GREMLIN Database
TRPD - Anthranilate phosphoribosyltransferase
UniProt: P50384 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (327)
Sequences: 4299 (2841)
Seq/√Len: 157.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
275_R280_K4.0181.00
18_I60_R3.4451.00
9_K20_E3.3651.00
100_L315_L3.2751.00
322_K325_E3.1561.00
225_V231_T3.0761.00
285_A317_E2.9891.00
15_D48_K2.9591.00
278_L320_L2.7461.00
249_T255_P2.6541.00
225_V294_V2.5911.00
199_D243_E2.5851.00
22_E60_R2.5791.00
271_I275_R2.5641.00
265_S268_D2.5001.00
93_A273_I2.4151.00
289_K313_D2.4051.00
22_E64_E2.3981.00
34_P166_T2.3441.00
138_E142_K2.3321.00
140_V146_V2.3181.00
198_L234_K2.3161.00
26_K65_L2.2531.00
40_A43_V2.2391.00
56_V207_E2.1891.00
101_V315_L2.1451.00
257_P260_K2.1141.00
314_H318_K2.1141.00
17_E20_E2.0211.00
24_L41_I1.9901.00
136_A146_V1.9781.00
263_V269_S1.9471.00
97_L288_I1.9071.00
304_D307_E1.8941.00
235_I244_V1.8751.00
101_V296_L1.8731.00
206_Y236_V1.8711.00
214_I298_A1.8641.00
21_A58_F1.8621.00
9_K14_S1.8541.00
34_P37_L1.8481.00
195_K232_F1.8471.00
227_P256_I1.8381.00
124_A267_E1.8361.00
26_K64_E1.8351.00
219_E232_F1.8351.00
132_P135_R1.7951.00
199_D203_K1.7911.00
30_R65_L1.7891.00
310_E313_D1.7861.00
247_N250_D1.7831.00
233_M244_V1.7601.00
214_I294_V1.7571.00
234_K241_I1.7481.00
57_G61_A1.7311.00
247_N255_P1.6841.00
28_I38_V1.6691.00
27_A32_E1.6261.00
143_T322_K1.6251.00
137_K141_N1.5891.00
62_M180_T1.5891.00
127_Y326_I1.5841.00
90_V287_F1.5831.00
98_L295_A1.5641.00
274_V327_I1.5621.00
212_K237_S1.5481.00
43_V169_I1.5461.00
26_K61_A1.5411.00
100_L322_K1.5341.00
58_F172_I1.5261.00
18_I57_G1.5241.00
321_D324_N1.5221.00
230_N245_K1.5171.00
131_V135_R1.5051.00
78_A188_Q1.4991.00
320_L324_N1.4961.00
302_V308_G1.4831.00
293_A308_G1.4721.00
175_I197_H1.4671.00
213_I236_V1.4551.00
143_T329_M1.4441.00
293_A297_F1.4281.00
94_S292_T1.4271.00
259_E262_I1.4131.00
40_A167_L1.4131.00
186_K211_N1.4111.00
25_A58_F1.4101.00
99_S322_K1.4091.00
279_G317_E1.4061.00
145_F326_I1.4021.00
121_V273_I1.3961.00
219_E229_G1.3911.00
220_P229_G1.3881.00
324_N327_I1.3791.00
35_E166_T1.3431.00
11_I169_I1.3421.00
70_D137_K1.3411.00
75_I295_A1.3371.00
68_K184_N1.3361.00
46_R50_E1.3361.00
125_L270_A1.3351.00
205_A213_I1.3341.00
301_R311_Y1.3291.00
256_I283_H1.3171.00
303_G307_E1.3161.00
18_I207_E1.3151.00
85_L222_I1.3141.00
232_F243_E1.3121.00
313_D317_E1.3111.00
274_V278_L1.3091.00
127_Y327_I1.2941.00
210_F213_I1.2901.00
285_A313_D1.2751.00
274_V324_N1.2711.00
43_V47_M1.2651.00
264_N269_S1.2641.00
135_R138_E1.2591.00
131_V139_L1.2511.00
289_K309_Y1.2261.00
230_N247_N1.2241.00
321_D325_E1.2241.00
110_R120_D1.2231.00
24_L33_V1.2211.00
36_I166_T1.2191.00
121_V270_A1.2181.00
38_V163_V1.2161.00
53_N207_E1.2121.00
52_K204_S1.2041.00
11_I43_V1.1991.00
52_K56_V1.1911.00
6_I24_L1.1901.00
293_A309_Y1.1781.00
234_K243_E1.1271.00
324_N328_S1.1261.00
36_I39_S1.1241.00
139_L329_M1.1221.00
61_A65_L1.1121.00
308_G312_A1.1121.00
264_N268_D1.1081.00
74_A185_A1.1051.00
119_A149_F1.1041.00
33_V38_V1.1041.00
212_K235_I1.1041.00
157_M160_V1.1031.00
218_G229_G1.1010.99
282_E286_E1.0930.99
276_A284_V1.0770.99
22_E61_A1.0770.99
232_F245_K1.0720.99
206_Y241_I1.0720.99
225_V290_I1.0700.99
21_A57_G1.0650.99
203_K206_Y1.0620.99
160_V163_V1.0600.99
225_V246_L1.0540.99
10_L44_A1.0500.99
98_L103_P1.0470.99
94_S98_L1.0420.99
219_E230_N1.0380.99
41_I58_F1.0340.99
26_K30_R1.0330.99
246_L251_F1.0280.99
231_T248_V1.0140.99
251_F309_Y1.0110.99
110_R123_E1.0060.99
277_F319_S1.0030.99
325_E328_S1.0010.99
227_P287_F0.9990.99
306_R310_E0.9920.99
136_A153_Y0.9870.99
62_M157_M0.9770.99
235_I297_F0.9730.99
98_L104_V0.9720.99
37_L166_T0.9690.99
253_I290_I0.9670.99
11_I46_R0.9640.99
127_Y145_F0.9630.99
19_N22_E0.9620.99
36_I163_V0.9590.99
302_V311_Y0.9510.99
188_Q210_F0.9490.98
226_S229_G0.9490.98
271_I274_V0.9490.98
311_Y314_H0.9400.98
162_N166_T0.9370.98
88_V272_K0.9310.98
247_N251_F0.9310.98
29_I62_M0.9280.98
50_E170_R0.9280.98
59_A208_L0.9160.98
276_A288_I0.9130.98
256_I286_E0.9050.98
142_K325_E0.9050.98
187_Y211_N0.8970.98
310_E314_H0.8960.98
74_A105_A0.8950.98
260_K283_H0.8920.98
15_D53_N0.8920.98
50_E55_I0.8880.98
77_T94_S0.8870.98
10_L41_I0.8870.98
48_K54_E0.8840.98
187_Y212_K0.8770.97
4_N8_K0.8770.97
112_V151_Q0.8760.97
189_L216_V0.8760.97
227_P261_L0.8760.97
56_V60_R0.8760.97
236_V241_I0.8700.97
236_V239_R0.8670.97
274_V320_L0.8650.97
187_Y298_A0.8640.97
78_A118_S0.8640.97
52_K203_K0.8620.97
136_A140_V0.8620.97
53_N57_G0.8610.97
311_Y315_L0.8580.97
55_I204_S0.8570.97
8_K12_N0.8550.97
98_L101_V0.8520.97
286_E313_D0.8490.97
16_L54_E0.8420.97
281_D284_V0.8400.97
75_I104_V0.8400.97
38_V160_V0.8390.97
214_I297_F0.8390.97
270_A274_V0.8350.97
103_P141_N0.8320.97
253_I309_Y0.8300.96
77_T95_A0.8300.96
27_A33_V0.8280.96
219_E245_K0.8250.96
266_A270_A0.8220.96
256_I261_L0.8220.96
3_I24_L0.8210.96
35_E163_V0.8210.96
201_L215_L0.8200.96
33_V37_L0.8190.96
92_T122_L0.8180.96
3_I27_A0.8150.96
63_R184_N0.8150.96
217_Y221_G0.8070.96
56_V204_S0.8040.96
44_A48_K0.8020.96
28_I160_V0.8020.96
115_K265_S0.7990.96
83_D87_T0.7990.96
77_T188_Q0.7980.96
11_I47_M0.7940.95
52_K207_E0.7930.95
297_F302_V0.7930.95
267_E271_I0.7920.95
67_I155_P0.7900.95
289_K317_E0.7900.95
254_S286_E0.7880.95
192_V201_L0.7810.95
21_A172_I0.7780.95
62_M176_L0.7730.95
6_I23_E0.7720.95
300_D308_G0.7720.95
250_D306_R0.7720.95
78_A94_S0.7640.94
40_A169_I0.7620.94
72_P141_N0.7620.94
13_K47_M0.7610.94
218_G226_S0.7610.94
293_A305_F0.7600.94
96_I322_K0.7590.94
136_A148_L0.7570.94
35_E162_N0.7540.94
225_V251_F0.7500.94
93_A277_F0.7460.94
15_D51_S0.7460.94
22_E57_G0.7460.94
97_L316_I0.7440.94
130_I152_Y0.7440.94
125_L323_L0.7420.94
197_H200_L0.7390.93
138_E141_N0.7370.93
139_L146_V0.7360.93
73_N141_N0.7340.93
193_F197_H0.7340.93
282_E317_E0.7340.93
143_T326_I0.7340.93
18_I56_V0.7330.93
139_L143_T0.7310.93
133_P137_K0.7300.93
300_D311_Y0.7290.93
96_I145_F0.7270.93
85_L258_I0.7260.93
294_V305_F0.7260.93
211_N238_K0.7250.93
285_A289_K0.7240.93
199_D234_K0.7230.93
96_I326_I0.7230.93
29_I180_T0.7210.93
98_L292_T0.7210.93
31_G159_N0.7180.92
281_D317_E0.7170.92
69_I136_A0.7160.92
228_I257_P0.7150.92
23_E27_A0.7150.92
3_I6_I0.7110.92
63_R208_L0.7110.92
88_V284_V0.7100.92
283_H286_E0.7090.92
83_D86_G0.7080.92
77_T118_S0.7070.92
142_K329_M0.7040.92
124_A266_A0.7040.92
84_G113_S0.7030.92
235_I242_E0.6960.91
297_F304_D0.6910.91
97_L292_T0.6910.91
35_E159_N0.6900.91
190_M201_L0.6900.91
39_S163_V0.6870.91
214_I244_V0.6800.90
322_K326_I0.6790.90
220_P226_S0.6780.90
25_A172_I0.6780.90
157_M180_T0.6770.90
219_E226_S0.6740.90
323_L327_I0.6710.90
296_L301_R0.6700.90
116_S266_A0.6690.89
19_N23_E0.6670.89
66_A180_T0.6670.89
127_Y323_L0.6650.89
86_G262_I0.6640.89
52_K200_L0.6620.89
220_P231_T0.6620.89
297_F305_F0.6570.89
24_L28_I0.6570.89
206_Y240_G0.6560.89
87_T222_I0.6540.88
121_V125_L0.6540.88
83_D114_G0.6530.88
29_I159_N0.6510.88
132_P152_Y0.6470.88
22_E26_K0.6440.88
297_F308_G0.6420.88
189_L298_A0.6410.87
128_N135_R0.6400.87
222_I258_I0.6380.87
171_T174_N0.6350.87
214_I233_M0.6350.87
18_I53_N0.6310.87
220_P258_I0.6300.87
251_F305_F0.6280.86
45_L50_E0.6280.86
277_F320_L0.6270.86
203_K241_I0.6260.86
42_L157_M0.6260.86
135_R139_L0.6250.86
9_K13_K0.6240.86
296_L312_A0.6220.86
71_V140_V0.6170.85
55_I175_I0.6160.85
227_P253_I0.6150.85
205_A210_F0.6140.85
59_A62_M0.6140.85
59_A176_L0.6120.85
76_D82_G0.6110.85
195_K243_E0.6110.85
187_Y299_L0.6090.85
244_V297_F0.6080.85
54_E57_G0.6050.84
272_K276_A0.6040.84
43_V167_L0.6020.84
6_I27_A0.5970.83
95_A145_F0.5970.83
58_F176_L0.5970.83
227_P286_E0.5970.83
136_A139_L0.5960.83
296_L302_V0.5950.83
9_K17_E0.5940.83
268_D271_I0.5930.83
51_S54_E0.5930.83
206_Y239_R0.5930.83
105_A148_L0.5910.83
93_A276_A0.5880.83
237_S242_E0.5840.82
309_Y313_D0.5830.82
79_G91_S0.5810.82
228_I258_I0.5810.82
39_S43_V0.5780.81
305_F308_G0.5760.81
198_L232_F0.5760.81
98_L296_L0.5750.81
71_V137_K0.5750.81
75_I298_A0.5750.81
119_A123_E0.5750.81
214_I305_F0.5750.81
124_A270_A0.5740.81
289_K316_I0.5740.81
79_G82_G0.5740.81
315_L322_K0.5730.81
212_K300_D0.5710.81
289_K293_A0.5710.81
93_A116_S0.5680.80
5_E8_K0.5670.80
96_I100_L0.5650.80
151_Q165_K0.5650.80
61_A64_E0.5650.80
82_G177_G0.5640.80
96_I127_Y0.5640.80
44_A47_M0.5630.80
220_P228_I0.5620.80
203_K207_E0.5610.80
256_I260_K0.5580.79
79_G83_D0.5580.79
230_N255_P0.5560.79
86_G115_K0.5560.79
77_T295_A0.5550.79
300_D303_G0.5550.79
296_L308_G0.5550.79
99_S102_N0.5550.79
303_G311_Y0.5530.79
119_A147_F0.5520.78
307_E311_Y0.5520.78
198_L243_E0.5510.78
100_L319_S0.5510.78
325_E329_M0.5500.78
135_R329_M0.5490.78
40_A47_M0.5490.78
96_I323_L0.5490.78
142_K321_D0.5470.78
105_A140_V0.5460.78
202_S236_V0.5450.78
297_F301_R0.5450.78
74_A103_P0.5450.78
227_P283_H0.5430.77
212_K297_F0.5430.77
75_I299_L0.5400.77
3_I41_I0.5400.77
247_N290_I0.5390.77
134_E137_K0.5390.77
307_E310_E0.5390.77
59_A63_R0.5380.77
228_I260_K0.5370.77
125_L274_V0.5360.76
80_T83_D0.5360.76
270_A323_L0.5360.76
60_R64_E0.5360.76
79_G223_D0.5350.76
190_M215_L0.5330.76
87_T90_V0.5320.76
190_M205_A0.5310.76
66_A154_H0.5310.76
195_K219_E0.5300.76
118_S121_V0.5280.75
93_A288_I0.5280.75
315_L319_S0.5270.75
251_F290_I0.5270.75
67_I133_P0.5260.75
296_L311_Y0.5250.75
75_I185_A0.5250.75
28_I41_I0.5240.75
21_A25_A0.5240.75
59_A66_A0.5240.75
273_I277_F0.5210.74
89_N106_K0.5210.74
9_K16_L0.5200.74
36_I43_V0.5180.74
21_A54_E0.5180.74
271_I280_K0.5180.74
96_I277_F0.5180.74
77_T189_L0.5170.74
40_A163_V0.5150.74
10_L47_M0.5150.74
20_E57_G0.5140.73
128_N131_V0.5130.73
53_N56_V0.5130.73
103_P144_N0.5110.73
71_V74_A0.5110.73
46_R168_G0.5110.73
75_I187_Y0.5080.73
293_A312_A0.5070.72
80_T177_G0.5040.72
319_S323_L0.5040.72
81_G178_P0.5040.72
188_Q213_I0.5040.72
261_L287_F0.5040.72
73_N186_K0.5030.72
249_T254_S0.5030.72
13_K48_K0.5020.72
4_N168_G0.5010.72
293_A304_D0.5010.72
281_D286_E0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o17A 2 1 100 0.091 Contact Map
4giuA 2 0.9594 100 0.096 Contact Map
1khdA 2 0.9391 100 0.109 Contact Map
1vquA 2 0.9507 100 0.112 Contact Map
4hkmA 2 0.942 100 0.114 Contact Map
4gtnA 2 0.9362 100 0.117 Contact Map
2elcA 4 0.9362 100 0.142 Contact Map
4muoA 2 0.8667 100 0.173 Contact Map
3h5qA 2 0.8841 100 0.345 Contact Map
4eadA 2 0.8725 100 0.346 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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