GREMLIN Database
TRPF - N-(5'-phosphoribosyl)anthranilate isomerase
UniProt: P50386 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (193)
Sequences: 3782 (3101)
Seq/√Len: 223.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_N73_S3.6451.00
61_V65_E3.0411.00
11_T14_D2.9981.00
6_I177_I2.9591.00
179_I185_D2.9371.00
15_I46_V2.8671.00
60_N81_V2.3401.00
31_D37_F2.3261.00
4_L193_V2.1681.00
150_G170_W2.1671.00
29_I174_S2.1561.00
16_I49_Y2.1161.00
31_D59_V2.0551.00
9_N15_I2.0201.00
75_Y100_I2.0021.00
173_I192_I1.9851.00
21_L189_V1.9381.00
104_P128_V1.9201.00
91_K121_D1.8911.00
136_Y163_F1.8861.00
66_I86_E1.8691.00
62_Q65_E1.8261.00
39_K42_F1.7841.00
29_I57_V1.7771.00
55_V75_Y1.7621.00
173_I177_I1.7481.00
60_N82_L1.7451.00
82_L101_L1.7261.00
156_S176_S1.7071.00
105_A138_V1.6911.00
6_I189_V1.6881.00
190_K194_E1.6481.00
42_F45_F1.6431.00
83_D86_E1.6031.00
18_F189_V1.5801.00
100_I122_M1.5551.00
161_S195_V1.5451.00
58_K66_I1.5451.00
30_T43_L1.5441.00
30_T56_N1.5271.00
17_E186_I1.5001.00
3_K25_Y1.4841.00
160_I171_L1.4701.00
177_I189_V1.4551.00
78_I90_L1.4451.00
44_T70_L1.4171.00
151_V163_F1.4031.00
100_I150_G1.3971.00
112_Y115_R1.3641.00
86_E90_L1.3631.00
171_L192_I1.3541.00
161_S165_D1.3331.00
162_N165_D1.3071.00
35_Q181_P1.2971.00
25_Y150_G1.2891.00
125_V149_L1.2871.00
61_V66_I1.2841.00
47_K71_L1.2841.00
187_N190_K1.2621.00
122_M150_G1.2571.00
63_I86_E1.2461.00
14_D186_I1.2451.00
44_T48_R1.2441.00
23_V193_V1.2431.00
58_K73_S1.2431.00
11_T183_K1.2281.00
4_L197_K1.2261.00
187_N191_K1.2241.00
12_L49_Y1.2241.00
103_V123_V1.2171.00
94_D97_K1.1851.00
17_E21_L1.1841.00
191_K195_V1.1761.00
18_F23_V1.1701.00
133_G159_N1.1581.00
160_I192_I1.1551.00
67_E93_Y1.1451.00
88_E119_T1.1451.00
17_E189_V1.1401.00
151_V166_L1.1401.00
19_S54_I1.1361.00
41_E70_L1.1351.00
19_S51_E1.1321.00
106_S128_V1.1311.00
155_I171_L1.1241.00
67_E94_D1.1211.00
75_Y98_R1.1201.00
30_T58_K1.1131.00
6_I193_V1.0981.00
110_K113_L1.0901.00
31_D35_Q1.0801.00
21_L190_K1.0801.00
12_L16_I1.0781.00
51_E54_I1.0771.00
43_L71_L1.0731.00
78_I99_I1.0661.00
105_A125_V1.0541.00
3_K170_W1.0521.00
65_E68_R1.0471.00
193_V196_V1.0401.00
164_I196_V1.0391.00
194_E198_Y1.0381.00
58_K61_V1.0311.00
18_F26_L1.0261.00
78_I82_L1.0261.00
61_V86_E1.0241.00
109_Y112_Y1.0121.00
19_S50_V1.0111.00
160_I164_I1.0081.00
155_I192_I1.0021.00
21_L193_V0.9941.00
135_D138_V0.9901.00
125_V139_V0.9811.00
10_A183_K0.9811.00
24_D197_K0.9691.00
120_V123_V0.9581.00
15_I26_L0.9531.00
10_A14_D0.9481.00
3_K169_A0.9451.00
195_V198_Y0.9431.00
81_V104_P0.9421.00
38_V42_F0.9331.00
86_E89_L0.9190.99
17_E190_K0.9130.99
129_K132_V0.9130.99
164_I171_L0.9110.99
20_K186_I0.9090.99
163_F166_L0.9030.99
10_A42_F0.8970.99
191_K194_E0.8900.99
12_L42_F0.8700.99
47_K72_V0.8670.99
66_I76_F0.8650.99
40_S44_T0.8650.99
177_I192_I0.8640.99
173_I196_V0.8630.99
157_I191_K0.8600.99
186_I190_K0.8570.99
33_V37_F0.8570.99
179_I188_M0.8520.99
50_V54_I0.8450.99
100_I124_L0.8420.99
63_I67_E0.8380.99
17_E20_K0.8370.99
111_K114_E0.8200.99
152_G175_S0.8170.99
159_N163_F0.8150.99
115_R118_D0.8130.99
62_Q86_E0.8090.99
160_I195_V0.8070.99
63_I89_L0.8030.99
20_K190_K0.8030.99
25_Y100_I0.8010.99
149_L168_P0.7990.99
24_D193_V0.7980.99
4_L196_V0.7940.99
32_V65_E0.7930.98
25_Y75_Y0.7860.98
189_V193_V0.7840.98
16_I20_K0.7820.98
13_S16_I0.7810.98
114_E117_I0.7810.98
12_L46_V0.7800.98
80_R101_L0.7780.98
185_D188_M0.7770.98
133_G136_Y0.7760.98
30_T37_F0.7710.98
155_I173_I0.7680.98
12_L45_F0.7670.98
66_I90_L0.7670.98
37_F40_S0.7660.98
9_N26_L0.7590.98
127_S134_V0.7550.98
75_Y122_M0.7500.98
30_T73_S0.7480.98
15_I50_V0.7470.98
158_D191_K0.7460.98
64_S67_E0.7450.98
60_N101_L0.7380.98
76_F94_D0.7360.98
15_I28_I0.7360.98
84_D88_E0.7360.98
3_K24_D0.7350.98
76_F97_K0.7330.97
87_L99_I0.7300.97
14_D183_K0.7230.97
40_S70_L0.7210.97
173_I176_S0.7210.97
127_S130_K0.7200.97
76_F90_L0.7190.97
89_L93_Y0.7190.97
113_L125_V0.7160.97
58_K76_F0.7100.97
139_V143_L0.7090.97
45_F48_R0.7020.97
64_S68_R0.7010.97
143_L149_L0.7010.97
139_V149_L0.6960.97
18_F22_D0.6950.97
15_I19_S0.6930.96
40_S68_R0.6910.96
5_K8_G0.6810.96
91_K99_I0.6760.96
9_N18_F0.6750.96
28_I49_Y0.6710.96
104_P129_K0.6660.96
149_L166_L0.6660.96
14_D18_F0.6610.95
14_D189_V0.6590.95
28_I47_K0.6480.95
84_D116_A0.6470.95
16_I19_S0.6470.95
32_V37_F0.6450.95
179_I183_K0.6440.95
113_L123_V0.6430.95
60_N80_R0.6430.95
82_L86_E0.6420.95
188_M191_K0.6400.95
155_I163_F0.6390.95
28_I50_V0.6360.94
118_D146_Y0.6360.94
30_T71_L0.6350.94
21_L186_I0.6310.94
109_Y116_A0.6300.94
60_N78_I0.6270.94
192_I196_V0.6270.94
105_A134_V0.6260.94
171_L193_V0.6190.94
12_L28_I0.6180.93
10_A181_P0.6140.93
137_N140_S0.6120.93
10_A182_G0.6120.93
139_V144_K0.6100.93
114_E145_D0.6100.93
15_I49_Y0.6100.93
87_L120_V0.6040.93
63_I90_L0.6010.93
160_I173_I0.6000.92
157_I195_V0.5970.92
178_E184_K0.5960.92
139_V142_F0.5940.92
28_I43_L0.5930.92
101_L116_A0.5910.92
154_K175_S0.5860.92
134_V139_V0.5860.92
28_I71_L0.5850.92
180_Y183_K0.5810.91
122_M170_W0.5780.91
126_D134_V0.5780.91
88_E92_S0.5770.91
9_N29_I0.5720.91
33_V59_V0.5700.90
36_R178_E0.5690.90
25_Y54_I0.5660.90
174_S192_I0.5640.90
90_L99_I0.5640.90
164_I168_P0.5640.90
157_I176_S0.5610.90
174_S189_V0.5590.90
28_I40_S0.5520.89
128_V175_S0.5500.89
84_D119_T0.5490.89
47_K73_S0.5480.89
126_D131_G0.5470.89
149_L169_A0.5470.89
14_D17_E0.5430.88
46_V49_Y0.5430.88
85_S88_E0.5420.88
158_D188_M0.5360.88
25_Y170_W0.5350.87
22_D51_E0.5340.87
124_L150_G0.5290.87
45_F49_Y0.5280.87
30_T34_S0.5270.87
105_A128_V0.5240.86
38_V43_L0.5200.86
43_L47_K0.5180.86
19_S23_V0.5160.86
31_D61_V0.5150.85
10_A38_V0.5140.85
64_S89_L0.5140.85
117_I145_D0.5140.85
31_D34_S0.5100.85
172_D175_S0.5090.85
103_V125_V0.5070.85
133_G162_N0.5070.85
25_Y122_M0.5030.84
102_Y124_L0.5020.84
78_I87_L0.5010.84
56_N71_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v5xA 2 0.9363 100 0.137 Contact Map
4aajA 1 0.9069 100 0.142 Contact Map
1nsjA 2 0.9461 100 0.233 Contact Map
1piiA 1 0.951 100 0.245 Contact Map
4wuiA 1 0.9559 100 0.29 Contact Map
3ctlA 4 0.9363 99.8 0.685 Contact Map
2tpsA 1 0.9412 99.8 0.688 Contact Map
2fliA 5 0.9216 99.8 0.699 Contact Map
3ovpA 2 0.951 99.8 0.702 Contact Map
1xi3A 2 0.9314 99.8 0.705 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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