GREMLIN Database
SAHH - Adenosylhomocysteinase
UniProt: P50252 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (412)
Sequences: 1874 (664)
Seq/√Len: 32.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_R386_E4.6301.00
301_V331_L4.4131.00
212_A255_I4.0121.00
300_D303_G3.8301.00
221_I268_A3.4921.00
209_A225_L3.3831.00
231_R251_D3.2791.00
47_S113_I3.2761.00
262_G265_F3.2201.00
39_K42_K3.1921.00
18_I57_A3.1471.00
263_D284_K3.1411.00
161_E375_K3.0471.00
134_H167_K3.0211.00
260_K282_N2.9641.00
265_F275_I2.9401.00
333_A342_A2.7801.00
34_R38_E2.6251.00
210_V262_G2.6061.00
368_N371_K2.6031.00
160_M165_V2.5471.00
233_I253_M2.5441.00
404_E408_E2.5241.00
363_E367_K2.5051.00
305_K311_V2.4951.00
111_E136_K2.3840.99
313_N319_D2.3760.99
311_V321_Y2.3710.99
290_S338_V2.3640.99
36_K65_I2.3290.99
210_V235_T2.3220.99
257_E398_Q2.3190.99
361_A379_M2.3170.99
272_T405_E2.3130.99
115_K137_V2.3020.99
214_Y248_D2.2980.99
265_F287_A2.2720.99
277_V281_L2.2580.99
102_N105_E2.2260.99
5_I8_L2.2010.99
235_T400_D2.1950.99
45_N69_N2.1870.99
255_I258_A2.1870.99
44_I120_N2.1540.99
44_I366_V2.1460.99
34_R363_E2.1030.98
312_R320_E2.1020.98
273_K405_E2.0820.98
121_I362_V2.0340.98
259_S265_F2.0250.98
281_L325_N2.0000.98
265_F283_M1.9910.98
108_S112_S1.9900.98
194_D198_R1.9100.97
320_E328_R1.8810.97
364_Y372_L1.8700.97
379_M383_L1.8660.97
273_K300_D1.8470.96
276_R279_H1.8460.96
78_L334_D1.8220.96
146_G170_L1.7880.96
110_I132_Y1.7650.95
5_I89_V1.7420.95
17_Q83_D1.7250.95
4_K108_S1.7130.94
193_I225_L1.7080.94
73_A113_I1.7060.94
141_L167_K1.7050.94
111_E137_V1.6880.94
31_I356_A1.6380.93
35_F66_G1.6370.93
146_G168_Y1.6180.93
15_K61_K1.6160.92
35_F65_I1.6140.92
212_A235_T1.6130.92
21_A58_A1.6010.92
138_S167_K1.5920.92
196_I338_V1.5730.91
262_G287_A1.5630.91
176_A379_M1.5490.91
133_I143_I1.5390.90
3_Y8_L1.5350.90
66_G359_A1.5200.90
193_I228_M1.5190.90
373_E377_Y1.5190.90
333_A338_V1.5160.90
256_A278_E1.5100.90
310_K322_T1.4960.89
135_E138_S1.4960.89
407_K411_E1.4850.89
45_N120_N1.4830.89
33_K37_A1.4710.88
285_D328_R1.4590.88
39_K65_I1.4500.88
193_I204_I1.4460.87
22_E61_K1.4420.87
255_I259_S1.4400.87
98_W109_N1.4390.87
112_S115_K1.4360.87
305_K321_Y1.4240.87
277_V303_G1.4210.87
214_Y250_F1.4130.86
202_I288_I1.4100.86
323_L327_K1.4070.86
254_P257_E1.3900.85
289_L329_V1.3870.85
111_E132_Y1.3840.85
204_I228_M1.3790.85
238_D241_R1.3770.85
233_I261_V1.3750.85
259_S262_G1.3730.85
208_I231_R1.3720.85
276_R300_D1.3680.84
193_I209_A1.3620.84
257_E260_K1.3600.84
195_G199_A1.3500.84
4_K98_W1.3460.83
185_R248_D1.3410.83
64_K93_I1.3410.83
66_G363_E1.3310.83
13_E17_Q1.3300.83
130_H170_L1.3180.82
235_T255_I1.3170.82
277_V306_E1.2970.81
223_N248_D1.2960.81
320_E330_Y1.2860.80
208_I233_I1.2810.80
121_I147_T1.2780.80
178_T357_N1.2770.80
381_M385_Y1.2710.80
156_R159_A1.2550.79
210_V255_I1.2500.78
38_E367_K1.2470.78
48_A72_L1.2470.78
280_M329_V1.2450.78
192_A292_A1.2440.78
204_I230_A1.2440.78
398_Q401_E1.2380.78
389_R401_E1.2270.77
23_R285_D1.2260.77
111_E115_K1.2250.77
254_P258_A1.2110.76
35_F359_A1.2100.76
280_M289_L1.2090.76
4_K109_N1.2090.76
303_G307_T1.1950.75
144_Y369_R1.1920.75
199_A342_A1.1870.75
22_E32_R1.1860.75
13_E83_D1.1780.74
271_N410_L1.1780.74
273_K276_R1.1760.74
266_V338_V1.1750.74
30_E33_K1.1740.74
17_Q54_K1.1690.74
73_A110_I1.1690.74
253_M258_A1.1600.73
41_L362_V1.1570.73
302_K331_L1.1550.73
281_L323_L1.1520.72
49_V110_I1.1460.72
361_A383_L1.1460.72
41_L66_G1.1450.72
404_E414_K1.1440.72
190_Q194_D1.1410.72
202_I207_K1.1380.72
256_A282_N1.1370.71
30_E393_K1.1230.71
177_Y240_I1.1230.71
266_V290_S1.1220.70
121_I365_L1.1180.70
386_E389_R1.1130.70
99_K317_Y1.1100.70
272_T297_V1.1020.69
46_I63_L1.0890.68
86_A89_V1.0870.68
208_I251_D1.0850.68
255_I265_F1.0760.67
275_I283_M1.0760.67
401_E407_K1.0730.67
404_E407_K1.0680.67
12_S90_E1.0680.67
312_R322_T1.0600.66
374_K377_Y1.0590.66
357_N387_V1.0580.66
190_Q197_L1.0450.65
108_S111_E1.0440.65
120_N123_M1.0440.65
254_P398_Q1.0400.65
127_A170_L1.0390.64
8_L89_V1.0390.64
255_I279_H1.0350.64
98_W102_N1.0310.64
256_A279_H1.0310.64
286_G320_E1.0290.64
171_V361_A1.0280.64
6_K98_W1.0250.63
61_K91_E1.0230.63
204_I264_I1.0200.63
122_V168_Y1.0200.63
4_K112_S1.0140.63
209_A266_V1.0090.62
24_H349_E1.0080.62
277_V307_T1.0050.62
185_R244_E1.0010.61
73_A129_L0.9960.61
301_V305_K0.9940.61
107_Y416_G0.9870.60
106_Y128_D0.9830.60
55_E348_S0.9790.60
211_V221_I0.9780.60
15_K91_E0.9770.60
321_Y331_L0.9760.60
262_G275_I0.9670.59
71_A96_F0.9630.58
15_K90_E0.9610.58
197_L228_M0.9600.58
255_I262_G0.9550.58
176_A361_A0.9550.58
85_A95_V0.9550.58
60_V72_L0.9510.58
177_Y180_Y0.9500.57
137_V141_L0.9420.57
408_E414_K0.9400.57
251_D261_V0.9380.56
32_R62_T0.9330.56
275_I280_M0.9330.56
122_V133_I0.9280.56
13_E316_P0.9280.56
144_Y365_L0.9260.55
152_T337_L0.9210.55
151_T174_N0.9190.55
113_I129_L0.9180.55
211_V225_L0.9120.54
393_K398_Q0.9080.54
223_N226_R0.9080.54
98_W108_S0.9060.54
154_V171_V0.9020.53
198_R344_E0.9000.53
58_A61_K0.9000.53
209_A264_I0.8930.53
311_V319_D0.8890.52
123_M147_T0.8890.52
216_W244_E0.8870.52
18_I87_A0.8860.52
106_Y354_S0.8850.52
178_T243_L0.8810.52
32_R65_I0.8800.52
188_T292_A0.8780.52
47_S117_H0.8780.52
98_W105_E0.8760.51
123_M154_V0.8750.51
207_K264_I0.8740.51
210_V265_F0.8730.51
246_V397_I0.8710.51
210_V233_I0.8690.51
147_T366_V0.8690.51
311_V334_D0.8680.51
70_V93_I0.8670.51
49_V73_A0.8650.50
130_H146_G0.8630.50
17_Q55_E0.8620.50
96_F117_H0.8600.50
301_V321_Y0.8600.50
255_I275_I0.8590.50
385_Y389_R0.8580.50
5_I9_S0.8570.50
350_V357_N0.8410.48
161_E374_K0.8350.48
71_A117_H0.8340.48
44_I121_I0.8310.48
148_E153_G0.8300.48
141_L168_Y0.8290.47
22_E29_M0.8280.47
8_L90_E0.8220.47
364_Y368_N0.8220.47
309_V323_L0.8170.46
52_V60_V0.8140.46
48_A60_V0.8110.46
352_D391_K0.8080.46
281_L327_K0.8070.46
254_P400_D0.8040.45
402_L410_L0.8020.45
177_Y238_D0.8000.45
23_R286_G0.7980.45
52_V72_L0.7980.45
133_I140_K0.7940.45
300_D306_E0.7940.45
18_I58_A0.7930.44
190_Q224_R0.7860.44
276_R281_L0.7850.44
221_I292_A0.7800.43
277_V280_M0.7800.43
262_G283_M0.7780.43
28_L59_L0.7760.43
54_K83_D0.7750.43
30_E390_I0.7720.43
40_P66_G0.7700.43
195_G198_R0.7690.43
7_D10_L0.7680.42
54_K344_E0.7670.42
101_E109_N0.7630.42
171_V237_V0.7580.42
53_T348_S0.7570.42
89_V96_F0.7550.41
60_V88_L0.7550.41
208_I261_V0.7540.41
34_R389_R0.7540.41
351_M358_Q0.7540.41
246_V395_M0.7540.41
351_M355_F0.7530.41
144_Y366_V0.7510.41
403_T410_L0.7510.41
87_A91_E0.7500.41
135_E160_M0.7500.41
278_E281_L0.7490.41
31_I359_A0.7470.41
359_A363_E0.7460.41
37_A142_D0.7460.41
128_D294_H0.7450.41
253_M398_Q0.7420.40
364_Y367_K0.7410.40
76_N128_D0.7390.40
325_N328_R0.7380.40
248_D333_A0.7350.40
46_I366_V0.7350.40
115_K139_S0.7340.40
149_E351_M0.7330.40
171_V255_I0.7330.40
221_I224_R0.7320.40
392_L397_I0.7310.39
22_E58_A0.7310.39
303_G331_L0.7280.39
237_V400_D0.7260.39
51_H294_H0.7260.39
309_V327_K0.7250.39
52_V55_E0.7250.39
318_V332_L0.7250.39
279_H283_M0.7230.39
54_K315_R0.7220.39
391_K395_M0.7200.39
137_V140_K0.7190.39
233_I258_A0.7180.38
127_A146_G0.7180.38
158_K389_R0.7170.38
134_H141_L0.7150.38
171_V364_Y0.7130.38
55_E343_A0.7110.38
296_N301_V0.7090.38
55_E344_E0.7090.38
337_L346_H0.7060.38
152_T294_H0.7050.37
5_I256_A0.7050.37
154_V376_V0.7050.37
15_K32_R0.7020.37
53_T344_E0.7010.37
11_A90_E0.7000.37
38_E363_E0.6990.37
401_E415_S0.6990.37
114_V137_V0.6970.37
162_K408_E0.6960.37
193_I197_L0.6960.37
212_A274_A0.6960.37
51_H79_S0.6950.37
32_R61_K0.6930.37
258_A262_G0.6930.37
212_A273_K0.6920.36
254_P401_E0.6920.36
48_A53_T0.6910.36
280_M283_M0.6910.36
345_G351_M0.6860.36
45_N117_H0.6850.36
197_L286_G0.6840.36
5_I168_Y0.6830.36
263_D286_G0.6810.36
142_D373_E0.6790.35
393_K411_E0.6780.35
322_T328_R0.6750.35
281_L306_E0.6740.35
302_K305_K0.6730.35
185_R223_N0.6730.35
115_K140_K0.6720.35
103_E129_L0.6710.35
217_V268_A0.6700.35
190_Q205_A0.6700.35
172_A376_V0.6650.34
128_D149_E0.6630.34
408_E412_Q0.6620.34
219_R296_N0.6620.34
53_T349_E0.6570.34
32_R36_K0.6570.34
294_H337_L0.6550.34
336_R340_L0.6550.34
233_I251_D0.6530.33
34_R403_T0.6520.33
276_R368_N0.6470.33
16_K312_R0.6430.33
176_A387_V0.6430.33
121_I366_V0.6430.33
29_M58_A0.6420.33
193_I224_R0.6420.33
197_L290_S0.6410.33
307_T323_L0.6410.33
313_N334_D0.6400.33
134_H168_Y0.6390.32
42_K118_E0.6380.32
346_H355_F0.6370.32
176_A216_W0.6350.32
38_E66_G0.6350.32
51_H337_L0.6340.32
196_I290_S0.6340.32
51_H76_N0.6330.32
264_I329_V0.6310.32
209_A221_I0.6290.32
254_P260_K0.6290.32
76_N80_T0.6280.32
27_T352_D0.6280.32
345_G355_F0.6280.32
257_E282_N0.6270.32
324_P327_K0.6270.32
13_E16_K0.6270.32
281_L324_P0.6270.32
346_H351_M0.6260.32
274_A329_V0.6250.31
3_Y90_E0.6250.31
288_I379_M0.6250.31
59_L359_A0.6250.31
140_K143_I0.6240.31
32_R162_K0.6230.31
180_Y216_W0.6210.31
200_T267_T0.6210.31
69_N325_N0.6210.31
154_V318_V0.6200.31
353_M356_A0.6190.31
97_A350_V0.6180.31
190_Q228_M0.6170.31
302_K306_E0.6160.31
121_I143_I0.6150.31
114_V133_I0.6130.31
99_K318_V0.6120.31
128_D156_R0.6110.30
219_R268_A0.6100.30
34_R360_L0.6090.30
64_K91_E0.6090.30
205_A338_V0.6090.30
105_E349_E0.6090.30
210_V259_S0.6070.30
21_A52_V0.6050.30
12_S16_K0.6040.30
337_L340_L0.6040.30
48_A75_S0.6030.30
267_T291_N0.6020.30
9_S162_K0.6020.30
29_M33_K0.6010.30
106_Y295_F0.6000.30
143_I365_L0.6000.30
176_A190_Q0.6000.30
407_K412_Q0.6000.30
142_D381_M0.6000.30
29_M32_R0.5990.30
110_I129_L0.5980.30
31_I363_E0.5980.30
158_K175_N0.5970.29
212_A258_A0.5960.29
190_Q338_V0.5960.29
241_R263_D0.5950.29
199_A333_A0.5950.29
130_H217_V0.5940.29
160_M167_K0.5920.29
27_T391_K0.5920.29
58_A62_T0.5920.29
55_E350_V0.5920.29
196_I332_L0.5910.29
401_E414_K0.5890.29
26_P239_P0.5870.29
379_M387_V0.5870.29
52_V199_A0.5860.29
220_G294_H0.5850.29
177_Y381_M0.5850.29
4_K96_F0.5820.28
149_E358_Q0.5820.28
214_Y223_N0.5820.28
210_V253_M0.5820.28
65_I91_E0.5820.28
407_K410_L0.5800.28
307_T324_P0.5800.28
109_N112_S0.5790.28
9_S408_E0.5770.28
294_H340_L0.5760.28
60_V123_M0.5750.28
161_E377_Y0.5740.28
133_I141_L0.5740.28
64_K70_V0.5730.28
365_L383_L0.5720.28
131_A167_K0.5710.28
243_L391_K0.5700.28
149_E354_S0.5700.28
34_R368_N0.5700.28
21_A348_S0.5700.28
277_V300_D0.5690.28
147_T154_V0.5690.28
161_E214_Y0.5690.28
11_A89_V0.5680.28
256_A276_R0.5670.27
6_K375_K0.5670.27
143_I168_Y0.5660.27
104_T108_S0.5660.27
280_M307_T0.5650.27
286_G328_R0.5650.27
28_L62_T0.5640.27
47_S111_E0.5640.27
97_A154_V0.5640.27
74_G349_E0.5620.27
290_S342_A0.5610.27
53_T357_N0.5610.27
129_L140_K0.5600.27
291_N294_H0.5600.27
6_K102_N0.5590.27
122_V129_L0.5590.27
185_R216_W0.5580.27
364_Y380_P0.5570.27
172_A342_A0.5560.27
132_Y138_S0.5560.27
176_A378_N0.5560.27
38_E65_I0.5560.27
301_V360_L0.5550.27
125_D183_D0.5540.27
76_N294_H0.5540.27
386_E390_I0.5540.27
49_V131_A0.5540.27
202_I264_I0.5530.27
58_A178_T0.5520.26
144_Y257_E0.5520.26
136_K140_K0.5520.26
128_D354_S0.5520.26
152_T346_H0.5500.26
259_S297_V0.5500.26
63_L354_S0.5500.26
151_T346_H0.5470.26
79_S157_L0.5460.26
50_L123_M0.5460.26
312_R328_R0.5440.26
151_T345_G0.5440.26
147_T362_V0.5430.26
278_E303_G0.5430.26
281_L307_T0.5420.26
7_D11_A0.5410.26
360_L386_E0.5400.26
8_L11_A0.5400.26
192_A221_I0.5400.26
162_K411_E0.5400.26
159_A163_D0.5380.26
277_V324_P0.5380.26
199_A318_V0.5380.26
374_K386_E0.5370.26
289_L408_E0.5360.25
258_A261_V0.5360.25
354_S362_V0.5350.25
212_A282_N0.5350.25
221_I266_V0.5350.25
155_I410_L0.5350.25
103_E110_I0.5340.25
42_K69_N0.5330.25
136_K393_K0.5320.25
58_A101_E0.5320.25
123_M362_V0.5320.25
41_L63_L0.5310.25
296_N346_H0.5300.25
209_A306_E0.5300.25
219_R240_I0.5290.25
125_D182_F0.5290.25
174_N182_F0.5290.25
102_N168_Y0.5280.25
185_R333_A0.5280.25
385_Y407_K0.5250.25
241_R244_E0.5250.25
76_N106_Y0.5240.25
104_T211_V0.5240.25
226_R307_T0.5230.25
97_A182_F0.5230.25
274_A297_V0.5230.25
361_A381_M0.5220.25
340_L345_G0.5220.25
114_V140_K0.5210.25
102_N132_Y0.5210.25
59_L149_E0.5210.25
404_E415_S0.5190.24
23_R328_R0.5190.24
296_N302_K0.5180.24
257_E261_V0.5180.24
54_K357_N0.5180.24
53_T350_V0.5170.24
103_E168_Y0.5140.24
41_L363_E0.5130.24
196_I266_V0.5130.24
408_E413_W0.5130.24
84_V315_R0.5130.24
118_E139_S0.5120.24
364_Y382_E0.5110.24
197_L204_I0.5090.24
49_V107_Y0.5090.24
163_D282_N0.5090.24
209_A230_A0.5080.24
274_A410_L0.5070.24
211_V266_V0.5070.24
151_T187_G0.5070.24
393_K396_G0.5070.24
25_M128_D0.5060.24
46_I115_K0.5040.23
163_D413_W0.5030.23
42_K90_E0.5030.23
103_E131_A0.5030.23
393_K404_E0.5020.23
58_A99_K0.5020.23
382_E389_R0.5020.23
62_T65_I0.5010.23
51_H291_N0.5010.23
104_T142_D0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ce6A 4 1 100 0.329 Contact Map
1v8bA 4 1 100 0.338 Contact Map
3d64A 4 0.9952 100 0.34 Contact Map
4lvcA 4 0.9952 100 0.341 Contact Map
3gvpA 4 0.9976 100 0.351 Contact Map
3h9uA 5 0.9976 100 0.375 Contact Map
3ondA 4 1 100 0.376 Contact Map
3x2fA 4 0.9736 100 0.397 Contact Map
1ygyA 4 0.7794 99.8 0.874 Contact Map
3fr7A 2 0.5851 99.8 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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