GREMLIN Database
PGK - Phosphoglycerate kinase
UniProt: P50317 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (382)
Sequences: 3708 (1884)
Seq/√Len: 96.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_I318_A3.8801.00
392_R397_E3.8121.00
38_D42_K3.5431.00
243_N296_V3.5031.00
20_L61_I3.3241.00
30_D34_K3.0321.00
306_T309_E2.9021.00
246_P297_T2.8011.00
81_L84_K2.7481.00
278_V310_I2.6991.00
181_E185_S2.6391.00
51_L56_N2.6171.00
12_I175_A2.6071.00
21_L51_L2.5451.00
38_D81_L2.4721.00
333_E366_E2.4471.00
50_E178_R2.3301.00
139_L143_L2.3261.00
195_D319_K2.2421.00
49_K53_N2.2401.00
57_S110_N2.2271.00
166_V170_L2.1851.00
25_I44_H2.1771.00
346_S353_V2.1701.00
108_L112_G2.1471.00
234_E300_I2.1291.00
275_E314_F2.1241.00
229_G327_M2.1181.00
109_E112_G2.1071.00
20_L168_F2.1051.00
108_L114_L2.0851.00
238_V251_I2.0661.00
261_I274_I2.0151.00
219_R263_R1.9831.00
215_E263_R1.9611.00
81_L85_Y1.9591.00
340_K368_M1.9571.00
96_V122_I1.9501.00
340_K344_K1.9201.00
308_A312_S1.9121.00
102_R145_P1.8991.00
18_K59_V1.8971.00
91_I112_G1.8901.00
141_K171_A1.8841.00
215_E259_S1.8731.00
50_E54_K1.8731.00
61_I147_F1.8641.00
278_V306_T1.8491.00
223_A226_I1.8241.00
76_E80_K1.8081.00
290_E306_T1.7831.00
337_S340_K1.7791.00
308_A341_S1.7771.00
344_K348_E1.7721.00
262_P266_K1.7651.00
10_D178_R1.7581.00
238_V254_K1.7521.00
309_E313_S1.7461.00
254_K258_L1.7431.00
219_R270_S1.7331.00
287_N298_G1.7231.00
315_I349_G1.7221.00
83_S89_E1.7091.00
266_K270_S1.7051.00
339_S363_A1.6981.00
190_I354_I1.6971.00
103_E107_K1.6911.00
273_P314_F1.6851.00
157_T165_I1.6621.00
240_K261_I1.6281.00
176_A399_L1.5831.00
14_I51_L1.5781.00
225_R275_E1.5651.00
93_V104_M1.5621.00
59_V147_F1.5591.00
199_I225_R1.5571.00
202_L214_I1.5511.00
227_L311_Y1.5491.00
16_S110_N1.5471.00
86_L113_I1.5251.00
74_S92_F1.5241.00
259_S263_R1.5101.00
104_M114_L1.5101.00
280_Y291_E1.5091.00
211_I253_E1.4951.00
10_D181_E1.4941.00
184_V396_L1.4931.00
262_P265_R1.4931.00
199_I315_I1.4861.00
45_I85_Y1.4851.00
49_K88_R1.4711.00
295_K298_G1.4631.00
52_I57_S1.4581.00
322_V388_L1.4411.00
294_S300_I1.4351.00
105_I114_L1.4341.00
151_I175_A1.4231.00
99_P102_R1.4181.00
288_V305_S1.4171.00
61_I119_I1.4120.99
141_K145_P1.4120.99
234_E280_Y1.4020.99
307_T311_Y1.3970.99
169_P398_A1.3830.99
18_K57_S1.3830.99
10_D50_E1.3730.99
130_P170_L1.3730.99
246_P299_I1.3710.99
29_V64_Q1.3710.99
180_M396_L1.3610.99
312_S345_A1.3450.99
99_P103_E1.3390.99
94_D100_Y1.3380.99
208_H250_E1.3370.99
20_L147_F1.3250.99
352_Y375_V1.3240.99
225_R314_F1.3240.99
42_K85_Y1.3220.99
316_K348_E1.3210.99
225_R273_P1.3150.99
255_L258_L1.3080.99
124_E139_L1.3020.99
161_S166_V1.3010.99
88_R112_G1.2990.99
21_L48_I1.2870.99
21_L60_L1.2850.99
91_I104_M1.2840.99
48_I60_L1.2690.99
253_E256_G1.2680.99
51_L58_V1.2650.99
23_I60_L1.2630.99
93_V101_A1.2600.99
190_I322_V1.2460.99
312_S316_K1.2300.99
225_R318_A1.2140.98
158_A180_M1.2090.98
341_S344_K1.2060.98
282_V289_I1.2040.98
365_D371_D1.2000.98
130_P138_F1.1980.98
140_V167_G1.1960.98
119_I139_L1.1950.98
313_S316_K1.1920.98
290_E293_A1.1830.98
188_A387_F1.1820.98
6_I401_M1.1780.98
122_I139_L1.1770.98
189_K195_D1.1720.98
79_A83_S1.1720.98
154_A157_T1.1670.98
100_Y104_M1.1600.98
12_I149_I1.1600.98
310_I314_F1.1570.98
105_I108_L1.1560.98
240_K265_R1.1540.98
21_L47_T1.1510.98
80_K83_S1.1430.98
349_G353_V1.1390.98
15_Q110_N1.1340.98
188_A192_N1.1220.97
227_L307_T1.1170.97
186_A352_Y1.1070.97
62_S75_L1.1060.97
128_E167_G1.1050.97
95_D98_G1.1030.97
327_M342_V1.0940.97
337_S341_S1.0920.97
258_L262_P1.0870.97
129_A138_F1.0840.97
315_I345_A1.0790.97
122_I142_K1.0760.97
244_L249_M1.0740.97
280_Y300_I1.0720.97
265_R273_P1.0680.97
225_R317_D1.0680.97
237_S242_M1.0660.96
140_V171_A1.0630.96
303_I327_M1.0630.96
52_I88_R1.0620.96
61_I168_F1.0600.96
283_E332_D1.0580.96
187_L387_F1.0570.96
70_K123_S1.0560.96
231_L248_N1.0520.96
76_E92_F1.0450.96
97_I122_I1.0440.96
15_Q55_G1.0380.96
30_D33_G1.0330.96
23_I44_H1.0320.96
282_V298_G1.0310.96
89_E112_G1.0270.96
128_E166_V1.0250.96
97_I142_K1.0220.96
289_I295_K1.0200.95
238_V243_N1.0180.95
140_V163_P1.0170.95
80_K84_K1.0140.95
39_S365_D1.0140.95
75_L92_F1.0120.95
7_P400_S0.9990.95
9_M51_L0.9980.95
242_M292_P0.9940.95
279_D304_G0.9920.95
97_I139_L0.9910.95
333_E336_K0.9900.95
237_S276_I0.9880.95
158_A165_I0.9860.95
93_V114_L0.9810.94
231_L244_L0.9770.94
211_I256_G0.9730.94
138_F142_K0.9680.94
48_I113_I0.9660.94
37_D365_D0.9660.94
185_S189_K0.9630.94
275_E311_Y0.9630.94
314_F317_D0.9590.94
321_V351_G0.9570.94
313_S317_D0.9560.94
289_I298_G0.9560.94
321_V346_S0.9530.93
370_I374_K0.9520.93
130_P171_A0.9490.93
83_S115_L0.9400.93
249_M254_K0.9390.93
336_K368_M0.9370.93
105_I146_L0.9360.93
308_A337_S0.9340.93
355_I364_L0.9330.93
336_K340_K0.9280.93
138_F141_K0.9250.92
94_D104_M0.9240.92
227_L314_F0.9240.92
76_E94_D0.9220.92
57_S105_I0.9180.92
8_T181_E0.9160.92
101_A116_L0.9160.92
220_K223_A0.9160.92
238_V249_M0.9140.92
30_D36_I0.9130.92
60_L115_L0.9130.92
147_F172_L0.9100.92
13_D54_K0.9060.92
209_D212_R0.9060.92
196_T224_D0.9040.92
45_I86_L0.9020.91
355_I360_M0.9020.91
259_S262_P0.9010.91
52_I113_I0.8990.91
200_F223_A0.8980.91
50_E53_N0.8950.91
74_S117_D0.8910.91
281_K288_V0.8910.91
281_K308_A0.8870.91
286_G334_R0.8830.91
71_D74_S0.8820.91
102_R142_K0.8800.90
96_V143_L0.8800.90
201_T346_S0.8800.90
397_E400_S0.8780.90
286_G332_D0.8780.90
57_S108_L0.8770.90
156_A380_G0.8750.90
244_L300_I0.8730.90
91_I107_K0.8730.90
255_L259_S0.8720.90
301_K332_D0.8710.90
42_K81_L0.8690.90
309_E312_S0.8660.90
38_D85_Y0.8660.90
315_I342_V0.8650.90
119_I143_L0.8600.89
102_R106_K0.8590.89
310_I313_S0.8500.89
308_A342_V0.8480.89
312_S341_S0.8470.89
251_I254_K0.8430.88
189_K352_Y0.8430.88
124_E142_K0.8380.88
165_I169_P0.8300.88
39_S43_A0.8300.88
361_I365_D0.8280.88
52_I112_G0.8280.88
169_P174_S0.8280.88
301_K329_V0.8260.87
234_E291_E0.8180.87
119_I164_S0.8160.87
13_D17_K0.8160.87
303_I338_G0.8150.87
152_N158_A0.8140.87
29_V36_I0.8140.87
39_S361_I0.8080.86
71_D121_L0.8060.86
186_A375_V0.8010.86
49_K87_D0.7990.86
35_I81_L0.7940.85
62_S157_T0.7920.85
242_M290_E0.7910.85
52_I58_V0.7910.85
237_S280_Y0.7890.85
48_I58_V0.7880.85
117_D121_L0.7860.85
256_G259_S0.7850.85
345_A349_G0.7840.85
78_H115_L0.7830.85
34_K80_K0.7780.84
212_R215_E0.7760.84
329_V332_D0.7750.84
157_T162_Q0.7730.84
29_V33_G0.7720.84
248_N299_I0.7720.84
238_V244_L0.7710.84
149_I175_A0.7690.83
303_I307_T0.7660.83
194_E320_V0.7650.83
250_E253_E0.7650.83
95_D101_A0.7650.83
299_I332_D0.7650.83
286_G298_G0.7630.83
364_L374_K0.7630.83
103_E106_K0.7610.83
8_T12_I0.7600.83
35_I82_I0.7590.83
275_E310_I0.7560.82
105_I112_G0.7540.82
100_Y103_E0.7530.82
21_L58_V0.7530.82
278_V307_T0.7520.82
130_P167_G0.7500.82
104_M107_K0.7450.81
392_R400_S0.7430.81
14_I19_V0.7420.81
219_R223_A0.7390.81
96_V139_L0.7370.81
260_L274_I0.7320.80
218_V272_A0.7320.80
152_N157_T0.7320.80
174_S399_L0.7310.80
346_S374_K0.7310.80
7_P12_I0.7280.80
187_L191_F0.7280.80
69_D126_L0.7240.80
76_E79_A0.7230.79
343_L364_L0.7230.79
92_F104_M0.7230.79
152_N162_Q0.7220.79
69_D73_T0.7210.79
45_I49_K0.7200.79
355_I374_K0.7190.79
142_K145_P0.7180.79
51_L151_I0.7160.79
218_V264_A0.7160.79
289_I294_S0.7160.79
41_I81_L0.7150.79
91_I108_L0.7140.79
376_H384_L0.7130.79
25_I60_L0.7100.78
95_D122_I0.7070.78
126_L162_Q0.7060.78
53_N88_R0.7040.78
336_K366_E0.7030.78
102_R146_L0.7030.78
308_A345_A0.7010.77
361_I364_L0.7010.77
386_L391_E0.7000.77
6_I11_D0.6990.77
29_V77_E0.6970.77
214_I218_V0.6950.77
281_K337_S0.6950.77
176_A180_M0.6950.77
231_L249_M0.6940.77
91_I114_L0.6940.77
83_S88_R0.6920.76
355_I361_I0.6910.76
98_G101_A0.6910.76
14_I54_K0.6900.76
96_V124_E0.6900.76
265_R271_G0.6880.76
6_I12_I0.6870.76
15_Q54_K0.6860.76
319_K350_Q0.6850.76
166_V398_A0.6820.75
199_I314_F0.6820.75
312_S348_E0.6760.75
96_V119_I0.6750.75
202_L361_I0.6750.75
59_V114_L0.6730.74
62_S119_I0.6730.74
321_V349_G0.6690.74
182_R186_A0.6680.74
333_E337_S0.6680.74
208_H252_L0.6680.74
233_A280_Y0.6660.74
212_R391_E0.6650.74
101_A104_M0.6620.73
60_L113_I0.6610.73
360_M384_L0.6600.73
282_V287_N0.6580.73
323_L343_L0.6580.73
334_R337_S0.6570.73
200_F227_L0.6560.73
234_E299_I0.6550.72
10_D54_K0.6550.72
340_K366_E0.6490.72
47_T178_R0.6490.72
92_F119_I0.6490.72
80_K89_E0.6480.72
178_R181_E0.6470.72
251_I255_L0.6470.72
184_V188_A0.6460.71
215_E260_L0.6430.71
73_T119_I0.6430.71
263_R266_K0.6420.71
152_N398_A0.6400.71
116_L143_L0.6390.71
285_N298_G0.6390.71
273_P310_I0.6370.70
58_V113_I0.6360.70
253_E376_H0.6360.70
129_A140_V0.6340.70
36_I362_S0.6330.70
197_P320_V0.6320.70
33_G77_E0.6310.70
264_A271_G0.6290.69
255_L262_P0.6290.69
154_A162_Q0.6260.69
61_I116_L0.6260.69
374_K377_I0.6260.69
119_I165_I0.6260.69
156_A179_V0.6240.69
143_L164_S0.6230.69
283_E286_G0.6220.69
263_R270_S0.6220.69
326_P330_I0.6210.68
205_G209_D0.6210.68
231_L329_V0.6190.68
284_I332_D0.6170.68
17_K148_D0.6170.68
51_L172_L0.6150.68
227_L275_E0.6140.68
348_E373_S0.6120.67
289_I293_A0.6110.67
242_M280_Y0.6100.67
306_T310_I0.6090.67
14_I56_N0.6090.67
218_V226_I0.6080.67
18_K106_K0.6080.67
371_D377_I0.6060.67
175_A400_S0.6040.66
96_V101_A0.6030.66
216_N219_R0.6010.66
59_V146_L0.6010.66
303_I308_A0.5980.66
45_I79_A0.5960.65
197_P224_D0.5950.65
208_H232_V0.5940.65
353_V375_V0.5920.65
23_I35_I0.5910.65
362_S366_E0.5910.65
209_D214_I0.5900.65
52_I110_N0.5900.65
239_A257_I0.5890.64
198_K322_V0.5880.64
140_V168_F0.5860.64
124_E129_A0.5850.64
216_N390_G0.5830.64
73_T126_L0.5820.63
44_H156_A0.5800.63
150_Y169_P0.5790.63
256_G260_L0.5780.63
23_I61_I0.5770.63
315_I318_A0.5750.63
119_I122_I0.5750.63
316_K345_A0.5750.63
7_P11_D0.5750.63
398_A401_M0.5720.62
152_N169_P0.5710.62
97_I143_L0.5700.62
215_E256_G0.5680.62
161_S167_G0.5680.62
209_D361_I0.5660.61
23_I62_S0.5650.61
199_I317_D0.5650.61
97_I101_A0.5600.61
124_E143_L0.5590.60
68_G126_L0.5580.60
101_A105_I0.5550.60
64_Q73_T0.5550.60
150_Y398_A0.5540.60
228_T232_V0.5540.60
231_L332_D0.5540.60
347_L373_S0.5510.59
202_L209_D0.5510.59
186_A354_I0.5510.59
59_V105_I0.5500.59
345_A348_E0.5490.59
239_A254_K0.5480.59
73_T121_L0.5480.59
182_R376_H0.5480.59
98_G104_M0.5480.59
147_F168_F0.5470.59
330_I363_A0.5470.59
96_V142_K0.5470.59
224_D270_S0.5460.59
150_Y162_Q0.5450.58
234_E294_S0.5450.58
21_L151_I0.5440.58
186_A190_I0.5440.58
7_P173_P0.5410.58
82_I90_V0.5410.58
62_S154_A0.5410.58
19_V175_A0.5400.58
397_E401_M0.5400.58
8_T11_D0.5390.58
237_S291_E0.5380.57
233_A277_P0.5360.57
6_I400_S0.5360.57
128_E165_I0.5360.57
212_R389_S0.5360.57
48_I82_I0.5350.57
25_I62_S0.5350.57
303_I342_V0.5350.57
361_I377_I0.5340.57
254_K257_I0.5340.57
59_V108_L0.5340.57
266_K271_G0.5340.57
95_D116_L0.5330.57
314_F318_A0.5320.57
208_H320_V0.5310.57
6_I9_M0.5310.57
327_M368_M0.5300.56
57_S109_E0.5260.56
284_I288_V0.5230.55
186_A189_K0.5210.55
64_Q78_H0.5210.55
358_G382_G0.5200.55
14_I149_I0.5190.55
282_V286_G0.5190.55
106_K110_N0.5170.55
216_N220_K0.5170.55
195_D352_Y0.5170.55
215_E219_R0.5170.55
242_M291_E0.5170.55
303_I311_Y0.5150.54
127_I130_P0.5150.54
212_R253_E0.5150.54
83_S91_I0.5140.54
9_M181_E0.5130.54
279_D307_T0.5130.54
93_V96_V0.5130.54
42_K365_D0.5120.54
18_K148_D0.5120.54
233_A237_S0.5110.54
8_T185_S0.5110.54
341_S345_A0.5110.54
243_N298_G0.5100.54
45_I60_L0.5100.54
98_G102_R0.5100.54
188_A191_F0.5070.53
216_N391_E0.5060.53
226_I274_I0.5060.53
93_V122_I0.5060.53
232_V320_V0.5050.53
130_P141_K0.5040.53
166_V169_P0.5040.53
9_M151_I0.5040.53
180_M399_L0.5030.53
209_D253_E0.5030.53
44_H48_I0.5030.53
116_L122_I0.5030.53
165_I395_A0.5020.52
280_Y292_P0.5020.52
355_I384_L0.5020.52
97_I146_L0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1phpA 1 0.9436 100 0.004 Contact Map
2cunA 2 0.9608 100 0.007 Contact Map
1vpeA 1 0.9461 100 0.008 Contact Map
3q3vA 1 0.9387 100 0.011 Contact Map
1v6sA 1 0.9338 100 0.014 Contact Map
16pkA 1 0.9461 100 0.015 Contact Map
4ng4A 1 0.9338 100 0.017 Contact Map
1qpgA 1 0.9657 100 0.022 Contact Map
3zlbA 1 0.9363 100 0.023 Contact Map
2wzbA 1 0.9534 100 0.023 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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