GREMLIN Database
TRPA - Tryptophan synthase alpha chain
UniProt: P50382 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (232)
Sequences: 3716 (2388)
Seq/√Len: 156.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_N20_S3.8141.00
26_I74_D3.6171.00
15_Y58_K3.3601.00
144_D180_R3.1481.00
91_Q98_M3.0731.00
54_K223_E2.9111.00
128_K155_D2.8431.00
72_R105_D2.7931.00
22_K70_D2.6141.00
190_I211_G2.4451.00
12_T56_Y2.3861.00
98_M101_D2.2761.00
9_V33_A2.2661.00
138_T147_I2.2151.00
96_L127_I2.1781.00
27_G31_N2.1761.00
70_D73_K2.1561.00
133_K155_D2.1031.00
97_N130_K2.0041.00
25_I36_L1.9641.00
93_E126_I1.9511.00
29_V77_V1.9061.00
59_V62_L1.8991.00
8_V190_I1.8481.00
25_I71_I1.8391.00
198_E202_R1.8351.00
88_W109_F1.7981.00
63_D66_P1.7931.00
69_E101_D1.7811.00
6_M211_G1.7641.00
197_S200_D1.7441.00
97_N101_D1.7211.00
29_V76_G1.6951.00
83_T87_D1.6831.00
179_N183_N1.6611.00
100_K130_K1.6561.00
83_T88_W1.6471.00
182_R189_L1.6351.00
10_Y56_Y1.6301.00
161_G191_V1.6011.00
148_H152_K1.5931.00
182_R210_D1.5821.00
66_P69_E1.5721.00
220_E224_R1.5631.00
109_F123_I1.5381.00
160_Y189_L1.5341.00
31_N235_K1.5231.00
69_E98_M1.5211.00
93_E129_N1.5211.00
191_V204_A1.5081.00
94_N97_N1.4891.00
24_F222_I1.4841.00
27_G30_E1.4781.00
25_I79_I1.4721.00
127_I134_N1.4661.00
98_M102_V1.4491.00
85_L112_L1.4271.00
148_H184_L1.4131.00
35_I80_I1.4091.00
124_D128_K1.4021.00
22_K26_I1.3971.00
232_N236_K1.3931.00
99_I132_L1.3911.00
94_N98_M1.3811.00
142_V147_I1.3711.00
233_L236_K1.3561.00
233_L238_R1.3521.00
23_D26_I1.3501.00
233_L237_F1.3481.00
147_I181_V1.3461.00
190_I213_A1.3431.00
191_V209_A1.3401.00
15_Y223_E1.3251.00
99_I104_L1.3061.00
85_L92_L1.3041.00
20_S23_D1.2941.00
195_L212_I1.2801.00
13_L38_L1.2731.00
11_M24_F1.2701.00
88_W95_F1.2701.00
230_A233_L1.2641.00
160_Y177_L1.2621.00
65_W99_I1.2561.00
40_I81_A1.2461.00
225_N233_L1.2451.00
118_D125_G1.2371.00
117_I136_I1.2311.00
66_P70_D1.2201.00
229_S233_L1.2171.00
18_V22_K1.2111.00
196_S220_E1.2071.00
80_I135_V1.1881.00
149_K152_K1.1851.00
195_L204_A1.1851.00
125_G129_N1.1531.00
154_S187_N1.1521.00
30_E235_K1.1411.00
96_L126_I1.1401.00
18_V63_D1.1401.00
82_L108_L1.1281.00
15_Y219_I1.1271.00
54_K57_D1.1261.00
5_K206_S1.1171.00
162_V169_P1.1081.00
36_L77_V1.1081.00
144_D183_N1.1061.00
158_L185_V1.0970.99
176_Q179_N1.0960.99
175_K179_N1.0960.99
85_L123_I1.0850.99
220_E223_E1.0840.99
100_K131_G1.0780.99
144_D184_L1.0720.99
91_Q94_N1.0580.99
12_T55_S1.0540.99
232_N235_K1.0520.99
199_S203_D1.0490.99
221_E225_N1.0480.99
134_N155_D1.0450.99
69_E102_V1.0380.99
217_V221_E1.0370.99
95_F107_I1.0120.99
168_V220_E1.0120.99
22_K74_D1.0060.99
29_V75_V0.9990.99
96_L107_I0.9950.99
30_E74_D0.9920.99
144_D148_H0.9910.99
26_I75_V0.9910.99
9_V218_F0.9830.99
169_P200_D0.9810.99
18_V62_L0.9780.99
26_I30_E0.9660.99
51_V220_E0.9620.99
177_L180_R0.9620.99
22_K67_L0.9570.99
51_V168_V0.9510.99
201_L212_I0.9490.98
231_I235_K0.9450.98
141_S163_R0.9440.98
149_K153_I0.9440.98
114_I153_I0.9420.98
225_N230_A0.9380.98
17_N60_K0.9370.98
58_K223_E0.9220.98
96_L123_I0.9200.98
80_I106_G0.9150.98
26_I29_V0.9140.98
8_V35_I0.9100.98
226_G229_S0.8950.98
206_S212_I0.8840.98
38_L68_I0.8830.98
126_I130_K0.8800.98
93_E97_N0.8780.97
9_V28_A0.8760.97
65_W98_M0.8750.97
96_L132_L0.8700.97
68_I79_I0.8660.97
22_K25_I0.8650.97
138_T142_V0.8570.97
13_L67_L0.8540.97
221_E224_R0.8470.97
97_N100_K0.8450.97
75_V79_I0.8440.97
13_L64_I0.8430.97
10_Y39_G0.8410.97
18_V21_F0.8370.97
231_I238_R0.8270.96
196_S200_D0.8250.96
118_D153_I0.8230.96
151_S184_L0.8220.96
20_S24_F0.8210.96
138_T154_S0.8120.96
160_Y181_V0.8110.96
29_V36_L0.8030.96
7_L218_F0.8020.96
229_S232_N0.7990.96
158_L181_V0.7970.96
160_Y208_G0.7970.96
71_I79_I0.7950.95
93_E130_K0.7930.95
136_I154_S0.7920.95
107_I134_N0.7890.95
25_I77_V0.7840.95
92_L126_I0.7830.95
92_L123_I0.7800.95
138_T181_V0.7760.95
136_I153_I0.7710.95
202_R207_A0.7670.95
52_I219_I0.7660.94
175_K203_D0.7650.94
69_E73_K0.7620.94
110_P213_A0.7590.94
18_V66_P0.7570.94
18_V60_K0.7490.94
230_A237_F0.7490.94
221_E233_L0.7470.94
79_I104_L0.7450.94
96_L130_K0.7350.93
71_I75_V0.7330.93
21_F38_L0.7260.93
192_G215_G0.7260.93
178_I189_L0.7250.93
136_I150_V0.7210.93
139_S142_V0.7170.92
234_V237_F0.7170.92
195_L201_L0.7160.92
18_V67_L0.7120.92
25_I38_L0.7100.92
50_P54_K0.7090.92
151_S187_N0.7060.92
168_V196_S0.7040.92
21_F67_L0.7020.92
40_I64_I0.6990.91
230_A238_R0.6980.91
19_Q70_D0.6980.91
175_K207_A0.6980.91
42_P46_K0.6980.91
204_A212_I0.6980.91
47_Y193_F0.6960.91
198_E201_L0.6920.91
9_V35_I0.6920.91
169_P172_V0.6910.91
68_I104_L0.6910.91
53_R78_P0.6900.91
114_I149_K0.6890.91
155_D187_N0.6880.91
117_I124_D0.6870.91
92_L96_L0.6800.90
180_R183_N0.6770.90
217_V220_E0.6770.90
151_S158_L0.6730.90
107_I127_I0.6730.90
80_I137_F0.6730.90
199_S202_R0.6710.90
92_L119_D0.6690.89
201_L206_S0.6660.89
170_I173_S0.6630.89
169_P196_S0.6620.89
10_Y55_S0.6560.89
81_A104_L0.6540.88
114_I136_I0.6530.88
214_I217_V0.6450.88
69_E152_K0.6450.88
147_I151_S0.6430.88
215_G219_I0.6420.87
68_I81_A0.6390.87
42_P85_L0.6370.87
5_K212_I0.6300.86
225_N229_S0.6300.86
115_D146_L0.6290.86
100_K132_L0.6280.86
119_D126_I0.6280.86
136_I158_L0.6170.85
85_L89_V0.6160.85
144_D147_I0.6140.85
71_I77_V0.6120.85
115_D149_K0.6110.85
35_I190_I0.6090.85
79_I105_D0.6080.84
218_F234_V0.6080.84
181_V185_V0.6050.84
108_L157_F0.6040.84
202_R206_S0.6030.84
30_E231_I0.6020.84
49_G193_F0.5960.83
175_K208_G0.5950.83
218_F221_E0.5950.83
82_L213_A0.5940.83
178_I208_G0.5910.83
185_V188_K0.5900.83
6_M34_D0.5880.82
123_I127_I0.5870.82
107_I132_L0.5870.82
133_K156_L0.5860.82
166_T193_F0.5850.82
126_I129_N0.5850.82
119_D125_G0.5840.82
39_G211_G0.5830.82
18_V70_D0.5820.82
151_S185_V0.5810.82
31_N231_I0.5780.81
228_K231_I0.5770.81
54_K58_K0.5750.81
6_M190_I0.5720.81
148_H151_S0.5710.81
176_Q180_R0.5710.81
118_D149_K0.5680.80
25_I29_V0.5680.80
27_G231_I0.5670.80
42_P86_E0.5660.80
13_L68_I0.5650.80
64_I68_I0.5650.80
24_F234_V0.5650.80
29_V71_I0.5640.80
176_Q183_N0.5640.80
148_H183_N0.5620.80
222_I225_N0.5610.79
204_A208_G0.5600.79
42_P162_V0.5570.79
14_G62_L0.5560.79
167_G193_F0.5530.78
142_V146_L0.5530.78
48_D108_L0.5530.78
28_A33_A0.5530.78
44_Y161_G0.5520.78
40_I83_T0.5500.78
22_K71_I0.5500.78
145_L149_K0.5490.78
224_R233_L0.5490.78
38_L79_I0.5490.78
110_P160_Y0.5460.78
19_Q22_K0.5460.78
51_V216_T0.5450.77
203_D207_A0.5440.77
21_F29_V0.5440.77
55_S219_I0.5420.77
123_I134_N0.5410.77
168_V172_V0.5380.77
228_K235_K0.5380.77
227_V231_I0.5340.76
204_A207_A0.5290.75
67_L70_D0.5290.75
168_V171_P0.5280.75
231_I237_F0.5270.75
3_M6_M0.5270.75
235_K238_R0.5240.75
231_I234_V0.5240.75
63_D67_L0.5210.74
40_I95_F0.5200.74
230_A234_V0.5190.74
11_M21_F0.5190.74
68_I72_R0.5180.74
27_G235_K0.5180.74
23_D228_K0.5180.74
4_G34_D0.5170.74
46_K85_L0.5170.74
178_I191_V0.5170.74
48_D136_I0.5150.73
49_G166_T0.5140.73
145_L148_H0.5130.73
26_I70_D0.5100.73
189_L210_D0.5060.72
49_G167_G0.5040.72
147_I180_R0.5030.72
42_P47_Y0.5020.72
25_I75_V0.5000.71
124_D134_N0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ujpA 1 0.902 100 0.432 Contact Map
3thaA 2 0.951 100 0.46 Contact Map
2ekcA 1 0.9673 100 0.484 Contact Map
3vndA 3 0.9469 100 0.504 Contact Map
4ht3A 1 0.9837 100 0.505 Contact Map
3navA 2 0.9551 100 0.518 Contact Map
1geqA 1 0.9633 100 0.519 Contact Map
1rd5A 6 0.9673 100 0.532 Contact Map
3cu2A 2 0.8449 100 0.597 Contact Map
2f6uA 2 0.7837 100 0.619 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.