GREMLIN Database
EF1A - Elongation factor 1-alpha
UniProt: P35021 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 435 (341)
Sequences: 15363 (6572)
Seq/√Len: 355.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
289_A295_I5.3741.00
165_R168_E4.5481.00
260_K288_K4.4921.00
150_A192_V4.2721.00
258_V288_K3.9701.00
264_K273_V3.8251.00
278_S285_K3.4281.00
263_D315_H2.8171.00
234_R256_S2.7281.00
216_E220_D2.6681.00
118_K156_L2.5221.00
233_L254_V2.5111.00
260_K263_D2.4381.00
261_V287_D2.3471.00
133_R176_F2.3301.00
281_T284_T2.2631.00
266_V273_V2.2441.00
170_V191_P2.2101.00
233_L259_L2.1751.00
110_A222_L2.1421.00
264_K275_E2.1271.00
281_T286_M2.1121.00
380_L386_A2.0861.00
190_V217_E2.0691.00
170_V189_F2.0611.00
80_E85_F2.0491.00
168_E172_Q2.0401.00
10_I108_A1.9861.00
217_E221_Q1.9831.00
290_E293_D1.9541.00
112_I150_A1.9471.00
259_L276_V1.9231.00
228_P231_K1.8741.00
266_V316_P1.8711.00
265_I276_V1.8701.00
170_V174_S1.8681.00
254_V289_A1.8561.00
235_I252_G1.8411.00
9_L86_F1.8341.00
261_V285_K1.8161.00
249_V296_G1.8061.00
231_K256_S1.8031.00
233_L265_I1.7981.00
25_R197_G1.7851.00
250_P307_I1.7771.00
192_V214_T1.7641.00
63_K67_E1.7621.00
258_V290_E1.7451.00
80_E83_K1.7271.00
136_I173_V1.7171.00
117_A151_V1.7051.00
78_R85_F1.7001.00
376_N379_F1.6481.00
11_V23_V1.6271.00
23_V88_I1.5981.00
376_N380_L1.5961.00
152_N194_A1.5861.00
261_V279_I1.5421.00
171_D175_K1.5371.00
326_F330_I1.5361.00
268_M314_G1.5311.00
25_R28_M1.5301.00
154_M198_D1.5261.00
286_M289_A1.5191.00
214_T218_Y1.5051.00
252_G297_F1.4931.00
377_P381_K1.4901.00
59_L77_M1.4891.00
151_V191_P1.4651.00
320_P324_D1.4591.00
22_L114_V1.4461.00
5_P84_Y1.4221.00
254_V295_I1.4171.00
328_A331_I1.4071.00
214_T217_E1.4021.00
229_V290_E1.3931.00
237_I250_P1.3931.00
377_P380_L1.3821.00
115_V132_T1.3781.00
149_V189_F1.3771.00
347_I356_C1.3761.00
241_Y251_V1.3711.00
325_E391_K1.3581.00
116_S119_K1.3561.00
169_I172_Q1.3521.00
378_Q385_V1.3511.00
33_I58_L1.3451.00
22_L194_A1.3381.00
167_K171_D1.3351.00
360_E389_K1.3331.00
380_L384_D1.3331.00
324_D330_I1.3261.00
253_R294_N1.3261.00
102_I138_L1.3211.00
328_A332_V1.3191.00
377_P383_G1.2921.00
378_Q381_K1.2911.00
89_I108_A1.2861.00
297_F313_V1.2821.00
362_V368_R1.2731.00
12_I139_A1.2701.00
111_A139_A1.2691.00
192_V199_N1.2661.00
273_V316_P1.2631.00
378_Q383_G1.2611.00
380_L383_G1.2601.00
139_A147_L1.2601.00
377_P382_Q1.2551.00
64_E72_I1.2481.00
326_F331_I1.2441.00
322_V330_I1.2331.00
381_K384_D1.2311.00
270_A311_D1.2301.00
266_V271_G1.2251.00
378_Q382_Q1.2171.00
322_V328_A1.2091.00
165_R169_I1.2071.00
84_Y219_L1.1971.00
274_G303_E1.1931.00
322_V331_I1.1911.00
322_V326_F1.1861.00
111_A144_L1.1851.00
181_G184_T1.1731.00
150_A194_A1.1671.00
235_I254_V1.1651.00
135_H138_L1.1631.00
167_K170_V1.1581.00
274_G302_V1.1551.00
119_K129_E1.1551.00
322_V329_R1.1531.00
279_I297_F1.1521.00
25_R200_I1.1501.00
5_P83_K1.1491.00
148_I222_L1.1461.00
62_L73_N1.1391.00
199_N202_H1.1291.00
12_I111_A1.1281.00
330_I388_V1.1251.00
266_V319_P1.1201.00
259_L297_F1.1171.00
378_Q384_D1.1171.00
322_V325_E1.1151.00
264_K316_P1.1131.00
325_E330_I1.1081.00
265_I313_V1.1041.00
359_S363_S1.1001.00
149_V173_V1.0961.00
376_N381_K1.0941.00
381_K385_V1.0941.00
267_F274_G1.0931.00
330_I333_V1.0891.00
26_L79_F1.0861.00
113_L149_V1.0801.00
315_H318_N1.0731.00
193_V196_A1.0651.00
280_E285_K1.0631.00
248_T328_A1.0611.00
329_R332_V1.0511.00
380_L385_V1.0501.00
29_D201_T1.0491.00
23_V59_L1.0411.00
362_V389_K1.0241.00
326_F392_P1.0221.00
155_D193_V1.0211.00
166_Y170_V1.0181.00
59_L71_T1.0161.00
8_N87_T1.0161.00
128_V132_T1.0091.00
154_M191_P1.0081.00
335_H338_A1.0071.00
117_A154_M1.0061.00
323_A330_I1.0041.00
154_M166_Y1.0001.00
81_T216_E0.9991.00
278_S298_N0.9971.00
376_N383_G0.9941.00
327_T330_I0.9941.00
335_H339_L0.9931.00
327_T387_I0.9931.00
12_I113_L0.9931.00
21_T194_A0.9831.00
321_T325_E0.9801.00
229_V258_V0.9751.00
151_V166_Y0.9711.00
214_T219_L0.9691.00
217_E220_D0.9691.00
183_N186_K0.9641.00
324_D332_V0.9641.00
232_P315_H0.9641.00
377_P384_D0.9641.00
376_N385_V0.9611.00
172_Q175_K0.9611.00
25_R29_D0.9601.00
382_Q386_A0.9601.00
382_Q385_V0.9591.00
329_R387_I0.9561.00
64_E68_R0.9531.00
133_R137_I0.9521.00
4_K84_Y0.9511.00
233_L276_V0.9481.00
136_I147_L0.9471.00
148_I190_V0.9441.00
327_T389_K0.9401.00
63_K66_R0.9401.00
112_I148_I0.9391.00
173_V181_G0.9361.00
260_K287_D0.9361.00
261_V278_S0.9331.00
170_V182_F0.9271.00
188_R221_Q0.9261.00
168_E171_D0.9251.00
272_K306_D0.9211.00
166_Y191_P0.9181.00
79_F88_I0.9181.00
267_F307_I0.9121.00
61_R75_T0.9121.00
267_F313_V0.9091.00
60_D65_E0.9091.00
333_V346_V0.9071.00
326_F329_R0.9061.00
265_I274_G0.9051.00
325_E389_K0.9021.00
279_I289_A0.8981.00
352_A358_V0.8951.00
252_G295_I0.8911.00
376_N382_Q0.8911.00
74_L89_I0.8901.00
82_K216_E0.8901.00
219_L223_E0.8851.00
86_F219_L0.8841.00
171_D174_S0.8821.00
22_L150_A0.8751.00
227_K291_P0.8741.00
174_S178_R0.8691.00
259_L265_I0.8671.00
61_R73_N0.8661.00
11_V112_I0.8621.00
320_P326_F0.8621.00
115_V149_V0.8591.00
79_F86_F0.8591.00
302_V307_I0.8521.00
320_P325_E0.8451.00
164_K168_E0.8431.00
30_R79_F0.8401.00
346_V353_S0.8371.00
364_K384_D0.8361.00
167_K191_P0.8321.00
259_L289_A0.8321.00
379_F383_G0.8301.00
55_F59_L0.8301.00
10_I91_A0.8291.00
215_L218_Y0.8291.00
235_I238_Q0.8281.00
149_V187_V0.8251.00
345_P348_H0.8241.00
269_P311_D0.8211.00
178_R184_T0.8201.00
118_K158_E0.8191.00
326_F332_V0.8171.00
59_L75_T0.8161.00
324_D328_A0.8151.00
179_S183_N0.8121.00
376_N387_I0.8111.00
266_V314_G0.8061.00
289_A293_D0.8051.00
128_V169_I0.8031.00
324_D329_R0.8001.00
181_G185_N0.7991.00
178_R181_G0.7991.00
229_V232_P0.7961.00
215_L219_L0.7961.00
16_D94_H0.7931.00
191_P198_D0.7901.00
376_N386_A0.7901.00
115_V173_V0.7851.00
330_I334_W0.7851.00
314_G320_P0.7811.00
180_Y183_N0.7771.00
229_V291_P0.7741.00
140_K147_L0.7701.00
16_D70_V0.7651.00
14_H17_H0.7621.00
378_Q387_I0.7591.00
324_D333_V0.7581.00
344_T347_I0.7571.00
320_P330_I0.7541.00
325_E331_I0.7531.00
320_P332_V0.7531.00
322_V332_V0.7501.00
27_L32_F0.7491.00
272_K305_K0.7491.00
15_I94_H0.7481.00
233_L315_H0.7481.00
254_V259_L0.7471.00
327_T333_V0.7461.00
230_D258_V0.7461.00
85_F281_T0.7451.00
344_T348_H0.7441.00
85_F293_D0.7421.00
188_R218_Y0.7391.00
110_A148_I0.7361.00
252_G313_V0.7351.00
216_E219_L0.7341.00
383_G387_I0.7341.00
308_K311_D0.7331.00
336_P347_I0.7321.00
327_T331_I0.7311.00
338_A341_N0.7311.00
379_F382_Q0.7291.00
274_G307_I0.7260.99
27_L58_L0.7240.99
321_T330_I0.7180.99
188_R215_L0.7160.99
386_A392_P0.7160.99
175_K178_R0.7160.99
95_R130_G0.7160.99
377_P386_A0.7150.99
28_M197_G0.7140.99
26_L215_L0.7110.99
33_I54_K0.7110.99
378_Q386_A0.7090.99
331_I335_H0.7080.99
346_V357_R0.7070.99
330_I335_H0.7060.99
180_Y187_V0.7050.99
55_F58_L0.7050.99
356_C390_F0.7050.99
356_C392_P0.7030.99
31_G34_D0.7000.99
13_G17_H0.6980.99
216_E221_Q0.6970.99
65_E69_G0.6970.99
377_P385_V0.6960.99
320_P323_A0.6960.99
65_E68_R0.6940.99
379_F384_D0.6940.99
78_R87_T0.6930.99
180_Y184_T0.6920.99
29_D197_G0.6900.99
148_I218_Y0.6890.99
235_I297_F0.6880.99
323_A327_T0.6850.99
245_G248_T0.6840.99
110_A223_E0.6810.99
151_V170_V0.6800.99
105_A142_M0.6780.99
266_V317_N0.6740.99
270_A308_K0.6740.99
15_I70_V0.6720.99
380_L388_V0.6700.99
113_L173_V0.6640.99
10_I111_A0.6640.99
343_Y348_H0.6630.99
382_Q387_I0.6630.99
232_P318_N0.6620.99
6_H87_T0.6620.99
243_I246_V0.6620.99
241_Y296_G0.6620.99
22_L200_I0.6600.99
261_V277_R0.6600.99
362_V366_D0.6580.99
114_V152_N0.6580.99
380_L387_I0.6550.99
237_I307_I0.6550.99
68_R72_I0.6550.99
258_V291_P0.6530.99
336_P339_L0.6530.99
376_N384_D0.6530.99
64_E360_E0.6520.99
259_L279_I0.6480.99
349_V352_A0.6470.99
379_F386_A0.6470.99
329_R333_V0.6470.99
107_Q236_P0.6470.99
12_I105_A0.6460.99
192_V200_I0.6450.99
244_S247_G0.6440.99
22_L214_T0.6410.99
29_D202_H0.6380.99
28_M35_E0.6380.99
379_F387_I0.6360.99
233_L258_V0.6350.99
215_L220_D0.6340.99
57_F66_R0.6340.99
238_Q251_V0.6320.99
334_W339_L0.6320.99
280_E283_H0.6310.99
227_K231_K0.6290.99
214_T220_D0.6290.99
386_A390_F0.6280.99
315_H319_P0.6270.99
385_V388_V0.6270.99
243_I249_V0.6260.99
184_T190_V0.6220.98
117_A164_K0.6210.98
74_L104_G0.6210.98
137_I379_F0.6200.98
174_S189_F0.6190.98
6_H85_F0.6170.98
281_T293_D0.6160.98
381_K386_A0.6150.98
140_K177_M0.6150.98
113_L132_T0.6140.98
348_H353_S0.6140.98
54_K58_L0.6110.98
280_E298_N0.6110.98
106_S255_E0.6090.98
359_S391_K0.6090.98
14_H132_T0.6060.98
325_E332_V0.6040.98
252_G289_A0.6030.98
91_A101_M0.6010.98
16_D153_K0.6010.98
326_F333_V0.5990.98
227_K256_S0.5980.98
379_F385_V0.5980.98
10_I105_A0.5980.98
325_E359_S0.5980.98
358_V362_V0.5960.98
16_D69_G0.5960.98
277_R298_N0.5930.98
237_I313_V0.5930.98
174_S183_N0.5920.98
26_L200_I0.5920.98
177_M181_G0.5910.98
113_L136_I0.5880.98
55_F66_R0.5870.98
314_G319_P0.5870.98
387_I390_F0.5870.98
389_K392_P0.5860.98
336_P345_P0.5850.98
340_A343_Y0.5840.98
324_D327_T0.5840.98
334_W337_T0.5830.98
82_K220_D0.5800.98
60_D69_G0.5770.97
361_L364_K0.5760.97
367_P370_G0.5750.97
16_D71_T0.5740.97
326_F390_F0.5730.97
197_G200_I0.5730.97
190_V201_T0.5730.97
101_M135_H0.5700.97
286_M293_D0.5680.97
322_V337_T0.5660.97
32_F79_F0.5640.97
325_E328_A0.5630.97
138_L142_M0.5630.97
324_D331_I0.5620.97
235_I259_L0.5610.97
53_E56_A0.5590.97
387_I392_P0.5570.97
323_A332_V0.5560.97
116_S153_K0.5560.97
320_P329_R0.5560.97
113_L135_H0.5560.97
136_I177_M0.5560.97
190_V199_N0.5550.97
214_T221_Q0.5550.97
164_K169_I0.5540.97
179_S182_F0.5530.97
6_H293_D0.5500.97
328_A388_V0.5480.97
198_D202_H0.5470.97
14_H129_E0.5460.97
347_I390_F0.5450.96
27_L77_M0.5440.96
173_V177_M0.5440.96
9_L218_Y0.5440.96
60_D66_R0.5440.96
181_G188_R0.5420.96
15_I71_T0.5410.96
316_P319_P0.5400.96
246_V278_S0.5400.96
323_A326_F0.5340.96
383_G386_A0.5340.96
70_V94_H0.5340.96
218_Y221_Q0.5330.96
190_V218_Y0.5330.96
115_V169_I0.5310.96
252_G259_L0.5310.96
182_F185_N0.5300.96
387_I391_K0.5280.96
54_K57_F0.5260.96
243_I247_G0.5250.96
64_E67_E0.5220.96
322_V361_L0.5220.96
111_A147_L0.5200.95
110_A218_Y0.5190.95
269_P272_K0.5190.95
35_E54_K0.5180.95
343_Y347_I0.5170.95
195_P198_D0.5160.95
165_R172_Q0.5160.95
218_Y222_L0.5150.95
381_K388_V0.5150.95
17_H119_K0.5150.95
78_R293_D0.5140.95
84_Y221_Q0.5130.95
249_V298_N0.5130.95
120_G128_V0.5110.95
377_P392_P0.5110.95
136_I140_K0.5110.95
86_F110_A0.5100.95
286_M295_I0.5090.95
235_I239_D0.5090.95
109_D253_R0.5050.95
320_P333_V0.5040.95
81_T84_Y0.5030.95
327_T335_H0.5020.94
331_I334_W0.5010.94
24_G57_F0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jnyA 1 0.9563 100 0.198 Contact Map
4d61i 1 0.977 100 0.216 Contact Map
1f60A 1 0.9793 100 0.22 Contact Map
4crnP 1 0.9793 100 0.221 Contact Map
1r5bA 1 0.8874 100 0.232 Contact Map
3mcaA 1 0.8161 100 0.24 Contact Map
3izq1 1 0.9793 100 0.243 Contact Map
3wy9A 1 0.9356 100 0.243 Contact Map
3p26A 1 0.9126 100 0.244 Contact Map
1zunB 1 0.8943 100 0.277 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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