EF1A - SULSO - GREMLIN Contacts

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EF1A - Elongation factor 1-alpha

UniProt:	P35021	Sequences: MSQKPHLNLIVIGHIDHGKSTLVGRLLMDRGFIDEKTVKEAEEAAKKLGKESEKFAFLLDRLKEERERGVTINLTFMRFETKKYFFTIIDAPGHRDFVKNMITGASQADAAILVVSAKKGEYEAGMSVEGQTREHIILAKTMGLDQLIVAVNKMDLTEPPYDEKRYKEIVDQVSKFMRSYGFNTNKVRFVPVVAPAGDNITHRSENMKWYNGPTLEEYLDQLELPPKPVDKPLRIPIQDVYSISGVGTVPVGRVESGVLKVGDKIVFMPAGKVGEVRSIETHHTKMDKAEPGDNIGFNVRGVEKKDIKRGDVVGHPNNPPTVADEFTARIIVVWHPTALANGYTPVIHVHTASVACRVSELVSKLDPRTGQEAEKNPQFLKQGDVAIVKFKPIKPLCVEKYNEFPPLGRFAMRDMGKTVGVGIIVDVKPAKVEIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	435 (341)
Sequences:	15363 (6572)
Seq/√Len:	355.9

ECOLI - CYSN EFTU2 EFTU1 SELB TYPA LEPA RF3 EFG
BACSU - EFTU TYPA LEPA EFG
HALSA - EF1A Q9HPE4 IF2G EF2 IF2P
SULSO - EF1A Q97W17 IF2G EF2 IF2P Q97ZV5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
289_A	295_I	5.374	1.00
165_R	168_E	4.548	1.00
260_K	288_K	4.492	1.00
150_A	192_V	4.272	1.00
258_V	288_K	3.970	1.00
264_K	273_V	3.825	1.00
278_S	285_K	3.428	1.00
263_D	315_H	2.817	1.00
234_R	256_S	2.728	1.00
216_E	220_D	2.668	1.00
118_K	156_L	2.522	1.00
233_L	254_V	2.511	1.00
260_K	263_D	2.438	1.00
261_V	287_D	2.347	1.00
133_R	176_F	2.330	1.00
281_T	284_T	2.263	1.00
266_V	273_V	2.244	1.00
170_V	191_P	2.210	1.00
233_L	259_L	2.175	1.00
110_A	222_L	2.142	1.00
264_K	275_E	2.127	1.00
281_T	286_M	2.112	1.00
380_L	386_A	2.086	1.00
190_V	217_E	2.069	1.00
170_V	189_F	2.061	1.00
80_E	85_F	2.049	1.00
168_E	172_Q	2.040	1.00
10_I	108_A	1.986	1.00
217_E	221_Q	1.983	1.00
290_E	293_D	1.954	1.00
112_I	150_A	1.947	1.00
259_L	276_V	1.923	1.00
228_P	231_K	1.874	1.00
266_V	316_P	1.871	1.00
265_I	276_V	1.870	1.00
170_V	174_S	1.868	1.00
254_V	289_A	1.856	1.00
235_I	252_G	1.841	1.00
9_L	86_F	1.834	1.00
261_V	285_K	1.816	1.00
249_V	296_G	1.806	1.00
231_K	256_S	1.803	1.00
233_L	265_I	1.798	1.00
25_R	197_G	1.785	1.00
250_P	307_I	1.777	1.00
192_V	214_T	1.764	1.00
63_K	67_E	1.762	1.00
258_V	290_E	1.745	1.00
80_E	83_K	1.727	1.00
136_I	173_V	1.717	1.00
117_A	151_V	1.705	1.00
78_R	85_F	1.700	1.00
376_N	379_F	1.648	1.00
11_V	23_V	1.627	1.00
23_V	88_I	1.598	1.00
376_N	380_L	1.596	1.00
152_N	194_A	1.586	1.00
261_V	279_I	1.542	1.00
171_D	175_K	1.537	1.00
326_F	330_I	1.536	1.00
268_M	314_G	1.531	1.00
25_R	28_M	1.530	1.00
154_M	198_D	1.526	1.00
286_M	289_A	1.519	1.00
214_T	218_Y	1.505	1.00
252_G	297_F	1.493	1.00
377_P	381_K	1.490	1.00
59_L	77_M	1.489	1.00
151_V	191_P	1.465	1.00
320_P	324_D	1.459	1.00
22_L	114_V	1.446	1.00
5_P	84_Y	1.422	1.00
254_V	295_I	1.417	1.00
328_A	331_I	1.407	1.00
214_T	217_E	1.402	1.00
229_V	290_E	1.393	1.00
237_I	250_P	1.393	1.00
377_P	380_L	1.382	1.00
115_V	132_T	1.378	1.00
149_V	189_F	1.377	1.00
347_I	356_C	1.376	1.00
241_Y	251_V	1.371	1.00
325_E	391_K	1.358	1.00
116_S	119_K	1.356	1.00
169_I	172_Q	1.352	1.00
378_Q	385_V	1.351	1.00
33_I	58_L	1.345	1.00
22_L	194_A	1.338	1.00
167_K	171_D	1.335	1.00
360_E	389_K	1.333	1.00
380_L	384_D	1.333	1.00
324_D	330_I	1.326	1.00
253_R	294_N	1.326	1.00
102_I	138_L	1.321	1.00
328_A	332_V	1.319	1.00
377_P	383_G	1.292	1.00
378_Q	381_K	1.291	1.00
89_I	108_A	1.286	1.00
297_F	313_V	1.282	1.00
362_V	368_R	1.273	1.00
12_I	139_A	1.270	1.00
111_A	139_A	1.269	1.00
192_V	199_N	1.266	1.00
273_V	316_P	1.263	1.00
378_Q	383_G	1.261	1.00
380_L	383_G	1.260	1.00
139_A	147_L	1.260	1.00
377_P	382_Q	1.255	1.00
64_E	72_I	1.248	1.00
326_F	331_I	1.244	1.00
322_V	330_I	1.233	1.00
381_K	384_D	1.231	1.00
270_A	311_D	1.230	1.00
266_V	271_G	1.225	1.00
378_Q	382_Q	1.217	1.00
322_V	328_A	1.209	1.00
165_R	169_I	1.207	1.00
84_Y	219_L	1.197	1.00
274_G	303_E	1.193	1.00
322_V	331_I	1.191	1.00
322_V	326_F	1.186	1.00
111_A	144_L	1.185	1.00
181_G	184_T	1.173	1.00
150_A	194_A	1.167	1.00
235_I	254_V	1.165	1.00
135_H	138_L	1.163	1.00
167_K	170_V	1.158	1.00
274_G	302_V	1.155	1.00
119_K	129_E	1.155	1.00
322_V	329_R	1.153	1.00
279_I	297_F	1.152	1.00
25_R	200_I	1.150	1.00
5_P	83_K	1.149	1.00
148_I	222_L	1.146	1.00
62_L	73_N	1.139	1.00
199_N	202_H	1.129	1.00
12_I	111_A	1.128	1.00
330_I	388_V	1.125	1.00
266_V	319_P	1.120	1.00
259_L	297_F	1.117	1.00
378_Q	384_D	1.117	1.00
322_V	325_E	1.115	1.00
264_K	316_P	1.113	1.00
325_E	330_I	1.108	1.00
265_I	313_V	1.104	1.00
359_S	363_S	1.100	1.00
149_V	173_V	1.096	1.00
376_N	381_K	1.094	1.00
381_K	385_V	1.094	1.00
267_F	274_G	1.093	1.00
330_I	333_V	1.089	1.00
26_L	79_F	1.086	1.00
113_L	149_V	1.080	1.00
315_H	318_N	1.073	1.00
193_V	196_A	1.065	1.00
280_E	285_K	1.063	1.00
248_T	328_A	1.061	1.00
329_R	332_V	1.051	1.00
380_L	385_V	1.050	1.00
29_D	201_T	1.049	1.00
23_V	59_L	1.041	1.00
362_V	389_K	1.024	1.00
326_F	392_P	1.022	1.00
155_D	193_V	1.021	1.00
166_Y	170_V	1.018	1.00
59_L	71_T	1.016	1.00
8_N	87_T	1.016	1.00
128_V	132_T	1.009	1.00
154_M	191_P	1.008	1.00
335_H	338_A	1.007	1.00
117_A	154_M	1.006	1.00
323_A	330_I	1.004	1.00
154_M	166_Y	1.000	1.00
81_T	216_E	0.999	1.00
278_S	298_N	0.997	1.00
376_N	383_G	0.994	1.00
327_T	330_I	0.994	1.00
335_H	339_L	0.993	1.00
327_T	387_I	0.993	1.00
12_I	113_L	0.993	1.00
21_T	194_A	0.983	1.00
321_T	325_E	0.980	1.00
229_V	258_V	0.975	1.00
151_V	166_Y	0.971	1.00
214_T	219_L	0.969	1.00
217_E	220_D	0.969	1.00
183_N	186_K	0.964	1.00
324_D	332_V	0.964	1.00
232_P	315_H	0.964	1.00
377_P	384_D	0.964	1.00
376_N	385_V	0.961	1.00
172_Q	175_K	0.961	1.00
25_R	29_D	0.960	1.00
382_Q	386_A	0.960	1.00
382_Q	385_V	0.959	1.00
329_R	387_I	0.956	1.00
64_E	68_R	0.953	1.00
133_R	137_I	0.952	1.00
4_K	84_Y	0.951	1.00
233_L	276_V	0.948	1.00
136_I	147_L	0.947	1.00
148_I	190_V	0.944	1.00
327_T	389_K	0.940	1.00
63_K	66_R	0.940	1.00
112_I	148_I	0.939	1.00
173_V	181_G	0.936	1.00
260_K	287_D	0.936	1.00
261_V	278_S	0.933	1.00
170_V	182_F	0.927	1.00
188_R	221_Q	0.926	1.00
168_E	171_D	0.925	1.00
272_K	306_D	0.921	1.00
166_Y	191_P	0.918	1.00
79_F	88_I	0.918	1.00
267_F	307_I	0.912	1.00
61_R	75_T	0.912	1.00
267_F	313_V	0.909	1.00
60_D	65_E	0.909	1.00
333_V	346_V	0.907	1.00
326_F	329_R	0.906	1.00
265_I	274_G	0.905	1.00
325_E	389_K	0.902	1.00
279_I	289_A	0.898	1.00
352_A	358_V	0.895	1.00
252_G	295_I	0.891	1.00
376_N	382_Q	0.891	1.00
74_L	89_I	0.890	1.00
82_K	216_E	0.890	1.00
219_L	223_E	0.885	1.00
86_F	219_L	0.884	1.00
171_D	174_S	0.882	1.00
22_L	150_A	0.875	1.00
227_K	291_P	0.874	1.00
174_S	178_R	0.869	1.00
259_L	265_I	0.867	1.00
61_R	73_N	0.866	1.00
11_V	112_I	0.862	1.00
320_P	326_F	0.862	1.00
115_V	149_V	0.859	1.00
79_F	86_F	0.859	1.00
302_V	307_I	0.852	1.00
320_P	325_E	0.845	1.00
164_K	168_E	0.843	1.00
30_R	79_F	0.840	1.00
346_V	353_S	0.837	1.00
364_K	384_D	0.836	1.00
167_K	191_P	0.832	1.00
259_L	289_A	0.832	1.00
379_F	383_G	0.830	1.00
55_F	59_L	0.830	1.00
10_I	91_A	0.829	1.00
215_L	218_Y	0.829	1.00
235_I	238_Q	0.828	1.00
149_V	187_V	0.825	1.00
345_P	348_H	0.824	1.00
269_P	311_D	0.821	1.00
178_R	184_T	0.820	1.00
118_K	158_E	0.819	1.00
326_F	332_V	0.817	1.00
59_L	75_T	0.816	1.00
324_D	328_A	0.815	1.00
179_S	183_N	0.812	1.00
376_N	387_I	0.811	1.00
266_V	314_G	0.806	1.00
289_A	293_D	0.805	1.00
128_V	169_I	0.803	1.00
324_D	329_R	0.800	1.00
181_G	185_N	0.799	1.00
178_R	181_G	0.799	1.00
229_V	232_P	0.796	1.00
215_L	219_L	0.796	1.00
16_D	94_H	0.793	1.00
191_P	198_D	0.790	1.00
376_N	386_A	0.790	1.00
115_V	173_V	0.785	1.00
330_I	334_W	0.785	1.00
314_G	320_P	0.781	1.00
180_Y	183_N	0.777	1.00
229_V	291_P	0.774	1.00
140_K	147_L	0.770	1.00
16_D	70_V	0.765	1.00
14_H	17_H	0.762	1.00
378_Q	387_I	0.759	1.00
324_D	333_V	0.758	1.00
344_T	347_I	0.757	1.00
320_P	330_I	0.754	1.00
325_E	331_I	0.753	1.00
320_P	332_V	0.753	1.00
322_V	332_V	0.750	1.00
27_L	32_F	0.749	1.00
272_K	305_K	0.749	1.00
15_I	94_H	0.748	1.00
233_L	315_H	0.748	1.00
254_V	259_L	0.747	1.00
327_T	333_V	0.746	1.00
230_D	258_V	0.746	1.00
85_F	281_T	0.745	1.00
344_T	348_H	0.744	1.00
85_F	293_D	0.742	1.00
188_R	218_Y	0.739	1.00
110_A	148_I	0.736	1.00
252_G	313_V	0.735	1.00
216_E	219_L	0.734	1.00
383_G	387_I	0.734	1.00
308_K	311_D	0.733	1.00
336_P	347_I	0.732	1.00
327_T	331_I	0.731	1.00
338_A	341_N	0.731	1.00
379_F	382_Q	0.729	1.00
274_G	307_I	0.726	0.99
27_L	58_L	0.724	0.99
321_T	330_I	0.718	0.99
188_R	215_L	0.716	0.99
386_A	392_P	0.716	0.99
175_K	178_R	0.716	0.99
95_R	130_G	0.716	0.99
377_P	386_A	0.715	0.99
28_M	197_G	0.714	0.99
26_L	215_L	0.711	0.99
33_I	54_K	0.711	0.99
378_Q	386_A	0.709	0.99
331_I	335_H	0.708	0.99
346_V	357_R	0.707	0.99
330_I	335_H	0.706	0.99
180_Y	187_V	0.705	0.99
55_F	58_L	0.705	0.99
356_C	390_F	0.705	0.99
356_C	392_P	0.703	0.99
31_G	34_D	0.700	0.99
13_G	17_H	0.698	0.99
216_E	221_Q	0.697	0.99
65_E	69_G	0.697	0.99
377_P	385_V	0.696	0.99
320_P	323_A	0.696	0.99
65_E	68_R	0.694	0.99
379_F	384_D	0.694	0.99
78_R	87_T	0.693	0.99
180_Y	184_T	0.692	0.99
29_D	197_G	0.690	0.99
148_I	218_Y	0.689	0.99
235_I	297_F	0.688	0.99
323_A	327_T	0.685	0.99
245_G	248_T	0.684	0.99
110_A	223_E	0.681	0.99
151_V	170_V	0.680	0.99
105_A	142_M	0.678	0.99
266_V	317_N	0.674	0.99
270_A	308_K	0.674	0.99
15_I	70_V	0.672	0.99
380_L	388_V	0.670	0.99
113_L	173_V	0.664	0.99
10_I	111_A	0.664	0.99
343_Y	348_H	0.663	0.99
382_Q	387_I	0.663	0.99
232_P	318_N	0.662	0.99
6_H	87_T	0.662	0.99
243_I	246_V	0.662	0.99
241_Y	296_G	0.662	0.99
22_L	200_I	0.660	0.99
261_V	277_R	0.660	0.99
362_V	366_D	0.658	0.99
114_V	152_N	0.658	0.99
380_L	387_I	0.655	0.99
237_I	307_I	0.655	0.99
68_R	72_I	0.655	0.99
258_V	291_P	0.653	0.99
336_P	339_L	0.653	0.99
376_N	384_D	0.653	0.99
64_E	360_E	0.652	0.99
259_L	279_I	0.648	0.99
349_V	352_A	0.647	0.99
379_F	386_A	0.647	0.99
329_R	333_V	0.647	0.99
107_Q	236_P	0.647	0.99
12_I	105_A	0.646	0.99
192_V	200_I	0.645	0.99
244_S	247_G	0.644	0.99
22_L	214_T	0.641	0.99
29_D	202_H	0.638	0.99
28_M	35_E	0.638	0.99
379_F	387_I	0.636	0.99
233_L	258_V	0.635	0.99
215_L	220_D	0.634	0.99
57_F	66_R	0.634	0.99
238_Q	251_V	0.632	0.99
334_W	339_L	0.632	0.99
280_E	283_H	0.631	0.99
227_K	231_K	0.629	0.99
214_T	220_D	0.629	0.99
386_A	390_F	0.628	0.99
315_H	319_P	0.627	0.99
385_V	388_V	0.627	0.99
243_I	249_V	0.626	0.99
184_T	190_V	0.622	0.98
117_A	164_K	0.621	0.98
74_L	104_G	0.621	0.98
137_I	379_F	0.620	0.98
174_S	189_F	0.619	0.98
6_H	85_F	0.617	0.98
281_T	293_D	0.616	0.98
381_K	386_A	0.615	0.98
140_K	177_M	0.615	0.98
113_L	132_T	0.614	0.98
348_H	353_S	0.614	0.98
54_K	58_L	0.611	0.98
280_E	298_N	0.611	0.98
106_S	255_E	0.609	0.98
359_S	391_K	0.609	0.98
14_H	132_T	0.606	0.98
325_E	332_V	0.604	0.98
252_G	289_A	0.603	0.98
91_A	101_M	0.601	0.98
16_D	153_K	0.601	0.98
326_F	333_V	0.599	0.98
227_K	256_S	0.598	0.98
379_F	385_V	0.598	0.98
10_I	105_A	0.598	0.98
325_E	359_S	0.598	0.98
358_V	362_V	0.596	0.98
16_D	69_G	0.596	0.98
277_R	298_N	0.593	0.98
237_I	313_V	0.593	0.98
174_S	183_N	0.592	0.98
26_L	200_I	0.592	0.98
177_M	181_G	0.591	0.98
113_L	136_I	0.588	0.98
55_F	66_R	0.587	0.98
314_G	319_P	0.587	0.98
387_I	390_F	0.587	0.98
389_K	392_P	0.586	0.98
336_P	345_P	0.585	0.98
340_A	343_Y	0.584	0.98
324_D	327_T	0.584	0.98
334_W	337_T	0.583	0.98
82_K	220_D	0.580	0.98
60_D	69_G	0.577	0.97
361_L	364_K	0.576	0.97
367_P	370_G	0.575	0.97
16_D	71_T	0.574	0.97
326_F	390_F	0.573	0.97
197_G	200_I	0.573	0.97
190_V	201_T	0.573	0.97
101_M	135_H	0.570	0.97
286_M	293_D	0.568	0.97
322_V	337_T	0.566	0.97
32_F	79_F	0.564	0.97
325_E	328_A	0.563	0.97
138_L	142_M	0.563	0.97
324_D	331_I	0.562	0.97
235_I	259_L	0.561	0.97
53_E	56_A	0.559	0.97
387_I	392_P	0.557	0.97
323_A	332_V	0.556	0.97
116_S	153_K	0.556	0.97
320_P	329_R	0.556	0.97
113_L	135_H	0.556	0.97
136_I	177_M	0.556	0.97
190_V	199_N	0.555	0.97
214_T	221_Q	0.555	0.97
164_K	169_I	0.554	0.97
179_S	182_F	0.553	0.97
6_H	293_D	0.550	0.97
328_A	388_V	0.548	0.97
198_D	202_H	0.547	0.97
14_H	129_E	0.546	0.97
347_I	390_F	0.545	0.96
27_L	77_M	0.544	0.96
173_V	177_M	0.544	0.96
9_L	218_Y	0.544	0.96
60_D	66_R	0.544	0.96
181_G	188_R	0.542	0.96
15_I	71_T	0.541	0.96
316_P	319_P	0.540	0.96
246_V	278_S	0.540	0.96
323_A	326_F	0.534	0.96
383_G	386_A	0.534	0.96
70_V	94_H	0.534	0.96
218_Y	221_Q	0.533	0.96
190_V	218_Y	0.533	0.96
115_V	169_I	0.531	0.96
252_G	259_L	0.531	0.96
182_F	185_N	0.530	0.96
387_I	391_K	0.528	0.96
54_K	57_F	0.526	0.96
243_I	247_G	0.525	0.96
64_E	67_E	0.522	0.96
322_V	361_L	0.522	0.96
111_A	147_L	0.520	0.95
110_A	218_Y	0.519	0.95
269_P	272_K	0.519	0.95
35_E	54_K	0.518	0.95
343_Y	347_I	0.517	0.95
195_P	198_D	0.516	0.95
165_R	172_Q	0.516	0.95
218_Y	222_L	0.515	0.95
381_K	388_V	0.515	0.95
17_H	119_K	0.515	0.95
78_R	293_D	0.514	0.95
84_Y	221_Q	0.513	0.95
249_V	298_N	0.513	0.95
120_G	128_V	0.511	0.95
377_P	392_P	0.511	0.95
136_I	140_K	0.511	0.95
86_F	110_A	0.510	0.95
286_M	295_I	0.509	0.95
235_I	239_D	0.509	0.95
109_D	253_R	0.505	0.95
320_P	333_V	0.504	0.95
81_T	84_Y	0.503	0.95
327_T	335_H	0.502	0.94
331_I	334_W	0.501	0.94
24_G	57_F	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jnyA	1	0.9563	100	0.198	Contact Map
4d61i	1	0.977	100	0.216	Contact Map
1f60A	1	0.9793	100	0.22	Contact Map
4crnP	1	0.9793	100	0.221	Contact Map
1r5bA	1	0.8874	100	0.232	Contact Map
3mcaA	1	0.8161	100	0.24	Contact Map
3izq1	1	0.9793	100	0.243	Contact Map
3wy9A	1	0.9356	100	0.243	Contact Map
3p26A	1	0.9126	100	0.244	Contact Map
1zunB	1	0.8943	100	0.277	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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