G3P - SULSO - GREMLIN Contacts

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G3P - Glyceraldehyde-3-phosphate dehydrogenase

UniProt:	P39460	Sequences: MINVAVNGYGTIGKRVADAIIKQPDMKLVGVAKTSPNYEAFIAHRRGIRIYVPQQSIKKFEESGIPVAGTVEDLIKTSDIVVDTTPNGVGAQYKPIYLQLQRNAIFQGGEKAEVADISFSALCNYNEALGKKYIRVVSCNTTALLRTICTVNKVSKVEKVRATIVRRAADQKEVKKGPINSLVPDPATVPSHHAKDVNSVIRNLDIATMAVIAPTTLMHMHFINITLKDKVEKKDILSVLENTPRIVLISSKYDAEATAELVEVARDLKRDRNDIPEVMIFSDSIYVKDDEVMLMYAVHQESIVVPENIDAIRASMKLMSAEDSMRITNESLGILKGYLI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	340 (333)
Sequences:	270 (179)
Seq/√Len:	9.8

HALSA - G3P
SULSO - G3P

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
112_A	116_D	4.776	1.00
147_T	294_L	4.636	1.00
24_P	327_I	4.548	1.00
5_A	78_S	4.236	0.99
5_A	81_V	4.152	0.99
6_V	28_L	3.951	0.99
4_V	80_I	3.566	0.97
2_I	318_L	3.519	0.97
94_K	98_L	3.423	0.96
161_R	291_E	3.268	0.95
134_I	315_S	3.190	0.94
74_L	78_S	3.160	0.94
147_T	240_L	3.059	0.93
319_M	323_D	2.978	0.92
29_V	74_L	2.644	0.86
246_I	280_I	2.599	0.85
151_V	211_V	2.554	0.84
122_L	243_T	2.541	0.84
181_S	259_A	2.380	0.80
320_S	323_D	2.296	0.77
180_N	184_P	2.291	0.77
5_A	74_L	2.290	0.77
227_L	292_V	2.211	0.74
159_K	226_T	2.193	0.74
278_V	296_Y	2.179	0.73
148_I	157_V	2.179	0.73
262_V	266_R	2.115	0.71
54_Q	72_E	2.012	0.67
106_F	133_Y	1.983	0.66
18_D	46_R	1.958	0.65
88_G	92_Q	1.882	0.61
121_A	324_S	1.872	0.61
237_L	285_I	1.855	0.60
14_K	263_E	1.841	0.60
50_I	275_I	1.840	0.60
147_T	278_V	1.804	0.58
31_V	261_L	1.768	0.56
144_L	296_Y	1.761	0.56
189_V	212_I	1.736	0.55
193_H	218_M	1.730	0.55
143_A	298_V	1.730	0.55
22_K	331_S	1.696	0.53
252_K	334_I	1.688	0.53
72_E	99_Q	1.671	0.52
174_V	260_E	1.642	0.51
148_I	231_V	1.639	0.51
33_K	193_H	1.639	0.51
29_V	78_S	1.613	0.49
158_E	228_K	1.611	0.49
250_S	282_S	1.599	0.49
90_G	176_K	1.597	0.49
158_E	323_D	1.593	0.48
180_N	217_L	1.588	0.48
241_E	282_S	1.582	0.48
81_V	288_K	1.577	0.48
6_V	78_S	1.573	0.48
14_K	267_D	1.571	0.47
6_V	264_V	1.565	0.47
184_P	281_F	1.557	0.47
90_G	308_N	1.553	0.47
152_N	329_N	1.553	0.47
322_E	326_R	1.498	0.44
20_I	264_V	1.494	0.44
78_S	102_R	1.494	0.44
74_L	273_N	1.493	0.44
28_L	48_I	1.488	0.44
168_A	178_P	1.483	0.43
42_I	235_D	1.479	0.43
10_G	13_G	1.475	0.43
133_Y	316_M	1.448	0.42
240_L	294_L	1.446	0.42
55_Q	267_D	1.437	0.41
81_V	203_N	1.437	0.41
2_I	80_I	1.436	0.41
33_K	218_M	1.425	0.41
148_I	160_V	1.420	0.41
151_V	225_I	1.419	0.41
326_R	330_E	1.385	0.39
72_E	234_K	1.374	0.39
183_V	291_E	1.366	0.38
158_E	226_T	1.366	0.38
278_V	303_I	1.359	0.38
8_G	13_G	1.355	0.38
60_F	218_M	1.340	0.37
163_T	224_N	1.337	0.37
75_I	102_R	1.336	0.37
82_V	312_I	1.331	0.37
144_L	223_I	1.321	0.36
134_I	320_S	1.313	0.36
23_Q	26_M	1.309	0.36
44_H	66_P	1.304	0.36
28_L	120_S	1.303	0.36
130_G	317_K	1.297	0.35
77_T	241_E	1.293	0.35
173_E	303_I	1.288	0.35
118_S	137_V	1.287	0.35
26_M	313_R	1.281	0.35
302_S	331_S	1.263	0.34
267_D	276_P	1.249	0.33
24_P	261_L	1.247	0.33
220_M	297_A	1.241	0.33
238_S	329_N	1.239	0.33
58_K	61_E	1.237	0.33
278_V	298_V	1.232	0.33
112_A	194_A	1.222	0.32
80_I	316_M	1.217	0.32
251_S	283_D	1.208	0.32
120_S	145_L	1.205	0.32
58_K	70_T	1.205	0.32
233_K	285_I	1.198	0.31
80_I	311_A	1.190	0.31
240_L	280_I	1.177	0.31
31_V	44_H	1.165	0.30
50_I	53_P	1.159	0.30
46_R	95_P	1.158	0.30
31_V	50_I	1.147	0.29
309_I	331_S	1.143	0.29
180_N	281_F	1.142	0.29
119_F	208_T	1.140	0.29
72_E	89_V	1.136	0.29
113_E	316_M	1.136	0.29
147_T	223_I	1.133	0.29
50_I	249_I	1.131	0.29
182_L	213_A	1.123	0.29
93_Y	164_I	1.110	0.28
144_L	148_I	1.108	0.28
296_Y	303_I	1.107	0.28
148_I	162_A	1.105	0.28
73_D	101_Q	1.103	0.28
129_L	317_K	1.102	0.28
157_V	228_K	1.098	0.28
276_P	293_M	1.098	0.28
194_A	293_M	1.096	0.28
185_D	283_D	1.086	0.27
226_T	290_D	1.076	0.27
8_G	12_I	1.070	0.27
60_F	300_Q	1.067	0.27
33_K	60_F	1.066	0.27
211_V	220_M	1.063	0.26
58_K	101_Q	1.060	0.26
250_S	253_Y	1.059	0.26
84_T	294_L	1.051	0.26
152_N	203_N	1.046	0.26
19_A	43_A	1.045	0.26
99_Q	242_N	1.041	0.26
57_I	234_K	1.036	0.25
145_L	149_C	1.035	0.25
54_Q	57_I	1.031	0.25
36_P	300_Q	1.030	0.25
144_L	297_A	1.028	0.25
4_V	12_I	1.025	0.25
120_S	123_C	1.023	0.25
112_A	115_A	1.020	0.25
80_I	249_I	1.017	0.25
148_I	225_I	1.016	0.25
103_N	132_K	1.013	0.25
82_V	175_K	1.011	0.25
178_P	299_H	1.010	0.25
218_M	300_Q	1.007	0.24
96_I	100_L	1.006	0.24
56_S	228_K	1.006	0.24
287_V	298_V	1.004	0.24
155_S	239_V	1.004	0.24
262_V	303_I	0.996	0.24
159_K	291_E	0.995	0.24
313_R	324_S	0.994	0.24
215_T	258_T	0.992	0.24
91_A	111_K	0.992	0.24
171_Q	216_T	0.990	0.24
3_N	182_L	0.987	0.24
225_I	292_V	0.987	0.24
41_F	50_I	0.983	0.24
266_R	273_N	0.983	0.24
165_V	295_M	0.979	0.24
249_I	316_M	0.979	0.24
161_R	183_V	0.974	0.23
327_I	331_S	0.974	0.23
165_V	209_M	0.974	0.23
173_E	205_D	0.963	0.23
47_G	267_D	0.962	0.23
229_D	236_I	0.959	0.23
62_E	229_D	0.953	0.23
147_T	225_I	0.948	0.23
14_K	19_A	0.947	0.23
2_I	20_I	0.942	0.22
120_S	149_C	0.936	0.22
218_M	297_A	0.936	0.22
11_T	218_M	0.935	0.22
14_K	39_E	0.933	0.22
73_D	232_E	0.932	0.22
188_T	220_M	0.925	0.22
4_V	10_G	0.922	0.22
4_V	13_G	0.922	0.22
118_S	135_R	0.921	0.22
182_L	296_Y	0.920	0.22
318_L	323_D	0.920	0.22
76_K	100_L	0.919	0.22
163_T	184_P	0.916	0.22
150_T	233_K	0.913	0.21
116_D	280_I	0.913	0.21
23_Q	331_S	0.912	0.21
18_D	21_I	0.906	0.21
243_T	298_V	0.905	0.21
28_L	331_S	0.902	0.21
16_V	82_V	0.899	0.21
278_V	294_L	0.896	0.21
76_K	126_N	0.896	0.21
173_E	210_A	0.896	0.21
215_T	297_A	0.894	0.21
132_K	164_I	0.893	0.21
9_Y	17_A	0.893	0.21
188_T	236_I	0.892	0.21
6_V	45_R	0.888	0.21
150_T	173_E	0.888	0.21
121_A	309_I	0.887	0.21
248_L	275_I	0.881	0.20
11_T	300_Q	0.881	0.20
165_V	289_D	0.880	0.20
48_I	105_I	0.880	0.20
56_S	235_D	0.876	0.20
22_K	31_V	0.874	0.20
85_T	174_V	0.872	0.20
215_T	300_Q	0.866	0.20
16_V	184_P	0.863	0.20
2_I	211_V	0.861	0.20
225_I	289_D	0.861	0.20
58_K	62_E	0.858	0.20
124_N	160_V	0.857	0.20
54_Q	59_K	0.856	0.20
165_V	261_L	0.854	0.20
266_R	301_E	0.853	0.20
3_N	62_E	0.853	0.20
223_I	296_Y	0.852	0.20
221_H	324_S	0.849	0.20
177_G	216_T	0.846	0.19
20_I	312_I	0.844	0.19
76_K	132_K	0.837	0.19
16_V	23_Q	0.834	0.19
258_T	297_A	0.832	0.19
147_T	182_L	0.832	0.19
251_S	258_T	0.831	0.19
81_V	125_Y	0.830	0.19
193_H	297_A	0.829	0.19
42_I	95_P	0.829	0.19
309_I	332_L	0.822	0.19
150_T	172_K	0.820	0.19
52_V	169_A	0.818	0.19
180_N	302_S	0.815	0.19
75_I	78_S	0.805	0.18
162_A	302_S	0.804	0.18
52_V	62_E	0.803	0.18
46_R	319_M	0.802	0.18
21_I	68_A	0.801	0.18
77_T	238_S	0.798	0.18
178_P	284_S	0.796	0.18
151_V	198_N	0.796	0.18
150_T	246_I	0.795	0.18
126_N	240_L	0.792	0.18
39_E	197_V	0.791	0.18
218_M	258_T	0.789	0.18
246_I	262_V	0.786	0.18
7_N	258_T	0.780	0.18
225_I	318_L	0.778	0.18
124_N	128_A	0.777	0.18
18_D	48_I	0.773	0.17
114_V	214_P	0.772	0.17
245_R	277_E	0.770	0.17
21_I	73_D	0.769	0.17
59_K	238_S	0.768	0.17
131_K	309_I	0.766	0.17
147_T	334_I	0.759	0.17
60_F	193_H	0.756	0.17
169_A	212_I	0.756	0.17
284_S	299_H	0.754	0.17
4_V	8_G	0.750	0.17
3_N	64_G	0.750	0.17
153_K	242_N	0.749	0.17
32_A	74_L	0.749	0.17
50_I	234_K	0.745	0.17
39_E	263_E	0.745	0.17
75_I	233_K	0.744	0.17
193_H	197_V	0.743	0.17
169_A	211_V	0.743	0.17
205_D	289_D	0.742	0.17
116_D	257_A	0.741	0.17
74_L	204_L	0.738	0.17
64_G	287_V	0.737	0.17
169_A	176_K	0.734	0.16
310_D	313_R	0.734	0.16
67_V	89_V	0.733	0.16
77_T	94_K	0.732	0.16
233_K	292_V	0.731	0.16
138_S	196_D	0.731	0.16
182_L	258_T	0.730	0.16
71_V	206_I	0.726	0.16
35_S	151_V	0.722	0.16
88_G	100_L	0.719	0.16
187_A	213_A	0.718	0.16
64_G	76_K	0.716	0.16
87_N	143_A	0.714	0.16
157_V	298_V	0.713	0.16
238_S	241_E	0.713	0.16
154_V	234_K	0.709	0.16
38_Y	180_N	0.708	0.16
123_C	184_P	0.708	0.16
10_G	15_R	0.706	0.16
33_K	300_Q	0.705	0.16
73_D	241_E	0.705	0.16
95_P	157_V	0.704	0.16
29_V	42_I	0.702	0.16
75_I	81_V	0.699	0.16
195_K	324_S	0.697	0.16
23_Q	119_F	0.695	0.16
75_I	101_Q	0.694	0.16
46_R	275_I	0.694	0.16
3_N	78_S	0.694	0.16
33_K	36_P	0.692	0.15
42_I	46_R	0.692	0.15
3_N	81_V	0.691	0.15
41_F	45_R	0.690	0.15
244_P	266_R	0.690	0.15
190_P	313_R	0.687	0.15
321_A	329_N	0.684	0.15
229_D	242_N	0.683	0.15
52_V	322_E	0.681	0.15
31_V	47_G	0.678	0.15
272_R	284_S	0.678	0.15
34_T	78_S	0.677	0.15
42_I	280_I	0.676	0.15
261_L	264_V	0.673	0.15
276_P	334_I	0.672	0.15
126_N	130_G	0.672	0.15
38_Y	143_A	0.669	0.15
61_E	70_T	0.667	0.15
141_T	192_H	0.666	0.15
24_P	165_V	0.664	0.15
29_V	326_R	0.664	0.15
97_Y	110_E	0.663	0.15
3_N	24_P	0.661	0.15
159_K	274_D	0.661	0.15
126_N	234_K	0.659	0.15
259_A	300_Q	0.657	0.15
20_I	261_L	0.656	0.15
122_L	244_P	0.656	0.15
147_T	276_P	0.656	0.15
143_A	296_Y	0.656	0.15
178_P	295_M	0.655	0.15
130_G	318_L	0.655	0.15
201_I	302_S	0.654	0.15
157_V	333_G	0.654	0.15
168_A	179_I	0.650	0.14
55_Q	95_P	0.650	0.14
163_T	182_L	0.648	0.14
75_I	229_D	0.646	0.14
183_V	210_A	0.646	0.14
125_Y	314_A	0.645	0.14
12_I	15_R	0.645	0.14
130_G	253_Y	0.641	0.14
59_K	251_S	0.641	0.14
46_R	132_K	0.641	0.14
37_N	260_E	0.641	0.14
104_A	272_R	0.639	0.14
161_R	207_A	0.637	0.14
27_K	202_R	0.637	0.14
203_N	334_I	0.634	0.14
169_A	179_I	0.634	0.14
207_A	248_L	0.632	0.14
23_Q	313_R	0.632	0.14
56_S	182_L	0.629	0.14
35_S	230_K	0.627	0.14
26_M	324_S	0.625	0.14
121_A	195_K	0.623	0.14
199_S	280_I	0.623	0.14
198_N	279_M	0.622	0.14
21_I	46_R	0.621	0.14
75_I	280_I	0.621	0.14
121_A	221_H	0.621	0.14
283_D	309_I	0.620	0.14
195_K	226_T	0.620	0.14
241_E	250_S	0.620	0.14
309_I	325_M	0.618	0.14
206_I	301_E	0.618	0.14
122_L	201_I	0.616	0.14
221_H	313_R	0.613	0.14
202_R	295_M	0.613	0.14
128_A	189_V	0.612	0.14
58_K	236_I	0.609	0.14
125_Y	280_I	0.608	0.14
80_I	96_I	0.608	0.14
124_N	274_D	0.607	0.14
178_P	181_S	0.603	0.13
98_L	315_S	0.603	0.13
54_Q	321_A	0.600	0.13
49_R	100_L	0.600	0.13
122_L	163_T	0.595	0.13
70_T	318_L	0.594	0.13
181_S	258_T	0.594	0.13
3_N	131_K	0.594	0.13
270_R	277_E	0.593	0.13
37_N	267_D	0.593	0.13
210_A	215_T	0.593	0.13
262_V	299_H	0.592	0.13
165_V	211_V	0.592	0.13
22_K	266_R	0.591	0.13
66_P	94_K	0.589	0.13
32_A	88_G	0.589	0.13
36_P	90_G	0.588	0.13
89_V	161_R	0.588	0.13
44_H	50_I	0.586	0.13
255_A	295_M	0.586	0.13
57_I	61_E	0.585	0.13
99_Q	330_E	0.585	0.13
82_V	221_H	0.584	0.13
197_V	206_I	0.584	0.13
2_I	202_R	0.582	0.13
276_P	294_L	0.581	0.13
66_P	232_E	0.579	0.13
131_K	201_I	0.579	0.13
148_I	227_L	0.578	0.13
94_K	99_Q	0.578	0.13
218_M	299_H	0.577	0.13
45_R	253_Y	0.576	0.13
40_A	308_N	0.576	0.13
256_E	260_E	0.576	0.13
95_P	100_L	0.574	0.13
241_E	323_D	0.573	0.13
250_S	279_M	0.572	0.13
71_V	74_L	0.571	0.13
21_I	41_F	0.571	0.13
61_E	66_P	0.570	0.13
33_K	179_I	0.569	0.13
113_E	319_M	0.569	0.13
68_A	280_I	0.568	0.13
234_K	256_E	0.568	0.13
109_G	142_T	0.564	0.13
200_V	234_K	0.563	0.13
54_Q	63_S	0.563	0.13
153_K	163_T	0.563	0.13
271_D	322_E	0.561	0.13
35_S	78_S	0.560	0.13
8_G	15_R	0.560	0.13
193_H	308_N	0.559	0.13
73_D	79_D	0.559	0.13
120_S	218_M	0.559	0.13
242_N	318_L	0.558	0.13
87_N	259_A	0.557	0.13
16_V	324_S	0.556	0.12
16_V	19_A	0.555	0.12
189_V	255_A	0.554	0.12
85_T	119_F	0.552	0.12
38_Y	298_V	0.551	0.12
187_A	240_L	0.550	0.12
121_A	208_T	0.550	0.12
41_F	253_Y	0.549	0.12
62_E	280_I	0.546	0.12
299_H	305_V	0.546	0.12
117_I	169_A	0.545	0.12
119_F	125_Y	0.544	0.12
101_Q	280_I	0.544	0.12
73_D	234_K	0.544	0.12
322_E	330_E	0.543	0.12
156_K	295_M	0.543	0.12
84_T	334_I	0.542	0.12
262_V	273_N	0.539	0.12
202_R	278_V	0.538	0.12
72_E	160_V	0.537	0.12
51_Y	68_A	0.535	0.12
209_M	260_E	0.530	0.12
26_M	221_H	0.529	0.12
34_T	74_L	0.529	0.12
94_K	232_E	0.528	0.12
46_R	323_D	0.527	0.12
161_R	263_E	0.525	0.12
151_V	238_S	0.521	0.12
15_R	30_G	0.521	0.12
158_E	322_E	0.520	0.12
89_V	187_A	0.518	0.12
31_V	143_A	0.518	0.12
87_N	258_T	0.518	0.12
124_N	206_I	0.515	0.12
68_A	323_D	0.515	0.12
9_Y	15_R	0.515	0.12
81_V	295_M	0.514	0.12
234_K	331_S	0.513	0.12
160_V	223_I	0.511	0.12
62_E	260_E	0.511	0.12
96_I	130_G	0.510	0.12
91_A	152_N	0.509	0.12
32_A	68_A	0.508	0.12
309_I	321_A	0.507	0.12
106_F	329_N	0.505	0.12
71_V	78_S	0.505	0.12
180_N	306_P	0.503	0.11
134_I	212_I	0.503	0.11
49_R	82_V	0.502	0.11
199_S	329_N	0.502	0.11
3_N	238_S	0.502	0.11
261_L	318_L	0.501	0.11
67_V	130_G	0.501	0.11
118_S	324_S	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1cf2P	4	0.9824	100	0.54	Contact Map
2yyyA	2	0.9853	100	0.548	Contact Map
1b7gO	4	1	100	0.551	Contact Map
2czcA	4	0.9765	100	0.557	Contact Map
4dibA	4	0.8324	100	0.821	Contact Map
3docA	4	0.8647	99.9	0.827	Contact Map
3idsC	4	0.8824	99.9	0.827	Contact Map
3h9eO	4	0.8706	99.9	0.831	Contact Map
3hjaA	4	0.8588	99.9	0.833	Contact Map
4o59O	4	0.8706	99.9	0.834	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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