GREMLIN Database
HIS6 - Imidazole glycerol phosphate synthase subunit HisF
UniProt: O33774 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (232)
Sequences: 6003 (3053)
Seq/√Len: 200.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_V116_S3.2641.00
143_K147_Y2.5801.00
114_K163_L2.5291.00
21_V178_T2.4771.00
161_E196_I2.4091.00
129_I157_A2.3791.00
85_T88_D2.3441.00
109_S115_K2.3421.00
37_S72_V2.3351.00
127_V160_V2.3021.00
139_I148_N2.2771.00
159_K163_L2.2721.00
37_S41_E2.1761.00
108_E143_K2.1751.00
234_K237_D2.1571.00
90_S94_R2.0961.00
139_I152_D2.0821.00
208_E211_Y2.0611.00
38_L42_E2.0321.00
116_S125_V1.9661.00
179_R232_I1.9621.00
208_E212_E1.9511.00
56_I146_T1.9101.00
40_E74_S1.8581.00
83_I92_A1.8561.00
139_I150_R1.8551.00
16_N28_L1.8281.00
89_V125_V1.8141.00
188_R192_D1.7981.00
63_Y91_M1.7681.00
107_V142_T1.7481.00
170_L186_L1.7341.00
152_D155_K1.7301.00
90_S119_E1.7251.00
161_E195_N1.7111.00
22_N178_T1.6961.00
31_D34_S1.6761.00
86_P116_S1.6631.00
211_Y241_Y1.6331.00
184_L212_E1.5971.00
47_I75_I1.5741.00
42_E236_K1.5631.00
224_A228_F1.5581.00
62_L65_V1.5541.00
31_D68_D1.5471.00
207_M233_I1.5421.00
151_L159_K1.5281.00
206_K209_H1.4991.00
204_A213_V1.4961.00
224_A227_I1.4901.00
158_K193_S1.4811.00
227_I233_I1.4701.00
14_D53_T1.4691.00
102_I105_A1.4651.00
99_K126_V1.4601.00
128_A169_L1.4601.00
111_Q115_K1.4491.00
64_N67_K1.4301.00
159_K162_E1.4021.00
7_I46_E1.3991.00
105_A112_I1.3931.00
141_F148_N1.3811.00
68_D71_S1.3781.00
138_W189_K1.3641.00
70_A77_L1.3611.00
86_P119_E1.3601.00
211_Y215_S1.3511.00
191_V198_V1.3411.00
87_D90_S1.3381.00
8_A44_A1.3381.00
207_M241_Y1.3341.00
192_D218_K1.3231.00
46_E99_K1.3141.00
233_I238_L1.3071.00
172_S183_D1.2921.00
49_F69_T1.2651.00
209_H212_E1.2631.00
114_K118_E1.2621.00
210_F227_I1.2531.00
29_K35_L1.2501.00
106_A127_V1.2231.00
67_K71_S1.2091.00
210_F224_A1.2001.00
128_A171_T1.1981.00
86_P115_K1.1981.00
13_K25_N1.1961.00
89_V100_V1.1951.00
214_F222_A1.1821.00
38_L41_E1.1801.00
42_E234_K1.1761.00
170_L190_I1.1751.00
66_I79_V1.1691.00
131_V170_L1.1561.00
104_T108_E1.1531.00
107_V151_L1.1471.00
154_I193_S1.1451.00
236_K240_S1.1381.00
21_V24_L1.1331.00
157_A190_I1.1321.00
67_K95_S1.1311.00
5_R46_E1.1241.00
182_Y204_A1.1211.00
166_G197_P1.1151.00
142_T147_Y1.1151.00
117_A122_S1.1101.00
16_N30_G1.0991.00
126_V169_L1.0881.00
133_K138_W1.0881.00
168_I196_I1.0871.00
169_L223_L1.0761.00
127_V165_A1.0671.00
158_K162_E1.0661.00
213_V222_A1.0621.00
184_L188_R1.0551.00
131_V186_L1.0541.00
133_K174_D1.0461.00
108_E142_T1.0451.00
190_I198_V1.0451.00
189_K193_S1.0441.00
79_V92_A1.0411.00
189_K192_D1.0391.00
161_E194_V1.0241.00
38_L231_G1.0231.00
42_E235_I1.0221.00
187_T191_V1.0191.00
237_D240_S1.0181.00
111_Q114_K1.0181.00
46_E76_P1.0171.00
90_S120_F1.0131.00
185_E188_R1.0131.00
70_A97_A1.0101.00
33_V65_V1.0071.00
117_A165_A1.0041.00
110_S159_K1.0011.00
17_V35_L0.9981.00
108_E147_Y0.9961.00
157_A194_V0.9901.00
131_V153_A0.9851.00
79_V97_A0.9831.00
213_V219_A0.9791.00
191_V217_A0.9751.00
33_V68_D0.9710.99
133_K185_E0.9690.99
46_E126_V0.9480.99
64_N68_D0.9460.99
207_M238_L0.9440.99
212_E215_S0.9430.99
153_A190_I0.9430.99
167_E197_P0.9420.99
93_L120_F0.9390.99
5_R45_D0.9350.99
40_E73_L0.9310.99
153_A157_A0.9260.99
126_V167_E0.9250.99
188_R217_A0.9250.99
19_K226_G0.9220.99
155_K159_K0.9220.99
87_D91_M0.9120.99
60_K91_M0.9120.99
35_L38_L0.9040.99
13_K26_L0.9030.99
226_G230_D0.9010.99
113_V127_V0.8940.99
27_Q30_G0.8940.99
191_V219_A0.8940.99
45_D76_P0.8920.99
78_T101_S0.8920.99
55_T104_T0.8820.99
207_M237_D0.8790.99
154_I189_K0.8780.99
207_M211_Y0.8770.99
142_T149_T0.8750.99
89_V120_F0.8750.99
67_K91_M0.8660.99
102_I116_S0.8630.99
132_K141_F0.8600.99
91_M95_S0.8590.99
70_A98_D0.8510.99
113_V160_V0.8410.99
37_S40_E0.8400.99
191_V220_D0.8370.98
214_F242_L0.8360.98
112_I116_S0.8340.98
234_K238_L0.8310.98
50_L169_L0.8260.98
132_K174_D0.8220.98
154_I158_K0.8220.98
39_Y229_H0.8160.98
68_D72_V0.8080.98
6_I224_A0.8080.98
60_K88_D0.8060.98
86_P120_F0.8020.98
73_L76_P0.7990.98
185_E189_K0.7990.98
66_I97_A0.7950.98
206_K210_F0.7910.98
40_E75_I0.7860.98
141_F173_I0.7840.98
184_L217_A0.7820.98
88_D91_M0.7770.98
205_G209_H0.7750.97
114_K159_K0.7740.97
76_P98_D0.7740.97
89_V93_L0.7740.97
167_E220_D0.7660.97
175_R180_L0.7620.97
204_A222_A0.7610.97
158_K161_E0.7580.97
107_V156_W0.7540.97
206_K232_I0.7510.97
131_V138_W0.7510.97
13_K53_T0.7490.97
5_R221_A0.7440.97
192_D217_A0.7350.97
154_I157_A0.7330.97
155_K158_K0.7320.96
99_K166_G0.7290.96
6_I222_A0.7260.96
153_A186_L0.7250.96
175_R178_T0.7240.96
197_P220_D0.7220.96
210_F233_I0.7220.96
50_L171_T0.7220.96
161_E168_I0.7130.96
34_S38_L0.7110.96
210_F238_L0.7100.96
86_P90_S0.7040.96
187_T198_V0.7040.96
63_Y92_A0.7030.96
61_A66_I0.7020.96
21_V226_G0.7010.96
33_V72_V0.7010.96
53_T58_A0.6980.95
7_I199_I0.6980.95
7_I126_V0.6960.95
109_S112_I0.6950.95
140_V156_W0.6950.95
65_V69_T0.6900.95
118_E162_E0.6900.95
60_K84_R0.6850.95
169_L199_I0.6800.95
54_A61_A0.6780.95
121_G167_E0.6760.95
101_S169_L0.6750.94
213_V217_A0.6740.94
210_F222_A0.6720.94
69_T77_L0.6710.94
98_D123_Q0.6690.94
34_S37_S0.6690.94
70_A95_S0.6680.94
63_Y67_K0.6650.94
129_I156_W0.6640.94
44_A235_I0.6630.94
187_T213_V0.6620.94
182_Y205_G0.6620.94
36_A69_T0.6580.94
91_M94_R0.6570.94
89_V102_I0.6570.94
235_I239_K0.6550.94
83_I89_V0.6520.93
199_I221_A0.6500.93
105_A109_S0.6500.93
217_A220_D0.6460.93
84_R108_E0.6440.93
183_D186_L0.6420.93
117_A121_G0.6380.93
127_V168_I0.6380.93
13_K56_I0.6370.93
57_E61_A0.6340.92
30_G34_S0.6320.92
67_K94_R0.6320.92
60_K63_Y0.6280.92
157_A168_I0.6250.92
133_K183_D0.6250.92
205_G232_I0.6220.92
16_N25_N0.6160.91
129_I140_V0.6160.91
105_A116_S0.6130.91
115_K118_E0.6120.91
58_A62_L0.6100.91
177_G203_G0.6080.91
49_F77_L0.6080.91
60_K92_A0.6060.91
190_I194_V0.6050.91
158_K194_V0.6020.90
7_I78_T0.6020.90
191_V218_K0.6010.90
138_W186_L0.5990.90
16_N27_Q0.5980.90
210_F228_F0.5950.90
138_W152_D0.5930.90
83_I102_I0.5850.89
19_K176_D0.5850.89
99_K167_E0.5830.89
187_T200_A0.5830.89
29_K230_D0.5830.89
53_T62_L0.5810.89
87_D94_R0.5800.89
167_E199_I0.5770.88
44_A238_L0.5760.88
142_T146_T0.5760.88
45_D239_K0.5760.88
204_A224_A0.5690.88
102_I113_V0.5660.88
228_F238_L0.5630.87
225_A229_H0.5620.87
123_Q167_E0.5620.87
210_F214_F0.5610.87
7_I99_K0.5610.87
21_V26_L0.5570.87
12_V49_F0.5520.86
79_V83_I0.5500.86
177_G181_G0.5470.86
116_S120_F0.5460.86
20_G145_G0.5450.85
204_A233_I0.5440.85
122_S166_G0.5400.85
117_A127_V0.5390.85
20_G26_L0.5360.85
182_Y209_H0.5360.85
18_V23_F0.5340.84
12_V65_V0.5330.84
234_K240_S0.5330.84
65_V77_L0.5330.84
12_V69_T0.5290.84
20_G103_N0.5250.83
20_G23_F0.5250.83
87_D115_K0.5250.83
128_A199_I0.5210.83
187_T219_A0.5210.83
22_N174_D0.5190.83
73_L77_L0.5190.83
181_G203_G0.5180.83
50_L128_A0.5160.82
157_A193_S0.5150.82
59_R88_D0.5110.82
151_L155_K0.5110.82
182_Y210_F0.5110.82
54_A60_K0.5100.82
51_D58_A0.5080.81
114_K162_E0.5070.81
171_T201_S0.5050.81
145_G173_I0.5040.81
19_K175_R0.5030.81
86_P112_I0.5020.81
46_E98_D0.5020.81
204_A210_F0.5000.80
38_L236_K0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jvnA 1 0.9602 100 0.267 Contact Map
2agkA 1 0.8645 100 0.28 Contact Map
1qo2A 1 0.9243 100 0.464 Contact Map
1thfD 2 0.996 100 0.465 Contact Map
4gj1A 1 0.8964 100 0.473 Contact Map
4evzA 1 1 100 0.478 Contact Map
1h5yA 1 0.996 100 0.502 Contact Map
2y88A 1 0.9522 100 0.508 Contact Map
2w6rA 1 0.8685 100 0.515 Contact Map
4u28A 1 0.9124 100 0.517 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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