GREMLIN Database
GLNA - Glutamine synthetase
UniProt: P23794 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 471 (422)
Sequences: 6335 (3250)
Seq/√Len: 158.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
427_E450_R5.1051.00
300_G389_I4.8371.00
269_L298_V3.9271.00
121_Q386_N3.9121.00
298_V381_A3.9041.00
190_E246_H3.8981.00
383_D387_K3.7201.00
117_Y386_N3.5091.00
93_K112_E3.4881.00
116_K120_E3.4701.00
297_Y388_K3.3291.00
434_K439_S3.1741.00
96_W100_K3.0431.00
304_T387_K3.0311.00
439_S443_D2.7451.00
10_K14_E2.7421.00
187_V191_I2.7411.00
114_A379_M2.7231.00
308_A429_D2.7051.00
134_F211_A2.6841.00
110_I441_I2.6401.00
462_P466_Y2.5801.00
280_L294_F2.5681.00
116_K119_T2.5311.00
239_A250_V2.4871.00
127_Y374_F2.4651.00
293_Q388_K2.3951.00
190_E245_K2.3901.00
223_S231_K2.3811.00
269_L377_L2.3531.00
223_S227_D2.3371.00
418_S421_E2.3061.00
424_D450_R2.2871.00
11_F15_N2.2861.00
312_I376_A2.2411.00
305_H383_D2.2021.00
119_T124_T2.1691.00
115_E226_V2.1671.00
296_R390_D2.1611.00
227_D231_K2.1591.00
311_A426_L2.1351.00
420_N457_Q2.1341.00
297_Y300_G2.0991.00
39_D197_K2.0811.00
313_V373_A2.0771.00
305_H429_D2.0581.00
136_F257_I2.0281.00
115_E225_L2.0091.00
307_R413_K1.9941.00
195_L238_V1.9611.00
417_R421_E1.9491.00
224_T227_D1.9381.00
426_L442_L1.9361.00
308_A432_F1.9151.00
199_F238_V1.9151.00
191_I239_A1.9041.00
6_E10_K1.8951.00
135_M187_V1.8761.00
22_L92_C1.8671.00
425_E428_S1.8551.00
104_E440_S1.8391.00
118_Q125_S1.8281.00
297_Y389_I1.8101.00
455_S467_Y1.7991.00
202_T221_R1.7911.00
18_K193_D1.7751.00
293_Q297_Y1.7541.00
294_F385_V1.7521.00
368_T373_A1.7351.00
291_I295_G1.6981.00
115_E224_T1.6941.00
300_G391_P1.6891.00
17_I80_L1.6841.00
46_L75_P1.6841.00
235_L239_A1.6761.00
423_L446_I1.6621.00
420_N424_D1.6481.00
307_R425_E1.6411.00
305_H380_A1.6371.00
134_F263_T1.6221.00
229_A374_F1.6181.00
131_L232_V1.5851.00
194_T242_I1.5821.00
312_I426_L1.5811.00
126_Y272_W1.5741.00
432_F436_V1.5491.00
110_I375_A1.5391.00
126_Y222_F1.5391.00
118_Q382_L1.5391.00
72_L95_F1.5341.00
77_T91_L1.5321.00
421_E424_D1.5201.00
125_S378_L1.5191.00
112_E226_V1.5161.00
304_T389_I1.5111.00
12_L38_A1.5031.00
379_M436_V1.4871.00
194_T198_Y1.4761.00
18_K197_K1.4701.00
311_A423_L1.4561.00
427_E446_I1.4441.00
135_M243_A1.4341.00
123_Y280_L1.4331.00
23_Q89_R1.4181.00
25_T233_Q1.3961.00
114_A375_A1.3881.00
297_Y390_D1.3871.00
228_T231_K1.3741.00
220_F228_T1.3731.00
15_N86_G1.3681.00
89_R234_T1.3551.00
114_A117_Y1.3491.00
398_N401_H1.3481.00
296_R391_P1.3371.00
195_L201_Y1.3331.00
293_Q390_D1.3251.00
361_Y377_L1.3161.00
454_R457_Q1.3131.00
269_L381_A1.3081.00
309_L313_V1.3041.00
137_D248_L1.2731.00
78_M88_A1.2691.00
294_F297_Y1.2671.00
12_L41_F1.2661.00
424_D427_E1.2641.00
424_D428_S1.2601.00
112_E116_K1.2581.00
427_E443_D1.2551.00
9_L42_D1.2401.00
54_D57_S1.2391.00
293_Q296_R1.2391.00
308_A425_E1.2351.00
106_D109_F1.2331.00
300_G392_G1.2321.00
299_I359_I1.2321.00
7_D10_K1.2271.00
184_L216_G1.2241.00
211_A261_N1.2211.00
309_L376_A1.2161.00
138_K244_A1.2121.00
449_K452_E1.2111.00
45_S50_F1.1911.00
434_K443_D1.1911.00
314_S319_S1.1801.00
307_R310_S1.1801.00
344_I359_I1.1761.00
190_E194_T1.1761.00
117_Y379_M1.1751.00
10_K13_K1.1751.00
209_E217_E1.1741.00
310_S363_P1.1541.00
308_A433_L1.1501.00
20_V41_F1.1481.00
456_L463_M1.1481.00
307_R421_E1.1471.00
53_L57_S1.1401.00
71_L94_V1.1361.00
426_L433_L1.1261.00
63_S66_E1.1251.00
31_L91_L1.1251.00
223_S228_T1.1211.00
431_E435_P1.1171.00
242_I246_H1.1161.00
454_R458_G1.1161.00
213_A260_D1.1141.00
299_I344_I1.1111.00
253_M318_N1.1101.00
59_R62_T1.1091.00
429_D434_K1.1031.00
205_A219_D1.1001.00
118_Q121_Q1.0960.99
303_L344_I1.0960.99
238_V242_I1.0940.99
17_I88_A1.0930.99
298_V377_L1.0900.99
267_T377_L1.0900.99
74_V93_K1.0830.99
434_K442_L1.0700.99
96_W104_E1.0690.99
309_L380_A1.0650.99
320_Y419_L1.0630.99
305_H387_K1.0630.99
8_V78_M1.0610.99
446_I450_R1.0530.99
135_M250_V1.0470.99
194_T245_K1.0410.99
306_A343_V1.0390.99
204_E221_R1.0370.99
282_Y290_E1.0330.99
71_L92_C1.0310.99
59_R63_S1.0240.99
311_A445_Y1.0240.99
136_F251_T1.0240.99
124_T274_K1.0230.99
319_S365_D1.0210.99
111_A225_L1.0210.99
243_A250_V1.0200.99
451_D455_S1.0140.99
426_L446_I1.0130.99
134_F261_N1.0110.99
267_T373_A1.0090.99
297_Y385_V1.0050.99
453_A457_Q0.9990.99
258_Y460_P0.9980.99
429_D433_L0.9940.99
210_V261_N0.9910.99
102_R109_F0.9860.99
321_R464_E0.9850.99
194_T238_V0.9840.99
343_V363_P0.9830.99
123_Y294_F0.9810.99
427_E439_S0.9680.99
9_L13_K0.9660.99
429_D432_F0.9640.99
460_P464_E0.9590.99
334_A412_I0.9550.99
31_L233_Q0.9530.99
65_Y398_N0.9530.99
337_K394_P0.9520.99
26_D32_H0.9510.99
209_E266_H0.9500.99
316_T367_S0.9440.98
456_L461_H0.9410.98
353_M356_A0.9400.98
443_D447_D0.9390.98
217_E266_H0.9380.98
283_D290_E0.9350.98
220_F235_L0.9350.98
79_T89_R0.9330.98
397_E402_L0.9320.98
300_G390_D0.9270.98
302_L359_I0.9260.98
110_I114_A0.9200.98
175_Y207_H0.9190.98
254_P365_D0.9180.98
312_I442_L0.9170.98
36_I45_S0.9140.98
303_L392_G0.9120.98
423_L453_A0.9120.98
124_T224_T0.9110.98
62_T66_E0.9100.98
428_S431_E0.9080.98
312_I437_F0.9070.98
187_V248_L0.9070.98
339_N400_Y0.9060.98
307_R333_I0.9050.98
383_D435_P0.9040.98
302_L344_I0.9030.98
7_D11_F0.9020.98
461_H464_E0.9010.98
199_F234_T0.8930.98
187_V242_I0.8920.98
383_D432_F0.8900.98
281_M295_G0.8880.98
105_R440_S0.8840.98
254_P367_S0.8840.98
232_V265_M0.8830.98
8_V90_V0.8780.98
402_L412_I0.8770.98
451_D454_R0.8680.97
341_S399_I0.8650.97
95_F102_R0.8640.97
423_L450_R0.8640.97
459_Y463_M0.8600.97
127_Y228_T0.8590.97
309_L433_L0.8580.97
420_N453_A0.8560.97
84_S87_V0.8550.97
15_N80_L0.8510.97
431_E434_K0.8510.97
130_E217_E0.8500.97
121_Q382_L0.8500.97
118_Q271_L0.8480.97
445_Y449_K0.8480.97
129_P232_V0.8470.97
271_L280_L0.8460.97
218_I235_L0.8460.97
375_A437_F0.8460.97
130_E209_E0.8450.97
269_L361_Y0.8450.97
61_F64_I0.8440.97
317_V419_L0.8380.97
118_Q123_Y0.8380.97
187_V246_H0.8300.97
330_P362_R0.8300.97
185_M189_V0.8270.96
450_R454_R0.8230.96
76_E227_D0.8220.96
334_A342_A0.8220.96
55_G59_R0.8220.96
8_V75_P0.8200.96
341_S400_Y0.8200.96
139_V142_D0.8200.96
127_Y298_V0.8190.96
20_V38_A0.8140.96
106_D110_I0.8120.96
192_V206_T0.8110.96
95_F109_F0.8010.96
51_G70_V0.8000.96
423_L449_K0.8000.96
274_K277_K0.7990.96
347_P358_R0.7990.96
54_D58_I0.7980.96
139_V143_V0.7980.96
183_Q244_A0.7970.96
305_H308_A0.7970.96
41_F90_V0.7930.96
306_A344_I0.7930.96
306_A333_I0.7880.95
193_D198_Y0.7860.95
302_L361_Y0.7820.95
272_W280_L0.7820.95
57_S62_T0.7790.95
433_L442_L0.7790.95
115_E125_S0.7790.95
102_R112_E0.7770.95
127_Y229_A0.7770.95
40_E44_E0.7770.95
39_D202_T0.7770.95
324_I331_V0.7730.95
114_A436_V0.7720.95
300_G304_T0.7720.95
190_E242_I0.7690.95
123_Y271_L0.7660.95
114_A118_Q0.7630.95
420_N450_R0.7620.94
125_S269_L0.7620.94
310_S415_L0.7620.94
254_P319_S0.7620.94
258_Y459_Y0.7610.94
298_V382_L0.7610.94
376_A437_F0.7600.94
442_L446_I0.7500.94
193_D197_K0.7500.94
74_V112_E0.7480.94
444_T447_D0.7440.94
302_L377_L0.7430.94
109_F113_E0.7430.94
339_N398_N0.7420.94
19_W192_V0.7380.93
342_A399_I0.7380.93
81_I89_R0.7380.93
186_D246_H0.7370.93
96_W99_G0.7370.93
62_T65_Y0.7360.93
334_A399_I0.7350.93
249_V469_L0.7320.93
125_S271_L0.7310.93
267_T374_F0.7310.93
296_R300_G0.7300.93
195_L235_L0.7290.93
460_P463_M0.7290.93
455_S458_G0.7280.93
93_K106_D0.7270.93
201_Y220_F0.7240.93
313_V429_D0.7240.93
121_Q280_L0.7240.93
270_S358_R0.7230.93
202_T231_K0.7220.93
132_E209_E0.7200.93
133_F191_I0.7160.92
80_L86_G0.7150.92
104_E438_N0.7130.92
437_F442_L0.7110.92
124_T272_W0.7110.92
325_P331_V0.7100.92
456_L467_Y0.7090.92
425_E429_D0.7050.92
51_G349_Y0.7040.92
317_V456_L0.7030.92
210_V328_E0.6960.91
42_D47_K0.6950.91
253_M321_R0.6950.91
271_L378_L0.6890.91
28_P448_L0.6870.91
46_L49_G0.6870.91
118_Q378_L0.6860.91
188_R206_T0.6850.91
6_E9_L0.6840.91
174_G177_P0.6820.91
109_F112_E0.6820.91
104_E109_F0.6800.90
312_I445_Y0.6790.90
59_R64_I0.6730.90
110_I113_E0.6730.90
465_L469_L0.6720.90
203_I218_I0.6720.90
439_S442_L0.6670.90
15_N78_M0.6670.90
192_V203_I0.6660.89
21_D33_H0.6650.89
35_T84_S0.6630.89
383_D389_I0.6620.89
19_W193_D0.6610.89
53_L176_Y0.6600.89
12_L17_I0.6590.89
310_S416_P0.6570.89
201_Y234_T0.6570.89
321_R456_L0.6560.89
22_L45_S0.6560.89
84_S186_D0.6540.89
17_I86_G0.6500.88
135_M191_I0.6500.88
300_G384_G0.6480.88
85_P186_D0.6470.88
131_L220_F0.6470.88
130_E268_H0.6470.88
12_L20_V0.6450.88
255_K262_G0.6440.88
236_K240_K0.6440.88
254_P316_T0.6430.88
229_A370_P0.6420.88
358_R362_R0.6410.88
340_R362_R0.6380.87
115_E119_T0.6370.87
386_N389_I0.6370.87
55_G58_I0.6360.87
339_N395_V0.6340.87
44_E355_K0.6340.87
289_A337_K0.6340.87
74_V77_T0.6330.87
298_V302_L0.6320.87
315_P367_S0.6300.87
128_G219_D0.6280.87
232_V374_F0.6280.87
79_T234_T0.6280.87
341_S398_N0.6280.87
336_S342_A0.6270.86
89_R199_F0.6270.86
45_S48_T0.6240.86
435_P439_S0.6240.86
441_I444_T0.6240.86
22_L50_F0.6230.86
127_Y269_L0.6230.86
364_P373_A0.6220.86
456_L459_Y0.6220.86
399_I402_L0.6210.86
317_V461_H0.6200.86
441_I445_Y0.6190.86
393_D396_D0.6180.86
315_P319_S0.6180.86
373_A376_A0.6180.86
313_V361_Y0.6170.86
335_W346_V0.6170.86
53_L56_S0.6170.86
96_W103_F0.6160.85
87_V189_V0.6160.85
75_P90_V0.6150.85
125_S225_L0.6150.85
46_L90_V0.6150.85
463_M467_Y0.6130.85
349_Y356_A0.6120.85
317_V464_E0.6110.85
297_Y391_P0.6090.85
326_G329_A0.6090.85
136_F256_P0.6050.84
289_A394_P0.6050.84
390_D393_D0.6040.84
121_Q388_K0.6030.84
11_F78_M0.6030.84
132_E217_E0.6020.84
40_E202_T0.6020.84
184_L248_L0.6010.84
44_E48_T0.6010.84
269_L302_L0.6010.84
59_R66_E0.6000.84
395_V399_I0.5990.84
132_E266_H0.5980.84
23_Q31_L0.5970.84
271_L294_F0.5940.83
191_I238_V0.5940.83
182_D241_N0.5930.83
191_I218_I0.5930.83
317_V453_A0.5930.83
426_L437_F0.5930.83
330_P341_S0.5920.83
130_E266_H0.5920.83
272_W275_D0.5910.83
399_I414_E0.5910.83
11_F80_L0.5910.83
126_Y270_S0.5900.83
113_E438_N0.5890.83
60_G66_E0.5890.83
131_L235_L0.5890.83
313_V363_P0.5880.83
305_H389_I0.5850.82
135_M184_L0.5850.82
241_N244_A0.5840.82
57_S210_V0.5830.82
83_W238_V0.5830.82
137_D170_R0.5820.82
304_T413_K0.5820.82
285_N290_E0.5820.82
402_L410_L0.5810.82
209_E268_H0.5810.82
27_V441_I0.5800.82
113_E117_Y0.5800.82
409_Q412_I0.5770.82
378_L382_L0.5770.82
41_F75_P0.5760.81
135_M248_L0.5760.81
128_G207_H0.5760.81
127_Y225_L0.5760.81
333_I413_K0.5750.81
173_E176_Y0.5750.81
24_F71_L0.5740.81
333_I343_V0.5740.81
204_E222_F0.5730.81
111_A375_A0.5720.81
207_H210_V0.5720.81
242_I245_K0.5710.81
263_T366_P0.5710.81
262_G322_R0.5700.81
317_V463_M0.5680.81
318_N464_E0.5680.81
237_Y241_N0.5680.81
305_H309_L0.5680.81
315_P368_T0.5660.80
222_F270_S0.5650.80
172_K260_D0.5650.80
204_E219_D0.5650.80
113_E116_K0.5640.80
30_R240_K0.5630.80
203_I206_T0.5630.80
308_A426_L0.5620.80
130_E340_R0.5610.80
382_L386_N0.5600.80
169_I173_E0.5580.79
381_A384_G0.5570.79
81_I199_F0.5560.79
313_V380_A0.5560.79
257_I260_D0.5550.79
56_S62_T0.5540.79
19_W35_T0.5540.79
7_D12_L0.5530.79
133_F218_I0.5520.79
21_D237_Y0.5520.79
364_P368_T0.5520.79
296_R335_W0.5510.79
48_T51_G0.5510.79
283_D296_R0.5500.78
438_N441_I0.5500.78
201_Y235_L0.5490.78
334_A402_L0.5490.78
456_L464_E0.5480.78
268_H358_R0.5480.78
13_K39_D0.5480.78
19_W84_S0.5470.78
24_F94_V0.5460.78
18_K86_G0.5450.78
179_P185_M0.5440.78
201_Y232_V0.5440.78
91_L234_T0.5430.78
54_D62_T0.5430.78
128_G222_F0.5420.77
324_I327_F0.5410.77
120_E386_N0.5410.77
138_K249_V0.5410.77
54_D59_R0.5400.77
455_S463_M0.5380.77
259_G458_G0.5350.77
327_F458_G0.5350.77
426_L429_D0.5340.76
435_P438_N0.5330.76
128_G270_S0.5320.76
21_D35_T0.5320.76
134_F255_K0.5310.76
70_V73_P0.5310.76
210_V327_F0.5300.76
308_A311_A0.5300.76
117_Y121_Q0.5290.76
460_P465_L0.5280.76
11_F16_N0.5280.76
204_E270_S0.5270.75
130_E360_E0.5270.75
28_P445_Y0.5260.75
82_P199_F0.5260.75
219_D358_R0.5250.75
274_K294_F0.5250.75
129_P265_M0.5250.75
78_M90_V0.5240.75
419_L423_L0.5230.75
222_F225_L0.5230.75
380_A384_G0.5230.75
32_H177_P0.5230.75
283_D293_Q0.5200.75
117_Y120_E0.5190.74
195_L203_I0.5190.74
129_P374_F0.5180.74
110_I437_F0.5170.74
201_Y231_K0.5160.74
313_V364_P0.5160.74
318_N321_R0.5160.74
397_E400_Y0.5150.74
282_Y357_K0.5150.74
306_A363_P0.5150.74
455_S459_Y0.5150.74
175_Y178_A0.5150.74
171_F214_G0.5150.74
187_V243_A0.5150.74
438_N442_L0.5130.74
60_G63_S0.5130.74
189_V193_D0.5130.74
272_W276_G0.5120.73
84_S189_V0.5110.73
137_D143_V0.5110.73
79_T227_D0.5110.73
271_L381_A0.5110.73
379_M433_L0.5100.73
266_H360_E0.5100.73
25_T31_L0.5090.73
321_R461_H0.5090.73
60_G64_I0.5090.73
215_Q263_T0.5080.73
217_E360_E0.5080.73
34_I176_Y0.5050.72
329_A400_Y0.5050.72
340_R360_E0.5050.72
304_T383_D0.5040.72
73_P90_V0.5040.72
428_S432_F0.5040.72
194_T199_F0.5040.72
23_Q234_T0.5030.72
59_R65_Y0.5020.72
6_E13_K0.5020.72
423_L427_E0.5020.72
13_K16_N0.5020.72
18_K198_Y0.5010.72
337_K346_V0.5010.72
19_W189_V0.5010.72
127_Y267_T0.5010.72
320_Y422_A0.5000.72
429_D442_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lniA 5 0.9299 100 0.098 Contact Map
4s17A 5 0.9278 100 0.107 Contact Map
4acfA 5 0.9703 100 0.112 Contact Map
3ng0A 5 0.9575 100 0.113 Contact Map
1f52A 5 0.9639 100 0.115 Contact Map
4hppA 3 0.8641 100 0.147 Contact Map
2j9iA 5 0.8747 100 0.181 Contact Map
3o6xA 3 0.8195 100 0.333 Contact Map
3fkyA 8 0.6964 100 0.35 Contact Map
2ojwA 5 0.7304 100 0.358 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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