GREMLIN Database
RS12 - 30S ribosomal protein S12
UniProt: P39573 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (138)
Sequences: 229 (119)
Seq/√Len: 10.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_V105_I5.1531.00
58_V85_T3.4810.97
27_Q30_Y3.3260.96
132_V145_P3.2820.96
136_A141_K3.1750.95
72_C122_V2.8270.90
74_R88_V2.3660.80
135_D139_K2.3010.78
34_I84_V2.2000.75
13_A17_R1.9220.64
31_K35_L1.8770.62
100_H108_I1.8450.61
75_V105_I1.8260.60
45_G51_R1.7900.58
90_G93_G1.7600.57
47_A84_V1.7540.57
87_F91_D1.7500.57
44_L105_I1.7280.56
105_I126_V1.6670.53
59_G69_V1.5980.50
55_L139_K1.5830.49
68_A136_A1.5780.49
26_S38_K1.5680.48
34_I41_Y1.5550.48
46_G52_G1.5450.47
44_L49_M1.5100.46
62_S69_V1.4800.44
64_Q107_G1.4610.43
28_R112_L1.4260.42
39_E42_D1.4210.42
21_L97_I1.4000.41
62_S119_L1.3740.40
116_M119_L1.3680.39
86_A91_D1.3570.39
19_K23_F1.3370.38
135_D141_K1.3250.37
63_R143_Q1.3210.37
64_Q67_S1.2910.36
104_I125_K1.2800.36
25_R31_K1.2650.35
41_Y78_V1.2620.35
27_Q32_T1.2600.35
28_R48_P1.2510.34
76_Q79_R1.2500.34
124_Y135_D1.2300.33
119_L125_K1.2280.33
99_E102_E1.2080.33
15_K96_F1.1950.32
83_V108_I1.1660.31
75_V80_N1.1660.31
40_K99_E1.1320.30
21_L32_T1.1190.29
142_K145_P1.1180.29
138_Y141_K1.1130.29
124_Y128_M1.1070.29
23_F26_S1.1070.29
100_H130_N1.1060.29
125_K139_K1.0980.28
81_G143_Q1.0960.28
98_D116_M1.0770.27
76_Q80_N1.0750.27
77_L80_N1.0430.26
60_I140_G1.0300.26
88_V93_G1.0290.26
88_V94_V1.0260.26
123_R129_V1.0200.25
27_Q49_M1.0180.25
13_A74_R1.0160.25
133_S136_A1.0100.25
49_M63_R1.0080.25
81_G142_K0.9980.25
95_N119_L0.9850.24
82_R111_T0.9780.24
74_R105_I0.9700.24
51_R83_V0.9700.24
91_D117_G0.9700.24
98_D138_Y0.9630.23
66_N118_D0.9580.23
116_M130_N0.9550.23
14_R21_L0.9460.23
93_G138_Y0.9440.23
84_V91_D0.9430.23
94_V98_D0.9410.23
83_V100_H0.9180.22
100_H116_M0.9100.22
61_E64_Q0.9070.22
70_R118_D0.9050.22
26_S29_K0.8990.21
10_I35_L0.8940.21
48_P51_R0.8910.21
93_G143_Q0.8880.21
28_R115_S0.8840.21
21_L124_Y0.8810.21
98_D137_L0.8790.21
112_L115_S0.8740.21
137_L143_Q0.8730.21
111_T123_R0.8700.21
52_G120_P0.8580.20
106_T125_K0.8490.20
104_I108_I0.8470.20
49_M128_M0.8440.20
19_K33_K0.8420.20
44_L126_V0.8410.20
75_V131_G0.8320.19
72_C80_N0.8040.19
43_P82_R0.7920.18
45_G55_L0.7910.18
7_P11_Y0.7900.18
30_Y68_A0.7860.18
12_A33_K0.7740.18
60_I84_V0.7720.18
9_G13_A0.7710.18
50_A89_P0.7690.18
76_Q128_M0.7660.18
38_K42_D0.7630.18
46_G53_I0.7610.17
73_V107_G0.7600.17
129_V134_L0.7580.17
21_L27_Q0.7560.17
80_N123_R0.7520.17
62_S118_D0.7500.17
101_D113_G0.7470.17
67_S107_G0.7450.17
128_M132_V0.7450.17
56_E142_K0.7370.17
133_S140_G0.7360.17
109_G118_D0.7310.17
43_P72_C0.7250.17
32_T83_V0.7240.17
96_F137_L0.7230.16
92_G117_G0.7220.16
92_G95_N0.7220.16
53_I58_V0.7110.16
68_A76_Q0.7100.16
20_R25_R0.7080.16
23_F139_K0.7070.16
49_M106_T0.7020.16
43_P79_R0.6990.16
42_D105_I0.6960.16
77_L121_G0.6930.16
9_G56_E0.6910.16
31_K37_L0.6810.15
55_L74_R0.6770.15
52_G122_V0.6730.15
37_L130_N0.6720.15
108_I141_K0.6670.15
13_A76_Q0.6660.15
10_I37_L0.6640.15
93_G100_H0.6610.15
37_L100_H0.6610.15
130_N140_G0.6540.15
61_E72_C0.6540.15
16_L92_G0.6510.15
12_A18_L0.6510.15
82_R88_V0.6500.15
10_I31_K0.6490.15
42_D114_R0.6420.15
62_S68_A0.6420.15
30_Y62_S0.6410.15
63_R69_V0.6340.14
36_K68_A0.6210.14
94_V97_I0.6210.14
38_K41_Y0.6190.14
18_L95_N0.6190.14
9_G20_R0.6190.14
47_A133_S0.6170.14
133_S142_K0.6160.14
11_Y55_L0.6150.14
51_R78_V0.6010.14
73_V102_E0.5990.14
11_Y48_P0.5990.14
45_G131_G0.5970.14
78_V132_V0.5920.13
35_L53_I0.5910.13
93_G108_I0.5900.13
21_L72_C0.5880.13
102_E113_G0.5830.13
37_L42_D0.5740.13
58_V138_Y0.5670.13
37_L45_G0.5640.13
12_A21_L0.5630.13
39_E45_G0.5600.13
54_V73_V0.5580.13
133_S141_K0.5570.13
115_S126_V0.5550.13
93_G96_F0.5520.13
63_R116_M0.5520.13
59_G132_V0.5490.13
18_L41_Y0.5480.13
20_R54_V0.5460.12
16_L54_V0.5440.12
22_K42_D0.5430.12
7_P10_I0.5420.12
44_L140_G0.5410.12
35_L139_K0.5410.12
36_K97_I0.5370.12
10_I128_M0.5350.12
46_G122_V0.5330.12
79_R82_R0.5270.12
44_L48_P0.5220.12
68_A72_C0.5220.12
120_P145_P0.5190.12
62_S70_R0.5180.12
63_R66_N0.5140.12
107_G134_L0.5070.12
27_Q111_T0.5020.12
22_K29_K0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j20N 1 0.9864 100 0.213 Contact Map
3zeyS 1 0.966 100 0.22 Contact Map
4ujpY 1 0.9796 100 0.224 Contact Map
4bpeL 1 0.9524 100 0.237 Contact Map
5aj3L 1 0.7007 100 0.59 Contact Map
4ji1L 1 0.7755 100 0.596 Contact Map
4rb5L 1 0.7823 100 0.598 Contact Map
2vawA 1 0.3333 9.7 0.967 Contact Map
2vxyA 2 0.2789 8.6 0.968 Contact Map
1ofuA 1 0.2857 8.5 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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