GREMLIN Database
HISX - Histidinol dehydrogenase
UniProt: O33775 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (389)
Sequences: 3747 (2064)
Seq/√Len: 104.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_S31_K4.0691.00
41_E47_K4.0411.00
31_K38_E3.5141.00
52_K168_E3.2611.00
119_K249_P3.1611.00
110_K140_E3.1351.00
25_I179_A3.1141.00
144_A181_L3.0261.00
235_E269_K2.9171.00
306_D309_T2.8051.00
80_L127_L2.7741.00
227_I292_A2.7731.00
81_K85_E2.7131.00
113_I130_G2.6901.00
308_Y365_N2.5421.00
286_D313_K2.5001.00
64_K155_P2.4921.00
75_T376_A2.4821.00
140_E168_E2.4801.00
260_D264_R2.4601.00
27_S39_L2.4341.00
283_K287_E2.3861.00
109_E315_V2.3111.00
269_K272_N2.3061.00
382_N394_G2.2971.00
62_A162_I2.2781.00
282_T288_A2.1941.00
134_K167_N2.1901.00
74_D163_K2.1591.00
58_L169_V2.1001.00
263_I279_I2.0791.00
33_D185_T2.0491.00
38_E42_K2.0491.00
263_I281_K2.0481.00
374_L397_Y2.0471.00
77_Y81_K2.0461.00
204_A208_L2.0311.00
382_N387_I2.0241.00
230_E259_D2.0091.00
248_G251_T1.9801.00
225_V292_A1.9781.00
378_I394_G1.9771.00
77_Y131_I1.9561.00
130_G166_V1.9521.00
192_Y347_K1.9451.00
139_K315_V1.9291.00
27_S38_E1.9251.00
31_K34_N1.9241.00
23_D27_S1.9111.00
20_V201_Y1.9041.00
289_I314_I1.8971.00
59_K63_S1.8831.00
26_E30_T1.8741.00
227_I288_A1.8631.00
267_E279_I1.8541.00
59_K162_I1.8471.00
224_L243_A1.8001.00
391_K394_G1.7921.00
109_E316_N1.7691.00
261_E265_R1.7681.00
257_S263_I1.7501.00
328_A392_S1.7231.00
81_K134_K1.7141.00
231_T305_K1.7111.00
109_E139_K1.7031.00
70_K74_D1.6841.00
22_K208_L1.6591.00
289_I310_L1.6561.00
183_F212_V1.6521.00
329_I377_S1.6321.00
52_K170_Y1.6321.00
108_I193_K1.6281.00
230_E258_N1.6241.00
54_R57_E1.6201.00
57_E171_K1.6151.00
239_L273_D1.6031.00
37_Y51_I1.5871.00
143_V161_A1.5851.00
284_N287_E1.5691.00
55_E59_K1.5691.00
302_L314_I1.5611.00
307_A322_L1.5301.00
258_N282_T1.5061.00
70_K159_Y1.5051.00
106_R361_T1.5041.00
203_Q218_I1.4911.00
33_D187_S1.4751.00
69_V383_Y1.4731.00
269_K273_D1.4591.00
60_T64_K1.4441.00
93_G100_S1.4291.00
255_L266_V1.4261.00
378_I382_N1.4261.00
172_I188_V1.4061.00
62_A159_Y1.3981.00
112_G181_L1.3941.00
77_Y127_L1.3711.00
127_L131_I1.3691.00
304_V310_L1.3681.00
170_Y189_K1.3681.00
89_P355_Y1.3581.00
148_T152_T1.3520.99
145_S153_V1.3450.99
334_A364_A1.3430.99
67_P71_Q1.3350.99
235_E272_N1.3300.99
72_A380_L1.3280.99
18_I22_K1.3100.99
144_A177_A1.3050.99
355_Y360_P1.3050.99
111_I193_K1.2990.99
378_I390_G1.2990.99
320_I361_T1.2990.99
265_R268_E1.2960.99
382_N390_G1.2940.99
230_E305_K1.2920.99
126_L143_V1.2890.99
303_Y324_N1.2870.99
72_A379_S1.2860.99
142_Y181_L1.2700.99
142_Y168_E1.2690.99
61_Q158_A1.2690.99
160_V164_L1.2650.99
183_F209_V1.2590.99
73_I163_K1.2510.99
159_Y162_I1.2430.99
262_L266_V1.2410.99
182_A209_V1.2340.99
18_I208_L1.2320.99
316_N359_K1.2260.99
225_V256_L1.2220.99
56_E60_T1.2220.99
55_E162_I1.2160.99
233_K236_Y1.2140.99
69_V156_A1.2140.99
77_Y163_K1.2120.99
25_I212_V1.2110.99
28_V179_A1.2050.99
53_A158_A1.1920.99
125_T129_A1.1910.99
231_T324_N1.1900.99
65_L70_K1.1860.99
390_G394_G1.1850.99
89_P358_I1.1820.99
200_V204_A1.1740.99
193_K356_D1.1720.99
55_E167_N1.1710.99
368_D371_K1.1700.99
144_A172_I1.1540.98
273_D391_K1.1460.98
292_A297_P1.1460.98
141_I167_N1.1430.98
60_T152_T1.1390.98
227_I256_L1.1360.98
370_N393_I1.1320.98
320_I363_Y1.1220.98
256_L291_I1.1140.98
22_K26_E1.1110.98
227_I302_L1.1100.98
34_N186_E1.1030.98
232_A237_V1.0990.98
237_V266_V1.0970.98
100_S365_N1.0970.98
36_L172_I1.0930.98
129_A339_I1.0920.98
25_I209_V1.0920.98
17_V204_A1.0900.98
209_V213_V1.0830.98
256_L282_T1.0810.97
106_R359_K1.0750.97
296_A346_A1.0720.97
235_E395_A1.0710.97
228_A262_L1.0670.97
113_I141_I1.0640.97
24_I175_A1.0540.97
39_L43_L1.0530.97
94_G97_Q1.0510.97
333_V376_A1.0480.97
19_P23_D1.0480.97
304_V307_A1.0450.97
234_A265_R1.0430.97
333_V377_S1.0380.97
53_A171_K1.0370.97
29_K212_V1.0350.97
345_W348_I1.0340.97
257_S279_I1.0330.97
40_T176_Q1.0270.97
73_I380_L1.0170.96
134_K164_L1.0170.96
89_P105_W1.0150.96
243_A328_A1.0100.96
108_I111_I1.0100.96
62_A70_K1.0090.96
257_S281_K1.0020.96
125_T339_I0.9970.96
268_E272_N0.9890.96
224_L301_S0.9860.96
85_E135_V0.9860.96
129_A195_V0.9820.96
51_I172_I0.9800.96
25_I183_F0.9790.95
233_K324_N0.9760.95
260_D281_K0.9750.95
353_T360_P0.9750.95
227_I289_I0.9750.95
282_T291_I0.9720.95
226_I241_M0.9650.95
92_I103_V0.9600.95
326_P392_S0.9580.95
256_L292_A0.9530.95
311_M322_L0.9500.95
339_I352_I0.9440.95
130_G164_L0.9420.94
53_A61_Q0.9410.94
285_L310_L0.9410.94
370_N374_L0.9410.94
21_V204_A0.9400.94
242_K388_I0.9390.94
78_E81_K0.9350.94
108_I214_G0.9350.94
73_I160_V0.9310.94
228_A232_A0.9280.94
267_E271_K0.9280.94
302_L322_L0.9280.94
366_V373_L0.9270.94
237_V262_L0.9270.94
329_I366_V0.9260.94
377_S393_I0.9210.94
28_V175_A0.9170.94
88_V358_I0.9140.94
24_I28_V0.9140.94
59_K62_A0.9120.93
66_D69_V0.9120.93
18_I204_A0.9060.93
391_K395_A0.9060.93
20_V23_D0.9050.93
71_Q74_D0.9040.93
115_V143_V0.8980.93
227_I285_L0.8950.93
258_N288_A0.8950.93
241_M255_L0.8930.93
34_N38_E0.8920.93
25_I29_K0.8910.93
27_S42_K0.8870.92
236_Y324_N0.8870.92
74_D159_Y0.8780.92
69_V379_S0.8770.92
329_I373_L0.8750.92
285_L288_A0.8750.92
273_D395_A0.8730.92
239_L395_A0.8730.92
204_A207_Y0.8730.92
58_L62_A0.8720.92
311_M363_Y0.8710.92
82_A86_M0.8690.92
68_K379_S0.8660.92
58_L162_I0.8650.92
40_T48_I0.8600.91
45_K150_E0.8590.91
180_A188_V0.8570.91
57_E152_T0.8560.91
31_K42_K0.8510.91
95_G99_I0.8510.91
29_K183_F0.8480.91
234_A266_V0.8400.90
319_A362_M0.8380.90
81_K131_I0.8370.90
351_G362_M0.8370.90
36_L175_A0.8360.90
287_E290_E0.8360.90
83_F336_P0.8360.90
109_E192_Y0.8330.90
84_H87_L0.8330.90
78_E82_A0.8320.90
371_K397_Y0.8310.90
258_N285_L0.8300.90
36_L180_A0.8280.90
113_I129_A0.8250.89
15_S19_P0.8240.89
72_A376_A0.8240.89
126_L160_V0.8240.89
319_A364_A0.8230.89
257_S262_L0.8210.89
168_E189_K0.8150.89
192_Y316_N0.8140.89
87_L337_N0.8130.89
319_A363_Y0.8120.89
24_I39_L0.8100.89
289_I313_K0.8090.89
314_I320_I0.8090.89
387_I391_K0.8070.88
142_Y189_K0.8050.88
36_L185_T0.8030.88
15_S22_K0.8010.88
129_A352_I0.8010.88
311_M320_I0.8000.88
76_A80_L0.8000.88
241_M270_I0.7990.88
41_E46_V0.7970.88
290_E293_N0.7930.88
293_N313_K0.7930.88
31_K35_A0.7900.87
92_I102_G0.7900.87
37_Y41_E0.7890.87
190_K212_V0.7880.87
46_V147_P0.7870.87
355_Y358_I0.7860.87
54_R171_K0.7810.87
235_E273_D0.7780.87
140_E170_Y0.7770.86
225_V295_I0.7770.86
194_I209_V0.7730.86
256_L288_A0.7730.86
123_P380_L0.7720.86
159_Y163_K0.7720.86
88_V135_V0.7710.86
381_A390_G0.7690.86
17_V200_V0.7690.86
82_A85_E0.7690.86
226_I237_V0.7680.86
190_K344_G0.7680.86
113_I195_V0.7670.86
232_A262_L0.7660.86
76_A333_V0.7650.86
120_Y386_F0.7640.86
23_D26_E0.7620.85
147_P153_V0.7610.85
214_G348_I0.7610.85
224_L253_I0.7610.85
103_V353_T0.7560.85
243_A392_S0.7520.85
142_Y170_Y0.7520.85
200_V250_D0.7500.85
25_I208_L0.7490.84
85_E88_V0.7490.84
350_G360_P0.7470.84
23_D42_K0.7450.84
39_L176_Q0.7450.84
185_T188_V0.7440.84
170_Y188_V0.7440.84
336_P364_A0.7440.84
16_R19_P0.7440.84
180_A185_T0.7430.84
353_T358_I0.7420.84
79_Q333_V0.7400.84
305_K324_N0.7400.84
352_I356_D0.7390.84
264_R267_E0.7390.84
31_K39_L0.7360.83
326_P370_N0.7360.83
37_Y50_N0.7320.83
207_Y211_S0.7310.83
329_I370_N0.7300.83
333_V373_L0.7290.83
97_Q372_Q0.7290.83
289_I304_V0.7290.83
325_T366_V0.7280.83
127_L160_V0.7270.83
121_S385_G0.7260.83
91_N105_W0.7260.83
379_S383_Y0.7260.83
20_V42_K0.7260.83
134_K166_V0.7250.82
52_K140_E0.7250.82
194_I213_V0.7240.82
268_E271_K0.7240.82
88_V91_N0.7240.82
62_A163_K0.7210.82
382_N391_K0.7210.82
105_W358_I0.7160.82
126_L166_V0.7150.82
230_E261_E0.7130.81
68_K375_E0.7130.81
209_V212_V0.7120.81
214_G349_R0.7120.81
319_A334_A0.7110.81
33_D186_E0.7110.81
140_E189_K0.7100.81
374_L378_I0.7090.81
129_A337_N0.7080.81
36_L40_T0.7080.81
264_R268_E0.7060.81
37_Y48_I0.7050.81
34_N37_Y0.7020.80
375_E379_S0.7000.80
236_Y303_Y0.7000.80
309_T312_D0.6990.80
93_G308_Y0.6960.80
321_S330_I0.6950.80
106_R315_V0.6940.80
78_E85_E0.6940.80
285_L289_I0.6930.80
232_A324_N0.6910.79
77_Y164_L0.6910.79
75_T333_V0.6870.79
370_N377_S0.6830.79
16_R20_V0.6810.78
366_V369_I0.6800.78
162_I169_V0.6770.78
41_E48_I0.6770.78
52_K55_E0.6770.78
74_D78_E0.6750.78
179_A209_V0.6720.77
36_L39_L0.6720.77
234_A262_L0.6690.77
75_T78_E0.6670.77
20_V39_L0.6660.77
112_G144_A0.6660.77
262_L265_R0.6660.77
27_S30_T0.6650.77
65_L159_Y0.6650.77
243_A388_I0.6640.77
253_I277_Y0.6620.76
40_T45_K0.6620.76
37_Y47_K0.6590.76
297_P300_L0.6580.76
317_A320_I0.6570.76
113_I166_V0.6550.76
37_Y49_D0.6540.76
172_I180_A0.6530.75
307_A311_M0.6520.75
285_L292_A0.6520.75
170_Y187_S0.6520.75
62_A158_A0.6510.75
19_P22_K0.6510.75
121_S154_N0.6450.75
35_A39_L0.6450.75
60_T63_S0.6440.74
104_I312_D0.6440.74
62_A74_D0.6430.74
293_N315_V0.6390.74
77_Y80_L0.6380.74
288_A292_A0.6380.74
110_K192_Y0.6370.74
156_A383_Y0.6360.73
73_I156_A0.6360.73
387_I394_G0.6320.73
232_A303_Y0.6290.73
93_G363_Y0.6290.73
108_I138_V0.6270.72
71_Q75_T0.6260.72
285_L304_V0.6260.72
17_V21_V0.6250.72
126_L164_L0.6220.72
79_Q377_S0.6160.71
325_T364_A0.6140.71
227_I304_V0.6120.71
293_N311_M0.6120.71
57_E60_T0.6110.70
13_D16_R0.6080.70
258_N284_N0.6070.70
218_I349_R0.6050.70
52_K142_Y0.6050.70
87_L103_V0.6030.70
36_L51_I0.6030.70
129_A143_V0.6020.69
236_Y395_A0.6020.69
219_E337_N0.6010.69
261_E264_R0.6010.69
73_I159_Y0.6000.69
191_V213_V0.5990.69
193_K214_G0.5990.69
119_K217_G0.5980.69
53_A147_P0.5970.69
245_A253_I0.5950.68
292_A314_I0.5940.68
307_A365_N0.5930.68
83_F362_M0.5920.68
237_V303_Y0.5920.68
286_D290_E0.5920.68
24_I43_L0.5860.67
64_K152_T0.5850.67
113_I143_V0.5850.67
53_A169_V0.5840.67
55_E58_L0.5840.67
267_E270_I0.5830.67
93_G102_G0.5810.67
331_D338_H0.5810.67
20_V28_V0.5810.67
81_K135_V0.5800.67
225_V291_I0.5760.66
195_V339_I0.5740.66
244_Q331_D0.5730.66
321_S327_P0.5730.66
110_K142_Y0.5730.66
269_K393_I0.5690.65
110_K191_V0.5680.65
28_V46_V0.5670.65
289_I320_I0.5650.65
58_L159_Y0.5650.65
290_E294_K0.5630.64
117_S120_Y0.5610.64
86_M92_I0.5610.64
242_K273_D0.5600.64
106_R363_Y0.5600.64
301_S337_N0.5590.64
263_I267_E0.5590.64
92_I104_I0.5590.64
104_I363_Y0.5580.64
143_V166_V0.5560.63
211_S348_I0.5560.63
122_Y386_F0.5560.63
36_L188_V0.5530.63
241_M253_I0.5510.63
53_A57_E0.5510.63
37_Y187_S0.5510.63
207_Y210_S0.5510.63
13_D17_V0.5500.62
33_D180_A0.5490.62
71_Q376_A0.5490.62
314_I361_T0.5490.62
56_E59_K0.5480.62
100_S367_R0.5470.62
252_Y295_I0.5450.62
25_I182_A0.5450.62
158_A169_V0.5440.62
91_N104_I0.5430.61
148_T151_G0.5430.61
58_L70_K0.5430.61
370_N397_Y0.5420.61
104_I361_T0.5410.61
61_Q159_Y0.5410.61
326_P374_L0.5400.61
25_I36_L0.5380.61
160_V380_L0.5380.61
109_E293_N0.5370.61
319_A336_P0.5350.60
68_K72_A0.5340.60
101_F319_A0.5340.60
140_E167_N0.5340.60
108_I356_D0.5330.60
147_P172_I0.5330.60
79_Q95_G0.5330.60
105_W360_P0.5320.60
76_A380_L0.5320.60
229_D232_A0.5320.60
294_K347_K0.5300.60
250_D276_I0.5300.60
231_T237_V0.5300.60
219_E321_S0.5300.60
65_L163_K0.5290.59
84_H135_V0.5290.59
103_V360_P0.5280.59
370_N395_A0.5260.59
195_V352_I0.5260.59
65_L69_V0.5240.59
21_V208_L0.5240.59
68_K71_Q0.5230.59
210_S349_R0.5230.59
70_K163_K0.5220.58
207_Y348_I0.5180.58
265_R269_K0.5170.58
203_Q219_E0.5170.58
158_A357_F0.5170.58
30_T268_E0.5170.58
217_G319_A0.5160.58
79_Q96_Y0.5160.58
144_A147_P0.5160.58
301_S327_P0.5160.58
71_Q78_E0.5140.57
122_Y203_Q0.5130.57
45_K176_Q0.5130.57
144_A170_Y0.5130.57
117_S146_P0.5130.57
328_A393_I0.5120.57
369_I373_L0.5120.57
327_P386_F0.5110.57
237_V255_L0.5110.57
280_I291_I0.5090.57
221_P250_D0.5080.56
66_D379_S0.5080.56
70_K162_I0.5080.56
121_S157_L0.5070.56
76_A127_L0.5060.56
84_H317_A0.5060.56
102_G308_Y0.5050.56
84_H337_N0.5040.56
92_I363_Y0.5030.56
111_I195_V0.5020.56
15_S18_I0.5010.55
337_N352_I0.5010.55
373_L377_S0.5010.55
218_I345_W0.5000.55
294_K344_G0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g09A 2 0.9849 100 0.023 Contact Map
1kaeA 2 0.9899 100 0.042 Contact Map
4gicA 2 0.8744 100 0.059 Contact Map
3my7A 2 0.7915 97.6 0.95 Contact Map
1o20A 3 0.8342 97.3 0.952 Contact Map
4itaA 2 0.8166 97.2 0.953 Contact Map
4jbeA 2 0.8317 97.2 0.953 Contact Map
4ghkA 3 0.7915 97.2 0.953 Contact Map
3lnsA 2 0.8166 96.7 0.956 Contact Map
3k9dA 2 0.8342 96.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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