GREMLIN Database
BGAL - Beta-galactosidase
UniProt: P22498 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 489 (421)
Sequences: 6796 (4148)
Seq/√Len: 202.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_S125_D4.3001.00
135_K197_L3.6731.00
409_V419_V3.1961.00
131_R197_L3.1761.00
71_Q140_R3.0711.00
64_K136_D3.0531.00
131_R193_K2.9391.00
136_D139_S2.9031.00
58_G61_G2.9011.00
455_W459_A2.8931.00
148_M190_I2.8371.00
124_K193_K2.8041.00
124_K128_N2.7361.00
321_Y405_H2.7171.00
128_N132_E2.7081.00
88_F189_Y2.6981.00
408_Q411_R2.6771.00
271_T274_D2.5981.00
25_G61_G2.5621.00
188_A192_W2.5501.00
68_D140_R2.5001.00
12_W75_L2.4731.00
402_L424_H2.3911.00
181_Y245_R2.3241.00
250_I258_V2.3121.00
373_T415_S2.2921.00
396_Y457_P2.2851.00
369_Y415_S2.2711.00
155_L159_D2.2661.00
445_K454_Y2.2371.00
143_Y199_D2.2051.00
77_I423_L2.2041.00
64_K132_E2.1871.00
400_Y404_S2.1701.00
38_H51_D2.1551.00
248_D252_S2.1371.00
59_Y129_H2.1261.00
59_Y78_A2.0621.00
67_H133_I2.0491.00
463_R467_T1.9641.00
82_V146_L1.9421.00
67_H140_R1.9351.00
134_F194_F1.9191.00
138_K197_L1.9001.00
369_Y411_R1.8841.00
80_L134_F1.8811.00
188_A249_G1.8751.00
188_A253_V1.8611.00
237_Y298_I1.8591.00
300_R304_K1.8581.00
184_A249_G1.8581.00
125_D128_N1.8551.00
35_K159_D1.8361.00
250_I256_K1.8331.00
23_T30_N1.8161.00
131_R135_K1.7941.00
136_D140_R1.7921.00
31_T85_S1.7631.00
35_K155_L1.7531.00
14_Q19_S1.7361.00
268_Q370_D1.7211.00
30_N35_K1.7031.00
257_P382_Y1.6981.00
10_F469_G1.6841.00
22_G25_G1.6771.00
68_D136_D1.6661.00
92_L160_P1.6641.00
137_L142_L1.6551.00
134_F138_K1.6501.00
135_K138_K1.6471.00
321_Y367_G1.6301.00
67_H136_D1.6281.00
184_A245_R1.6221.00
384_Y420_R1.6201.00
80_L133_I1.6091.00
366_E408_Q1.6061.00
179_T182_E1.5981.00
143_Y200_E1.5961.00
464_E467_T1.5921.00
297_E310_L1.5851.00
369_Y373_T1.5811.00
77_I145_I1.5791.00
374_K378_R1.5741.00
131_R194_F1.5671.00
372_L417_A1.5661.00
9_R77_I1.5581.00
63_Y132_E1.5511.00
62_N65_T1.5401.00
191_A250_I1.5391.00
67_H137_L1.5291.00
295_R380_H1.5291.00
372_L409_V1.5211.00
410_H414_N1.5071.00
202_S261_I1.5041.00
39_D42_N1.5031.00
88_F122_A1.4881.00
177_T238_N1.4751.00
283_N301_G1.4701.00
156_W160_P1.4631.00
290_F317_I1.4591.00
388_N422_Y1.4521.00
202_S316_W1.4521.00
226_Y231_L1.4491.00
14_Q78_A1.4491.00
424_H443_L1.4441.00
175_L231_L1.4381.00
368_L409_V1.4331.00
127_L189_Y1.4311.00
145_I423_L1.4311.00
461_V465_I1.4201.00
288_W302_N1.4191.00
236_M289_F1.4081.00
29_P91_P1.4051.00
70_A75_L1.3721.00
72_K459_A1.3701.00
172_S176_S1.3661.00
464_E468_N1.3551.00
58_G62_N1.3541.00
90_N93_P1.3461.00
249_G252_S1.3331.00
260_I293_I1.3291.00
82_V190_I1.3271.00
17_F50_G1.3261.00
200_E257_P1.3251.00
68_D72_K1.3111.00
297_E303_E1.3111.00
455_W460_L1.3011.00
406_V409_V1.2971.00
22_G61_G1.2931.00
80_L146_L1.2871.00
57_P428_A1.2801.00
181_Y184_A1.2741.00
199_D255_K1.2741.00
131_R196_D1.2741.00
82_V87_I1.2691.00
204_M242_A1.2641.00
404_S407_Y1.2481.00
297_E380_H1.2481.00
373_T417_A1.2471.00
148_M183_F1.2361.00
63_Y136_D1.2341.00
228_S231_L1.2321.00
358_D393_D1.2311.00
5_P413_I1.2281.00
92_L182_E1.2271.00
460_L463_R1.2241.00
376_W418_D1.2101.00
210_V239_I1.2031.00
247_Y251_K1.1971.00
403_V407_Y1.1871.00
192_W253_V1.1821.00
204_M239_I1.1781.00
70_A444_L1.1701.00
174_W179_T1.1681.00
187_S246_A1.1681.00
127_L193_K1.1671.00
59_Y133_I1.1661.00
184_A246_A1.1581.00
184_A188_A1.1531.00
291_D378_R1.1531.00
248_D311_K1.1471.00
14_Q80_L1.1461.00
410_H471_I1.1451.00
399_P461_V1.1381.00
448_Y451_K1.1351.00
134_F197_L1.1341.00
282_E374_K1.1321.00
191_A258_V1.1311.00
29_P156_W1.1301.00
23_T28_D1.1301.00
4_F410_H1.1301.00
160_P178_R1.1281.00
178_R181_Y1.1241.00
269_P278_V1.1231.00
22_G26_S1.1221.00
264_N371_V1.1171.00
269_P275_M1.1121.00
158_H226_Y1.1111.00
131_R138_K1.1091.00
191_A246_A1.1071.00
4_F413_I1.1041.00
410_H413_I1.1021.00
291_D295_R1.0991.00
238_N241_Q1.0981.00
90_N156_W1.0951.00
250_I254_S1.0911.00
462_Y466_A1.0891.00
153_L179_T1.0881.00
382_Y418_D1.0881.00
127_L131_R1.0861.00
187_S249_G1.0831.00
294_I381_L1.0831.00
180_V245_R1.0781.00
249_G253_V1.0771.00
12_W70_A1.0751.00
245_R249_G1.0721.00
270_L328_K1.0711.00
72_K455_W1.0701.00
178_R182_E1.0671.00
366_E370_D1.0661.00
158_H215_Y1.0611.00
145_I384_Y1.0601.00
382_Y420_R1.0561.00
276_E280_M1.0531.00
400_Y403_V1.0491.00
122_A189_Y1.0411.00
267_F281_A1.0361.00
273_K366_E1.0331.00
304_K307_R1.0281.00
134_F146_L1.0281.00
356_T362_E1.0241.00
145_I200_E1.0211.00
368_L419_V1.0201.00
62_N452_R1.0191.00
195_D256_K1.0081.00
279_E283_N1.0071.00
196_D256_K1.0041.00
186_F190_I1.0041.00
283_N287_W1.0011.00
324_R362_E1.0011.00
428_A446_V0.9981.00
248_D312_G0.9981.00
153_L173_G0.9941.00
189_Y193_K0.9931.00
275_M278_V0.9931.00
274_D329_R0.9871.00
447_D452_R0.9851.00
282_E286_R0.9821.00
9_R145_I0.9781.00
281_A327_V0.9741.00
368_L385_V0.9690.99
273_K329_R0.9660.99
259_G318_G0.9650.99
440_R448_Y0.9640.99
182_E185_R0.9620.99
19_S59_Y0.9580.99
7_S420_R0.9560.99
190_I194_F0.9540.99
29_P89_P0.9530.99
393_D438_S0.9510.99
282_E287_W0.9440.99
297_E300_R0.9440.99
87_I189_Y0.9430.99
413_I419_V0.9360.99
75_L427_L0.9350.99
376_W380_H0.9340.99
172_S175_L0.9340.99
328_K347_N0.9280.99
132_E135_K0.9260.99
128_N131_R0.9250.99
276_E279_E0.9240.99
392_D397_Q0.9230.99
156_W159_D0.9220.99
28_D85_S0.9220.99
305_I309_D0.9170.99
357_S390_I0.9150.99
324_R364_F0.9140.99
191_A256_K0.9130.99
94_R185_R0.9130.99
267_F278_V0.9120.99
246_A249_G0.9110.99
355_P404_S0.9090.99
438_S450_T0.9070.99
390_I397_Q0.9070.99
48_V438_S0.9060.99
457_P460_L0.9060.99
93_P156_W0.9040.99
203_T260_I0.9020.99
88_F93_P0.9010.99
283_N302_N0.8970.99
149_Y153_L0.8940.99
32_D158_H0.8940.99
304_K308_D0.8930.99
247_Y258_V0.8890.99
220_S227_L0.8880.99
187_S191_A0.8870.99
131_R134_F0.8860.99
262_Y290_F0.8860.99
391_A439_M0.8850.99
259_G316_W0.8830.99
27_E123_N0.8830.99
245_R248_D0.8830.99
127_L190_I0.8810.99
180_V241_Q0.8740.99
211_G235_A0.8730.99
279_E301_G0.8730.99
193_K197_L0.8720.99
355_P397_Q0.8710.99
202_S318_G0.8690.99
76_K469_G0.8670.99
155_L158_H0.8640.99
369_Y408_Q0.8630.99
63_Y67_H0.8630.99
68_D71_Q0.8560.99
70_A142_L0.8550.99
359_F439_M0.8530.99
407_Y411_R0.8500.99
364_F367_G0.8490.99
9_R143_Y0.8460.99
272_D275_M0.8450.99
460_L464_E0.8390.99
203_T243_H0.8380.99
129_H133_I0.8360.99
65_T68_D0.8350.99
243_H247_Y0.8340.98
73_M459_A0.8330.98
45_A48_V0.8310.98
73_M455_W0.8260.98
144_F199_D0.8250.98
138_K144_F0.8240.98
291_D379_Y0.8210.98
204_M210_V0.8190.98
66_F453_L0.8140.98
44_A48_V0.8140.98
91_P156_W0.8090.98
3_S6_N0.8090.98
396_Y400_Y0.8080.98
92_L156_W0.8070.98
270_L274_D0.8060.98
323_T362_E0.8030.98
319_V383_M0.8010.98
230_E234_R0.8010.98
287_W378_R0.7990.98
412_A417_A0.7970.98
50_G53_P0.7970.98
300_R303_E0.7950.98
209_V263_A0.7930.98
264_N319_V0.7930.98
175_L226_Y0.7900.98
149_Y152_P0.7900.98
368_L408_Q0.7900.98
176_S182_E0.7890.98
373_T377_N0.7870.98
366_E411_R0.7870.98
350_S356_T0.7860.98
72_K463_R0.7810.98
53_P436_G0.7800.98
324_R367_G0.7790.98
10_F406_V0.7750.98
75_L462_Y0.7750.98
13_S423_L0.7740.98
138_K143_Y0.7710.97
267_F327_V0.7690.97
28_D31_T0.7680.97
124_K131_R0.7660.97
32_D153_L0.7650.97
376_W417_A0.7650.97
261_I320_N0.7650.97
16_G83_E0.7640.97
122_A127_L0.7620.97
465_I470_A0.7620.97
444_L455_W0.7570.97
138_K199_D0.7560.97
7_S469_G0.7560.97
52_L451_K0.7550.97
383_M417_A0.7530.97
71_Q141_G0.7510.97
19_S57_P0.7500.97
83_E152_P0.7470.97
183_F187_S0.7460.97
372_L419_V0.7440.97
189_Y192_W0.7420.97
351_L354_L0.7400.97
88_F92_L0.7360.97
90_N94_R0.7350.97
62_N451_K0.7340.97
465_I469_G0.7330.97
195_D253_V0.7300.97
317_I381_L0.7290.96
14_Q428_A0.7290.96
191_A253_V0.7290.96
236_M288_W0.7270.96
276_E366_E0.7260.96
5_P418_D0.7250.96
146_L198_V0.7240.96
240_I310_L0.7240.96
87_I190_I0.7220.96
160_P182_E0.7220.96
363_F392_D0.7210.96
294_I314_L0.7210.96
137_L140_R0.7200.96
302_N306_V0.7170.96
266_S370_D0.7160.96
294_I317_I0.7160.96
3_S410_H0.7150.96
373_T376_W0.7140.96
310_L313_R0.7140.96
177_T241_Q0.7110.96
188_A252_S0.7100.96
279_E374_K0.7100.96
175_L235_A0.7070.96
268_Q324_R0.7070.96
69_N444_L0.7060.96
359_F391_A0.7040.96
240_I293_I0.7040.96
357_S361_W0.7030.96
192_W249_G0.7010.96
372_L412_A0.6990.96
198_V201_Y0.6970.95
157_L179_T0.6970.95
67_H142_L0.6970.95
180_V242_A0.6920.95
126_A129_H0.6880.95
92_L185_R0.6860.95
64_K68_D0.6860.95
213_L221_G0.6860.95
52_L58_G0.6850.95
19_S430_N0.6840.95
366_E369_Y0.6840.95
406_V424_H0.6820.95
24_P30_N0.6810.95
320_N386_T0.6800.95
296_G311_K0.6790.95
242_A246_A0.6780.95
427_L444_L0.6760.95
73_M443_L0.6740.95
358_D392_D0.6740.95
432_E441_F0.6730.95
443_L462_Y0.6720.94
80_L137_L0.6720.94
430_N441_F0.6710.94
30_N38_H0.6690.94
181_Y185_R0.6670.94
70_A427_L0.6660.94
135_K196_D0.6650.94
264_N375_Y0.6630.94
270_L326_V0.6600.94
88_F185_R0.6580.94
208_N263_A0.6570.94
158_H175_L0.6560.94
233_R306_V0.6540.94
406_V465_I0.6540.94
90_N160_P0.6540.94
203_T258_V0.6530.94
445_K456_R0.6530.94
330_T333_G0.6510.94
91_P157_L0.6500.93
23_T51_D0.6500.93
248_D313_R0.6490.93
399_P457_P0.6490.93
76_K143_Y0.6490.93
11_G423_L0.6470.93
82_V134_F0.6460.93
23_T83_E0.6460.93
275_M279_E0.6450.93
190_I201_Y0.6440.93
384_Y423_L0.6410.93
409_V413_I0.6410.93
180_V184_A0.6400.93
321_Y368_L0.6400.93
19_S78_A0.6390.93
183_F204_M0.6390.93
175_L234_R0.6380.93
185_R189_Y0.6370.93
411_R415_S0.6360.93
384_Y421_G0.6360.93
149_Y210_V0.6360.93
319_V375_Y0.6340.93
10_F76_K0.6340.93
302_N305_I0.6340.93
187_S190_I0.6330.93
209_V213_L0.6320.92
440_R445_K0.6310.92
355_P400_Y0.6290.92
15_A19_S0.6260.92
247_Y314_L0.6260.92
79_R205_N0.6260.92
78_A137_L0.6240.92
244_A312_G0.6220.92
30_N85_S0.6210.92
451_K455_W0.6200.92
357_S392_D0.6200.92
262_Y289_F0.6200.92
69_N428_A0.6200.92
304_K411_R0.6200.92
148_M187_S0.6190.92
47_L50_G0.6160.92
40_P43_M0.6160.92
403_V461_V0.6160.92
226_Y229_F0.6160.92
220_S228_S0.6150.91
257_P420_R0.6150.91
76_K466_A0.6130.91
127_L194_F0.6130.91
26_S60_W0.6110.91
287_W374_K0.6100.91
137_L141_G0.6100.91
357_S360_G0.6080.91
87_I127_L0.6070.91
132_E136_D0.6070.91
4_F469_G0.6070.91
271_T328_K0.6070.91
134_F198_V0.6060.91
37_V431_Y0.6040.91
465_I468_N0.6040.91
430_N433_W0.6030.91
375_Y383_M0.6030.91
200_E384_Y0.6020.91
22_G60_W0.5990.90
223_P228_S0.5990.90
445_K452_R0.5990.90
449_N452_R0.5980.90
214_G224_P0.5960.90
356_T360_G0.5950.90
328_K349_V0.5940.90
234_R238_N0.5940.90
341_G344_C0.5940.90
135_K139_S0.5930.90
30_N155_L0.5930.90
264_N286_R0.5930.90
4_F10_F0.5890.90
431_Y437_F0.5870.89
431_Y448_Y0.5870.89
358_D439_M0.5870.89
284_D302_N0.5860.89
264_N290_F0.5840.89
35_K39_D0.5830.89
9_R76_K0.5810.89
148_M191_A0.5810.89
468_N471_I0.5800.89
253_V256_K0.5770.89
281_A285_N0.5770.89
32_D149_Y0.5760.89
46_G438_S0.5750.89
259_G384_Y0.5730.88
71_Q139_S0.5730.88
195_D254_S0.5720.88
318_G386_T0.5710.88
383_M419_V0.5710.88
370_D373_T0.5700.88
90_N182_E0.5690.88
14_Q427_L0.5680.88
74_G463_R0.5670.88
224_P227_L0.5660.88
280_M329_R0.5650.88
93_P122_A0.5650.88
248_D251_K0.5640.88
138_K141_G0.5640.88
277_A281_A0.5640.88
402_L406_V0.5630.87
322_Y387_E0.5630.87
145_I202_S0.5620.87
265_S325_T0.5610.87
243_H293_I0.5600.87
266_S282_E0.5600.87
36_W223_P0.5590.87
22_G28_D0.5590.87
277_A280_M0.5580.87
174_W204_M0.5580.87
399_P403_V0.5570.87
157_L182_E0.5560.87
199_D257_P0.5550.87
7_S413_I0.5540.87
444_L459_A0.5530.87
9_R200_E0.5530.87
268_Q364_F0.5510.86
290_F375_Y0.5510.86
156_W182_E0.5500.86
215_Y223_P0.5490.86
396_Y399_P0.5490.86
36_W225_G0.5490.86
215_Y224_P0.5480.86
283_N374_K0.5480.86
7_S76_K0.5480.86
386_T420_R0.5470.86
367_G405_H0.5470.86
145_I420_R0.5470.86
358_D391_A0.5430.86
70_A78_A0.5430.86
426_S430_N0.5430.86
12_W426_S0.5420.85
244_A313_R0.5400.85
59_Y70_A0.5390.85
269_P274_D0.5380.85
359_F435_S0.5370.85
411_R414_N0.5370.85
346_R349_V0.5370.85
29_P88_F0.5360.85
147_N261_I0.5360.85
64_K67_H0.5350.85
349_V353_G0.5340.85
215_Y235_A0.5340.85
28_D152_P0.5340.85
288_W306_V0.5330.84
191_A249_G0.5330.84
350_S354_L0.5330.84
17_F37_V0.5330.84
3_S471_I0.5330.84
153_L158_H0.5330.84
72_K460_L0.5310.84
23_T38_H0.5300.84
177_T180_V0.5300.84
395_D458_S0.5280.84
69_N72_K0.5260.84
221_G435_S0.5260.84
59_Y67_H0.5260.84
425_W430_N0.5250.84
390_I394_A0.5240.83
19_S129_H0.5230.83
261_I386_T0.5220.83
221_G224_P0.5210.83
274_D328_K0.5210.83
75_L142_L0.5190.83
134_F144_F0.5180.83
287_W291_D0.5170.83
233_R309_D0.5150.82
407_Y410_H0.5150.82
33_W36_W0.5140.82
14_Q430_N0.5130.82
354_L362_E0.5130.82
261_I316_W0.5120.82
14_Q59_Y0.5120.82
17_F151_W0.5110.82
278_V327_V0.5110.82
271_T353_G0.5110.82
266_S371_V0.5100.82
262_Y293_I0.5100.82
93_P185_R0.5090.82
462_Y465_I0.5090.82
77_I384_Y0.5080.82
291_D297_E0.5060.81
192_W195_D0.5050.81
133_I137_L0.5040.81
290_F294_I0.5040.81
138_K196_D0.5040.81
446_V454_Y0.5030.81
37_V50_G0.5020.81
203_T246_A0.5020.81
184_A248_D0.5010.81
277_A327_V0.5010.81
376_W383_M0.5000.81
251_K257_P0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uwiA 4 1 100 0.162 Contact Map
2jf7A 5 0.8609 100 0.185 Contact Map
1v02A 2 0.8732 100 0.185 Contact Map
1v08A 2 0.8712 100 0.185 Contact Map
3ptmA 1 0.8712 100 0.187 Contact Map
2dgaA 5 0.8773 100 0.19 Contact Map
1cbgA 2 0.8712 100 0.191 Contact Map
3wq5A 1 0.8712 100 0.192 Contact Map
3w53A 1 0.8712 100 0.195 Contact Map
1qvbA 3 0.9775 100 0.196 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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