GREMLIN Database
G3P - Glyceraldehyde-3-phosphate dehydrogenase
UniProt: P39460 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 340 (333)
Sequences: 270 (179)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_A116_D4.7761.00
147_T294_L4.6361.00
24_P327_I4.5481.00
5_A78_S4.2360.99
5_A81_V4.1520.99
6_V28_L3.9510.99
4_V80_I3.5660.97
2_I318_L3.5190.97
94_K98_L3.4230.96
161_R291_E3.2680.95
134_I315_S3.1900.94
74_L78_S3.1600.94
147_T240_L3.0590.93
319_M323_D2.9780.92
29_V74_L2.6440.86
246_I280_I2.5990.85
151_V211_V2.5540.84
122_L243_T2.5410.84
181_S259_A2.3800.80
320_S323_D2.2960.77
180_N184_P2.2910.77
5_A74_L2.2900.77
227_L292_V2.2110.74
159_K226_T2.1930.74
278_V296_Y2.1790.73
148_I157_V2.1790.73
262_V266_R2.1150.71
54_Q72_E2.0120.67
106_F133_Y1.9830.66
18_D46_R1.9580.65
88_G92_Q1.8820.61
121_A324_S1.8720.61
237_L285_I1.8550.60
14_K263_E1.8410.60
50_I275_I1.8400.60
147_T278_V1.8040.58
31_V261_L1.7680.56
144_L296_Y1.7610.56
189_V212_I1.7360.55
193_H218_M1.7300.55
143_A298_V1.7300.55
22_K331_S1.6960.53
252_K334_I1.6880.53
72_E99_Q1.6710.52
174_V260_E1.6420.51
148_I231_V1.6390.51
33_K193_H1.6390.51
29_V78_S1.6130.49
158_E228_K1.6110.49
250_S282_S1.5990.49
90_G176_K1.5970.49
158_E323_D1.5930.48
180_N217_L1.5880.48
241_E282_S1.5820.48
81_V288_K1.5770.48
6_V78_S1.5730.48
14_K267_D1.5710.47
6_V264_V1.5650.47
184_P281_F1.5570.47
90_G308_N1.5530.47
152_N329_N1.5530.47
322_E326_R1.4980.44
20_I264_V1.4940.44
78_S102_R1.4940.44
74_L273_N1.4930.44
28_L48_I1.4880.44
168_A178_P1.4830.43
42_I235_D1.4790.43
10_G13_G1.4750.43
133_Y316_M1.4480.42
240_L294_L1.4460.42
55_Q267_D1.4370.41
81_V203_N1.4370.41
2_I80_I1.4360.41
33_K218_M1.4250.41
148_I160_V1.4200.41
151_V225_I1.4190.41
326_R330_E1.3850.39
72_E234_K1.3740.39
183_V291_E1.3660.38
158_E226_T1.3660.38
278_V303_I1.3590.38
8_G13_G1.3550.38
60_F218_M1.3400.37
163_T224_N1.3370.37
75_I102_R1.3360.37
82_V312_I1.3310.37
144_L223_I1.3210.36
134_I320_S1.3130.36
23_Q26_M1.3090.36
44_H66_P1.3040.36
28_L120_S1.3030.36
130_G317_K1.2970.35
77_T241_E1.2930.35
173_E303_I1.2880.35
118_S137_V1.2870.35
26_M313_R1.2810.35
302_S331_S1.2630.34
267_D276_P1.2490.33
24_P261_L1.2470.33
220_M297_A1.2410.33
238_S329_N1.2390.33
58_K61_E1.2370.33
278_V298_V1.2320.33
112_A194_A1.2220.32
80_I316_M1.2170.32
251_S283_D1.2080.32
120_S145_L1.2050.32
58_K70_T1.2050.32
233_K285_I1.1980.31
80_I311_A1.1900.31
240_L280_I1.1770.31
31_V44_H1.1650.30
50_I53_P1.1590.30
46_R95_P1.1580.30
31_V50_I1.1470.29
309_I331_S1.1430.29
180_N281_F1.1420.29
119_F208_T1.1400.29
72_E89_V1.1360.29
113_E316_M1.1360.29
147_T223_I1.1330.29
50_I249_I1.1310.29
182_L213_A1.1230.29
93_Y164_I1.1100.28
144_L148_I1.1080.28
296_Y303_I1.1070.28
148_I162_A1.1050.28
73_D101_Q1.1030.28
129_L317_K1.1020.28
157_V228_K1.0980.28
276_P293_M1.0980.28
194_A293_M1.0960.28
185_D283_D1.0860.27
226_T290_D1.0760.27
8_G12_I1.0700.27
60_F300_Q1.0670.27
33_K60_F1.0660.27
211_V220_M1.0630.26
58_K101_Q1.0600.26
250_S253_Y1.0590.26
84_T294_L1.0510.26
152_N203_N1.0460.26
19_A43_A1.0450.26
99_Q242_N1.0410.26
57_I234_K1.0360.25
145_L149_C1.0350.25
54_Q57_I1.0310.25
36_P300_Q1.0300.25
144_L297_A1.0280.25
4_V12_I1.0250.25
120_S123_C1.0230.25
112_A115_A1.0200.25
80_I249_I1.0170.25
148_I225_I1.0160.25
103_N132_K1.0130.25
82_V175_K1.0110.25
178_P299_H1.0100.25
218_M300_Q1.0070.24
96_I100_L1.0060.24
56_S228_K1.0060.24
287_V298_V1.0040.24
155_S239_V1.0040.24
262_V303_I0.9960.24
159_K291_E0.9950.24
313_R324_S0.9940.24
215_T258_T0.9920.24
91_A111_K0.9920.24
171_Q216_T0.9900.24
3_N182_L0.9870.24
225_I292_V0.9870.24
41_F50_I0.9830.24
266_R273_N0.9830.24
165_V295_M0.9790.24
249_I316_M0.9790.24
161_R183_V0.9740.23
327_I331_S0.9740.23
165_V209_M0.9740.23
173_E205_D0.9630.23
47_G267_D0.9620.23
229_D236_I0.9590.23
62_E229_D0.9530.23
147_T225_I0.9480.23
14_K19_A0.9470.23
2_I20_I0.9420.22
120_S149_C0.9360.22
218_M297_A0.9360.22
11_T218_M0.9350.22
14_K39_E0.9330.22
73_D232_E0.9320.22
188_T220_M0.9250.22
4_V10_G0.9220.22
4_V13_G0.9220.22
118_S135_R0.9210.22
182_L296_Y0.9200.22
318_L323_D0.9200.22
76_K100_L0.9190.22
163_T184_P0.9160.22
150_T233_K0.9130.21
116_D280_I0.9130.21
23_Q331_S0.9120.21
18_D21_I0.9060.21
243_T298_V0.9050.21
28_L331_S0.9020.21
16_V82_V0.8990.21
278_V294_L0.8960.21
76_K126_N0.8960.21
173_E210_A0.8960.21
215_T297_A0.8940.21
132_K164_I0.8930.21
9_Y17_A0.8930.21
188_T236_I0.8920.21
6_V45_R0.8880.21
150_T173_E0.8880.21
121_A309_I0.8870.21
248_L275_I0.8810.20
11_T300_Q0.8810.20
165_V289_D0.8800.20
48_I105_I0.8800.20
56_S235_D0.8760.20
22_K31_V0.8740.20
85_T174_V0.8720.20
215_T300_Q0.8660.20
16_V184_P0.8630.20
2_I211_V0.8610.20
225_I289_D0.8610.20
58_K62_E0.8580.20
124_N160_V0.8570.20
54_Q59_K0.8560.20
165_V261_L0.8540.20
266_R301_E0.8530.20
3_N62_E0.8530.20
223_I296_Y0.8520.20
221_H324_S0.8490.20
177_G216_T0.8460.19
20_I312_I0.8440.19
76_K132_K0.8370.19
16_V23_Q0.8340.19
258_T297_A0.8320.19
147_T182_L0.8320.19
251_S258_T0.8310.19
81_V125_Y0.8300.19
193_H297_A0.8290.19
42_I95_P0.8290.19
309_I332_L0.8220.19
150_T172_K0.8200.19
52_V169_A0.8180.19
180_N302_S0.8150.19
75_I78_S0.8050.18
162_A302_S0.8040.18
52_V62_E0.8030.18
46_R319_M0.8020.18
21_I68_A0.8010.18
77_T238_S0.7980.18
178_P284_S0.7960.18
151_V198_N0.7960.18
150_T246_I0.7950.18
126_N240_L0.7920.18
39_E197_V0.7910.18
218_M258_T0.7890.18
246_I262_V0.7860.18
7_N258_T0.7800.18
225_I318_L0.7780.18
124_N128_A0.7770.18
18_D48_I0.7730.17
114_V214_P0.7720.17
245_R277_E0.7700.17
21_I73_D0.7690.17
59_K238_S0.7680.17
131_K309_I0.7660.17
147_T334_I0.7590.17
60_F193_H0.7560.17
169_A212_I0.7560.17
284_S299_H0.7540.17
4_V8_G0.7500.17
3_N64_G0.7500.17
153_K242_N0.7490.17
32_A74_L0.7490.17
50_I234_K0.7450.17
39_E263_E0.7450.17
75_I233_K0.7440.17
193_H197_V0.7430.17
169_A211_V0.7430.17
205_D289_D0.7420.17
116_D257_A0.7410.17
74_L204_L0.7380.17
64_G287_V0.7370.17
169_A176_K0.7340.16
310_D313_R0.7340.16
67_V89_V0.7330.16
77_T94_K0.7320.16
233_K292_V0.7310.16
138_S196_D0.7310.16
182_L258_T0.7300.16
71_V206_I0.7260.16
35_S151_V0.7220.16
88_G100_L0.7190.16
187_A213_A0.7180.16
64_G76_K0.7160.16
87_N143_A0.7140.16
157_V298_V0.7130.16
238_S241_E0.7130.16
154_V234_K0.7090.16
38_Y180_N0.7080.16
123_C184_P0.7080.16
10_G15_R0.7060.16
33_K300_Q0.7050.16
73_D241_E0.7050.16
95_P157_V0.7040.16
29_V42_I0.7020.16
75_I81_V0.6990.16
195_K324_S0.6970.16
23_Q119_F0.6950.16
75_I101_Q0.6940.16
46_R275_I0.6940.16
3_N78_S0.6940.16
33_K36_P0.6920.15
42_I46_R0.6920.15
3_N81_V0.6910.15
41_F45_R0.6900.15
244_P266_R0.6900.15
190_P313_R0.6870.15
321_A329_N0.6840.15
229_D242_N0.6830.15
52_V322_E0.6810.15
31_V47_G0.6780.15
272_R284_S0.6780.15
34_T78_S0.6770.15
42_I280_I0.6760.15
261_L264_V0.6730.15
276_P334_I0.6720.15
126_N130_G0.6720.15
38_Y143_A0.6690.15
61_E70_T0.6670.15
141_T192_H0.6660.15
24_P165_V0.6640.15
29_V326_R0.6640.15
97_Y110_E0.6630.15
3_N24_P0.6610.15
159_K274_D0.6610.15
126_N234_K0.6590.15
259_A300_Q0.6570.15
20_I261_L0.6560.15
122_L244_P0.6560.15
147_T276_P0.6560.15
143_A296_Y0.6560.15
178_P295_M0.6550.15
130_G318_L0.6550.15
201_I302_S0.6540.15
157_V333_G0.6540.15
168_A179_I0.6500.14
55_Q95_P0.6500.14
163_T182_L0.6480.14
75_I229_D0.6460.14
183_V210_A0.6460.14
125_Y314_A0.6450.14
12_I15_R0.6450.14
130_G253_Y0.6410.14
59_K251_S0.6410.14
46_R132_K0.6410.14
37_N260_E0.6410.14
104_A272_R0.6390.14
161_R207_A0.6370.14
27_K202_R0.6370.14
203_N334_I0.6340.14
169_A179_I0.6340.14
207_A248_L0.6320.14
23_Q313_R0.6320.14
56_S182_L0.6290.14
35_S230_K0.6270.14
26_M324_S0.6250.14
121_A195_K0.6230.14
199_S280_I0.6230.14
198_N279_M0.6220.14
21_I46_R0.6210.14
75_I280_I0.6210.14
121_A221_H0.6210.14
283_D309_I0.6200.14
195_K226_T0.6200.14
241_E250_S0.6200.14
309_I325_M0.6180.14
206_I301_E0.6180.14
122_L201_I0.6160.14
221_H313_R0.6130.14
202_R295_M0.6130.14
128_A189_V0.6120.14
58_K236_I0.6090.14
125_Y280_I0.6080.14
80_I96_I0.6080.14
124_N274_D0.6070.14
178_P181_S0.6030.13
98_L315_S0.6030.13
54_Q321_A0.6000.13
49_R100_L0.6000.13
122_L163_T0.5950.13
70_T318_L0.5940.13
181_S258_T0.5940.13
3_N131_K0.5940.13
270_R277_E0.5930.13
37_N267_D0.5930.13
210_A215_T0.5930.13
262_V299_H0.5920.13
165_V211_V0.5920.13
22_K266_R0.5910.13
66_P94_K0.5890.13
32_A88_G0.5890.13
36_P90_G0.5880.13
89_V161_R0.5880.13
44_H50_I0.5860.13
255_A295_M0.5860.13
57_I61_E0.5850.13
99_Q330_E0.5850.13
82_V221_H0.5840.13
197_V206_I0.5840.13
2_I202_R0.5820.13
276_P294_L0.5810.13
66_P232_E0.5790.13
131_K201_I0.5790.13
148_I227_L0.5780.13
94_K99_Q0.5780.13
218_M299_H0.5770.13
45_R253_Y0.5760.13
40_A308_N0.5760.13
256_E260_E0.5760.13
95_P100_L0.5740.13
241_E323_D0.5730.13
250_S279_M0.5720.13
71_V74_L0.5710.13
21_I41_F0.5710.13
61_E66_P0.5700.13
33_K179_I0.5690.13
113_E319_M0.5690.13
68_A280_I0.5680.13
234_K256_E0.5680.13
109_G142_T0.5640.13
200_V234_K0.5630.13
54_Q63_S0.5630.13
153_K163_T0.5630.13
271_D322_E0.5610.13
35_S78_S0.5600.13
8_G15_R0.5600.13
193_H308_N0.5590.13
73_D79_D0.5590.13
120_S218_M0.5590.13
242_N318_L0.5580.13
87_N259_A0.5570.13
16_V324_S0.5560.12
16_V19_A0.5550.12
189_V255_A0.5540.12
85_T119_F0.5520.12
38_Y298_V0.5510.12
187_A240_L0.5500.12
121_A208_T0.5500.12
41_F253_Y0.5490.12
62_E280_I0.5460.12
299_H305_V0.5460.12
117_I169_A0.5450.12
119_F125_Y0.5440.12
101_Q280_I0.5440.12
73_D234_K0.5440.12
322_E330_E0.5430.12
156_K295_M0.5430.12
84_T334_I0.5420.12
262_V273_N0.5390.12
202_R278_V0.5380.12
72_E160_V0.5370.12
51_Y68_A0.5350.12
209_M260_E0.5300.12
26_M221_H0.5290.12
34_T74_L0.5290.12
94_K232_E0.5280.12
46_R323_D0.5270.12
161_R263_E0.5250.12
151_V238_S0.5210.12
15_R30_G0.5210.12
158_E322_E0.5200.12
89_V187_A0.5180.12
31_V143_A0.5180.12
87_N258_T0.5180.12
124_N206_I0.5150.12
68_A323_D0.5150.12
9_Y15_R0.5150.12
81_V295_M0.5140.12
234_K331_S0.5130.12
160_V223_I0.5110.12
62_E260_E0.5110.12
96_I130_G0.5100.12
91_A152_N0.5090.12
32_A68_A0.5080.12
309_I321_A0.5070.12
106_F329_N0.5050.12
71_V78_S0.5050.12
180_N306_P0.5030.11
134_I212_I0.5030.11
49_R82_V0.5020.11
199_S329_N0.5020.11
3_N238_S0.5020.11
261_L318_L0.5010.11
67_V130_G0.5010.11
118_S324_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cf2P 4 0.9824 100 0.54 Contact Map
2yyyA 2 0.9853 100 0.548 Contact Map
1b7gO 4 1 100 0.551 Contact Map
2czcA 4 0.9765 100 0.557 Contact Map
4dibA 4 0.8324 100 0.821 Contact Map
3docA 4 0.8647 99.9 0.827 Contact Map
3idsC 4 0.8824 99.9 0.827 Contact Map
3h9eO 4 0.8706 99.9 0.831 Contact Map
3hjaA 4 0.8588 99.9 0.833 Contact Map
4o59O 4 0.8706 99.9 0.834 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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