AGLU - SULSO - GREMLIN Contacts

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AGLU - Alpha-glucosidase

UniProt:	P0CD66	Sequences: MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDLKEHIIGLGEKAFELDRKRKRYVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVATGYFFNSASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLEKYTELTGKPFLPPMWAFGYMISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELHKRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTREWWAGLISEWLSQGVDGIWLDMNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHYLRGKRVKHEKVRNAYPLYEAMATFKGFRTSHRNEIFILSRAGYAGIQRYAFIWTGDNTPSWDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSHKATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDDDDMYRIEDEYMVGKYLLYAPIVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPIYLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKFSREIYVSKLTITSEKPVSKIIVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	693 (606)
Sequences:	4102 (2608)
Seq/√Len:	105.9

ECOLI - XYLS YIHQ
SULSO - AGLU XYLS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
231_E	234_K	4.707	1.00
198_I	202_E	4.359	1.00
240_H	315_D	4.082	1.00
163_T	168_K	3.867	1.00
197_D	201_K	3.842	1.00
193_V	238_E	3.816	1.00
204_F	505_V	3.791	1.00
198_I	201_K	3.630	1.00
644_I	647_S	3.360	1.00
462_D	565_E	3.306	1.00
537_F	551_M	3.245	1.00
381_M	385_K	3.226	1.00
237_D	241_K	3.188	1.00
117_F	404_A	3.169	1.00
515_I	552_V	3.031	1.00
540_D	571_T	3.025	1.00
548_D	568_R	2.970	1.00
164_E	168_K	2.940	1.00
203_G	506_E	2.928	1.00
233_K	237_D	2.863	1.00
393_N	646_V	2.841	1.00
157_D	160_E	2.786	1.00
555_Y	606_S	2.781	1.00
446_I	471_A	2.733	1.00
576_K	585_I	2.648	1.00
549_E	557_L	2.632	1.00
579_N	582_N	2.593	1.00
569_L	593_K	2.592	1.00
63_H	75_D	2.591	1.00
303_A	389_T	2.558	1.00
533_L	549_E	2.555	1.00
269_K	298_T	2.529	1.00
268_G	272_E	2.514	1.00
520_L	524_E	2.493	1.00
197_D	242_R	2.480	1.00
154_R	157_D	2.473	1.00
576_K	587_N	2.399	1.00
64_I	105_F	2.392	1.00
594_S	597_E	2.371	1.00
559_A	570_V	2.332	1.00
203_G	502_K	2.306	1.00
18_G	29_E	2.288	1.00
206_V	244_V	2.272	1.00
233_K	312_Q	2.268	1.00
119_N	146_E	2.257	1.00
460_S	564_K	2.210	1.00
199_M	490_P	2.209	1.00
196_V	206_V	2.173	1.00
500_K	504_I	2.170	1.00
567_S	593_K	2.124	1.00
104_L	115_G	2.123	1.00
262_P	266_G	2.112	1.00
307_S	311_S	2.106	1.00
398_L	411_F	2.106	1.00
361_L	366_V	2.090	1.00
425_K	563_S	2.089	1.00
156_E	536_E	2.085	1.00
202_E	498_K	2.084	1.00
273_I	277_E	2.083	1.00
173_P	176_A	2.042	1.00
300_E	304_G	2.032	1.00
521_E	525_K	2.026	1.00
296_E	360_Y	1.943	1.00
502_K	506_E	1.943	1.00
569_L	591_V	1.942	1.00
559_A	568_R	1.924	1.00
402_G	406_I	1.913	1.00
572_L	601_Y	1.905	1.00
16_V	29_E	1.894	1.00
119_N	148_Y	1.887	1.00
543_M	571_T	1.876	1.00
609_P	628_N	1.874	1.00
297_D	300_E	1.861	1.00
189_Q	193_V	1.860	1.00
155_I	538_Q	1.850	1.00
576_K	604_E	1.849	1.00
435_S	532_P	1.849	1.00
150_I	161_K	1.841	1.00
503_E	596_H	1.840	1.00
295_R	298_T	1.818	1.00
291_P	298_T	1.815	1.00
29_E	36_K	1.808	1.00
307_S	389_T	1.807	1.00
267_M	297_D	1.807	1.00
177_F	519_A	1.805	1.00
586_I	601_Y	1.805	1.00
259_N	264_L	1.805	1.00
260_Y	263_F	1.798	1.00
531_R	536_E	1.790	1.00
468_Y	501_V	1.784	1.00
224_W	232_P	1.782	1.00
559_A	601_Y	1.767	1.00
579_N	597_E	1.761	1.00
234_K	238_E	1.758	1.00
446_I	477_Y	1.746	1.00
551_M	577_W	1.700	1.00
213_I	249_I	1.690	1.00
160_E	525_K	1.670	1.00
17_I	26_F	1.653	1.00
580_Y	600_I	1.642	1.00
115_G	158_V	1.635	1.00
428_L	562_V	1.620	1.00
59_D	109_K	1.615	1.00
465_V	497_Y	1.589	1.00
27_P	36_K	1.587	1.00
197_D	238_E	1.587	1.00
511_F	556_L	1.584	1.00
639_K	657_V	1.578	1.00
162_Y	404_A	1.576	1.00
211_L	246_L	1.575	1.00
189_Q	235_L	1.567	1.00
558_Y	600_I	1.567	1.00
30_Q	35_N	1.563	1.00
64_I	107_S	1.558	1.00
495_D	499_E	1.557	1.00
196_V	244_V	1.548	1.00
192_V	211_L	1.543	1.00
381_M	409_Y	1.542	1.00
85_N	101_S	1.541	1.00
542_D	591_V	1.540	1.00
155_I	534_F	1.538	1.00
561_I	568_R	1.537	1.00
543_M	546_I	1.521	1.00
521_E	554_K	1.514	1.00
556_L	602_L	1.504	1.00
307_S	390_S	1.502	1.00
519_A	529_V	1.497	1.00
190_D	194_E	1.492	1.00
533_L	551_M	1.484	1.00
196_V	209_V	1.478	1.00
465_V	595_T	1.473	1.00
236_I	246_L	1.472	1.00
18_G	27_P	1.467	1.00
470_L	550_Y	1.460	1.00
527_H	535_Y	1.452	1.00
152_G	157_D	1.450	1.00
263_F	266_G	1.449	1.00
572_L	592_V	1.447	1.00
473_F	600_I	1.446	1.00
304_G	308_E	1.438	1.00
431_V	442_V	1.435	1.00
602_L	631_I	1.435	1.00
556_L	608_I	1.431	1.00
58_L	64_I	1.427	1.00
499_E	502_K	1.412	1.00
27_P	39_S	1.411	1.00
465_V	500_K	1.411	1.00
444_C	474_F	1.406	1.00
106_I	155_I	1.406	1.00
248_T	314_V	1.401	1.00
118_F	140_I	1.401	1.00
160_E	527_H	1.397	1.00
225_H	228_R	1.394	1.00
521_E	527_H	1.391	1.00
518_L	521_E	1.390	1.00
300_E	389_T	1.384	1.00
555_Y	603_R	1.380	1.00
378_Y	381_M	1.377	1.00
199_M	206_V	1.367	1.00
421_W	462_D	1.366	1.00
189_Q	231_E	1.366	1.00
203_G	615_L	1.366	1.00
262_P	265_S	1.362	1.00
610_L	629_A	1.360	1.00
580_Y	610_L	1.357	1.00
414_T	430_L	1.348	1.00
504_I	598_L	1.340	0.99
494_P	497_Y	1.339	0.99
265_S	305_L	1.338	0.99
179_Y	199_M	1.337	0.99
308_E	311_S	1.334	0.99
180_M	210_F	1.329	0.99
607_I	630_E	1.324	0.99
496_Y	499_E	1.320	0.99
207_A	509_Y	1.313	0.99
172_P	177_F	1.305	0.99
452_R	486_I	1.302	0.99
474_F	550_Y	1.298	0.99
510_K	627_D	1.292	0.99
304_G	307_S	1.289	0.99
264_L	270_F	1.288	0.99
124_V	140_I	1.282	0.99
80_R	127_D	1.279	0.99
187_Y	191_K	1.275	0.99
388_R	648_K	1.272	0.99
384_F	388_R	1.271	0.99
204_F	498_K	1.269	0.99
462_D	564_K	1.269	0.99
20_P	23_P	1.266	0.99
269_K	295_R	1.264	0.99
421_W	564_K	1.264	0.99
377_L	406_I	1.263	0.99
175_W	316_G	1.263	0.99
56_K	136_V	1.259	0.99
200_Q	242_R	1.259	0.99
303_A	386_G	1.257	0.99
520_L	657_V	1.257	0.99
465_V	469_A	1.257	0.99
533_L	546_I	1.255	0.99
260_Y	266_G	1.254	0.99
305_L	308_E	1.246	0.99
440_P	522_A	1.241	0.99
299_R	382_A	1.238	0.99
580_Y	602_L	1.233	0.99
36_K	39_S	1.232	0.99
196_V	239_L	1.223	0.99
245_K	315_D	1.220	0.99
324_P	368_H	1.220	0.99
278_L	289_V	1.219	0.99
579_N	584_E	1.218	0.99
156_E	527_H	1.215	0.99
424_L	470_L	1.214	0.99
578_Y	604_E	1.213	0.99
295_R	360_Y	1.210	0.99
296_E	300_E	1.207	0.99
462_D	595_T	1.205	0.99
294_F	366_V	1.201	0.99
150_I	165_L	1.200	0.99
431_V	444_C	1.192	0.99
641_S	650_T	1.190	0.99
272_E	278_L	1.187	0.99
628_N	660_I	1.183	0.99
482_A	485_G	1.183	0.99
385_K	388_R	1.174	0.99
234_K	237_D	1.173	0.99
193_V	242_R	1.173	0.99
174_M	516_Y	1.169	0.99
100_V	402_G	1.162	0.98
14_K	31_K	1.157	0.98
32_I	35_N	1.155	0.98
104_L	158_V	1.150	0.98
270_F	289_V	1.146	0.98
166_T	407_Q	1.145	0.98
479_S	488_T	1.143	0.98
189_Q	230_P	1.141	0.98
521_E	639_K	1.138	0.98
247_I	316_G	1.137	0.98
299_R	303_A	1.133	0.98
311_S	390_S	1.133	0.98
181_I	199_M	1.126	0.98
181_I	186_Y	1.122	0.98
510_K	610_L	1.121	0.98
182_S	210_F	1.118	0.98
400_R	416_D	1.117	0.98
20_P	25_E	1.117	0.98
266_G	270_F	1.114	0.98
215_Y	309_W	1.111	0.98
649_L	654_E	1.106	0.98
491_V	494_P	1.105	0.98
464_L	479_S	1.099	0.98
186_Y	489_E	1.096	0.98
320_D	416_D	1.093	0.98
105_F	128_V	1.091	0.98
55_E	137_I	1.089	0.98
431_V	530_I	1.088	0.98
82_V	125_I	1.085	0.98
556_L	600_I	1.085	0.98
250_V	306_I	1.082	0.98
179_Y	479_S	1.082	0.98
63_H	545_R	1.079	0.98
497_Y	501_V	1.078	0.98
536_E	603_R	1.073	0.97
194_E	198_I	1.071	0.97
271_C	290_Y	1.069	0.97
602_L	608_I	1.069	0.97
196_V	242_R	1.068	0.97
537_F	603_R	1.063	0.97
159_L	535_Y	1.061	0.97
299_R	381_M	1.060	0.97
192_V	209_V	1.056	0.97
257_D	264_L	1.054	0.97
239_L	244_V	1.054	0.97
113_A	153_P	1.049	0.97
179_Y	477_Y	1.049	0.97
461_M	494_P	1.049	0.97
67_L	128_V	1.048	0.97
177_F	515_I	1.046	0.97
35_N	38_L	1.046	0.97
633_S	637_E	1.042	0.97
570_V	601_Y	1.042	0.97
200_Q	244_V	1.041	0.97
280_V	287_T	1.040	0.97
633_S	638_I	1.039	0.97
413_W	416_D	1.037	0.97
172_P	519_A	1.033	0.97
260_Y	264_L	1.032	0.97
236_I	314_V	1.026	0.97
34_S	37_S	1.026	0.97
447_G	464_L	1.024	0.97
152_G	158_V	1.024	0.97
237_D	240_H	1.024	0.97
536_E	551_M	1.023	0.97
506_E	613_D	1.022	0.97
581_W	597_E	1.021	0.97
414_T	434_L	1.019	0.97
473_F	598_L	1.017	0.97
494_P	498_K	1.016	0.96
153_P	161_K	1.016	0.96
532_P	535_Y	1.010	0.96
561_I	594_S	1.010	0.96
473_F	558_Y	1.009	0.96
108_V	113_A	1.008	0.96
180_M	208_G	1.007	0.96
208_G	245_K	1.007	0.96
550_Y	558_Y	1.006	0.96
102_I	166_T	1.005	0.96
83_M	126_F	1.005	0.96
472_L	504_I	1.003	0.96
536_E	554_K	1.001	0.96
102_I	404_A	0.999	0.96
359_H	368_H	0.997	0.96
412_I	434_L	0.997	0.96
503_E	597_E	0.994	0.96
74_L	432_L	0.994	0.96
218_S	221_L	0.991	0.96
637_E	661_I	0.990	0.96
34_S	39_S	0.990	0.96
200_Q	616_I	0.988	0.96
184_Y	214_H	0.986	0.96
500_K	596_H	0.984	0.96
217_D	220_K	0.984	0.96
191_K	487_D	0.984	0.96
263_F	267_M	0.981	0.96
243_N	619_G	0.979	0.96
396_F	411_F	0.978	0.96
34_S	38_L	0.978	0.96
306_I	317_I	0.975	0.96
436_I	534_F	0.972	0.95
249_I	318_W	0.970	0.95
555_Y	608_I	0.970	0.95
238_E	241_K	0.967	0.95
518_L	529_V	0.967	0.95
377_L	409_Y	0.964	0.95
303_A	385_K	0.964	0.95
420_S	423_D	0.959	0.95
388_R	651_I	0.959	0.95
211_L	229_F	0.959	0.95
122_S	142_E	0.956	0.95
108_V	544_Y	0.955	0.95
220_K	257_D	0.955	0.95
514_Y	609_P	0.954	0.95
474_F	530_I	0.954	0.95
163_T	526_G	0.954	0.95
31_K	34_S	0.954	0.95
16_V	32_I	0.953	0.95
377_L	408_R	0.952	0.95
465_V	501_V	0.952	0.95
269_K	297_D	0.951	0.95
632_T	662_V	0.950	0.95
263_F	289_V	0.949	0.95
615_L	619_G	0.948	0.95
15_V	151_E	0.947	0.95
168_K	526_G	0.939	0.95
191_K	194_E	0.938	0.95
261_S	264_L	0.937	0.94
464_L	501_V	0.933	0.94
221_L	254_I	0.923	0.94
39_S	57_S	0.920	0.94
432_L	530_I	0.919	0.94
586_I	592_V	0.918	0.94
171_L	519_A	0.918	0.94
53_I	139_T	0.915	0.94
156_E	535_Y	0.913	0.94
299_R	385_K	0.910	0.94
20_P	27_P	0.908	0.94
468_Y	479_S	0.906	0.93
263_F	305_L	0.904	0.93
367_K	370_K	0.904	0.93
616_I	620_E	0.902	0.93
424_L	562_V	0.899	0.93
218_S	257_D	0.898	0.93
414_T	442_V	0.897	0.93
240_H	245_K	0.897	0.93
639_K	659_K	0.896	0.93
267_M	278_L	0.894	0.93
473_F	507_L	0.892	0.93
118_F	124_V	0.890	0.93
626_Y	642_R	0.890	0.93
163_T	440_P	0.890	0.93
80_R	125_I	0.889	0.93
400_R	413_W	0.887	0.93
35_N	39_S	0.884	0.93
87_D	99_Y	0.882	0.92
302_W	383_T	0.877	0.92
182_S	480_H	0.877	0.92
648_K	651_I	0.876	0.92
169_P	440_P	0.876	0.92
62_E	107_S	0.875	0.92
432_L	532_P	0.873	0.92
413_W	480_H	0.873	0.92
261_S	289_V	0.872	0.92
190_D	193_V	0.872	0.92
501_V	505_V	0.871	0.92
503_E	506_E	0.869	0.92
67_L	81_Y	0.866	0.92
441_F	519_A	0.865	0.92
504_I	581_W	0.865	0.92
67_L	105_F	0.865	0.92
380_A	410_A	0.864	0.92
394_E	643_E	0.862	0.92
490_P	501_V	0.861	0.92
500_K	595_T	0.860	0.92
35_N	41_L	0.859	0.91
466_K	469_A	0.859	0.91
105_F	136_V	0.858	0.91
239_L	246_L	0.858	0.91
421_W	463_L	0.855	0.91
280_V	289_V	0.851	0.91
583_G	629_A	0.848	0.91
399_S	410_A	0.847	0.91
551_M	555_Y	0.843	0.91
251_D	321_M	0.842	0.91
421_W	424_L	0.841	0.91
261_S	266_G	0.840	0.91
58_L	77_K	0.839	0.91
74_L	534_F	0.838	0.90
195_L	491_V	0.837	0.90
435_S	528_P	0.836	0.90
540_D	543_M	0.836	0.90
321_M	325_T	0.835	0.90
384_F	648_K	0.834	0.90
399_S	412_I	0.834	0.90
141_P	369_E	0.833	0.90
392_R	649_L	0.832	0.90
120_S	142_E	0.832	0.90
54_V	147_F	0.831	0.90
151_E	161_K	0.831	0.90
117_F	162_Y	0.829	0.90
632_T	638_I	0.828	0.90
522_A	525_K	0.827	0.90
83_M	101_S	0.827	0.90
472_L	477_Y	0.825	0.90
320_D	400_R	0.823	0.90
521_E	531_R	0.822	0.90
546_I	549_E	0.822	0.90
268_G	295_R	0.819	0.89
461_M	497_Y	0.814	0.89
427_Q	474_F	0.813	0.89
413_W	449_F	0.811	0.89
368_H	372_R	0.811	0.89
126_F	138_V	0.811	0.89
471_A	477_Y	0.810	0.89
46_V	49_G	0.809	0.89
533_L	543_M	0.809	0.89
616_I	619_G	0.807	0.89
125_I	139_T	0.806	0.89
104_L	162_Y	0.800	0.88
19_E	26_F	0.800	0.88
188_P	228_R	0.800	0.88
620_E	624_K	0.799	0.88
499_E	503_E	0.799	0.88
29_E	34_S	0.799	0.88
128_V	136_V	0.795	0.88
172_P	441_F	0.794	0.88
200_Q	207_A	0.793	0.88
17_I	28_L	0.793	0.88
310_L	387_F	0.792	0.88
121_A	374_A	0.790	0.88
604_E	633_S	0.790	0.88
415_G	449_F	0.789	0.88
406_I	410_A	0.788	0.88
300_E	303_A	0.788	0.88
210_F	476_F	0.787	0.87
514_Y	553_G	0.786	0.87
120_S	124_V	0.786	0.87
414_T	431_V	0.784	0.87
28_L	149_V	0.783	0.87
39_S	42_G	0.782	0.87
204_F	502_K	0.782	0.87
640_F	660_I	0.780	0.87
522_A	529_V	0.778	0.87
55_E	135_K	0.777	0.87
193_V	235_L	0.777	0.87
63_H	544_Y	0.776	0.87
436_I	532_P	0.776	0.87
192_V	246_L	0.775	0.87
252_H	375_Y	0.775	0.87
612_G	627_D	0.775	0.87
181_I	489_E	0.773	0.87
213_I	321_M	0.772	0.86
175_W	245_K	0.770	0.86
579_N	601_Y	0.769	0.86
171_L	516_Y	0.768	0.86
120_S	143_D	0.766	0.86
518_L	522_A	0.765	0.86
578_Y	585_I	0.763	0.86
67_L	126_F	0.762	0.86
206_V	209_V	0.762	0.86
416_D	480_H	0.762	0.86
213_I	251_D	0.762	0.86
58_L	129_G	0.760	0.86
107_S	114_T	0.760	0.86
310_L	313_G	0.759	0.86
189_Q	234_K	0.754	0.85
99_Y	415_G	0.753	0.85
517_S	640_F	0.753	0.85
537_F	575_G	0.753	0.85
431_V	474_F	0.753	0.85
177_F	529_V	0.753	0.85
43_L	47_Q	0.752	0.85
477_Y	505_V	0.750	0.85
358_V	361_L	0.748	0.85
322_N	379_E	0.747	0.85
174_M	642_R	0.747	0.85
188_P	191_K	0.747	0.85
268_G	278_L	0.747	0.85
171_L	520_L	0.746	0.85
44_T	47_Q	0.744	0.84
16_V	31_K	0.743	0.84
193_V	239_L	0.741	0.84
473_F	552_V	0.740	0.84
197_D	200_Q	0.740	0.84
105_F	116_Y	0.740	0.84
189_Q	238_E	0.739	0.84
610_L	627_D	0.739	0.84
82_V	123_K	0.739	0.84
178_G	207_A	0.738	0.84
264_L	289_V	0.736	0.84
183_R	212_D	0.735	0.84
613_D	624_K	0.734	0.84
435_S	530_I	0.732	0.83
216_M	251_D	0.732	0.83
651_I	655_K	0.731	0.83
265_S	278_L	0.730	0.83
411_F	476_F	0.729	0.83
27_P	41_L	0.727	0.83
104_L	117_F	0.726	0.83
31_K	35_N	0.725	0.83
361_L	365_R	0.725	0.83
73_E	547_E	0.718	0.82
445_D	478_R	0.717	0.82
548_D	562_V	0.714	0.82
388_R	395_I	0.714	0.82
322_N	399_S	0.712	0.82
453_N	460_S	0.711	0.82
223_T	259_N	0.711	0.82
148_Y	165_L	0.710	0.82
70_K	76_R	0.708	0.81
72_F	76_R	0.707	0.81
185_S	214_H	0.707	0.81
387_F	397_I	0.704	0.81
294_F	378_Y	0.703	0.81
448_G	467_Y	0.703	0.81
251_D	285_P	0.703	0.81
162_Y	166_T	0.700	0.81
118_F	126_F	0.700	0.81
506_E	615_L	0.700	0.81
533_L	571_T	0.700	0.81
282_K	287_T	0.699	0.81
271_C	357_V	0.699	0.81
30_Q	34_S	0.698	0.80
324_P	375_Y	0.698	0.80
184_Y	249_I	0.697	0.80
406_I	439_V	0.697	0.80
172_P	176_A	0.696	0.80
121_A	403_Y	0.696	0.80
184_Y	449_F	0.695	0.80
28_L	34_S	0.695	0.80
89_G	450_Q	0.695	0.80
518_L	554_K	0.693	0.80
613_D	620_E	0.692	0.80
61_K	109_K	0.692	0.80
302_W	379_E	0.691	0.80
160_E	163_T	0.691	0.80
207_A	617_V	0.690	0.80
105_F	114_T	0.688	0.79
202_E	491_V	0.688	0.79
213_I	219_Y	0.688	0.79
416_D	445_D	0.687	0.79
76_R	81_Y	0.685	0.79
542_D	571_T	0.684	0.79
609_P	640_F	0.684	0.79
469_A	503_E	0.682	0.79
449_F	480_H	0.682	0.79
25_E	39_S	0.682	0.79
496_Y	596_H	0.682	0.79
561_I	565_E	0.682	0.79
589_K	593_K	0.682	0.79
613_D	616_I	0.681	0.79
419_P	488_T	0.681	0.79
412_I	439_V	0.681	0.79
256_V	287_T	0.680	0.79
181_I	209_V	0.678	0.78
267_M	270_F	0.678	0.78
317_I	387_F	0.678	0.78
573_P	577_W	0.677	0.78
400_R	480_H	0.677	0.78
469_A	596_H	0.674	0.78
177_F	441_F	0.673	0.78
194_E	201_K	0.672	0.78
143_D	370_K	0.672	0.78
263_F	278_L	0.671	0.78
650_T	655_K	0.670	0.78
102_I	439_V	0.670	0.78
470_L	474_F	0.669	0.78
549_E	559_A	0.669	0.78
376_P	401_A	0.669	0.78
34_S	40_E	0.668	0.77
220_K	259_N	0.668	0.77
212_D	416_D	0.667	0.77
61_K	541_D	0.666	0.77
163_T	528_P	0.666	0.77
184_Y	251_D	0.666	0.77
212_D	478_R	0.664	0.77
14_K	26_F	0.663	0.77
118_F	147_F	0.662	0.77
366_V	371_V	0.661	0.77
199_M	203_G	0.659	0.77
183_R	489_E	0.659	0.77
160_E	168_K	0.658	0.76
28_L	38_L	0.657	0.76
466_K	561_I	0.656	0.76
635_S	638_I	0.654	0.76
387_F	395_I	0.653	0.76
538_Q	543_M	0.653	0.76
386_G	389_T	0.653	0.76
507_L	581_W	0.652	0.76
195_L	199_M	0.652	0.76
414_T	417_N	0.651	0.76
495_D	498_K	0.651	0.76
84_Y	372_R	0.649	0.75
184_Y	213_I	0.649	0.75
113_A	158_V	0.648	0.75
581_W	600_I	0.648	0.75
102_I	437_S	0.647	0.75
507_L	600_I	0.642	0.75
400_R	449_F	0.641	0.75
194_E	197_D	0.640	0.74
534_F	544_Y	0.639	0.74
579_N	583_G	0.639	0.74
100_V	412_I	0.638	0.74
518_L	551_M	0.637	0.74
320_D	480_H	0.637	0.74
171_L	523_S	0.637	0.74
29_E	32_I	0.637	0.74
43_L	46_V	0.637	0.74
540_D	574_R	0.636	0.74
551_M	573_P	0.636	0.74
213_I	216_M	0.635	0.74
510_K	613_D	0.634	0.74
198_I	498_K	0.634	0.74
85_N	401_A	0.633	0.74
69_E	430_L	0.633	0.74
498_K	502_K	0.633	0.74
163_T	438_G	0.631	0.73
654_E	659_K	0.631	0.73
199_M	491_V	0.630	0.73
321_M	327_F	0.629	0.73
23_P	26_F	0.628	0.73
518_L	531_R	0.628	0.73
435_S	522_A	0.628	0.73
261_S	265_S	0.627	0.73
380_A	399_S	0.625	0.73
537_F	540_D	0.625	0.73
533_L	559_A	0.625	0.73
234_K	241_K	0.625	0.73
30_Q	151_E	0.624	0.73
152_G	161_K	0.624	0.73
210_F	247_I	0.622	0.72
190_D	197_D	0.621	0.72
429_Q	433_G	0.620	0.72
509_Y	512_L	0.620	0.72
179_Y	501_V	0.619	0.72
518_L	638_I	0.619	0.72
644_I	649_L	0.618	0.72
558_Y	598_L	0.618	0.72
606_S	609_P	0.617	0.72
303_A	382_A	0.616	0.72
604_E	631_I	0.615	0.71
400_R	415_G	0.613	0.71
192_V	235_L	0.612	0.71
637_E	659_K	0.611	0.71
603_R	606_S	0.611	0.71
585_I	603_R	0.610	0.71
580_Y	629_A	0.610	0.71
250_V	317_I	0.609	0.71
300_E	385_K	0.608	0.71
615_L	618_Y	0.607	0.70
572_L	589_K	0.606	0.70
445_D	449_F	0.605	0.70
468_Y	505_V	0.605	0.70
175_W	208_G	0.605	0.70
418_T	450_Q	0.603	0.70
614_E	618_Y	0.602	0.70
34_S	41_L	0.602	0.70
52_V	145_V	0.602	0.70
181_I	195_L	0.600	0.70
56_K	147_F	0.599	0.69
84_Y	123_K	0.599	0.69
490_P	505_V	0.599	0.69
590_S	593_K	0.598	0.69
468_Y	477_Y	0.597	0.69
99_Y	321_M	0.597	0.69
575_G	588_G	0.597	0.69
416_D	449_F	0.597	0.69
552_V	558_Y	0.596	0.69
256_V	289_V	0.596	0.69
274_E	356_N	0.596	0.69
179_Y	505_V	0.596	0.69
102_I	412_I	0.594	0.69
578_Y	631_I	0.594	0.69
215_Y	250_V	0.594	0.69
64_I	67_L	0.593	0.69
208_G	247_I	0.593	0.69
530_I	550_Y	0.592	0.69
421_W	466_K	0.592	0.69
415_G	445_D	0.589	0.68
264_L	301_W	0.588	0.68
30_Q	153_P	0.586	0.68
16_V	35_N	0.584	0.68
214_H	219_Y	0.580	0.67
382_A	386_G	0.580	0.67
43_L	48_Q	0.580	0.67
445_D	480_H	0.580	0.67
190_D	238_E	0.580	0.67
152_G	162_Y	0.579	0.67
184_Y	482_A	0.579	0.67
614_E	619_G	0.578	0.67
477_Y	508_R	0.577	0.67
238_E	242_R	0.576	0.66
402_G	439_V	0.576	0.66
120_S	140_I	0.576	0.66
156_E	554_K	0.575	0.66
435_S	440_P	0.574	0.66
271_C	359_H	0.572	0.66
509_Y	516_Y	0.572	0.66
28_L	40_E	0.572	0.66
84_Y	355_D	0.571	0.66
464_L	488_T	0.570	0.66
584_E	601_Y	0.570	0.66
637_E	663_D	0.570	0.66
186_Y	195_L	0.569	0.66
216_M	253_G	0.569	0.66
464_L	468_Y	0.568	0.65
587_N	590_S	0.568	0.65
37_S	40_E	0.568	0.65
320_D	449_F	0.567	0.65
435_S	527_H	0.567	0.65
138_V	147_F	0.566	0.65
25_E	41_L	0.566	0.65
201_K	663_D	0.566	0.65
19_E	22_P	0.566	0.65
118_F	138_V	0.565	0.65
154_R	538_Q	0.564	0.65
179_Y	468_Y	0.564	0.65
307_S	386_G	0.564	0.65
481_K	485_G	0.564	0.65
372_R	376_P	0.564	0.65
413_W	445_D	0.563	0.65
306_I	383_T	0.562	0.65
318_W	414_T	0.562	0.65
22_P	32_I	0.561	0.64
429_Q	432_L	0.561	0.64
626_Y	660_I	0.561	0.64
607_I	628_N	0.560	0.64
132_E	136_V	0.560	0.64
503_E	510_K	0.560	0.64
192_V	239_L	0.559	0.64
184_Y	321_M	0.559	0.64
284_W	449_F	0.558	0.64
366_V	370_K	0.558	0.64
38_L	41_L	0.556	0.64
62_E	114_T	0.556	0.64
640_F	658_S	0.555	0.64
65_I	543_M	0.554	0.63
195_L	489_E	0.553	0.63
637_E	654_E	0.553	0.63
383_T	397_I	0.553	0.63
166_T	404_A	0.553	0.63
18_G	32_I	0.552	0.63
505_V	509_Y	0.552	0.63
184_Y	212_D	0.552	0.63
611_E	614_E	0.551	0.63
321_M	476_F	0.551	0.63
35_N	40_E	0.551	0.63
533_L	573_P	0.550	0.63
253_G	290_Y	0.550	0.63
206_V	491_V	0.550	0.63
358_V	367_K	0.550	0.63
159_L	163_T	0.549	0.63
102_I	162_Y	0.548	0.63
491_V	498_K	0.548	0.63
542_D	545_R	0.548	0.63
219_Y	253_G	0.548	0.63
106_I	159_L	0.548	0.63
102_I	407_Q	0.547	0.63
248_T	317_I	0.547	0.63
425_K	547_E	0.547	0.63
37_S	41_L	0.544	0.62
572_L	588_G	0.544	0.62
27_P	32_I	0.543	0.62
258_Q	264_L	0.543	0.62
507_L	580_Y	0.543	0.62
293_F	302_W	0.543	0.62
107_S	113_A	0.542	0.62
30_Q	39_S	0.542	0.62
233_K	311_S	0.542	0.62
531_R	551_M	0.541	0.62
122_S	370_K	0.540	0.62
155_I	544_Y	0.540	0.62
219_Y	249_I	0.540	0.62
45_I	48_Q	0.540	0.62
25_E	40_E	0.539	0.61
174_M	611_E	0.539	0.61
199_M	489_E	0.539	0.61
614_E	620_E	0.538	0.61
527_H	554_K	0.538	0.61
62_E	109_K	0.538	0.61
75_D	545_R	0.537	0.61
291_P	382_A	0.537	0.61
651_I	654_E	0.537	0.61
69_E	100_V	0.537	0.61
212_D	318_W	0.537	0.61
318_W	324_P	0.536	0.61
281_G	284_W	0.536	0.61
571_T	574_R	0.535	0.61
310_L	391_H	0.535	0.61
548_D	559_A	0.535	0.61
212_D	480_H	0.535	0.61
159_L	436_I	0.534	0.61
174_M	645_Y	0.532	0.60
588_G	599_P	0.532	0.60
313_G	588_G	0.531	0.60
615_L	620_E	0.530	0.60
214_H	321_M	0.530	0.60
52_V	142_E	0.530	0.60
557_L	572_L	0.529	0.60
193_V	197_D	0.529	0.60
35_N	42_G	0.529	0.60
415_G	480_H	0.528	0.60
224_W	233_K	0.528	0.60
256_V	280_V	0.527	0.60
283_M	321_M	0.526	0.60
611_E	615_L	0.526	0.60
21_F	28_L	0.526	0.60
260_Y	265_S	0.526	0.60
546_I	571_T	0.526	0.60
522_A	527_H	0.525	0.59
440_P	529_V	0.524	0.59
177_F	516_Y	0.524	0.59
316_G	396_F	0.524	0.59
425_K	548_D	0.524	0.59
318_W	449_F	0.524	0.59
433_G	437_S	0.523	0.59
517_S	524_E	0.522	0.59
406_I	412_I	0.520	0.59
574_R	634_S	0.520	0.59
651_I	663_D	0.520	0.59
534_F	543_M	0.520	0.59
193_V	196_V	0.520	0.59
318_W	321_M	0.520	0.59
425_K	429_Q	0.519	0.59
614_E	617_V	0.519	0.59
200_Q	615_L	0.518	0.58
571_T	591_V	0.517	0.58
487_D	492_F	0.517	0.58
22_P	31_K	0.517	0.58
24_I	28_L	0.516	0.58
320_D	413_W	0.516	0.58
434_L	437_S	0.516	0.58
150_I	158_V	0.516	0.58
355_D	359_H	0.516	0.58
156_E	528_P	0.516	0.58
319_L	430_L	0.516	0.58
122_S	369_E	0.515	0.58
265_S	289_V	0.514	0.58
480_H	489_E	0.514	0.58
163_T	527_H	0.513	0.58
18_G	21_F	0.513	0.58
359_H	372_R	0.512	0.58
470_L	562_V	0.512	0.58
118_F	122_S	0.512	0.58
283_M	288_T	0.512	0.58
25_E	35_N	0.512	0.58
300_E	539_D	0.512	0.58
58_L	136_V	0.511	0.57
293_F	382_A	0.511	0.57
516_Y	520_L	0.511	0.57
445_D	448_G	0.511	0.57
503_E	581_W	0.511	0.57
70_K	96_D	0.510	0.57
626_Y	640_F	0.510	0.57
174_M	512_L	0.510	0.57
317_I	383_T	0.509	0.57
323_E	400_R	0.509	0.57
551_M	603_R	0.509	0.57
243_N	616_I	0.509	0.57
85_N	373_N	0.508	0.57
20_P	31_K	0.507	0.57
294_F	371_V	0.507	0.57
512_L	617_V	0.507	0.57
41_L	57_S	0.507	0.57
634_S	663_D	0.506	0.57
473_F	550_Y	0.506	0.57
179_Y	490_P	0.505	0.56
207_A	508_R	0.505	0.56
586_I	590_S	0.505	0.56
421_W	561_I	0.504	0.56
357_V	360_Y	0.504	0.56
183_R	213_I	0.504	0.56
498_K	505_V	0.504	0.56
493_L	501_V	0.504	0.56
514_Y	555_Y	0.503	0.56
23_P	34_S	0.503	0.56
318_W	480_H	0.503	0.56
101_S	373_N	0.502	0.56
428_L	432_L	0.501	0.56
204_F	490_P	0.500	0.56
36_K	41_L	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lppA	3	0.9755	100	0.097	Contact Map
3l4yA	1	0.9755	100	0.104	Contact Map
3weoA	1	0.9726	100	0.104	Contact Map
3topA	1	0.9784	100	0.106	Contact Map
4ba0A	2	0.9365	100	0.118	Contact Map
3nsxA	2	0.9105	100	0.162	Contact Map
2xvlA	1	0.9452	100	0.163	Contact Map
2g3mA	5	0.9567	100	0.174	Contact Map
4kmqA	1	0.9206	100	0.189	Contact Map
4amwA	1	0.9812	100	0.191	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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