	0.838	0.99
47_V	75_E	0.834	0.99
165_E	169_K	0.834	0.99
23_P	30_S	0.829	0.99
24_G	41_E	0.828	0.99
111_N	155_F	0.827	0.99
70_A	74_E	0.820	0.99
77_A	81_A	0.819	0.99
136_N	143_S	0.813	0.99
220_E	224_M	0.804	0.99
102_Y	229_A	0.800	0.99
131_D	134_L	0.796	0.99
105_V	178_A	0.796	0.99
116_F	188_T	0.794	0.99
106_T	153_N	0.792	0.99
100_G	222_S	0.784	0.99
33_L	36_P	0.777	0.99
42_N	78_M	0.774	0.99
24_G	27_R	0.774	0.99
105_V	130_P	0.772	0.99
66_G	184_A	0.764	0.99
99_L	214_I	0.763	0.99
17_V	76_L	0.754	0.99
223_V	227_A	0.747	0.99
218_E	222_S	0.746	0.99
26_A	48_Y	0.741	0.99
60_A	76_L	0.738	0.99
71_I	74_E	0.733	0.98
89_T	204_S	0.732	0.98
26_A	61_T	0.725	0.98
221_K	224_M	0.720	0.98
36_P	48_Y	0.717	0.98
185_T	189_L	0.714	0.98
34_Q	54_G	0.706	0.98
215_T	219_L	0.705	0.98
129_T	132_F	0.705	0.98
105_V	108_A	0.701	0.98
224_M	227_A	0.699	0.98
95_P	208_A	0.698	0.98
117_Y	120_L	0.698	0.98
141_S	232_D	0.697	0.98
103_I	203_V	0.695	0.98
180_E	199_T	0.694	0.98
128_S	188_T	0.688	0.98
17_V	58_S	0.685	0.98
29_L	87_Y	0.684	0.98
32_L	224_M	0.673	0.97
84_F	195_W	0.673	0.97
129_T	191_K	0.669	0.97
114_G	123_N	0.668	0.97
142_F	229_A	0.666	0.97
168_V	173_S	0.665	0.97
89_T	215_T	0.660	0.97
202_V	218_E	0.659	0.97
71_I	75_E	0.658	0.97
70_A	185_T	0.658	0.97
30_S	59_I	0.657	0.97
74_E	189_L	0.656	0.97
93_L	207_L	0.655	0.97
179_V	205_D	0.652	0.97
166_E	171_W	0.652	0.97
32_L	228_K	0.650	0.97
104_I	151_V	0.650	0.97
90_T	201_L	0.646	0.97
77_A	80_G	0.643	0.97
100_G	218_E	0.637	0.96
214_I	222_S	0.637	0.96
28_L	32_L	0.632	0.96
109_S	176_N	0.629	0.96
187_F	198_A	0.629	0.96
15_E	55_E	0.628	0.96
136_N	151_V	0.626	0.96
138_L	141_S	0.625	0.96
216_K	219_L	0.624	0.96
220_E	223_V	0.624	0.96
179_V	207_L	0.614	0.96
40_N	47_V	0.614	0.96
131_D	137_K	0.614	0.96
31_T	224_M	0.613	0.96
102_Y	202_V	0.612	0.95
161_Y	179_V	0.611	0.95
163_E	166_E	0.610	0.95
62_H	73_L	0.609	0.95
115_L	189_L	0.607	0.95
163_E	192_V	0.607	0.95
217_E	220_E	0.607	0.95
22_D	25_R	0.604	0.95
97_I	103_I	0.603	0.95
86_R	89_T	0.600	0.95
160_F	181_M	0.597	0.95
183_C	201_L	0.596	0.95
117_Y	122_D	0.595	0.95
45_F	72_V	0.592	0.95
204_S	223_V	0.589	0.94
108_A	154_V	0.589	0.94
22_D	86_R	0.589	0.94
123_N	126_V	0.583	0.94
109_S	153_N	0.583	0.94
106_T	132_F	0.579	0.94
94_V	150_Y	0.578	0.94
218_E	221_K	0.574	0.94
109_S	126_V	0.571	0.93
27_R	46_L	0.569	0.93
90_T	103_I	0.567	0.93
134_L	137_K	0.566	0.93
47_V	79_L	0.562	0.93
144_K	147_L	0.561	0.93
73_L	186_L	0.561	0.93
45_F	64_I	0.560	0.93
183_C	187_F	0.559	0.93
20_V	29_L	0.558	0.93
19_V	73_L	0.555	0.93
153_N	174_R	0.554	0.92
97_I	203_V	0.554	0.92
41_E	44_G	0.551	0.92
40_N	44_G	0.551	0.92
105_V	187_F	0.551	0.92
168_V	207_L	0.549	0.92
147_L	228_K	0.548	0.92
36_P	39_T	0.546	0.92
21_G	86_R	0.545	0.92
132_F	139_V	0.543	0.92
76_L	81_A	0.542	0.92
77_A	82_N	0.542	0.92
120_L	174_R	0.540	0.91
137_K	140_T	0.538	0.91
40_N	78_M	0.534	0.91
106_T	129_T	0.531	0.91
208_A	211_G	0.531	0.91
80_G	195_W	0.530	0.91
207_L	211_G	0.529	0.91
89_T	219_L	0.528	0.91
67_P	158_D	0.527	0.90
110_Y	174_R	0.526	0.90
46_L	61_T	0.519	0.90
108_A	197_S	0.518	0.90
132_F	151_V	0.518	0.90
27_R	30_S	0.513	0.89
25_R	86_R	0.511	0.89
43_R	193_K	0.509	0.89
95_P	172_S	0.508	0.89
20_V	61_T	0.508	0.89
24_G	220_E	0.507	0.89
132_F	138_L	0.505	0.89
165_E	170_K	0.504	0.88
26_A	46_L	0.504	0.88
147_L	225_D	0.503	0.88
155_F	170_K	0.502	0.88
155_F	179_V	0.502	0.88
143_S	146_N	0.501	0.88
126_V	188_T	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3phcA	5	0.9873	100	0.208	Contact Map
3bjeA	2	0.9958	100	0.209	Contact Map
1je0A	3	0.9619	100	0.21	Contact Map
1odkA	3	0.9831	100	0.218	Contact Map
4tymA	5	0.9788	100	0.225	Contact Map
2b94A	4	0.9449	100	0.228	Contact Map
4mchA	3	0.9703	100	0.229	Contact Map
3u40A	4	0.9788	100	0.231	Contact Map
4m3nA	3	0.9703	100	0.232	Contact Map
3mb8A	4	0.9831	100	0.234	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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