GREMLIN Database
HIS5 - Imidazole glycerol phosphate synthase subunit HisH
UniProt: O33777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (191)
Sequences: 3847 (2495)
Seq/√Len: 180.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_L30_D3.2761.00
84_E96_G3.2731.00
85_K101_I2.9481.00
157_S165_A2.8531.00
28_T35_N2.8421.00
56_L59_R2.7351.00
126_C168_C2.6741.00
191_E195_G2.5891.00
103_D146_Y2.5561.00
4_L37_Y2.3911.00
32_K35_N2.3331.00
20_L41_V2.2901.00
105_I163_Y2.1541.00
83_F145_A2.0071.00
48_F94_G1.9731.00
84_E99_K1.9671.00
53_E57_R1.9051.00
129_T166_L1.8911.00
139_Y165_A1.8781.00
18_S21_K1.8561.00
119_V137_V1.8161.00
51_V77_L1.8001.00
17_S21_K1.7821.00
83_F167_V1.7311.00
155_M166_L1.6951.00
131_G192_N1.6711.00
54_F57_R1.6711.00
40_I65_L1.6691.00
85_K91_E1.6571.00
158_Q162_E1.6571.00
87_T103_D1.6551.00
188_I191_E1.6481.00
154_Y168_C1.6431.00
135_K185_T1.5951.00
5_V17_S1.5871.00
102_V145_A1.5821.00
153_V164_P1.5791.00
25_F194_K1.5771.00
65_L70_T1.5761.00
137_V185_T1.5731.00
65_L68_S1.5711.00
128_L173_V1.5651.00
156_K162_E1.5571.00
66_R97_W1.5391.00
152_Y169_D1.4931.00
132_L135_K1.4871.00
20_L25_F1.4761.00
144_V161_I1.4751.00
3_A194_K1.4701.00
166_L175_T1.4701.00
109_V160_G1.4601.00
87_T101_I1.4411.00
13_L29_I1.4201.00
82_M172_V1.4131.00
105_I144_V1.3991.00
30_D35_N1.3871.00
17_S29_I1.3841.00
137_V189_F1.3751.00
99_K152_Y1.3641.00
147_P153_V1.3551.00
17_S27_V1.3271.00
84_E100_G1.3161.00
85_K93_N1.3141.00
49_S90_K1.3111.00
113_H163_Y1.3101.00
5_V20_L1.3091.00
103_D144_V1.3071.00
75_V190_L1.2771.00
22_R187_K1.2721.00
30_D37_Y1.2711.00
118_L134_K1.2701.00
98_F152_Y1.2591.00
49_S89_G1.2561.00
87_T91_E1.2561.00
175_T189_F1.2521.00
64_D68_S1.2511.00
119_V155_M1.2481.00
85_K90_K1.2481.00
59_R63_N1.2431.00
127_E168_C1.2381.00
130_Y195_G1.2191.00
58_Y62_F1.2161.00
61_L65_L1.2151.00
49_S92_S1.2001.00
188_I192_N1.1991.00
58_Y61_L1.1881.00
4_L40_I1.1801.00
79_M174_G1.1761.00
21_K26_E1.1671.00
63_N97_W1.1641.00
122_V156_K1.1451.00
82_M97_W1.1311.00
158_Q161_I1.1161.00
131_G188_I1.1111.00
83_F102_V1.0851.00
149_S152_Y1.0801.00
66_R72_F1.0761.00
21_K27_V1.0711.00
24_G27_V1.0631.00
114_I140_V1.0571.00
8_Y11_G1.0451.00
83_F98_F1.0150.99
79_M145_A1.0110.99
84_E101_I1.0080.99
20_L27_V1.0030.99
144_V164_P0.9940.99
14_Y18_S0.9930.99
128_L192_N0.9870.99
83_F100_G0.9860.99
45_V77_L0.9710.99
118_L136_Y0.9660.99
120_F134_K0.9640.99
42_F72_F0.9640.99
119_V165_A0.9610.99
126_C173_V0.9570.99
126_C154_Y0.9560.99
154_Y166_L0.9530.99
101_I146_Y0.9440.99
89_G92_S0.9360.99
73_L175_T0.9330.99
121_E133_D0.9230.99
87_T104_K0.9030.99
132_L192_N0.9010.99
157_S163_Y0.9000.99
168_C173_V0.8960.99
60_E63_N0.8940.99
139_Y157_S0.8810.98
72_F97_W0.8700.98
120_F158_Q0.8600.98
47_A89_G0.8580.98
113_H141_H0.8530.98
5_V27_V0.8430.98
63_N67_R0.8370.98
9_G54_F0.8350.98
39_L193_L0.8130.97
20_L194_K0.8090.97
69_G170_K0.8060.97
48_F81_I0.8040.97
6_I42_F0.8020.97
52_A56_L0.7980.97
59_R62_F0.7970.97
55_I59_R0.7950.97
109_V159_Y0.7940.97
23_V194_K0.7910.97
14_Y17_S0.7900.97
105_I111_L0.7890.97
52_A92_S0.7890.97
93_N96_G0.7810.97
51_V81_I0.7790.97
62_F97_W0.7760.97
20_L190_L0.7680.96
84_E98_F0.7630.96
3_A39_L0.7620.96
98_F167_V0.7560.96
3_A25_F0.7500.96
72_F82_M0.7480.96
7_N31_N0.7440.96
113_H157_S0.7430.96
48_F92_S0.7420.96
106_N161_I0.7370.95
60_E64_D0.7340.95
155_M165_A0.7320.95
113_H117_D0.7300.95
120_F156_K0.7280.95
33_P61_L0.7260.95
119_V189_F0.7240.95
56_L93_N0.7230.95
19_A23_V0.7230.95
33_P60_E0.7190.95
147_P164_P0.7160.95
97_W172_V0.7130.95
45_V79_M0.7080.94
27_V41_V0.7020.94
4_L28_T0.7000.94
66_R69_G0.6910.94
40_I62_F0.6890.93
72_F172_V0.6860.93
10_V14_Y0.6800.93
39_L71_N0.6730.93
52_A59_R0.6720.93
4_L35_N0.6710.93
47_A90_K0.6700.92
62_F65_L0.6700.92
130_Y188_I0.6630.92
125_S130_Y0.6630.92
61_L66_R0.6610.92
64_D67_R0.6610.92
6_I40_I0.6600.92
55_I58_Y0.6600.92
49_S53_E0.6570.92
40_I68_S0.6570.92
8_Y51_V0.6480.91
123_K151_D0.6470.91
23_V187_K0.6460.91
100_G145_A0.6460.91
16_I75_V0.6450.91
114_I136_Y0.6440.91
167_V174_G0.6420.91
47_A92_S0.6360.90
108_N160_G0.6330.90
146_Y161_I0.6330.90
119_V135_K0.6320.90
5_V29_I0.6270.90
121_E155_M0.6260.90
6_I62_F0.6260.90
135_K188_I0.6250.90
99_K169_D0.6250.90
120_F162_E0.6160.89
20_L23_V0.6140.89
120_F133_D0.6100.89
147_P152_Y0.6090.88
122_V162_E0.6060.88
30_D58_Y0.6050.88
146_Y150_G0.6050.88
40_I61_L0.6050.88
53_E56_L0.6010.88
16_I77_L0.5990.88
125_S154_Y0.5970.87
10_V13_L0.5930.87
39_L183_S0.5920.87
104_K143_Y0.5920.87
99_K149_S0.5890.87
69_G171_N0.5880.87
77_L81_I0.5870.87
122_V125_S0.5860.86
16_I19_A0.5850.86
18_S187_K0.5820.86
98_F172_V0.5770.86
55_I62_F0.5680.85
121_E135_K0.5670.85
14_Y163_Y0.5650.84
136_Y185_T0.5630.84
27_V77_L0.5630.84
73_L193_L0.5590.84
40_I70_T0.5580.84
47_A50_A0.5570.84
86_G105_I0.5570.84
56_L92_S0.5550.83
23_V190_L0.5530.83
128_L189_F0.5510.83
51_V54_F0.5490.83
154_Y173_V0.5480.83
117_D159_Y0.5470.83
129_T155_M0.5460.82
16_I41_V0.5450.82
50_A110_K0.5420.82
173_V193_L0.5400.82
10_V51_V0.5400.82
9_G50_A0.5390.82
89_G143_Y0.5370.81
137_V177_F0.5360.81
13_L110_K0.5360.81
127_E130_Y0.5330.81
123_K126_C0.5330.81
15_S18_S0.5320.81
153_V156_K0.5310.81
154_Y174_G0.5300.81
114_I139_Y0.5280.80
42_F45_V0.5260.80
150_G164_P0.5250.80
27_V194_K0.5250.80
145_A167_V0.5250.80
9_G102_V0.5210.79
31_N54_F0.5210.79
132_L137_V0.5200.79
69_G172_V0.5190.79
48_F86_G0.5180.79
52_A87_T0.5180.79
9_G160_G0.5150.79
19_A187_K0.5140.79
32_K37_Y0.5120.78
30_D61_L0.5090.78
48_F83_F0.5090.78
119_V163_Y0.5090.78
14_Y21_K0.5090.78
50_A54_F0.5080.78
58_Y66_R0.5060.77
121_E125_S0.5060.77
86_G92_S0.5060.77
10_V50_A0.5040.77
39_L173_V0.5040.77
5_V13_L0.5030.77
96_G99_K0.5020.77
139_Y163_Y0.5020.77
42_F81_I0.5000.77
100_G147_P0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jvnA 1 0.9799 100 0.438 Contact Map
4gudA 1 0.9598 100 0.489 Contact Map
1ka9H 1 0.9497 100 0.505 Contact Map
1gpwB 1 0.9497 100 0.516 Contact Map
3uowA 2 0.9447 100 0.532 Contact Map
2v4uA 1 0.9497 100 0.561 Contact Map
2w7tA 1 0.9447 100 0.578 Contact Map
3d54D 1 0.9296 100 0.58 Contact Map
2ywdA 1 0.9196 100 0.581 Contact Map
2issD 1 0.8844 100 0.582 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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