GREMLIN Database
AGLU - Alpha-glucosidase
UniProt: P0CD66 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 693 (606)
Sequences: 4102 (2608)
Seq/√Len: 105.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_E234_K4.7071.00
198_I202_E4.3591.00
240_H315_D4.0821.00
163_T168_K3.8671.00
197_D201_K3.8421.00
193_V238_E3.8161.00
204_F505_V3.7911.00
198_I201_K3.6301.00
644_I647_S3.3601.00
462_D565_E3.3061.00
537_F551_M3.2451.00
381_M385_K3.2261.00
237_D241_K3.1881.00
117_F404_A3.1691.00
515_I552_V3.0311.00
540_D571_T3.0251.00
548_D568_R2.9701.00
164_E168_K2.9401.00
203_G506_E2.9281.00
233_K237_D2.8631.00
393_N646_V2.8411.00
157_D160_E2.7861.00
555_Y606_S2.7811.00
446_I471_A2.7331.00
576_K585_I2.6481.00
549_E557_L2.6321.00
579_N582_N2.5931.00
569_L593_K2.5921.00
63_H75_D2.5911.00
303_A389_T2.5581.00
533_L549_E2.5551.00
269_K298_T2.5291.00
268_G272_E2.5141.00
520_L524_E2.4931.00
197_D242_R2.4801.00
154_R157_D2.4731.00
576_K587_N2.3991.00
64_I105_F2.3921.00
594_S597_E2.3711.00
559_A570_V2.3321.00
203_G502_K2.3061.00
18_G29_E2.2881.00
206_V244_V2.2721.00
233_K312_Q2.2681.00
119_N146_E2.2571.00
460_S564_K2.2101.00
199_M490_P2.2091.00
196_V206_V2.1731.00
500_K504_I2.1701.00
567_S593_K2.1241.00
104_L115_G2.1231.00
262_P266_G2.1121.00
307_S311_S2.1061.00
398_L411_F2.1061.00
361_L366_V2.0901.00
425_K563_S2.0891.00
156_E536_E2.0851.00
202_E498_K2.0841.00
273_I277_E2.0831.00
173_P176_A2.0421.00
300_E304_G2.0321.00
521_E525_K2.0261.00
296_E360_Y1.9431.00
502_K506_E1.9431.00
569_L591_V1.9421.00
559_A568_R1.9241.00
402_G406_I1.9131.00
572_L601_Y1.9051.00
16_V29_E1.8941.00
119_N148_Y1.8871.00
543_M571_T1.8761.00
609_P628_N1.8741.00
297_D300_E1.8611.00
189_Q193_V1.8601.00
155_I538_Q1.8501.00
576_K604_E1.8491.00
435_S532_P1.8491.00
150_I161_K1.8411.00
503_E596_H1.8401.00
295_R298_T1.8181.00
291_P298_T1.8151.00
29_E36_K1.8081.00
307_S389_T1.8071.00
267_M297_D1.8071.00
177_F519_A1.8051.00
586_I601_Y1.8051.00
259_N264_L1.8051.00
260_Y263_F1.7981.00
531_R536_E1.7901.00
468_Y501_V1.7841.00
224_W232_P1.7821.00
559_A601_Y1.7671.00
579_N597_E1.7611.00
234_K238_E1.7581.00
446_I477_Y1.7461.00
551_M577_W1.7001.00
213_I249_I1.6901.00
160_E525_K1.6701.00
17_I26_F1.6531.00
580_Y600_I1.6421.00
115_G158_V1.6351.00
428_L562_V1.6201.00
59_D109_K1.6151.00
465_V497_Y1.5891.00
27_P36_K1.5871.00
197_D238_E1.5871.00
511_F556_L1.5841.00
639_K657_V1.5781.00
162_Y404_A1.5761.00
211_L246_L1.5751.00
189_Q235_L1.5671.00
558_Y600_I1.5671.00
30_Q35_N1.5631.00
64_I107_S1.5581.00
495_D499_E1.5571.00
196_V244_V1.5481.00
192_V211_L1.5431.00
381_M409_Y1.5421.00
85_N101_S1.5411.00
542_D591_V1.5401.00
155_I534_F1.5381.00
561_I568_R1.5371.00
543_M546_I1.5211.00
521_E554_K1.5141.00
556_L602_L1.5041.00
307_S390_S1.5021.00
519_A529_V1.4971.00
190_D194_E1.4921.00
533_L551_M1.4841.00
196_V209_V1.4781.00
465_V595_T1.4731.00
236_I246_L1.4721.00
18_G27_P1.4671.00
470_L550_Y1.4601.00
527_H535_Y1.4521.00
152_G157_D1.4501.00
263_F266_G1.4491.00
572_L592_V1.4471.00
473_F600_I1.4461.00
304_G308_E1.4381.00
431_V442_V1.4351.00
602_L631_I1.4351.00
556_L608_I1.4311.00
58_L64_I1.4271.00
499_E502_K1.4121.00
27_P39_S1.4111.00
465_V500_K1.4111.00
444_C474_F1.4061.00
106_I155_I1.4061.00
248_T314_V1.4011.00
118_F140_I1.4011.00
160_E527_H1.3971.00
225_H228_R1.3941.00
521_E527_H1.3911.00
518_L521_E1.3901.00
300_E389_T1.3841.00
555_Y603_R1.3801.00
378_Y381_M1.3771.00
199_M206_V1.3671.00
421_W462_D1.3661.00
189_Q231_E1.3661.00
203_G615_L1.3661.00
262_P265_S1.3621.00
610_L629_A1.3601.00
580_Y610_L1.3571.00
414_T430_L1.3481.00
504_I598_L1.3400.99
494_P497_Y1.3390.99
265_S305_L1.3380.99
179_Y199_M1.3370.99
308_E311_S1.3340.99
180_M210_F1.3290.99
607_I630_E1.3240.99
496_Y499_E1.3200.99
207_A509_Y1.3130.99
172_P177_F1.3050.99
452_R486_I1.3020.99
474_F550_Y1.2980.99
510_K627_D1.2920.99
304_G307_S1.2890.99
264_L270_F1.2880.99
124_V140_I1.2820.99
80_R127_D1.2790.99
187_Y191_K1.2750.99
388_R648_K1.2720.99
384_F388_R1.2710.99
204_F498_K1.2690.99
462_D564_K1.2690.99
20_P23_P1.2660.99
269_K295_R1.2640.99
421_W564_K1.2640.99
377_L406_I1.2630.99
175_W316_G1.2630.99
56_K136_V1.2590.99
200_Q242_R1.2590.99
303_A386_G1.2570.99
520_L657_V1.2570.99
465_V469_A1.2570.99
533_L546_I1.2550.99
260_Y266_G1.2540.99
305_L308_E1.2460.99
440_P522_A1.2410.99
299_R382_A1.2380.99
580_Y602_L1.2330.99
36_K39_S1.2320.99
196_V239_L1.2230.99
245_K315_D1.2200.99
324_P368_H1.2200.99
278_L289_V1.2190.99
579_N584_E1.2180.99
156_E527_H1.2150.99
424_L470_L1.2140.99
578_Y604_E1.2130.99
295_R360_Y1.2100.99
296_E300_E1.2070.99
462_D595_T1.2050.99
294_F366_V1.2010.99
150_I165_L1.2000.99
431_V444_C1.1920.99
641_S650_T1.1900.99
272_E278_L1.1870.99
628_N660_I1.1830.99
482_A485_G1.1830.99
385_K388_R1.1740.99
234_K237_D1.1730.99
193_V242_R1.1730.99
174_M516_Y1.1690.99
100_V402_G1.1620.98
14_K31_K1.1570.98
32_I35_N1.1550.98
104_L158_V1.1500.98
270_F289_V1.1460.98
166_T407_Q1.1450.98
479_S488_T1.1430.98
189_Q230_P1.1410.98
521_E639_K1.1380.98
247_I316_G1.1370.98
299_R303_A1.1330.98
311_S390_S1.1330.98
181_I199_M1.1260.98
181_I186_Y1.1220.98
510_K610_L1.1210.98
182_S210_F1.1180.98
400_R416_D1.1170.98
20_P25_E1.1170.98
266_G270_F1.1140.98
215_Y309_W1.1110.98
649_L654_E1.1060.98
491_V494_P1.1050.98
464_L479_S1.0990.98
186_Y489_E1.0960.98
320_D416_D1.0930.98
105_F128_V1.0910.98
55_E137_I1.0890.98
431_V530_I1.0880.98
82_V125_I1.0850.98
556_L600_I1.0850.98
250_V306_I1.0820.98
179_Y479_S1.0820.98
63_H545_R1.0790.98
497_Y501_V1.0780.98
536_E603_R1.0730.97
194_E198_I1.0710.97
271_C290_Y1.0690.97
602_L608_I1.0690.97
196_V242_R1.0680.97
537_F603_R1.0630.97
159_L535_Y1.0610.97
299_R381_M1.0600.97
192_V209_V1.0560.97
257_D264_L1.0540.97
239_L244_V1.0540.97
113_A153_P1.0490.97
179_Y477_Y1.0490.97
461_M494_P1.0490.97
67_L128_V1.0480.97
177_F515_I1.0460.97
35_N38_L1.0460.97
633_S637_E1.0420.97
570_V601_Y1.0420.97
200_Q244_V1.0410.97
280_V287_T1.0400.97
633_S638_I1.0390.97
413_W416_D1.0370.97
172_P519_A1.0330.97
260_Y264_L1.0320.97
236_I314_V1.0260.97
34_S37_S1.0260.97
447_G464_L1.0240.97
152_G158_V1.0240.97
237_D240_H1.0240.97
536_E551_M1.0230.97
506_E613_D1.0220.97
581_W597_E1.0210.97
414_T434_L1.0190.97
473_F598_L1.0170.97
494_P498_K1.0160.96
153_P161_K1.0160.96
532_P535_Y1.0100.96
561_I594_S1.0100.96
473_F558_Y1.0090.96
108_V113_A1.0080.96
180_M208_G1.0070.96
208_G245_K1.0070.96
550_Y558_Y1.0060.96
102_I166_T1.0050.96
83_M126_F1.0050.96
472_L504_I1.0030.96
536_E554_K1.0010.96
102_I404_A0.9990.96
359_H368_H0.9970.96
412_I434_L0.9970.96
503_E597_E0.9940.96
74_L432_L0.9940.96
218_S221_L0.9910.96
637_E661_I0.9900.96
34_S39_S0.9900.96
200_Q616_I0.9880.96
184_Y214_H0.9860.96
500_K596_H0.9840.96
217_D220_K0.9840.96
191_K487_D0.9840.96
263_F267_M0.9810.96
243_N619_G0.9790.96
396_F411_F0.9780.96
34_S38_L0.9780.96
306_I317_I0.9750.96
436_I534_F0.9720.95
249_I318_W0.9700.95
555_Y608_I0.9700.95
238_E241_K0.9670.95
518_L529_V0.9670.95
377_L409_Y0.9640.95
303_A385_K0.9640.95
420_S423_D0.9590.95
388_R651_I0.9590.95
211_L229_F0.9590.95
122_S142_E0.9560.95
108_V544_Y0.9550.95
220_K257_D0.9550.95
514_Y609_P0.9540.95
474_F530_I0.9540.95
163_T526_G0.9540.95
31_K34_S0.9540.95
16_V32_I0.9530.95
377_L408_R0.9520.95
465_V501_V0.9520.95
269_K297_D0.9510.95
632_T662_V0.9500.95
263_F289_V0.9490.95
615_L619_G0.9480.95
15_V151_E0.9470.95
168_K526_G0.9390.95
191_K194_E0.9380.95
261_S264_L0.9370.94
464_L501_V0.9330.94
221_L254_I0.9230.94
39_S57_S0.9200.94
432_L530_I0.9190.94
586_I592_V0.9180.94
171_L519_A0.9180.94
53_I139_T0.9150.94
156_E535_Y0.9130.94
299_R385_K0.9100.94
20_P27_P0.9080.94
468_Y479_S0.9060.93
263_F305_L0.9040.93
367_K370_K0.9040.93
616_I620_E0.9020.93
424_L562_V0.8990.93
218_S257_D0.8980.93
414_T442_V0.8970.93
240_H245_K0.8970.93
639_K659_K0.8960.93
267_M278_L0.8940.93
473_F507_L0.8920.93
118_F124_V0.8900.93
626_Y642_R0.8900.93
163_T440_P0.8900.93
80_R125_I0.8890.93
400_R413_W0.8870.93
35_N39_S0.8840.93
87_D99_Y0.8820.92
302_W383_T0.8770.92
182_S480_H0.8770.92
648_K651_I0.8760.92
169_P440_P0.8760.92
62_E107_S0.8750.92
432_L532_P0.8730.92
413_W480_H0.8730.92
261_S289_V0.8720.92
190_D193_V0.8720.92
501_V505_V0.8710.92
503_E506_E0.8690.92
67_L81_Y0.8660.92
441_F519_A0.8650.92
504_I581_W0.8650.92
67_L105_F0.8650.92
380_A410_A0.8640.92
394_E643_E0.8620.92
490_P501_V0.8610.92
500_K595_T0.8600.92
35_N41_L0.8590.91
466_K469_A0.8590.91
105_F136_V0.8580.91
239_L246_L0.8580.91
421_W463_L0.8550.91
280_V289_V0.8510.91
583_G629_A0.8480.91
399_S410_A0.8470.91
551_M555_Y0.8430.91
251_D321_M0.8420.91
421_W424_L0.8410.91
261_S266_G0.8400.91
58_L77_K0.8390.91
74_L534_F0.8380.90
195_L491_V0.8370.90
435_S528_P0.8360.90
540_D543_M0.8360.90
321_M325_T0.8350.90
384_F648_K0.8340.90
399_S412_I0.8340.90
141_P369_E0.8330.90
392_R649_L0.8320.90
120_S142_E0.8320.90
54_V147_F0.8310.90
151_E161_K0.8310.90
117_F162_Y0.8290.90
632_T638_I0.8280.90
522_A525_K0.8270.90
83_M101_S0.8270.90
472_L477_Y0.8250.90
320_D400_R0.8230.90
521_E531_R0.8220.90
546_I549_E0.8220.90
268_G295_R0.8190.89
461_M497_Y0.8140.89
427_Q474_F0.8130.89
413_W449_F0.8110.89
368_H372_R0.8110.89
126_F138_V0.8110.89
471_A477_Y0.8100.89
46_V49_G0.8090.89
533_L543_M0.8090.89
616_I619_G0.8070.89
125_I139_T0.8060.89
104_L162_Y0.8000.88
19_E26_F0.8000.88
188_P228_R0.8000.88
620_E624_K0.7990.88
499_E503_E0.7990.88
29_E34_S0.7990.88
128_V136_V0.7950.88
172_P441_F0.7940.88
200_Q207_A0.7930.88
17_I28_L0.7930.88
310_L387_F0.7920.88
121_A374_A0.7900.88
604_E633_S0.7900.88
415_G449_F0.7890.88
406_I410_A0.7880.88
300_E303_A0.7880.88
210_F476_F0.7870.87
514_Y553_G0.7860.87
120_S124_V0.7860.87
414_T431_V0.7840.87
28_L149_V0.7830.87
39_S42_G0.7820.87
204_F502_K0.7820.87
640_F660_I0.7800.87
522_A529_V0.7780.87
55_E135_K0.7770.87
193_V235_L0.7770.87
63_H544_Y0.7760.87
436_I532_P0.7760.87
192_V246_L0.7750.87
252_H375_Y0.7750.87
612_G627_D0.7750.87
181_I489_E0.7730.87
213_I321_M0.7720.86
175_W245_K0.7700.86
579_N601_Y0.7690.86
171_L516_Y0.7680.86
120_S143_D0.7660.86
518_L522_A0.7650.86
578_Y585_I0.7630.86
67_L126_F0.7620.86
206_V209_V0.7620.86
416_D480_H0.7620.86
213_I251_D0.7620.86
58_L129_G0.7600.86
107_S114_T0.7600.86
310_L313_G0.7590.86
189_Q234_K0.7540.85
99_Y415_G0.7530.85
517_S640_F0.7530.85
537_F575_G0.7530.85
431_V474_F0.7530.85
177_F529_V0.7530.85
43_L47_Q0.7520.85
477_Y505_V0.7500.85
358_V361_L0.7480.85
322_N379_E0.7470.85
174_M642_R0.7470.85
188_P191_K0.7470.85
268_G278_L0.7470.85
171_L520_L0.7460.85
44_T47_Q0.7440.84
16_V31_K0.7430.84
193_V239_L0.7410.84
473_F552_V0.7400.84
197_D200_Q0.7400.84
105_F116_Y0.7400.84
189_Q238_E0.7390.84
610_L627_D0.7390.84
82_V123_K0.7390.84
178_G207_A0.7380.84
264_L289_V0.7360.84
183_R212_D0.7350.84
613_D624_K0.7340.84
435_S530_I0.7320.83
216_M251_D0.7320.83
651_I655_K0.7310.83
265_S278_L0.7300.83
411_F476_F0.7290.83
27_P41_L0.7270.83
104_L117_F0.7260.83
31_K35_N0.7250.83
361_L365_R0.7250.83
73_E547_E0.7180.82
445_D478_R0.7170.82
548_D562_V0.7140.82
388_R395_I0.7140.82
322_N399_S0.7120.82
453_N460_S0.7110.82
223_T259_N0.7110.82
148_Y165_L0.7100.82
70_K76_R0.7080.81
72_F76_R0.7070.81
185_S214_H0.7070.81
387_F397_I0.7040.81
294_F378_Y0.7030.81
448_G467_Y0.7030.81
251_D285_P0.7030.81
162_Y166_T0.7000.81
118_F126_F0.7000.81
506_E615_L0.7000.81
533_L571_T0.7000.81
282_K287_T0.6990.81
271_C357_V0.6990.81
30_Q34_S0.6980.80
324_P375_Y0.6980.80
184_Y249_I0.6970.80
406_I439_V0.6970.80
172_P176_A0.6960.80
121_A403_Y0.6960.80
184_Y449_F0.6950.80
28_L34_S0.6950.80
89_G450_Q0.6950.80
518_L554_K0.6930.80
613_D620_E0.6920.80
61_K109_K0.6920.80
302_W379_E0.6910.80
160_E163_T0.6910.80
207_A617_V0.6900.80
105_F114_T0.6880.79
202_E491_V0.6880.79
213_I219_Y0.6880.79
416_D445_D0.6870.79
76_R81_Y0.6850.79
542_D571_T0.6840.79
609_P640_F0.6840.79
469_A503_E0.6820.79
449_F480_H0.6820.79
25_E39_S0.6820.79
496_Y596_H0.6820.79
561_I565_E0.6820.79
589_K593_K0.6820.79
613_D616_I0.6810.79
419_P488_T0.6810.79
412_I439_V0.6810.79
256_V287_T0.6800.79
181_I209_V0.6780.78
267_M270_F0.6780.78
317_I387_F0.6780.78
573_P577_W0.6770.78
400_R480_H0.6770.78
469_A596_H0.6740.78
177_F441_F0.6730.78
194_E201_K0.6720.78
143_D370_K0.6720.78
263_F278_L0.6710.78
650_T655_K0.6700.78
102_I439_V0.6700.78
470_L474_F0.6690.78
549_E559_A0.6690.78
376_P401_A0.6690.78
34_S40_E0.6680.77
220_K259_N0.6680.77
212_D416_D0.6670.77
61_K541_D0.6660.77
163_T528_P0.6660.77
184_Y251_D0.6660.77
212_D478_R0.6640.77
14_K26_F0.6630.77
118_F147_F0.6620.77
366_V371_V0.6610.77
199_M203_G0.6590.77
183_R489_E0.6590.77
160_E168_K0.6580.76
28_L38_L0.6570.76
466_K561_I0.6560.76
635_S638_I0.6540.76
387_F395_I0.6530.76
538_Q543_M0.6530.76
386_G389_T0.6530.76
507_L581_W0.6520.76
195_L199_M0.6520.76
414_T417_N0.6510.76
495_D498_K0.6510.76
84_Y372_R0.6490.75
184_Y213_I0.6490.75
113_A158_V0.6480.75
581_W600_I0.6480.75
102_I437_S0.6470.75
507_L600_I0.6420.75
400_R449_F0.6410.75
194_E197_D0.6400.74
534_F544_Y0.6390.74
579_N583_G0.6390.74
100_V412_I0.6380.74
518_L551_M0.6370.74
320_D480_H0.6370.74
171_L523_S0.6370.74
29_E32_I0.6370.74
43_L46_V0.6370.74
540_D574_R0.6360.74
551_M573_P0.6360.74
213_I216_M0.6350.74
510_K613_D0.6340.74
198_I498_K0.6340.74
85_N401_A0.6330.74
69_E430_L0.6330.74
498_K502_K0.6330.74
163_T438_G0.6310.73
654_E659_K0.6310.73
199_M491_V0.6300.73
321_M327_F0.6290.73
23_P26_F0.6280.73
518_L531_R0.6280.73
435_S522_A0.6280.73
261_S265_S0.6270.73
380_A399_S0.6250.73
537_F540_D0.6250.73
533_L559_A0.6250.73
234_K241_K0.6250.73
30_Q151_E0.6240.73
152_G161_K0.6240.73
210_F247_I0.6220.72
190_D197_D0.6210.72
429_Q433_G0.6200.72
509_Y512_L0.6200.72
179_Y501_V0.6190.72
518_L638_I0.6190.72
644_I649_L0.6180.72
558_Y598_L0.6180.72
606_S609_P0.6170.72
303_A382_A0.6160.72
604_E631_I0.6150.71
400_R415_G0.6130.71
192_V235_L0.6120.71
637_E659_K0.6110.71
603_R606_S0.6110.71
585_I603_R0.6100.71
580_Y629_A0.6100.71
250_V317_I0.6090.71
300_E385_K0.6080.71
615_L618_Y0.6070.70
572_L589_K0.6060.70
445_D449_F0.6050.70
468_Y505_V0.6050.70
175_W208_G0.6050.70
418_T450_Q0.6030.70
614_E618_Y0.6020.70
34_S41_L0.6020.70
52_V145_V0.6020.70
181_I195_L0.6000.70
56_K147_F0.5990.69
84_Y123_K0.5990.69
490_P505_V0.5990.69
590_S593_K0.5980.69
468_Y477_Y0.5970.69
99_Y321_M0.5970.69
575_G588_G0.5970.69
416_D449_F0.5970.69
552_V558_Y0.5960.69
256_V289_V0.5960.69
274_E356_N0.5960.69
179_Y505_V0.5960.69
102_I412_I0.5940.69
578_Y631_I0.5940.69
215_Y250_V0.5940.69
64_I67_L0.5930.69
208_G247_I0.5930.69
530_I550_Y0.5920.69
421_W466_K0.5920.69
415_G445_D0.5890.68
264_L301_W0.5880.68
30_Q153_P0.5860.68
16_V35_N0.5840.68
214_H219_Y0.5800.67
382_A386_G0.5800.67
43_L48_Q0.5800.67
445_D480_H0.5800.67
190_D238_E0.5800.67
152_G162_Y0.5790.67
184_Y482_A0.5790.67
614_E619_G0.5780.67
477_Y508_R0.5770.67
238_E242_R0.5760.66
402_G439_V0.5760.66
120_S140_I0.5760.66
156_E554_K0.5750.66
435_S440_P0.5740.66
271_C359_H0.5720.66
509_Y516_Y0.5720.66
28_L40_E0.5720.66
84_Y355_D0.5710.66
464_L488_T0.5700.66
584_E601_Y0.5700.66
637_E663_D0.5700.66
186_Y195_L0.5690.66
216_M253_G0.5690.66
464_L468_Y0.5680.65
587_N590_S0.5680.65
37_S40_E0.5680.65
320_D449_F0.5670.65
435_S527_H0.5670.65
138_V147_F0.5660.65
25_E41_L0.5660.65
201_K663_D0.5660.65
19_E22_P0.5660.65
118_F138_V0.5650.65
154_R538_Q0.5640.65
179_Y468_Y0.5640.65
307_S386_G0.5640.65
481_K485_G0.5640.65
372_R376_P0.5640.65
413_W445_D0.5630.65
306_I383_T0.5620.65
318_W414_T0.5620.65
22_P32_I0.5610.64
429_Q432_L0.5610.64
626_Y660_I0.5610.64
607_I628_N0.5600.64
132_E136_V0.5600.64
503_E510_K0.5600.64
192_V239_L0.5590.64
184_Y321_M0.5590.64
284_W449_F0.5580.64
366_V370_K0.5580.64
38_L41_L0.5560.64
62_E114_T0.5560.64
640_F658_S0.5550.64
65_I543_M0.5540.63
195_L489_E0.5530.63
637_E654_E0.5530.63
383_T397_I0.5530.63
166_T404_A0.5530.63
18_G32_I0.5520.63
505_V509_Y0.5520.63
184_Y212_D0.5520.63
611_E614_E0.5510.63
321_M476_F0.5510.63
35_N40_E0.5510.63
533_L573_P0.5500.63
253_G290_Y0.5500.63
206_V491_V0.5500.63
358_V367_K0.5500.63
159_L163_T0.5490.63
102_I162_Y0.5480.63
491_V498_K0.5480.63
542_D545_R0.5480.63
219_Y253_G0.5480.63
106_I159_L0.5480.63
102_I407_Q0.5470.63
248_T317_I0.5470.63
425_K547_E0.5470.63
37_S41_L0.5440.62
572_L588_G0.5440.62
27_P32_I0.5430.62
258_Q264_L0.5430.62
507_L580_Y0.5430.62
293_F302_W0.5430.62
107_S113_A0.5420.62
30_Q39_S0.5420.62
233_K311_S0.5420.62
531_R551_M0.5410.62
122_S370_K0.5400.62
155_I544_Y0.5400.62
219_Y249_I0.5400.62
45_I48_Q0.5400.62
25_E40_E0.5390.61
174_M611_E0.5390.61
199_M489_E0.5390.61
614_E620_E0.5380.61
527_H554_K0.5380.61
62_E109_K0.5380.61
75_D545_R0.5370.61
291_P382_A0.5370.61
651_I654_E0.5370.61
69_E100_V0.5370.61
212_D318_W0.5370.61
318_W324_P0.5360.61
281_G284_W0.5360.61
571_T574_R0.5350.61
310_L391_H0.5350.61
548_D559_A0.5350.61
212_D480_H0.5350.61
159_L436_I0.5340.61
174_M645_Y0.5320.60
588_G599_P0.5320.60
313_G588_G0.5310.60
615_L620_E0.5300.60
214_H321_M0.5300.60
52_V142_E0.5300.60
557_L572_L0.5290.60
193_V197_D0.5290.60
35_N42_G0.5290.60
415_G480_H0.5280.60
224_W233_K0.5280.60
256_V280_V0.5270.60
283_M321_M0.5260.60
611_E615_L0.5260.60
21_F28_L0.5260.60
260_Y265_S0.5260.60
546_I571_T0.5260.60
522_A527_H0.5250.59
440_P529_V0.5240.59
177_F516_Y0.5240.59
316_G396_F0.5240.59
425_K548_D0.5240.59
318_W449_F0.5240.59
433_G437_S0.5230.59
517_S524_E0.5220.59
406_I412_I0.5200.59
574_R634_S0.5200.59
651_I663_D0.5200.59
534_F543_M0.5200.59
193_V196_V0.5200.59
318_W321_M0.5200.59
425_K429_Q0.5190.59
614_E617_V0.5190.59
200_Q615_L0.5180.58
571_T591_V0.5170.58
487_D492_F0.5170.58
22_P31_K0.5170.58
24_I28_L0.5160.58
320_D413_W0.5160.58
434_L437_S0.5160.58
150_I158_V0.5160.58
355_D359_H0.5160.58
156_E528_P0.5160.58
319_L430_L0.5160.58
122_S369_E0.5150.58
265_S289_V0.5140.58
480_H489_E0.5140.58
163_T527_H0.5130.58
18_G21_F0.5130.58
359_H372_R0.5120.58
470_L562_V0.5120.58
118_F122_S0.5120.58
283_M288_T0.5120.58
25_E35_N0.5120.58
300_E539_D0.5120.58
58_L136_V0.5110.57
293_F382_A0.5110.57
516_Y520_L0.5110.57
445_D448_G0.5110.57
503_E581_W0.5110.57
70_K96_D0.5100.57
626_Y640_F0.5100.57
174_M512_L0.5100.57
317_I383_T0.5090.57
323_E400_R0.5090.57
551_M603_R0.5090.57
243_N616_I0.5090.57
85_N373_N0.5080.57
20_P31_K0.5070.57
294_F371_V0.5070.57
512_L617_V0.5070.57
41_L57_S0.5070.57
634_S663_D0.5060.57
473_F550_Y0.5060.57
179_Y490_P0.5050.56
207_A508_R0.5050.56
586_I590_S0.5050.56
421_W561_I0.5040.56
357_V360_Y0.5040.56
183_R213_I0.5040.56
498_K505_V0.5040.56
493_L501_V0.5040.56
514_Y555_Y0.5030.56
23_P34_S0.5030.56
318_W480_H0.5030.56
101_S373_N0.5020.56
428_L432_L0.5010.56
204_F490_P0.5000.56
36_K41_L0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lppA 3 0.9755 100 0.097 Contact Map
3l4yA 1 0.9755 100 0.104 Contact Map
3weoA 1 0.9726 100 0.104 Contact Map
3topA 1 0.9784 100 0.106 Contact Map
4ba0A 2 0.9365 100 0.118 Contact Map
3nsxA 2 0.9105 100 0.162 Contact Map
2xvlA 1 0.9452 100 0.163 Contact Map
2g3mA 5 0.9567 100 0.174 Contact Map
4kmqA 1 0.9206 100 0.189 Contact Map
4amwA 1 0.9812 100 0.191 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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