GREMLIN Database
SYS - Serine--tRNA ligase
UniProt: O33780 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 457 (417)
Sequences: 4311 (2311)
Seq/√Len: 113.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
423_R429_E4.4481.00
261_F275_F4.0211.00
206_Y330_I3.7721.00
123_P126_F3.7661.00
335_E432_K3.3101.00
312_T315_D3.2481.00
39_K89_E3.2091.00
53_Q75_E3.1321.00
317_W378_T3.1101.00
46_E82_I3.0011.00
159_K167_D2.8101.00
315_D318_K2.7161.00
202_F333_Q2.7151.00
187_Y260_M2.7071.00
435_R442_P2.6511.00
391_D398_G2.5951.00
429_E435_R2.5901.00
353_A378_T2.5871.00
170_H189_F2.5811.00
102_S227_Q2.5111.00
114_N345_S2.4251.00
155_K424_E2.3941.00
329_S333_Q2.3941.00
32_K96_E2.3861.00
22_R114_N2.3651.00
125_K328_E2.3591.00
206_Y333_Q2.3541.00
274_K322_E2.3391.00
164_M428_V2.3211.00
125_K340_I2.3171.00
17_K31_D2.3011.00
432_K435_R2.2701.00
418_L428_V2.2411.00
205_D437_Y2.1361.00
65_S73_I2.1291.00
12_N15_D2.0851.00
92_E96_E2.0461.00
328_E332_Q2.0411.00
319_Y322_E2.0201.00
176_K264_E2.0021.00
423_R427_V1.9981.00
109_A317_W1.9871.00
210_Q329_S1.9591.00
180_I187_Y1.9331.00
171_L192_I1.8911.00
336_L360_V1.8791.00
390_V397_R1.8751.00
309_I319_Y1.8741.00
223_G248_Y1.8591.00
209_Q333_Q1.8551.00
220_M242_I1.8501.00
18_N22_R1.8441.00
225_V262_F1.8341.00
215_V260_M1.8181.00
127_W332_Q1.8151.00
337_P420_N1.8091.00
133_Y156_W1.8071.00
343_I355_K1.8021.00
251_A255_H1.7961.00
64_L67_E1.7941.00
60_Q63_K1.7591.00
111_D354_K1.7571.00
52_H56_V1.7311.00
129_K132_V1.7301.00
35_E39_K1.7031.00
342_N354_K1.7011.00
109_A378_T1.7001.00
18_N21_K1.6991.00
219_Y282_F1.6791.00
10_R37_D1.6751.00
70_K74_E1.6611.00
391_D394_N1.6491.00
165_L172_G1.6471.00
95_N99_R1.6431.00
19_N110_D1.6171.00
108_V348_L1.6161.00
267_E270_K1.6081.00
94_E98_D1.6041.00
50_L79_L1.5971.00
352_A355_K1.5921.00
217_P256_P1.5911.00
78_N82_I1.5911.00
32_K35_E1.5851.00
329_S332_Q1.5811.00
179_E264_E1.5491.00
268_K312_T1.5451.00
56_V60_Q1.5431.00
108_V345_S1.5401.00
316_S401_H1.5371.00
8_L12_N1.5201.00
44_L48_E1.5001.00
350_A380_W1.4971.00
274_K309_I1.4951.00
224_E262_F1.4881.00
19_N22_R1.4801.00
116_P120_Y1.4801.00
186_Y299_V1.4771.00
220_M247_L1.4741.00
51_R87_E1.4691.00
42_Q46_E1.4581.00
245_E284_K1.4581.00
82_I85_E1.4561.00
160_G163_E1.4531.00
196_D303_H1.4441.00
408_I413_T1.4261.00
38_K42_Q1.4241.00
176_K260_M1.4121.00
120_Y344_A1.4051.00
53_Q56_V1.4031.00
312_T389_Y1.3981.00
46_E49_K1.3961.00
70_K73_I1.3961.00
166_E175_L1.3951.00
177_A186_Y1.3921.00
43_V90_L1.3891.00
274_K319_Y1.3721.00
223_G246_D1.3641.00
257_I277_G1.3611.00
310_F400_V1.3531.00
8_L15_D1.3401.00
69_R73_I1.3381.00
22_R345_S1.3381.00
13_P34_V1.3361.00
268_K392_R1.3351.00
189_F213_T1.3321.00
88_K92_E1.3301.00
57_L76_S1.3301.00
181_A247_L1.3061.00
43_V93_I1.3030.99
261_F310_F1.2860.99
311_S319_Y1.2830.99
316_S376_N1.2710.99
39_K42_Q1.2660.99
74_E78_N1.2590.99
321_S356_F1.2560.99
223_G236_K1.2550.99
37_D41_R1.2510.99
335_E421_Y1.2460.99
85_E89_E1.2400.99
236_K248_Y1.2390.99
365_Q369_R1.2390.99
125_K324_I1.2380.99
206_Y209_Q1.2300.99
117_D120_Y1.2270.99
14_E18_N1.2220.99
317_W353_A1.2150.99
325_T332_Q1.2110.99
440_A443_K1.2080.99
49_K53_Q1.2080.99
421_Y430_V1.2010.99
81_K85_E1.2000.99
132_V155_K1.1990.99
160_G364_A1.1940.99
80_L84_E1.1940.99
206_Y329_S1.1900.99
222_R225_V1.1900.99
126_F130_F1.1850.99
40_W44_L1.1820.99
88_K91_E1.1810.99
130_F337_P1.1750.99
19_N108_V1.1730.99
332_Q338_Y1.1640.99
340_I358_L1.1570.99
77_K80_L1.1550.99
257_I377_C1.1540.99
332_Q340_I1.1540.99
297_F415_T1.1470.99
75_E78_N1.1450.99
8_L16_L1.1440.99
323_L374_C1.1380.99
313_P389_Y1.1360.99
309_I322_E1.1350.99
374_C405_S1.1280.99
200_L278_I1.1280.99
43_V86_K1.1260.99
99_R103_S1.1230.98
111_D317_W1.1210.98
387_I400_V1.1190.98
323_L377_C1.1180.98
133_Y158_P1.1130.98
84_E87_E1.1120.98
125_K332_Q1.1120.98
206_Y210_Q1.1060.98
89_E92_E1.1060.98
60_Q64_L1.1030.98
17_K30_V1.0930.98
191_D441_F1.0920.98
71_K75_E1.0870.98
352_A377_C1.0810.98
265_E388_R1.0810.98
163_E166_E1.0760.98
63_K66_G1.0730.98
64_L72_K1.0730.98
10_R41_R1.0690.98
68_E71_K1.0600.98
324_I340_I1.0590.98
342_N348_L1.0580.98
202_F433_V1.0560.98
203_A330_I1.0550.98
36_L93_I1.0480.98
228_S385_M1.0430.98
270_K273_L1.0400.98
215_V257_I1.0380.97
423_R443_K1.0370.97
241_K248_Y1.0330.97
121_N344_A1.0260.97
91_E95_N1.0230.97
386_K399_Y1.0230.97
429_E443_K1.0230.97
33_A100_L1.0190.97
317_W321_S1.0170.97
430_V435_R1.0140.97
194_W205_D1.0140.97
109_A112_V1.0130.97
32_K100_L1.0120.97
362_M369_R1.0110.97
78_N81_K1.0110.97
382_A402_T1.0070.97
309_I326_N1.0060.97
159_K163_E1.0000.97
45_Q49_K0.9960.97
427_V443_K0.9950.97
84_E88_K0.9940.97
7_E11_K0.9930.97
9_L12_N0.9930.97
333_Q433_V0.9930.97
93_I97_R0.9920.97
417_I421_Y0.9880.97
389_Y398_G0.9860.97
321_S324_I0.9830.97
226_I239_I0.9820.96
241_K246_D0.9800.96
362_M415_T0.9780.96
71_K74_E0.9760.96
15_D18_N0.9710.96
324_I358_L0.9700.96
265_E397_R0.9700.96
47_V83_L0.9690.96
4_S9_L0.9680.96
391_D395_N0.9670.96
232_L239_I0.9650.96
177_A181_A0.9460.96
258_A308_F0.9460.96
263_K386_K0.9450.96
19_N107_L0.9410.96
57_L60_Q0.9400.95
15_D19_N0.9380.95
58_S76_S0.9370.95
216_L303_H0.9370.95
35_E38_K0.9330.95
33_A104_L0.9270.95
318_K322_E0.9260.95
133_Y155_K0.9260.95
39_K96_E0.9220.95
9_L33_A0.9200.95
234_T238_A0.9190.95
219_Y280_P0.9170.95
117_D346_G0.9170.95
268_K391_D0.9140.95
50_L82_I0.9120.95
39_K93_I0.9110.95
430_V438_L0.9050.94
59_S62_S0.9030.94
65_S69_R0.9020.94
156_W424_E0.8980.94
274_K326_N0.8970.94
268_K271_L0.8930.94
210_Q326_N0.8920.94
438_L441_F0.8910.94
54_H80_L0.8910.94
207_I407_A0.8830.94
204_I208_T0.8800.94
48_E51_R0.8750.93
223_G227_Q0.8740.93
87_E91_E0.8710.93
4_S16_L0.8700.93
325_T328_E0.8680.93
123_P339_R0.8640.93
112_V342_N0.8640.93
128_G131_K0.8630.93
96_E99_R0.8610.93
4_S8_L0.8600.93
328_E338_Y0.8580.93
181_A222_R0.8560.93
13_P30_V0.8560.93
47_V87_E0.8540.93
191_D440_A0.8530.93
261_F273_L0.8490.92
312_T391_D0.8480.92
257_I275_F0.8460.92
335_E429_E0.8400.92
325_T329_S0.8400.92
43_V89_E0.8390.92
335_E433_V0.8360.92
205_D436_K0.8360.92
131_K429_E0.8290.91
212_Y309_I0.8280.91
242_I247_L0.8240.91
191_D438_L0.8170.91
200_L410_S0.8150.91
265_E390_V0.8130.91
100_L103_S0.8120.91
330_I408_I0.8100.90
23_R349_G0.8090.90
76_S79_L0.8050.90
376_N401_H0.8050.90
261_F266_I0.8010.90
209_Q329_S0.7990.90
98_D102_S0.7980.90
219_Y303_H0.7970.90
59_S63_K0.7930.90
58_S62_S0.7930.90
320_H356_F0.7920.89
24_A116_P0.7910.89
181_A225_V0.7900.89
194_W208_T0.7900.89
36_L96_E0.7860.89
280_P303_H0.7810.89
219_Y301_Q0.7770.89
196_D216_L0.7760.88
364_A415_T0.7730.88
124_I342_N0.7730.88
48_E90_L0.7730.88
76_S80_L0.7700.88
421_Y433_V0.7630.88
267_E390_V0.7620.88
225_V259_A0.7580.87
230_I351_C0.7550.87
297_F369_R0.7520.87
116_P344_A0.7510.87
47_V51_R0.7510.87
172_G186_Y0.7490.87
435_R441_F0.7460.86
240_Y284_K0.7440.86
62_S73_I0.7430.86
394_N398_G0.7390.86
122_V342_N0.7380.86
260_M275_F0.7370.86
165_L169_L0.7370.86
392_R395_N0.7360.86
33_A97_R0.7340.86
124_I356_F0.7340.86
212_Y326_N0.7330.86
73_I77_K0.7270.85
170_H190_N0.7270.85
160_G415_T0.7260.85
46_E86_K0.7230.85
364_A367_K0.7210.85
164_M422_Q0.7210.85
93_I96_E0.7200.84
28_S32_K0.7200.84
112_V348_L0.7190.84
188_L414_I0.7170.84
32_K36_L0.7170.84
131_K337_P0.7160.84
307_Q323_L0.7160.84
44_L94_E0.7160.84
43_V46_E0.7150.84
48_E52_H0.7150.84
47_V90_L0.7130.84
219_Y250_I0.7110.84
253_A256_P0.7110.84
171_L418_L0.7100.84
6_L101_L0.7100.84
194_W439_E0.7090.84
317_W376_N0.7080.83
176_K187_Y0.7050.83
182_G247_L0.7050.83
189_F215_V0.7040.83
198_S438_L0.7020.83
343_I352_A0.7020.83
207_I276_A0.6980.83
15_D110_D0.6980.83
430_V443_K0.6980.83
38_K41_R0.6980.83
57_L72_K0.6950.82
53_Q57_L0.6940.82
57_L75_E0.6940.82
231_D259_A0.6920.82
117_D121_N0.6900.82
265_E386_K0.6890.82
177_A187_Y0.6890.82
118_D341_V0.6890.82
171_L191_D0.6880.82
232_L236_K0.6840.81
324_I374_C0.6840.81
188_L303_H0.6830.81
253_A276_A0.6830.81
62_S77_K0.6820.81
184_R371_M0.6810.81
95_N98_D0.6800.81
96_E100_L0.6800.81
31_D35_E0.6770.81
258_A377_C0.6760.81
21_K27_V0.6750.80
241_K244_N0.6750.80
429_E442_P0.6750.80
181_A242_I0.6750.80
184_R292_D0.6700.80
266_I270_K0.6700.80
51_R83_L0.6700.80
74_E77_K0.6690.80
36_L97_R0.6690.80
171_L189_F0.6680.80
72_K75_E0.6650.79
261_F387_I0.6650.79
14_E17_K0.6640.79
202_F206_Y0.6640.79
9_L16_L0.6640.79
345_S348_L0.6640.79
90_L93_I0.6630.79
77_K81_K0.6600.79
169_L192_I0.6580.79
421_Y432_K0.6570.79
172_G188_L0.6540.78
60_Q72_K0.6530.78
207_I307_Q0.6510.78
65_S70_K0.6500.78
30_V33_A0.6500.78
64_L68_E0.6500.78
181_A221_L0.6500.78
158_P364_A0.6490.78
62_S69_R0.6480.78
313_P398_G0.6470.78
165_L418_L0.6460.78
190_N213_T0.6460.78
47_V86_K0.6440.77
39_K43_V0.6440.77
273_L276_A0.6430.77
81_K84_E0.6430.77
54_H83_L0.6420.77
221_L256_P0.6400.77
89_E93_I0.6350.76
239_I251_A0.6350.76
40_W97_R0.6340.76
155_K158_P0.6330.76
239_I255_H0.6320.76
40_W94_E0.6310.76
264_E270_K0.6290.76
215_V275_F0.6280.76
317_W320_H0.6270.75
204_I276_A0.6270.75
229_V308_F0.6260.75
21_K26_D0.6260.75
266_I400_V0.6260.75
348_L355_K0.6250.75
40_W93_I0.6250.75
310_F387_I0.6250.75
240_Y247_L0.6220.75
321_S354_K0.6210.75
314_E391_D0.6210.75
197_F214_L0.6200.75
162_A294_K0.6190.74
180_I225_V0.6170.74
60_Q68_E0.6170.74
236_K241_K0.6160.74
201_L278_I0.6160.74
212_Y307_Q0.6160.74
296_I415_T0.6160.74
229_V258_A0.6150.74
278_I303_H0.6140.74
308_F377_C0.6130.74
430_V441_F0.6130.74
130_F133_Y0.6120.74
82_I86_K0.6120.74
216_L280_P0.6080.73
17_K21_K0.6080.73
91_E94_E0.6080.73
86_K89_E0.6070.73
157_K163_E0.6070.73
216_L219_Y0.6040.73
180_I260_M0.6030.73
9_L34_V0.6020.72
191_D194_W0.6000.72
391_D396_R0.5990.72
124_I324_I0.5980.72
85_E88_K0.5960.72
220_M249_L0.5960.72
37_D101_L0.5960.72
174_T296_I0.5950.72
181_A220_M0.5950.72
59_S66_G0.5940.71
184_R369_R0.5920.71
164_M167_D0.5920.71
292_D369_R0.5910.71
417_I430_V0.5900.71
50_L83_L0.5900.71
133_Y157_K0.5900.71
327_A372_V0.5890.71
320_H324_I0.5860.70
242_I245_E0.5840.70
75_E82_I0.5830.70
429_E432_K0.5830.70
360_V416_A0.5830.70
127_W338_Y0.5820.70
259_A262_F0.5820.70
116_P119_S0.5790.70
371_M413_T0.5790.70
186_Y296_I0.5790.70
8_L13_P0.5780.69
323_L403_L0.5760.69
320_H374_C0.5760.69
115_G346_G0.5760.69
242_I284_K0.5750.69
299_V414_I0.5710.68
379_D401_H0.5710.68
69_R72_K0.5710.68
327_A358_L0.5710.68
351_C355_K0.5700.68
354_K376_N0.5690.68
368_F413_T0.5690.68
44_L47_V0.5680.68
288_A291_K0.5680.68
162_A174_T0.5670.68
64_L71_K0.5670.68
244_N284_K0.5660.68
22_R108_V0.5650.68
268_K395_N0.5640.68
221_L250_I0.5640.68
389_Y400_V0.5630.67
98_D227_Q0.5620.67
90_L94_E0.5620.67
179_E263_K0.5620.67
201_L205_D0.5610.67
330_I407_A0.5600.67
330_I333_Q0.5600.67
222_R247_L0.5600.67
109_A353_A0.5600.67
269_D392_R0.5590.67
273_L310_F0.5590.67
159_K164_M0.5590.67
322_E326_N0.5580.67
196_D410_S0.5580.67
284_K288_A0.5570.67
364_A369_R0.5560.66
351_C377_C0.5550.66
369_R411_T0.5550.66
391_D397_R0.5540.66
23_R108_V0.5540.66
8_L11_K0.5530.66
266_I273_L0.5520.66
436_K439_E0.5510.66
261_F264_E0.5510.66
54_H58_S0.5500.66
196_D411_T0.5490.65
239_I248_Y0.5490.65
208_T276_A0.5480.65
191_D208_T0.5470.65
46_E50_L0.5460.65
258_A402_T0.5460.65
31_D34_V0.5460.65
156_W422_Q0.5450.65
158_P422_Q0.5450.65
54_H79_L0.5440.65
165_L171_L0.5430.65
309_I323_L0.5420.64
56_V59_S0.5420.64
221_L226_I0.5410.64
16_L107_L0.5410.64
83_L87_E0.5400.64
5_I383_F0.5400.64
410_S413_T0.5380.64
372_V405_S0.5380.64
40_W90_L0.5380.64
129_K133_Y0.5370.64
188_L216_L0.5370.64
61_I76_S0.5340.63
17_K27_V0.5340.63
68_E73_I0.5340.63
45_Q48_E0.5330.63
178_A182_G0.5320.63
261_F400_V0.5320.63
236_K239_I0.5320.63
92_E95_N0.5310.63
242_I246_D0.5300.63
422_Q426_G0.5300.63
62_S65_S0.5290.63
253_A277_G0.5280.62
207_I210_Q0.5270.62
362_M367_K0.5270.62
362_M371_M0.5260.62
291_K341_V0.5260.62
173_N176_K0.5260.62
239_I279_S0.5250.62
337_P368_F0.5250.62
42_Q45_Q0.5250.62
13_P17_K0.5250.62
432_K442_P0.5240.62
342_N358_L0.5220.62
257_I276_A0.5220.62
9_L13_P0.5200.61
46_E89_E0.5200.61
97_R100_L0.5190.61
313_P400_V0.5190.61
203_A406_T0.5180.61
237_D284_K0.5180.61
23_R345_S0.5170.61
169_L428_V0.5170.61
111_D342_N0.5170.61
49_K52_H0.5160.61
229_V255_H0.5160.61
413_T417_I0.5150.61
66_G69_R0.5150.61
43_V47_V0.5150.61
251_A406_T0.5140.60
299_V415_T0.5130.60
109_A376_N0.5130.60
187_Y217_P0.5110.60
430_V440_A0.5110.60
27_V30_V0.5100.60
236_K243_E0.5090.60
57_L69_R0.5070.59
121_N346_G0.5070.59
196_D278_I0.5060.59
394_N397_R0.5050.59
204_I214_L0.5050.59
389_Y392_R0.5040.59
438_L442_P0.5040.59
417_I433_V0.5030.59
324_I356_F0.5030.59
289_A293_L0.5020.59
207_I330_I0.5010.58
126_F368_F0.5000.58
217_P277_G0.5000.58
379_D383_F0.5000.58
184_R291_K0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sesA 2 0.9168 100 0.274 Contact Map
2dq0A 2 0.9584 100 0.275 Contact Map
1wleA 2 0.9387 100 0.286 Contact Map
3lssA 2 0.9278 100 0.288 Contact Map
2dq3A 2 0.9212 100 0.29 Contact Map
3vbbA 2 0.9278 100 0.3 Contact Map
3qneA 2 0.9409 100 0.315 Contact Map
3errA 2 0.9103 100 0.397 Contact Map
2cjaA 2 0.8643 100 0.559 Contact Map
3w3sA 2 0.8534 100 0.619 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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