TRPF - SULSO - GREMLIN Contacts

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TRPF - N-(5'-phosphoribosyl)anthranilate isomerase

UniProt:	P50386	Sequences: MVKLKICGNATLSDIIEFSKLDVDYLGIITDVVSQRFVKSEFLTFVKRYVEKPIVNVKVNVQISEIERELLVSDYFQIHRVLDDSELELLKSYDFRKRIILYVPASFEYKKYLERAIDTVDMVLVDSVKKGVGVDYNVVSSFLKDYPYLGVGGKISIDNISNFIDLNPAWLDISSSIEIYPGKKDINMVKKIVEVVKYGSSSNK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	204 (193)
Sequences:	3782 (3101)
Seq/√Len:	223.2

ECOLI - TRPC
BACSU - TRPF
HALSA - TRPF
SULSO - TRPF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_N	73_S	3.645	1.00
61_V	65_E	3.041	1.00
11_T	14_D	2.998	1.00
6_I	177_I	2.959	1.00
179_I	185_D	2.937	1.00
15_I	46_V	2.867	1.00
60_N	81_V	2.340	1.00
31_D	37_F	2.326	1.00
4_L	193_V	2.168	1.00
150_G	170_W	2.167	1.00
29_I	174_S	2.156	1.00
16_I	49_Y	2.116	1.00
31_D	59_V	2.055	1.00
9_N	15_I	2.020	1.00
75_Y	100_I	2.002	1.00
173_I	192_I	1.985	1.00
21_L	189_V	1.938	1.00
104_P	128_V	1.920	1.00
91_K	121_D	1.891	1.00
136_Y	163_F	1.886	1.00
66_I	86_E	1.869	1.00
62_Q	65_E	1.826	1.00
39_K	42_F	1.784	1.00
29_I	57_V	1.777	1.00
55_V	75_Y	1.762	1.00
173_I	177_I	1.748	1.00
60_N	82_L	1.745	1.00
82_L	101_L	1.726	1.00
156_S	176_S	1.707	1.00
105_A	138_V	1.691	1.00
6_I	189_V	1.688	1.00
190_K	194_E	1.648	1.00
42_F	45_F	1.643	1.00
83_D	86_E	1.603	1.00
18_F	189_V	1.580	1.00
100_I	122_M	1.555	1.00
161_S	195_V	1.545	1.00
58_K	66_I	1.545	1.00
30_T	43_L	1.544	1.00
30_T	56_N	1.527	1.00
17_E	186_I	1.500	1.00
3_K	25_Y	1.484	1.00
160_I	171_L	1.470	1.00
177_I	189_V	1.455	1.00
78_I	90_L	1.445	1.00
44_T	70_L	1.417	1.00
151_V	163_F	1.403	1.00
100_I	150_G	1.397	1.00
112_Y	115_R	1.364	1.00
86_E	90_L	1.363	1.00
171_L	192_I	1.354	1.00
161_S	165_D	1.333	1.00
162_N	165_D	1.307	1.00
35_Q	181_P	1.297	1.00
25_Y	150_G	1.289	1.00
125_V	149_L	1.287	1.00
61_V	66_I	1.284	1.00
47_K	71_L	1.284	1.00
187_N	190_K	1.262	1.00
122_M	150_G	1.257	1.00
63_I	86_E	1.246	1.00
14_D	186_I	1.245	1.00
44_T	48_R	1.244	1.00
23_V	193_V	1.243	1.00
58_K	73_S	1.243	1.00
11_T	183_K	1.228	1.00
4_L	197_K	1.226	1.00
187_N	191_K	1.224	1.00
12_L	49_Y	1.224	1.00
103_V	123_V	1.217	1.00
94_D	97_K	1.185	1.00
17_E	21_L	1.184	1.00
191_K	195_V	1.176	1.00
18_F	23_V	1.170	1.00
133_G	159_N	1.158	1.00
160_I	192_I	1.155	1.00
67_E	93_Y	1.145	1.00
88_E	119_T	1.145	1.00
17_E	189_V	1.140	1.00
151_V	166_L	1.140	1.00
19_S	54_I	1.136	1.00
41_E	70_L	1.135	1.00
19_S	51_E	1.132	1.00
106_S	128_V	1.131	1.00
155_I	171_L	1.124	1.00
67_E	94_D	1.121	1.00
75_Y	98_R	1.120	1.00
30_T	58_K	1.113	1.00
6_I	193_V	1.098	1.00
110_K	113_L	1.090	1.00
31_D	35_Q	1.080	1.00
21_L	190_K	1.080	1.00
12_L	16_I	1.078	1.00
51_E	54_I	1.077	1.00
43_L	71_L	1.073	1.00
78_I	99_I	1.066	1.00
105_A	125_V	1.054	1.00
3_K	170_W	1.052	1.00
65_E	68_R	1.047	1.00
193_V	196_V	1.040	1.00
164_I	196_V	1.039	1.00
194_E	198_Y	1.038	1.00
58_K	61_V	1.031	1.00
18_F	26_L	1.026	1.00
78_I	82_L	1.026	1.00
61_V	86_E	1.024	1.00
109_Y	112_Y	1.012	1.00
19_S	50_V	1.011	1.00
160_I	164_I	1.008	1.00
155_I	192_I	1.002	1.00
21_L	193_V	0.994	1.00
135_D	138_V	0.990	1.00
125_V	139_V	0.981	1.00
10_A	183_K	0.981	1.00
24_D	197_K	0.969	1.00
120_V	123_V	0.958	1.00
15_I	26_L	0.953	1.00
10_A	14_D	0.948	1.00
3_K	169_A	0.945	1.00
195_V	198_Y	0.943	1.00
81_V	104_P	0.942	1.00
38_V	42_F	0.933	1.00
86_E	89_L	0.919	0.99
17_E	190_K	0.913	0.99
129_K	132_V	0.913	0.99
164_I	171_L	0.911	0.99
20_K	186_I	0.909	0.99
163_F	166_L	0.903	0.99
10_A	42_F	0.897	0.99
191_K	194_E	0.890	0.99
12_L	42_F	0.870	0.99
47_K	72_V	0.867	0.99
66_I	76_F	0.865	0.99
40_S	44_T	0.865	0.99
177_I	192_I	0.864	0.99
173_I	196_V	0.863	0.99
157_I	191_K	0.860	0.99
186_I	190_K	0.857	0.99
33_V	37_F	0.857	0.99
179_I	188_M	0.852	0.99
50_V	54_I	0.845	0.99
100_I	124_L	0.842	0.99
63_I	67_E	0.838	0.99
17_E	20_K	0.837	0.99
111_K	114_E	0.820	0.99
152_G	175_S	0.817	0.99
159_N	163_F	0.815	0.99
115_R	118_D	0.813	0.99
62_Q	86_E	0.809	0.99
160_I	195_V	0.807	0.99
63_I	89_L	0.803	0.99
20_K	190_K	0.803	0.99
25_Y	100_I	0.801	0.99
149_L	168_P	0.799	0.99
24_D	193_V	0.798	0.99
4_L	196_V	0.794	0.99
32_V	65_E	0.793	0.98
25_Y	75_Y	0.786	0.98
189_V	193_V	0.784	0.98
16_I	20_K	0.782	0.98
13_S	16_I	0.781	0.98
114_E	117_I	0.781	0.98
12_L	46_V	0.780	0.98
80_R	101_L	0.778	0.98
185_D	188_M	0.777	0.98
133_G	136_Y	0.776	0.98
30_T	37_F	0.771	0.98
155_I	173_I	0.768	0.98
12_L	45_F	0.767	0.98
66_I	90_L	0.767	0.98
37_F	40_S	0.766	0.98
9_N	26_L	0.759	0.98
127_S	134_V	0.755	0.98
75_Y	122_M	0.750	0.98
30_T	73_S	0.748	0.98
15_I	50_V	0.747	0.98
158_D	191_K	0.746	0.98
64_S	67_E	0.745	0.98
60_N	101_L	0.738	0.98
76_F	94_D	0.736	0.98
15_I	28_I	0.736	0.98
84_D	88_E	0.736	0.98
3_K	24_D	0.735	0.98
76_F	97_K	0.733	0.97
87_L	99_I	0.730	0.97
14_D	183_K	0.723	0.97
40_S	70_L	0.721	0.97
173_I	176_S	0.721	0.97
127_S	130_K	0.720	0.97
76_F	90_L	0.719	0.97
89_L	93_Y	0.719	0.97
113_L	125_V	0.716	0.97
58_K	76_F	0.710	0.97
139_V	143_L	0.709	0.97
45_F	48_R	0.702	0.97
64_S	68_R	0.701	0.97
143_L	149_L	0.701	0.97
139_V	149_L	0.696	0.97
18_F	22_D	0.695	0.97
15_I	19_S	0.693	0.96
40_S	68_R	0.691	0.96
5_K	8_G	0.681	0.96
91_K	99_I	0.676	0.96
9_N	18_F	0.675	0.96
28_I	49_Y	0.671	0.96
104_P	129_K	0.666	0.96
149_L	166_L	0.666	0.96
14_D	18_F	0.661	0.95
14_D	189_V	0.659	0.95
28_I	47_K	0.648	0.95
84_D	116_A	0.647	0.95
16_I	19_S	0.647	0.95
32_V	37_F	0.645	0.95
179_I	183_K	0.644	0.95
113_L	123_V	0.643	0.95
60_N	80_R	0.643	0.95
82_L	86_E	0.642	0.95
188_M	191_K	0.640	0.95
155_I	163_F	0.639	0.95
28_I	50_V	0.636	0.94
118_D	146_Y	0.636	0.94
30_T	71_L	0.635	0.94
21_L	186_I	0.631	0.94
109_Y	116_A	0.630	0.94
60_N	78_I	0.627	0.94
192_I	196_V	0.627	0.94
105_A	134_V	0.626	0.94
171_L	193_V	0.619	0.94
12_L	28_I	0.618	0.93
10_A	181_P	0.614	0.93
137_N	140_S	0.612	0.93
10_A	182_G	0.612	0.93
139_V	144_K	0.610	0.93
114_E	145_D	0.610	0.93
15_I	49_Y	0.610	0.93
87_L	120_V	0.604	0.93
63_I	90_L	0.601	0.93
160_I	173_I	0.600	0.92
157_I	195_V	0.597	0.92
178_E	184_K	0.596	0.92
139_V	142_F	0.594	0.92
28_I	43_L	0.593	0.92
101_L	116_A	0.591	0.92
154_K	175_S	0.586	0.92
134_V	139_V	0.586	0.92
28_I	71_L	0.585	0.92
180_Y	183_K	0.581	0.91
122_M	170_W	0.578	0.91
126_D	134_V	0.578	0.91
88_E	92_S	0.577	0.91
9_N	29_I	0.572	0.91
33_V	59_V	0.570	0.90
36_R	178_E	0.569	0.90
25_Y	54_I	0.566	0.90
174_S	192_I	0.564	0.90
90_L	99_I	0.564	0.90
164_I	168_P	0.564	0.90
157_I	176_S	0.561	0.90
174_S	189_V	0.559	0.90
28_I	40_S	0.552	0.89
128_V	175_S	0.550	0.89
84_D	119_T	0.549	0.89
47_K	73_S	0.548	0.89
126_D	131_G	0.547	0.89
149_L	169_A	0.547	0.89
14_D	17_E	0.543	0.88
46_V	49_Y	0.543	0.88
85_S	88_E	0.542	0.88
158_D	188_M	0.536	0.88
25_Y	170_W	0.535	0.87
22_D	51_E	0.534	0.87
124_L	150_G	0.529	0.87
45_F	49_Y	0.528	0.87
30_T	34_S	0.527	0.87
105_A	128_V	0.524	0.86
38_V	43_L	0.520	0.86
43_L	47_K	0.518	0.86
19_S	23_V	0.516	0.86
31_D	61_V	0.515	0.85
10_A	38_V	0.514	0.85
64_S	89_L	0.514	0.85
117_I	145_D	0.514	0.85
31_D	34_S	0.510	0.85
172_D	175_S	0.509	0.85
103_V	125_V	0.507	0.85
133_G	162_N	0.507	0.85
25_Y	122_M	0.503	0.84
102_Y	124_L	0.502	0.84
78_I	87_L	0.501	0.84
56_N	71_L	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1v5xA	2	0.9363	100	0.137	Contact Map
4aajA	1	0.9069	100	0.142	Contact Map
1nsjA	2	0.9461	100	0.233	Contact Map
1piiA	1	0.951	100	0.245	Contact Map
4wuiA	1	0.9559	100	0.29	Contact Map
3ctlA	4	0.9363	99.8	0.685	Contact Map
2tpsA	1	0.9412	99.8	0.688	Contact Map
2fliA	5	0.9216	99.8	0.699	Contact Map
3ovpA	2	0.951	99.8	0.702	Contact Map
1xi3A	2	0.9314	99.8	0.705	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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