DPOL1 - SULSO - GREMLIN Contacts

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DPOL1 - DNA polymerase 1

UniProt:	P26811	Sequences: MTKQLTLFDIPSSKPAKSEQNTQQSQQSAPVEEKKVVRREWLEEAQENKIYFLLQVDYDGKKGKAVCKLFDKETQKIYALYDNTGHKPYFLVDLEPDKVGKIPKIVRDPSFDHIETVSKIDPYTWNKFKLTKIVVRDPLAVRRLRNDVPKAYEAHIKYFNNYMYDIGLIPGMPYVVKNGKLESVYLSLDEKDVEEIKKAFADSDEMTRQMAVDWLPIFETEIPKIKRVAIDIEVYTPVKGRIPDSQKAEFPIISIALAGSDGLKKVLVLNRNDVNEGSVKLDGISVERFNTEYELLGRFFDILLEYPIVLTFNGDDFDLPYIYFRALKLGYFPEEIPIDVAGKDEAKYLAGLHIDLYKFFFNKAVRNYAFEGKYNEYNLDAVAKALLGTSKVKVDTLISFLDVEKLIEYNFRDAEITLQLTTFNNDLTMKLIVLFSRISRLGIEELTRTEISTWVKNLYYWEHRKRNWLIPLKEEILAKSSNIRTSALIKGKGYKGAVVIDPPAGIFFNITVLDFASLYPSIIRTWNLSYETVDIQQCKKPYEVKDETGEVLHIVCMDRPGITAVITGLLRDFRVKIYKKKAKNPNNSEEQKLLYDVVQRAMKVFINATYGVFGAETFPLYAPAVAESVTALGRYVITSTVKKAREEGLTVLYGDTDSLFLLNPPKNSLENIIKWVKTTFNLDLEVDKTYKFVAFSGLKKNYFGVYQDGKVDIKGMLVKKRNTPEFVKKVFNEVKELMISINSPNDVKEIKRKIVDVVKGSYEKLKNKGYNLDELAFKVMLSKPLDAYKKNTPQHVKAALQLRPFGVNVLPRDIIYYVKVRSKDGVKPVQLAKVTEIDAEKYLEALRSTFEQILRAFGVSWDEIAATMSIDSFFSYPSKGNS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	882 (778)
Sequences:	1674 (1031)
Seq/√Len:	36.9

ECOLI - DPO2
HALSA - Q9HRV9 Q9HHJ8
SULSO - DPOL1 DPOL3 DPOL2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
677_K	680_F	8.654	1.00
673_I	677_K	8.557	1.00
673_I	680_F	7.704	1.00
677_K	681_N	7.676	1.00
255_I	299_F	6.982	1.00
673_I	681_N	6.193	1.00
676_V	680_F	5.980	1.00
503_P	650_T	5.785	1.00
673_I	676_V	5.447	1.00
252_I	322_I	5.155	1.00
729_K	774_E	4.801	1.00
119_K	467_N	4.799	1.00
389_T	419_Q	4.610	1.00
672_I	680_F	4.552	1.00
764_K	769_G	4.452	1.00
89_Y	165_D	4.257	1.00
670_E	680_F	4.219	1.00
560_P	568_G	4.079	1.00
672_I	677_K	3.998	1.00
671_N	675_W	3.982	1.00
760_G	764_K	3.782	1.00
672_I	676_V	3.744	1.00
670_E	673_I	3.678	1.00
232_I	255_I	3.578	1.00
118_S	127_K	3.515	1.00
670_E	677_K	3.467	1.00
765_L	775_L	3.312	1.00
670_E	676_V	3.218	1.00
730_V	761_S	3.190	1.00
135_V	144_L	3.139	1.00
672_I	681_N	3.129	1.00
230_I	299_F	2.978	1.00
291_T	294_E	2.907	1.00
298_R	301_D	2.814	1.00
674_K	678_T	2.771	1.00
303_L	309_V	2.750	1.00
585_P	591_Q	2.522	1.00
397_L	400_F	2.514	1.00
289_F	298_R	2.511	1.00
641_V	645_R	2.464	1.00
313_N	318_D	2.458	1.00
256_A	414_A	2.429	1.00
732_N	736_E	2.422	1.00
115_E	132_K	2.419	1.00
440_R	461_W	2.414	1.00
676_V	681_N	2.395	1.00
818_V	837_I	2.383	1.00
675_W	681_N	2.372	1.00
462_E	465_K	2.356	1.00
819_K	841_K	2.354	1.00
118_S	129_K	2.336	1.00
158_Y	165_D	2.332	1.00
318_D	413_D	2.320	1.00
337_P	341_A	2.282	0.99
466_R	565_V	2.252	0.99
65_A	71_D	2.250	0.99
690_Y	712_D	2.242	0.99
120_I	127_K	2.234	0.99
83_N	162_Y	2.219	0.99
733_E	737_L	2.217	0.99
828_P	831_L	2.216	0.99
675_W	679_T	2.204	0.99
672_I	675_W	2.189	0.99
581_K	595_Y	2.163	0.99
68_K	71_D	2.147	0.99
384_K	390_S	2.144	0.99
670_E	681_N	2.131	0.99
672_I	679_T	2.124	0.99
553_H	628_S	2.110	0.99
67_C	71_D	2.104	0.99
122_P	125_W	2.101	0.99
151_A	154_A	2.051	0.99
225_I	308_I	2.049	0.99
456_K	619_P	2.035	0.99
717_L	852_Q	2.031	0.99
80_L	197_K	2.018	0.99
383_A	416_I	2.015	0.99
462_E	569_L	2.011	0.99
673_I	679_T	1.992	0.98
860_S	863_E	1.951	0.98
827_K	831_L	1.942	0.98
167_G	465_K	1.918	0.98
67_C	162_Y	1.906	0.98
335_E	339_D	1.906	0.98
231_D	409_Y	1.901	0.98
580_K	583_K	1.874	0.98
676_V	679_T	1.854	0.98
389_T	412_R	1.830	0.97
563_T	613_F	1.794	0.97
766_K	840_E	1.789	0.97
561_G	564_A	1.769	0.97
293_Y	297_G	1.767	0.97
114_I	131_T	1.762	0.97
233_E	413_D	1.758	0.97
138_P	158_Y	1.749	0.97
65_A	68_K	1.740	0.96
289_F	295_L	1.731	0.96
88_P	153_E	1.720	0.96
737_L	753_K	1.720	0.96
335_E	338_I	1.718	0.96
826_V	831_L	1.716	0.96
132_K	165_D	1.712	0.96
157_K	160_N	1.709	0.96
670_E	675_W	1.708	0.96
670_E	674_K	1.703	0.96
292_E	325_R	1.703	0.96
568_G	572_D	1.696	0.96
119_K	122_P	1.691	0.96
585_P	588_S	1.662	0.95
626_A	633_G	1.645	0.95
496_G	499_V	1.645	0.95
165_D	467_N	1.645	0.95
779_V	817_Y	1.644	0.95
828_P	832_A	1.628	0.95
736_E	740_S	1.601	0.94
287_E	298_R	1.592	0.94
458_L	605_F	1.580	0.94
89_Y	132_K	1.573	0.94
756_D	760_G	1.561	0.93
526_W	636_V	1.555	0.93
231_D	413_D	1.554	0.93
829_V	832_A	1.551	0.93
121_D	125_W	1.550	0.93
336_I	339_D	1.548	0.93
228_V	257_L	1.544	0.93
795_H	798_A	1.542	0.93
496_G	630_T	1.538	0.93
516_A	685_E	1.537	0.93
233_E	318_D	1.530	0.93
703_F	716_M	1.528	0.93
92_V	133_I	1.521	0.93
755_V	859_V	1.513	0.92
98_K	101_K	1.511	0.92
254_S	407_I	1.505	0.92
56_V	67_C	1.501	0.92
688_K	712_D	1.499	0.92
757_V	761_S	1.499	0.92
703_F	739_I	1.492	0.92
665_P	669_L	1.477	0.91
197_K	202_D	1.470	0.91
435_F	601_A	1.469	0.91
589_E	592_K	1.467	0.91
338_I	341_A	1.466	0.91
463_H	562_I	1.466	0.91
313_N	317_F	1.463	0.91
231_D	318_D	1.456	0.91
184_V	204_D	1.455	0.91
413_D	630_T	1.448	0.91
671_N	679_T	1.447	0.91
391_K	413_D	1.445	0.90
51_Y	55_Q	1.437	0.90
313_N	365_V	1.436	0.90
654_G	658_S	1.434	0.90
104_K	108_D	1.431	0.90
229_A	417_T	1.427	0.90
393_K	413_D	1.422	0.90
84_T	204_D	1.412	0.89
87_K	113_H	1.408	0.89
840_E	844_E	1.401	0.89
645_R	650_T	1.400	0.89
527_N	532_T	1.400	0.89
584_N	853_I	1.399	0.89
233_E	313_N	1.399	0.89
311_T	314_G	1.398	0.89
688_K	704_G	1.389	0.89
55_Q	58_Y	1.386	0.89
675_W	680_F	1.386	0.89
499_V	699_K	1.383	0.88
141_V	146_N	1.379	0.88
517_S	604_V	1.378	0.88
667_N	678_T	1.377	0.88
639_S	642_K	1.376	0.88
515_F	521_S	1.374	0.88
801_Q	830_Q	1.372	0.88
527_N	561_G	1.372	0.88
512_V	660_F	1.368	0.88
781_L	796_V	1.367	0.88
229_A	414_A	1.367	0.88
50_I	175_V	1.364	0.88
232_I	252_I	1.361	0.88
576_K	580_K	1.358	0.88
256_A	410_N	1.356	0.87
67_C	70_F	1.355	0.87
512_V	704_G	1.353	0.87
246_Q	324_F	1.353	0.87
442_G	445_E	1.347	0.87
727_V	849_T	1.339	0.87
98_K	105_I	1.339	0.87
580_K	584_N	1.338	0.87
512_V	688_K	1.326	0.86
300_F	304_L	1.326	0.86
790_K	793_P	1.325	0.86
65_A	88_P	1.314	0.86
339_D	347_K	1.312	0.86
650_T	662_L	1.306	0.85
394_V	397_L	1.302	0.85
612_V	618_F	1.295	0.85
730_V	757_V	1.295	0.85
638_T	642_K	1.287	0.84
592_K	596_D	1.284	0.84
98_K	102_I	1.283	0.84
227_R	308_I	1.281	0.84
171_G	724_P	1.276	0.84
335_E	340_V	1.273	0.84
102_I	106_V	1.271	0.84
308_I	429_M	1.271	0.84
360_F	443_I	1.269	0.84
571_R	606_I	1.268	0.84
640_T	659_L	1.262	0.83
276_E	279_V	1.261	0.83
112_D	136_R	1.261	0.83
171_G	433_V	1.259	0.83
391_K	416_I	1.258	0.83
132_K	467_N	1.256	0.83
138_P	141_V	1.256	0.83
504_A	698_L	1.255	0.83
456_K	612_V	1.255	0.83
313_N	413_D	1.254	0.83
821_R	836_E	1.250	0.83
93_D	152_Y	1.245	0.82
582_A	596_D	1.244	0.82
340_V	343_K	1.242	0.82
140_A	146_N	1.241	0.82
69_L	83_N	1.237	0.82
413_D	496_G	1.234	0.82
671_N	680_F	1.230	0.82
65_A	138_P	1.229	0.82
360_F	460_Y	1.220	0.81
838_D	849_T	1.218	0.81
233_E	409_Y	1.216	0.81
501_D	524_R	1.216	0.81
672_I	678_T	1.213	0.81
228_V	303_L	1.210	0.81
318_D	391_K	1.200	0.80
272_N	275_N	1.196	0.80
733_E	736_E	1.191	0.80
81_Y	174_Y	1.189	0.79
309_V	356_L	1.185	0.79
713_I	716_M	1.184	0.79
259_G	306_Y	1.184	0.79
168_L	729_K	1.182	0.79
153_E	165_D	1.182	0.79
561_G	565_V	1.179	0.79
81_Y	203_S	1.174	0.79
103_P	107_R	1.171	0.78
432_I	443_I	1.168	0.78
119_K	464_R	1.167	0.78
127_K	467_N	1.166	0.78
577_I	602_M	1.166	0.78
668_S	671_N	1.165	0.78
674_K	680_F	1.163	0.78
763_E	767_N	1.154	0.77
121_D	124_T	1.152	0.77
574_R	599_Q	1.151	0.77
509_N	662_L	1.145	0.77
252_I	296_L	1.143	0.77
124_T	535_I	1.141	0.77
113_H	134_V	1.136	0.76
397_L	401_L	1.134	0.76
596_D	599_Q	1.131	0.76
99_V	103_P	1.131	0.76
585_P	595_Y	1.128	0.76
141_V	145_R	1.126	0.76
706_Y	710_K	1.123	0.75
258_A	418_L	1.121	0.75
545_K	632_L	1.119	0.75
90_F	736_E	1.111	0.75
675_W	678_T	1.111	0.75
100_G	103_P	1.108	0.74
317_F	365_V	1.107	0.74
375_N	728_K	1.106	0.74
64_K	68_K	1.103	0.74
826_V	830_Q	1.101	0.74
586_N	589_E	1.100	0.74
719_K	722_N	1.099	0.74
122_P	468_W	1.098	0.74
376_E	381_A	1.095	0.73
396_T	401_L	1.094	0.73
56_V	159_F	1.093	0.73
719_K	795_H	1.092	0.73
156_I	460_Y	1.092	0.73
90_F	144_L	1.091	0.73
460_Y	470_I	1.091	0.73
582_A	592_K	1.089	0.73
695_F	714_K	1.086	0.73
412_R	415_E	1.086	0.73
538_C	541_P	1.085	0.73
796_V	799_A	1.085	0.73
143_R	146_N	1.084	0.73
793_P	796_V	1.084	0.73
636_V	682_L	1.084	0.73
295_L	501_D	1.082	0.73
233_E	317_F	1.082	0.73
359_F	440_R	1.082	0.73
670_E	679_T	1.081	0.72
809_V	814_I	1.078	0.72
778_K	814_I	1.078	0.72
117_V	122_P	1.077	0.72
379_L	601_A	1.075	0.72
666_K	691_K	1.072	0.72
526_W	682_L	1.067	0.72
65_A	70_F	1.064	0.71
317_F	413_D	1.063	0.71
619_P	852_Q	1.058	0.71
452_S	621_Y	1.057	0.71
655_D	700_K	1.057	0.71
610_Y	626_A	1.055	0.71
89_Y	161_N	1.055	0.71
324_F	327_L	1.053	0.70
387_L	416_I	1.053	0.70
510_I	662_L	1.049	0.70
342_G	348_Y	1.048	0.70
334_E	339_D	1.041	0.70
90_F	141_V	1.040	0.70
166_I	207_T	1.036	0.69
252_I	807_V	1.035	0.69
606_I	721_R	1.034	0.69
57_D	68_K	1.032	0.69
846_L	850_F	1.030	0.69
66_V	69_L	1.028	0.69
439_S	693_V	1.027	0.69
133_I	138_P	1.023	0.68
637_I	690_Y	1.022	0.68
380_D	390_S	1.022	0.68
543_E	557_M	1.022	0.68
784_P	787_A	1.019	0.68
570_L	602_M	1.019	0.68
603_K	611_G	1.017	0.68
88_P	154_A	1.013	0.67
202_D	205_E	1.010	0.67
52_F	57_D	1.009	0.67
409_Y	413_D	1.007	0.67
827_K	832_A	1.006	0.67
81_Y	205_E	1.006	0.67
434_L	598_V	1.005	0.67
250_F	321_Y	1.002	0.67
636_V	640_T	1.002	0.67
130_L	469_L	1.002	0.67
363_K	608_A	1.002	0.67
367_N	371_E	1.001	0.67
153_E	156_I	0.998	0.66
516_A	564_A	0.998	0.66
138_P	154_A	0.998	0.66
717_L	720_K	0.997	0.66
116_T	119_K	0.997	0.66
83_N	205_E	0.991	0.66
716_M	731_F	0.988	0.66
81_Y	176_V	0.987	0.65
266_V	269_L	0.985	0.65
546_D	552_L	0.984	0.65
199_A	202_D	0.982	0.65
570_L	799_A	0.982	0.65
462_E	566_I	0.981	0.65
409_Y	416_I	0.981	0.65
198_K	203_S	0.980	0.65
666_K	677_K	0.978	0.65
394_V	401_L	0.970	0.64
68_K	82_D	0.967	0.64
270_N	274_V	0.965	0.64
666_K	669_L	0.964	0.64
137_D	140_A	0.961	0.63
722_N	779_V	0.961	0.63
785_L	800_L	0.960	0.63
379_L	496_G	0.957	0.63
471_P	505_G	0.956	0.63
784_P	811_P	0.955	0.63
90_F	596_D	0.955	0.63
598_V	606_I	0.954	0.63
841_K	852_Q	0.953	0.63
335_E	341_A	0.952	0.63
364_A	417_T	0.952	0.63
510_I	802_L	0.950	0.62
701_N	717_L	0.950	0.62
264_K	268_V	0.949	0.62
374_Y	382_V	0.949	0.62
182_E	204_D	0.948	0.62
434_L	437_R	0.948	0.62
85_G	113_H	0.943	0.62
130_L	516_A	0.940	0.62
458_L	497_A	0.935	0.61
374_Y	377_Y	0.934	0.61
765_L	843_L	0.933	0.61
143_R	147_D	0.932	0.61
337_P	340_V	0.928	0.61
170_P	440_R	0.928	0.61
270_N	273_D	0.927	0.61
745_N	755_V	0.926	0.60
208_R	211_A	0.926	0.60
120_I	125_W	0.926	0.60
466_R	562_I	0.925	0.60
507_F	529_S	0.924	0.60
510_I	813_D	0.923	0.60
528_L	547_E	0.923	0.60
549_G	553_H	0.922	0.60
663_N	672_I	0.921	0.60
161_N	165_D	0.921	0.60
696_S	793_P	0.921	0.60
268_V	272_N	0.921	0.60
91_L	197_K	0.919	0.60
152_Y	469_L	0.918	0.60
705_V	708_D	0.916	0.60
359_F	852_Q	0.916	0.60
510_I	652_L	0.916	0.60
233_E	391_K	0.915	0.59
614_G	658_S	0.914	0.59
241_R	244_D	0.913	0.59
717_L	731_F	0.910	0.59
231_D	313_N	0.909	0.59
286_V	373_K	0.909	0.59
706_Y	775_L	0.909	0.59
516_A	604_V	0.907	0.59
101_K	105_I	0.906	0.59
577_I	581_K	0.906	0.59
730_V	734_V	0.906	0.59
338_I	343_K	0.904	0.59
464_R	467_N	0.903	0.58
149_P	168_L	0.900	0.58
838_D	842_Y	0.898	0.58
764_K	770_Y	0.898	0.58
318_D	409_Y	0.895	0.58
504_A	631_A	0.895	0.58
140_A	143_R	0.893	0.58
516_A	683_D	0.893	0.58
588_S	591_Q	0.892	0.58
265_K	268_V	0.891	0.57
89_Y	158_Y	0.890	0.57
379_L	499_V	0.889	0.57
306_Y	423_F	0.889	0.57
500_I	719_K	0.887	0.57
349_L	860_S	0.887	0.57
293_Y	329_L	0.887	0.57
522_I	682_L	0.880	0.56
273_D	278_S	0.880	0.56
701_N	775_L	0.879	0.56
237_P	247_K	0.879	0.56
379_L	413_D	0.876	0.56
312_F	420_L	0.876	0.56
301_D	304_L	0.876	0.56
334_E	337_P	0.875	0.56
532_T	561_G	0.873	0.56
54_L	81_Y	0.873	0.56
817_Y	842_Y	0.872	0.56
411_F	684_L	0.870	0.56
522_I	529_S	0.870	0.56
93_D	128_F	0.870	0.56
336_I	340_V	0.870	0.56
494_Y	626_A	0.868	0.55
799_A	838_D	0.868	0.55
81_Y	85_G	0.867	0.55
268_V	275_N	0.867	0.55
105_I	109_P	0.867	0.55
391_K	409_Y	0.866	0.55
54_L	57_D	0.865	0.55
703_F	726_F	0.863	0.55
639_S	643_K	0.863	0.55
120_I	468_W	0.862	0.55
801_Q	826_V	0.862	0.55
850_F	854_L	0.861	0.55
284_I	411_F	0.860	0.55
369_A	780_M	0.859	0.55
723_T	727_V	0.859	0.55
359_F	651_V	0.858	0.55
364_A	421_T	0.858	0.55
313_N	391_K	0.856	0.54
99_V	105_I	0.856	0.54
790_K	844_E	0.851	0.54
450_E	701_N	0.851	0.54
612_V	626_A	0.851	0.54
61_K	64_K	0.849	0.54
435_F	439_S	0.849	0.54
515_F	651_V	0.848	0.54
120_I	559_R	0.847	0.54
833_K	836_E	0.845	0.53
109_P	291_T	0.844	0.53
97_D	101_K	0.843	0.53
511_T	661_L	0.839	0.53
145_R	154_A	0.838	0.53
114_I	291_T	0.837	0.53
119_K	469_L	0.837	0.53
312_F	382_V	0.837	0.53
135_V	141_V	0.836	0.53
526_W	637_I	0.836	0.53
254_S	410_N	0.836	0.53
232_I	313_N	0.834	0.52
94_L	131_T	0.834	0.52
121_D	126_N	0.833	0.52
570_L	838_D	0.833	0.52
797_K	800_L	0.831	0.52
272_N	278_S	0.831	0.52
550_E	553_H	0.831	0.52
423_F	523_I	0.830	0.52
275_N	278_S	0.830	0.52
725_E	772_L	0.830	0.52
176_V	205_E	0.828	0.52
551_V	628_S	0.828	0.52
106_V	109_P	0.828	0.52
615_A	688_K	0.826	0.52
502_P	637_I	0.826	0.52
262_G	267_L	0.826	0.52
252_I	270_N	0.824	0.52
720_K	788_Y	0.824	0.52
462_E	466_R	0.824	0.52
614_G	626_A	0.823	0.51
231_D	317_F	0.823	0.51
363_K	496_G	0.822	0.51
660_F	704_G	0.816	0.51
760_G	769_G	0.815	0.51
263_L	269_L	0.814	0.51
231_D	391_K	0.813	0.51
74_T	221_E	0.813	0.51
660_F	777_F	0.812	0.51
619_P	717_L	0.812	0.51
297_G	301_D	0.810	0.50
550_E	635_Y	0.810	0.50
738_M	840_E	0.808	0.50
106_V	173_P	0.806	0.50
321_Y	325_R	0.806	0.50
413_D	416_I	0.806	0.50
671_N	677_K	0.805	0.50
777_F	852_Q	0.804	0.50
612_V	620_L	0.804	0.50
279_V	283_G	0.804	0.50
296_L	304_L	0.803	0.50
56_V	69_L	0.803	0.50
435_F	454_W	0.802	0.50
130_L	160_N	0.802	0.50
800_L	803_R	0.799	0.49
110_S	136_R	0.798	0.49
653_Y	658_S	0.796	0.49
718_V	849_T	0.795	0.49
497_A	630_T	0.795	0.49
99_V	104_K	0.794	0.49
266_V	272_N	0.794	0.49
322_I	331_Y	0.793	0.49
391_K	496_G	0.792	0.49
62_K	329_L	0.792	0.49
798_A	815_I	0.790	0.49
574_R	634_R	0.789	0.48
138_P	142_R	0.789	0.48
275_N	642_K	0.788	0.48
573_F	576_K	0.788	0.48
234_V	321_Y	0.788	0.48
756_D	759_K	0.788	0.48
608_A	630_T	0.787	0.48
318_D	365_V	0.787	0.48
233_E	496_G	0.786	0.48
93_D	150_K	0.785	0.48
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267_L	596_D	0.782	0.48
611_G	656_T	0.782	0.48
204_D	210_M	0.781	0.48
379_L	409_Y	0.778	0.48
102_I	105_I	0.778	0.48
243_P	321_Y	0.777	0.47
334_E	338_I	0.777	0.47
117_V	120_I	0.776	0.47
340_V	347_K	0.775	0.47
820_V	854_L	0.775	0.47
138_P	165_D	0.774	0.47
772_L	821_R	0.774	0.47
494_Y	614_G	0.774	0.47
548_T	553_H	0.773	0.47
415_E	419_Q	0.772	0.47
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496_G	614_G	0.772	0.47
133_I	148_V	0.771	0.47
218_F	756_D	0.769	0.47
646_E	689_T	0.769	0.47
733_E	757_V	0.769	0.47
517_S	658_S	0.768	0.47
841_K	845_A	0.768	0.47
260_S	418_L	0.768	0.47
463_H	531_E	0.765	0.46
622_A	712_D	0.765	0.46
779_V	795_H	0.765	0.46
497_A	516_A	0.763	0.46
92_V	729_K	0.763	0.46
581_K	584_N	0.762	0.46
655_D	699_K	0.762	0.46
674_K	679_T	0.761	0.46
377_Y	722_N	0.760	0.46
70_F	80_L	0.760	0.46
358_K	720_K	0.760	0.46
603_K	656_T	0.758	0.46
449_T	625_V	0.758	0.46
452_S	615_A	0.757	0.46
754_I	857_F	0.756	0.46
826_V	829_V	0.756	0.46
51_Y	54_L	0.756	0.46
583_K	596_D	0.755	0.46
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92_V	151_A	0.754	0.45
564_A	606_I	0.753	0.45
362_N	367_N	0.753	0.45
313_N	416_I	0.753	0.45
273_D	279_V	0.753	0.45
222_I	433_V	0.752	0.45
53_L	58_Y	0.752	0.45
429_M	650_T	0.751	0.45
67_C	538_C	0.750	0.45
757_V	799_A	0.748	0.45
356_L	772_L	0.747	0.45
65_A	69_L	0.746	0.45
150_K	474_E	0.745	0.45
610_Y	633_G	0.745	0.45
265_K	272_N	0.745	0.45
420_L	499_V	0.744	0.45
145_R	148_V	0.744	0.45
580_K	787_A	0.742	0.44
230_I	319_L	0.742	0.44
464_R	470_I	0.739	0.44
160_N	453_T	0.738	0.44
311_T	358_K	0.738	0.44
402_D	405_K	0.738	0.44
128_F	175_V	0.737	0.44
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345_E	348_Y	0.735	0.44
312_F	785_L	0.734	0.44
83_N	294_E	0.734	0.44
142_R	145_R	0.733	0.44
319_L	812_R	0.732	0.44
695_F	721_R	0.731	0.43
513_L	672_I	0.730	0.43
168_L	332_F	0.729	0.43
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723_T	848_S	0.728	0.43
515_F	622_A	0.728	0.43
797_K	801_Q	0.728	0.43
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142_R	668_S	0.728	0.43
644_A	695_F	0.727	0.43
658_S	661_L	0.727	0.43
131_T	140_A	0.726	0.43
595_Y	636_V	0.726	0.43
114_I	119_K	0.725	0.43
226_K	306_Y	0.725	0.43
547_E	553_H	0.725	0.43
63_G	67_C	0.724	0.43
53_L	56_V	0.724	0.43
406_L	438_I	0.723	0.43
606_I	612_V	0.721	0.43
642_K	645_R	0.719	0.42
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247_K	756_D	0.716	0.42
502_P	518_L	0.714	0.42
289_F	294_E	0.713	0.42
613_F	628_S	0.712	0.42
54_L	58_Y	0.712	0.42
335_E	347_K	0.712	0.42
232_I	416_I	0.710	0.42
666_K	673_I	0.710	0.42
453_T	497_A	0.710	0.42
704_G	717_L	0.710	0.42
614_G	795_H	0.709	0.42
257_L	299_F	0.709	0.42
167_G	464_R	0.709	0.42
266_V	271_R	0.707	0.41
225_I	459_Y	0.707	0.41
266_V	270_N	0.707	0.41
233_E	416_I	0.707	0.41
599_Q	634_R	0.706	0.41
435_F	776_A	0.705	0.41
108_D	116_T	0.704	0.41
151_A	160_N	0.703	0.41
80_L	202_D	0.703	0.41
719_K	723_T	0.703	0.41
502_P	634_R	0.702	0.41
576_K	581_K	0.702	0.41
367_N	428_T	0.701	0.41
133_I	144_L	0.700	0.41
529_S	532_T	0.699	0.41
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78_Y	81_Y	0.698	0.41
326_A	775_L	0.697	0.41
252_I	584_N	0.697	0.41
450_E	720_K	0.697	0.41
452_S	456_K	0.694	0.40
603_K	657_D	0.694	0.40
506_I	856_A	0.694	0.40
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569_L	576_K	0.692	0.40
720_K	724_P	0.692	0.40
851_E	861_W	0.691	0.40
347_K	684_L	0.690	0.40
427_L	430_K	0.690	0.40
180_K	183_S	0.690	0.40
359_F	717_L	0.690	0.40
656_T	700_K	0.690	0.40
133_I	669_L	0.688	0.40
577_I	598_V	0.687	0.40
791_N	796_V	0.686	0.40
838_D	841_K	0.686	0.40
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469_L	642_K	0.685	0.39
851_E	855_R	0.685	0.39
515_F	653_Y	0.684	0.39
410_N	414_A	0.683	0.39
514_D	519_Y	0.682	0.39
126_N	503_P	0.682	0.39
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660_F	703_F	0.680	0.39
510_I	693_V	0.679	0.39
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419_Q	684_L	0.675	0.39
228_V	686_V	0.675	0.39
521_S	577_I	0.673	0.38
794_Q	798_A	0.673	0.38
615_A	621_Y	0.672	0.38
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726_F	846_L	0.670	0.38
524_R	567_T	0.670	0.38
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218_F	294_E	0.670	0.38
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613_F	727_V	0.670	0.38
116_T	120_I	0.669	0.38
611_G	715_G	0.669	0.38
104_K	107_R	0.668	0.38
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536_Q	540_K	0.668	0.38
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380_D	391_K	0.666	0.38
858_G	863_E	0.665	0.38
73_E	76_K	0.665	0.38
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263_L	272_N	0.665	0.38
725_E	728_K	0.665	0.38
657_D	715_G	0.665	0.38
233_E	242_I	0.664	0.38
795_H	805_F	0.663	0.38
356_L	428_T	0.662	0.38
434_L	690_Y	0.661	0.37
341_A	347_K	0.660	0.37
65_A	158_Y	0.659	0.37
474_E	846_L	0.659	0.37
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560_P	565_V	0.658	0.37
454_W	530_Y	0.658	0.37
227_R	276_E	0.657	0.37
434_L	814_I	0.657	0.37
252_I	708_D	0.656	0.37
64_K	69_L	0.656	0.37
252_I	279_V	0.654	0.37
370_F	719_K	0.653	0.37
168_L	172_M	0.653	0.37
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558_D	760_G	0.652	0.37
544_V	552_L	0.652	0.37
499_V	505_G	0.651	0.37
615_A	692_F	0.651	0.37
427_L	626_A	0.651	0.37
89_Y	138_P	0.651	0.37
73_E	286_V	0.651	0.37
108_D	330_G	0.650	0.37
270_N	275_N	0.650	0.37
700_K	720_K	0.650	0.37
293_Y	331_Y	0.649	0.37
858_G	865_A	0.649	0.37
175_V	180_K	0.649	0.37
660_F	663_N	0.648	0.36
599_Q	721_R	0.648	0.36
367_N	429_M	0.647	0.36
163_M	170_P	0.646	0.36
621_Y	814_I	0.645	0.36
229_A	438_I	0.645	0.36
603_K	715_G	0.644	0.36
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269_L	272_N	0.642	0.36
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490_K	493_G	0.641	0.36
786_D	789_K	0.641	0.36
271_R	275_N	0.640	0.36
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471_P	496_G	0.639	0.36
184_V	510_I	0.639	0.36
147_D	182_E	0.639	0.36
54_L	60_G	0.638	0.36
308_I	388_G	0.637	0.36
99_V	114_I	0.637	0.36
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205_E	208_R	0.635	0.35
601_A	694_A	0.634	0.35
336_I	347_K	0.633	0.35
363_K	630_T	0.633	0.35
556_C	560_P	0.633	0.35
165_D	171_G	0.632	0.35
103_P	109_P	0.631	0.35
611_G	700_K	0.631	0.35
67_C	159_F	0.631	0.35
387_L	567_T	0.631	0.35
111_F	114_I	0.631	0.35
55_Q	67_C	0.631	0.35
508_F	711_V	0.631	0.35
273_D	276_E	0.631	0.35
171_G	310_L	0.630	0.35
285_S	709_G	0.630	0.35
51_Y	56_V	0.629	0.35
525_T	613_F	0.629	0.35
776_A	818_V	0.628	0.35
299_F	408_E	0.626	0.35
493_G	616_E	0.626	0.35
657_D	700_K	0.626	0.35
97_D	338_I	0.626	0.35
155_H	161_N	0.624	0.34
231_D	630_T	0.624	0.34
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493_G	510_I	0.623	0.34
158_Y	523_I	0.622	0.34
177_K	252_I	0.622	0.34
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816_Y	828_P	0.620	0.34
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102_I	109_P	0.619	0.34
369_A	722_N	0.619	0.34
682_L	815_I	0.619	0.34
152_Y	155_H	0.619	0.34
533_V	817_Y	0.619	0.34
66_V	84_T	0.618	0.34
626_A	728_K	0.617	0.34
318_D	630_T	0.616	0.34
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267_L	270_N	0.615	0.34
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840_E	865_A	0.613	0.34
614_G	654_G	0.612	0.34
781_L	795_H	0.611	0.33
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522_I	714_K	0.608	0.33
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518_L	633_G	0.608	0.33
69_L	73_E	0.608	0.33
450_E	644_A	0.607	0.33
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603_K	700_K	0.606	0.33
152_Y	864_I	0.606	0.33
209_Q	580_K	0.606	0.33
266_V	274_V	0.605	0.33
366_R	448_R	0.605	0.33
91_L	132_K	0.605	0.33
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100_G	180_K	0.603	0.33
619_P	720_K	0.603	0.33
120_I	334_E	0.603	0.33
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517_S	571_R	0.603	0.33
229_A	310_L	0.603	0.33
520_P	715_G	0.601	0.33
255_I	818_V	0.600	0.33
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739_I	794_Q	0.600	0.33
318_D	496_G	0.599	0.33
528_L	601_A	0.599	0.33
313_N	496_G	0.599	0.33
795_H	817_Y	0.598	0.32
629_V	761_S	0.598	0.32
263_L	268_V	0.597	0.32
762_Y	766_K	0.597	0.32
577_I	763_E	0.597	0.32
103_P	108_D	0.596	0.32
861_W	864_I	0.596	0.32
174_Y	316_D	0.595	0.32
379_L	391_K	0.595	0.32
359_F	703_F	0.595	0.32
847_R	865_A	0.594	0.32
298_R	302_I	0.594	0.32
59_D	66_V	0.593	0.32
450_E	779_V	0.593	0.32
71_D	76_K	0.592	0.32
112_D	642_K	0.592	0.32
247_K	523_I	0.592	0.32
197_K	201_A	0.592	0.32
382_V	685_E	0.591	0.32
246_Q	328_K	0.591	0.32
377_Y	814_I	0.591	0.32
272_N	279_V	0.591	0.32
81_Y	179_G	0.590	0.32
322_I	593_L	0.590	0.32
82_D	452_S	0.589	0.32
264_K	269_L	0.589	0.32
611_G	658_S	0.588	0.32
515_F	570_L	0.588	0.32
173_P	838_D	0.587	0.32
451_I	457_N	0.587	0.32
433_V	443_I	0.587	0.32
713_I	735_K	0.586	0.32
52_F	58_Y	0.586	0.32
66_V	71_D	0.586	0.32
643_K	646_E	0.586	0.32
606_I	609_T	0.585	0.31
171_G	429_M	0.585	0.31
232_I	242_I	0.585	0.31
361_F	377_Y	0.584	0.31
607_N	633_G	0.583	0.31
242_I	407_I	0.583	0.31
595_Y	782_S	0.583	0.31
98_K	106_V	0.583	0.31
713_I	718_V	0.583	0.31
530_Y	731_F	0.583	0.31
634_R	700_K	0.583	0.31
344_D	347_K	0.582	0.31
64_K	84_T	0.582	0.31
859_V	864_I	0.582	0.31
228_V	299_F	0.581	0.31
592_K	667_N	0.580	0.31
859_V	862_D	0.580	0.31
178_N	756_D	0.579	0.31
517_S	524_R	0.579	0.31
516_A	701_N	0.578	0.31
450_E	682_L	0.578	0.31
690_Y	727_V	0.578	0.31
700_K	715_G	0.578	0.31
724_P	727_V	0.577	0.31
803_R	844_E	0.576	0.31
604_V	620_L	0.576	0.31
113_H	760_G	0.576	0.31
420_L	424_N	0.576	0.31
297_G	308_I	0.575	0.31
117_V	133_I	0.575	0.31
518_L	653_Y	0.575	0.31
296_L	506_I	0.573	0.31
766_K	843_L	0.573	0.31
300_F	326_A	0.573	0.31
394_V	405_K	0.573	0.31
535_I	604_V	0.572	0.30
420_L	805_F	0.571	0.30
445_E	453_T	0.571	0.30
69_L	174_Y	0.571	0.30
522_I	636_V	0.570	0.30
805_F	826_V	0.570	0.30
210_M	642_K	0.570	0.30
114_I	252_I	0.570	0.30
130_L	152_Y	0.569	0.30
123_Y	159_F	0.568	0.30
317_F	383_A	0.568	0.30
772_L	818_V	0.568	0.30
827_K	830_Q	0.567	0.30
317_F	409_Y	0.566	0.30
73_E	201_A	0.566	0.30
300_F	767_N	0.566	0.30
269_L	275_N	0.566	0.30
232_I	317_F	0.565	0.30
787_A	823_K	0.565	0.30
228_V	408_E	0.565	0.30
266_V	276_E	0.565	0.30
410_N	413_D	0.564	0.30
141_V	330_G	0.564	0.30
510_I	754_I	0.564	0.30
767_N	804_P	0.563	0.30
520_P	610_Y	0.562	0.30
274_V	278_S	0.562	0.30
720_K	779_V	0.562	0.30
339_D	343_K	0.561	0.30
293_Y	332_F	0.561	0.30
231_D	379_L	0.561	0.30
456_K	618_F	0.560	0.30
75_Q	116_T	0.560	0.30
162_Y	648_G	0.560	0.30
115_E	118_S	0.559	0.30
600_R	721_R	0.559	0.30
434_L	609_T	0.559	0.30
451_I	620_L	0.559	0.30
703_F	799_A	0.558	0.29
97_D	109_P	0.558	0.29
676_V	803_R	0.557	0.29
505_G	601_A	0.557	0.29
796_V	813_D	0.555	0.29
817_Y	837_I	0.555	0.29
530_Y	613_F	0.555	0.29
102_I	107_R	0.553	0.29
312_F	374_Y	0.553	0.29
618_F	721_R	0.553	0.29
134_V	569_L	0.553	0.29
459_Y	524_R	0.552	0.29
139_L	146_N	0.551	0.29
243_P	250_F	0.551	0.29
532_T	634_R	0.550	0.29
77_I	414_A	0.550	0.29
815_I	828_P	0.550	0.29
252_I	325_R	0.550	0.29
674_K	677_K	0.550	0.29
91_L	295_L	0.549	0.29
204_D	678_T	0.549	0.29
90_F	476_I	0.549	0.29
107_R	128_F	0.547	0.29
135_V	148_V	0.547	0.29
777_F	841_K	0.547	0.29
371_E	600_R	0.547	0.29
501_D	602_M	0.546	0.29
583_K	592_K	0.546	0.29
725_E	774_E	0.546	0.29
168_L	174_Y	0.546	0.29
329_L	561_G	0.545	0.28
783_K	800_L	0.545	0.28
299_F	420_L	0.545	0.28
765_L	773_D	0.544	0.28
88_P	858_G	0.544	0.28
199_A	661_L	0.544	0.28
231_D	410_N	0.544	0.28
125_W	455_V	0.544	0.28
279_V	646_E	0.543	0.28
233_E	379_L	0.543	0.28
546_D	708_D	0.543	0.28
114_I	565_V	0.543	0.28
618_F	621_Y	0.543	0.28
574_R	656_T	0.542	0.28
309_V	554_I	0.542	0.28
170_P	358_K	0.542	0.28
340_V	642_K	0.541	0.28
719_K	819_K	0.540	0.28
365_V	421_T	0.540	0.28
255_I	267_L	0.540	0.28
265_K	276_E	0.540	0.28
615_A	712_D	0.540	0.28
262_G	271_R	0.539	0.28
262_G	765_L	0.539	0.28
260_S	645_R	0.539	0.28
571_R	852_Q	0.539	0.28
111_F	116_T	0.539	0.28
452_S	463_H	0.539	0.28
518_L	521_S	0.538	0.28
405_K	408_E	0.538	0.28
690_Y	812_R	0.538	0.28
602_M	690_Y	0.537	0.28
376_E	660_F	0.536	0.28
160_N	171_G	0.536	0.28
137_D	142_R	0.536	0.28
227_R	310_L	0.536	0.28
252_I	324_F	0.536	0.28
738_M	745_N	0.536	0.28
315_D	841_K	0.536	0.28
73_E	92_V	0.534	0.28
625_V	688_K	0.534	0.28
296_L	322_I	0.534	0.28
502_P	527_N	0.533	0.28
272_N	276_E	0.533	0.28
539_K	542_Y	0.533	0.28
142_R	148_V	0.532	0.28
847_R	862_D	0.532	0.28
260_S	758_V	0.532	0.28
392_V	408_E	0.531	0.27
401_L	405_K	0.530	0.27
462_E	573_F	0.530	0.27
313_N	409_Y	0.530	0.27
596_D	678_T	0.530	0.27
413_D	685_E	0.529	0.27
410_N	854_L	0.529	0.27
279_V	595_Y	0.528	0.27
359_F	548_T	0.528	0.27
328_K	643_K	0.528	0.27
500_I	813_D	0.528	0.27
625_V	637_I	0.528	0.27
420_L	494_Y	0.528	0.27
284_I	661_L	0.528	0.27
845_A	848_S	0.528	0.27
456_K	473_K	0.527	0.27
660_F	693_V	0.527	0.27
725_E	729_K	0.526	0.27
516_A	606_I	0.526	0.27
310_L	421_T	0.526	0.27
145_R	161_N	0.526	0.27
518_L	654_G	0.525	0.27
686_V	721_R	0.525	0.27
311_T	720_K	0.524	0.27
295_L	491_G	0.524	0.27
364_A	860_S	0.524	0.27
371_E	382_V	0.524	0.27
162_Y	166_I	0.523	0.27
322_I	326_A	0.523	0.27
694_A	703_F	0.523	0.27
297_G	331_Y	0.523	0.27
529_S	634_R	0.522	0.27
315_D	448_R	0.522	0.27
98_K	109_P	0.522	0.27
466_R	632_L	0.522	0.27
100_G	214_W	0.521	0.27
231_D	496_G	0.520	0.27
627_E	632_L	0.520	0.27
83_N	116_T	0.519	0.27
303_L	776_A	0.519	0.27
520_P	842_Y	0.519	0.27
820_V	837_I	0.519	0.27
451_I	717_L	0.519	0.27
350_A	397_L	0.519	0.27
245_S	250_F	0.518	0.27
474_E	684_L	0.518	0.27
182_E	708_D	0.518	0.27
788_Y	793_P	0.517	0.27
286_V	406_L	0.516	0.26
612_V	721_R	0.516	0.26
626_A	775_L	0.516	0.26
669_L	674_K	0.516	0.26
145_R	149_P	0.516	0.26
233_E	630_T	0.515	0.26
494_Y	499_V	0.514	0.26
454_W	598_V	0.514	0.26
117_V	329_L	0.514	0.26
529_S	819_K	0.513	0.26
521_S	653_Y	0.513	0.26
710_K	773_D	0.513	0.26
122_P	136_R	0.512	0.26
500_I	614_G	0.512	0.26
232_I	409_Y	0.512	0.26
236_T	243_P	0.511	0.26
92_V	303_L	0.511	0.26
580_K	674_K	0.510	0.26
549_G	555_V	0.510	0.26
788_Y	794_Q	0.510	0.26
339_D	342_G	0.509	0.26
691_K	733_E	0.509	0.26
468_W	580_K	0.509	0.26
229_A	418_L	0.508	0.26
414_A	801_Q	0.508	0.26
701_N	720_K	0.508	0.26
60_G	63_G	0.508	0.26
677_K	686_V	0.507	0.26
309_V	327_L	0.507	0.26
816_Y	827_K	0.507	0.26
274_V	678_T	0.507	0.26
664_P	703_F	0.506	0.26
859_V	863_E	0.505	0.26
305_E	804_P	0.505	0.26
252_I	772_L	0.505	0.26
734_V	815_I	0.505	0.26
534_D	642_K	0.504	0.26
164_Y	171_G	0.504	0.26
230_I	336_I	0.504	0.26
496_G	700_K	0.504	0.26
197_K	200_F	0.504	0.26
576_K	818_V	0.503	0.26
329_L	342_G	0.503	0.26
609_T	622_A	0.503	0.26
285_S	305_E	0.503	0.26
103_P	666_K	0.503	0.26
123_Y	126_N	0.502	0.26
785_L	788_Y	0.502	0.26
458_L	659_L	0.501	0.25
582_A	595_Y	0.501	0.25
303_L	725_E	0.501	0.25
361_F	445_E	0.501	0.25
157_K	164_Y	0.501	0.25
736_E	822_S	0.501	0.25
151_A	172_M	0.501	0.25
100_G	108_D	0.500	0.25
99_V	108_D	0.500	0.25
311_T	318_D	0.500	0.25
525_T	530_Y	0.500	0.25
696_S	716_M	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3iayA	1	0.8957	100	0.24	Contact Map
1s5jA	1	0.8005	100	0.248	Contact Map
4qclA	1	0.8776	100	0.249	Contact Map
4fvmA	1	0.8379	100	0.259	Contact Map
2gv9A	1	0.9501	100	0.276	Contact Map
1qhtA	1	0.7721	100	0.302	Contact Map
4m8oA	1	0.8934	100	0.326	Contact Map
3k59A	1	0.8231	100	0.326	Contact Map
3qexA	1	0.8141	100	0.388	Contact Map
2py5A	2	0.5068	100	0.71	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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