GREMLIN Database
TRPB1 - Tryptophan synthase beta chain 1
UniProt: P50383 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 425 (358)
Sequences: 5721 (2930)
Seq/√Len: 154.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_T400_V4.9221.00
144_A151_S4.6511.00
279_R348_E4.5561.00
356_E385_D3.7101.00
80_R93_R3.6991.00
253_I281_I3.3801.00
52_Q231_L3.2651.00
254_L267_F3.2261.00
234_S238_Q3.0541.00
157_K186_E3.0341.00
154_F202_L3.0261.00
78_L400_V2.8781.00
152_T176_N2.8131.00
217_E265_G2.7691.00
93_R398_V2.6861.00
152_T178_Y2.6381.00
249_E398_V2.5991.00
87_Y363_I2.5481.00
150_K176_N2.5411.00
267_F402_N2.5051.00
300_F342_T2.4481.00
157_K190_K2.4351.00
283_V382_A2.4151.00
80_R85_E2.3431.00
241_I274_N2.3371.00
202_L206_M2.3041.00
240_T267_F2.2541.00
253_I279_R2.2361.00
198_H201_S2.2001.00
80_R95_Y2.1631.00
211_E225_V2.1601.00
82_K86_E2.1381.00
76_T102_T2.1061.00
161_E168_S2.0921.00
126_H202_L2.0611.00
104_T142_L2.0601.00
376_S404_S1.9581.00
252_D397_K1.9071.00
254_L280_Y1.8991.00
390_A397_K1.8901.00
237_G270_P1.8891.00
186_E190_K1.8881.00
83_R86_E1.8651.00
286_A353_N1.8611.00
75_P242_T1.8431.00
96_F364_F1.8371.00
237_G267_F1.8281.00
201_S205_A1.8241.00
313_I343_K1.8211.00
244_L400_V1.7771.00
281_I348_E1.7721.00
363_I384_V1.7581.00
55_I121_E1.7431.00
158_V161_E1.7381.00
362_K418_M1.7271.00
242_T245_D1.7201.00
353_N356_E1.7021.00
338_L349_W1.6871.00
88_L384_V1.6841.00
350_R382_A1.6811.00
244_L398_V1.6561.00
93_R247_L1.6561.00
361_A377_A1.6521.00
376_S403_L1.6301.00
119_A123_G1.6111.00
51_Q54_T1.6031.00
171_Q176_N1.6001.00
72_I102_T1.5821.00
116_A213_A1.5731.00
355_R359_E1.5601.00
360_A381_R1.5441.00
304_A311_K1.5421.00
87_Y367_N1.5321.00
340_L344_E1.5231.00
391_R397_K1.5171.00
142_L173_Y1.4931.00
352_Y381_R1.4521.00
383_V401_F1.4441.00
255_I383_V1.4391.00
68_R113_I1.4361.00
95_Y398_V1.4311.00
358_F374_P1.4291.00
313_I342_T1.4271.00
272_I347_V1.4171.00
267_F280_Y1.4101.00
283_V350_R1.4021.00
299_D315_L1.3881.00
120_K123_G1.3821.00
69_Y72_I1.3801.00
223_G227_D1.3561.00
282_A349_W1.3511.00
206_M209_A1.3511.00
126_H150_K1.3441.00
244_L247_L1.3391.00
79_F98_Y1.3321.00
189_R321_P1.3301.00
380_I401_F1.3201.00
84_L380_I1.3091.00
253_I390_A1.3031.00
253_I399_I1.3021.00
140_V153_I1.2771.00
386_E389_E1.2711.00
255_I386_E1.2581.00
132_G137_G1.2571.00
196_P218_F1.2551.00
49_L53_F1.2431.00
120_K149_M1.2321.00
72_I76_T1.2271.00
362_K366_E1.2251.00
95_Y247_L1.2211.00
44_L207_S1.2161.00
254_L271_F1.2151.00
312_M339_S1.2121.00
95_Y244_L1.2091.00
307_L312_M1.2021.00
84_L363_I1.1891.00
197_Q201_S1.1871.00
124_I219_R1.1861.00
412_S416_S1.1811.00
130_E153_I1.1771.00
382_A386_E1.1771.00
286_A351_E1.1751.00
283_V352_Y1.1711.00
202_L205_A1.1681.00
381_R385_D1.1681.00
268_T280_Y1.1671.00
253_I386_E1.1661.00
391_R395_E1.1591.00
160_Y179_A1.1571.00
281_I382_A1.1561.00
168_S171_Q1.1511.00
196_P200_G1.1441.00
359_E363_I1.1431.00
62_P65_V1.1431.00
255_I283_V1.1351.00
205_A209_A1.1311.00
50_R54_T1.1301.00
118_F228_V1.1271.00
116_A127_V1.1231.00
358_F417_M1.1221.00
46_K50_R1.1181.00
88_L363_I1.1121.00
253_I397_K1.1090.99
116_A147_Y1.1070.99
65_V69_Y1.1060.99
379_A401_F1.1030.99
360_A380_I1.1010.99
104_T109_I1.0930.99
93_R396_R1.0890.99
127_V144_A1.0770.99
196_P214_L1.0760.99
60_K63_E1.0720.99
88_L388_I1.0720.99
84_L94_I1.0660.99
66_R238_Q1.0530.99
287_E354_E1.0520.99
255_I281_I1.0510.99
157_K161_E1.0490.99
53_F227_D1.0460.99
207_S210_I1.0440.99
244_L251_A1.0440.99
76_T106_S1.0430.99
247_L398_V1.0420.99
62_P66_R1.0420.99
413_N417_M1.0420.99
59_I63_E1.0410.99
157_K160_Y1.0410.99
168_S415_E1.0360.99
127_V152_T1.0340.99
363_I367_N1.0320.99
112_A143_A1.0320.99
388_I391_R1.0310.99
240_T402_N1.0250.99
238_Q270_P1.0240.99
88_L383_V1.0230.99
258_V282_A1.0230.99
361_A414_Y1.0210.99
83_R367_N1.0190.99
53_F57_R1.0130.99
250_D278_K1.0120.99
312_M333_G1.0070.99
214_L217_E1.0060.99
325_Y358_F0.9970.99
372_P377_A0.9890.99
85_E91_P0.9830.99
141_A175_A0.9820.99
46_K49_L0.9810.99
413_N416_S0.9770.99
251_A400_V0.9760.99
356_E381_R0.9700.99
383_V399_I0.9680.99
386_E390_A0.9660.99
283_V351_E0.9610.99
365_I371_V0.9590.99
189_R194_T0.9550.98
240_T271_F0.9540.98
79_F100_G0.9500.98
255_I382_A0.9490.98
265_G338_L0.9460.98
259_G328_G0.9420.98
120_K147_Y0.9410.98
125_E150_K0.9400.98
169_I371_V0.9330.98
290_K293_K0.9320.98
281_I386_E0.9290.98
82_K146_M0.9200.98
157_K179_A0.9200.98
160_Y171_Q0.9170.98
372_P376_S0.9170.98
268_T345_G0.9150.98
252_D398_V0.9150.98
249_E252_D0.9140.98
197_Q200_G0.9120.98
99_E404_S0.9110.98
329_L378_H0.9060.98
234_S270_P0.9010.98
254_L270_P0.8970.98
196_P216_N0.8960.98
138_T169_I0.8960.98
143_A213_A0.8950.98
236_I402_N0.8940.98
412_S415_E0.8920.98
205_A208_E0.8850.98
387_A390_A0.8840.97
310_V314_T0.8810.97
237_G271_F0.8800.97
45_P49_L0.8790.97
187_Y194_T0.8750.97
68_R146_M0.8750.97
168_S172_L0.8720.97
56_E231_L0.8690.97
218_F310_V0.8680.97
230_L337_T0.8670.97
98_Y101_A0.8660.97
352_Y382_A0.8650.97
167_R177_V0.8630.97
47_E50_R0.8610.97
200_G203_G0.8610.97
61_I65_V0.8600.97
364_F380_I0.8530.97
75_P243_Q0.8530.97
236_I263_N0.8520.97
304_A313_I0.8520.97
240_T254_L0.8510.97
372_P403_L0.8510.97
91_P390_A0.8500.97
167_R171_Q0.8490.97
51_Q55_I0.8490.97
78_L244_L0.8460.97
380_I403_L0.8440.97
161_E416_S0.8410.97
382_A385_D0.8370.97
52_Q232_H0.8360.96
64_E120_K0.8350.96
245_D248_G0.8340.96
275_K278_K0.8300.96
140_V144_A0.8170.96
227_D231_L0.8170.96
119_A127_V0.8160.96
172_L362_K0.8130.96
281_I350_R0.8120.96
44_L47_E0.8100.96
194_T198_H0.8100.96
62_P69_Y0.8080.96
352_Y385_D0.8070.96
53_F56_E0.8060.96
411_L415_E0.8050.96
55_I58_Y0.8040.96
242_T246_L0.7980.95
250_D274_N0.7970.95
248_G252_D0.7940.95
383_V387_A0.7940.95
201_S204_I0.7910.95
350_R385_D0.7900.95
72_I113_I0.7870.95
81_A84_L0.7860.95
231_L234_S0.7850.95
168_S411_L0.7820.95
347_V350_R0.7820.95
311_K314_T0.7780.95
170_M175_A0.7760.95
109_I142_L0.7750.95
314_T319_Y0.7730.95
52_Q56_E0.7700.94
77_P101_A0.7690.94
43_I46_K0.7680.94
126_H152_T0.7680.94
244_L249_E0.7680.94
196_P202_L0.7630.94
137_G170_M0.7620.94
191_I194_T0.7600.94
188_G193_E0.7600.94
67_D70_L0.7580.94
66_R70_L0.7560.94
365_I372_P0.7480.94
168_S418_M0.7460.93
279_R397_K0.7440.93
364_F403_L0.7430.93
85_E94_I0.7420.93
272_I341_L0.7410.93
127_V149_M0.7390.93
127_V150_K0.7390.93
385_D388_I0.7390.93
241_I271_F0.7340.93
158_V190_K0.7340.93
188_G194_T0.7330.93
118_F122_E0.7310.93
82_K85_E0.7290.93
91_P395_E0.7250.92
359_E384_V0.7250.92
270_P273_G0.7230.92
238_Q242_T0.7210.92
370_I403_L0.7210.92
155_M170_M0.7180.92
85_E92_A0.7180.92
163_K327_G0.7170.92
376_S379_A0.7130.92
116_A143_A0.7100.92
290_K334_V0.7100.92
196_P201_S0.7050.91
298_Y301_P0.7050.91
254_L400_V0.7020.91
94_I383_V0.7000.91
253_I348_E0.6940.91
63_E67_D0.6940.91
398_V402_N0.6930.91
286_A293_K0.6910.91
294_G299_D0.6890.90
274_N278_K0.6850.90
199_P203_G0.6840.90
116_A140_V0.6830.90
152_T202_L0.6820.90
267_F270_P0.6820.90
92_A399_I0.6810.90
151_S175_A0.6790.90
67_D82_K0.6780.90
241_I245_D0.6780.90
187_Y190_K0.6750.90
107_H263_N0.6750.90
116_A149_M0.6750.90
377_A380_I0.6710.89
109_I146_M0.6680.89
167_R179_A0.6670.89
390_A399_I0.6640.89
120_K125_E0.6640.89
258_V334_V0.6640.89
92_A390_A0.6630.89
250_D271_F0.6630.89
169_I411_L0.6620.89
132_G373_A0.6610.89
288_I293_K0.6610.89
91_P391_R0.6610.89
55_I60_K0.6590.88
84_L87_Y0.6570.88
110_N235_V0.6560.88
214_L218_F0.6550.88
352_Y357_I0.6540.88
169_I173_Y0.6520.88
196_P322_P0.6520.88
141_A153_I0.6520.88
94_I387_A0.6510.88
158_V321_P0.6490.88
194_T197_Q0.6480.88
187_Y198_H0.6450.87
195_N198_H0.6440.87
168_S412_S0.6440.87
68_R147_Y0.6430.87
356_E359_E0.6410.87
129_T203_G0.6400.87
375_E378_H0.6400.87
142_L146_M0.6390.87
200_G204_I0.6350.87
229_V233_Q0.6350.87
189_R197_Q0.6350.87
364_F372_P0.6330.86
372_P380_I0.6320.86
188_G191_I0.6310.86
246_L249_E0.6310.86
197_Q205_A0.6310.86
92_A396_R0.6310.86
301_P351_E0.6290.86
54_T59_I0.6290.86
190_K194_T0.6270.86
46_K53_F0.6270.86
269_Y337_T0.6260.86
50_R53_F0.6260.86
282_A338_L0.6250.86
306_L333_G0.6230.85
228_V232_H0.6210.85
353_N385_D0.6210.85
58_Y121_E0.6210.85
285_S329_L0.6190.85
241_I270_P0.6190.85
154_F198_H0.6170.85
96_F403_L0.6170.85
258_V404_S0.6160.85
138_T170_M0.6150.85
280_Y346_I0.6150.85
364_F370_I0.6150.85
265_G337_T0.6150.85
157_K189_R0.6140.85
265_G269_Y0.6140.85
91_P399_I0.6110.84
308_P332_H0.6110.84
195_N199_P0.6100.84
407_G410_D0.6090.84
45_P48_V0.6080.84
241_I250_D0.6080.84
204_I207_S0.6080.84
179_A186_E0.6060.84
81_A96_F0.6050.84
303_S316_G0.6040.84
256_G263_N0.6030.84
315_L320_V0.6020.84
187_Y201_S0.6020.84
360_A384_V0.6010.83
278_K346_I0.6010.83
144_A213_A0.5980.83
306_L311_K0.5980.83
231_L269_Y0.5970.83
288_I322_P0.5960.83
100_G404_S0.5950.83
200_G207_S0.5940.83
354_E357_I0.5930.83
350_R389_E0.5930.83
342_T349_W0.5920.82
88_L367_N0.5910.82
234_S269_Y0.5910.82
198_H202_L0.5880.82
163_K373_A0.5880.82
294_G318_D0.5880.82
92_A383_V0.5880.82
102_T109_I0.5850.82
238_Q273_G0.5830.82
271_F278_K0.5830.82
192_L224_S0.5820.81
66_R242_T0.5820.81
112_A139_A0.5810.81
307_L319_Y0.5810.81
92_A397_K0.5780.81
414_Y418_M0.5760.81
216_N310_V0.5760.81
92_A387_A0.5760.81
380_I383_V0.5720.80
281_I347_V0.5710.80
326_A357_I0.5700.80
64_E121_E0.5700.80
121_E124_I0.5680.80
74_R110_N0.5680.80
44_L48_V0.5670.80
339_S342_T0.5660.80
55_I62_P0.5640.79
126_H210_I0.5630.79
79_F82_K0.5620.79
299_D333_G0.5620.79
238_Q274_N0.5600.79
56_E62_P0.5580.79
66_R235_V0.5570.79
163_K374_P0.5560.78
203_G209_A0.5550.78
133_A163_K0.5540.78
77_P312_M0.5540.78
199_P206_M0.5520.78
48_V273_G0.5520.78
169_I172_L0.5520.78
133_A373_A0.5510.78
84_L364_F0.5500.78
230_L269_Y0.5480.77
267_F400_V0.5480.77
366_E418_M0.5470.77
240_T244_L0.5470.77
206_M210_I0.5450.77
160_Y180_S0.5450.77
91_P388_I0.5450.77
258_V376_S0.5450.77
312_M319_Y0.5450.77
224_S233_Q0.5440.77
342_T346_I0.5440.77
133_A331_Y0.5430.77
361_A374_P0.5430.77
120_K124_I0.5410.77
329_L375_E0.5410.77
83_R368_Q0.5400.76
110_N233_Q0.5390.76
302_D309_L0.5370.76
287_E321_P0.5370.76
240_T270_P0.5360.76
140_V151_S0.5360.76
288_I323_P0.5350.76
233_Q376_S0.5330.75
99_E376_S0.5320.75
356_E360_A0.5320.75
390_A396_R0.5290.75
96_F380_I0.5290.75
314_T320_V0.5280.75
66_R69_Y0.5280.75
371_V414_Y0.5270.75
136_W233_Q0.5260.75
63_E70_L0.5260.75
84_L384_V0.5260.75
241_I275_K0.5260.75
358_F414_Y0.5250.74
63_E242_T0.5210.74
89_K395_E0.5210.74
119_A225_V0.5210.74
127_V213_A0.5210.74
211_E316_G0.5200.74
300_F349_W0.5190.74
163_K405_G0.5180.73
207_S211_E0.5180.73
272_I280_Y0.5180.73
218_F312_M0.5170.73
95_Y249_E0.5160.73
340_L343_K0.5160.73
237_G274_N0.5150.73
119_A149_M0.5140.73
78_L81_A0.5130.73
190_K193_E0.5130.73
376_S380_I0.5120.73
89_K396_R0.5120.73
226_L336_P0.5110.72
244_L250_D0.5110.72
57_R62_P0.5090.72
333_G336_P0.5090.72
98_Y403_L0.5080.72
214_L312_M0.5080.72
342_T347_V0.5070.72
88_L387_A0.5050.72
200_G205_A0.5040.71
334_V342_T0.5040.71
291_F294_G0.5040.71
194_T201_S0.5030.71
304_A339_S0.5030.71
307_L310_V0.5030.71
131_T375_E0.5020.71
85_E93_R0.5010.71
196_P199_P0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qysB 2 0.9576 100 0.296 Contact Map
3ss7X 1 0.9059 100 0.341 Contact Map
1tdjA 2 0.7741 100 0.351 Contact Map
2gn0A 2 0.7694 100 0.371 Contact Map
1v71A 2 0.7435 100 0.378 Contact Map
2d1fA 2 0.7694 100 0.382 Contact Map
2zsjA 2 0.7647 100 0.383 Contact Map
3aeyA 2 0.7624 100 0.383 Contact Map
4negA 2 0.76 100 0.384 Contact Map
1x1qA 2 0.9035 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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