GREMLIN Database
HIS7 - Imidazoleglycerol-phosphate dehydratase
UniProt: O33773 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (191)
Sequences: 2733 (1354)
Seq/√Len: 98.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_E15_K4.0031.00
79_I142_F3.3671.00
6_N19_L3.2171.00
104_V166_A2.9261.00
29_K53_I2.7001.00
139_F171_L2.6701.00
136_P158_Y2.6661.00
152_I167_S2.5481.00
106_V170_A2.5091.00
15_K57_T2.3161.00
105_L153_S2.2941.00
8_T17_E2.2411.00
130_L135_V2.1601.00
80_K147_G2.1511.00
19_L53_I2.1471.00
56_A71_V2.0601.00
119_N153_S2.0591.00
28_V45_L2.0221.00
73_I145_N1.9931.00
106_V152_I1.9751.00
127_I164_I1.9481.00
96_I105_L1.9231.00
56_A67_I1.9061.00
33_P38_N1.8401.00
137_H141_S1.8251.00
110_I148_I1.7911.00
153_S156_S1.7901.00
105_L155_L1.7821.00
135_V164_I1.7631.00
37_F68_V1.7621.00
24_R51_T1.7531.00
123_K160_T1.6791.00
29_K55_S1.6531.00
120_L167_S1.6491.00
90_K177_E1.6391.00
31_S55_S1.6011.00
46_T189_T1.5741.00
90_K180_R1.5641.00
142_F171_L1.5581.00
136_P140_Q1.5431.00
117_F156_S1.5351.00
83_L179_T1.5181.00
90_K182_V1.4701.00
18_V54_V1.4601.00
26_G51_T1.4491.00
87_R185_E1.4161.00
6_N17_E1.4061.00
64_D134_N1.3910.99
37_F71_V1.3780.99
35_P61_P1.3660.99
22_I179_T1.3320.99
8_T15_K1.3270.99
110_I175_L1.3250.99
77_L145_N1.3120.99
160_T163_I1.3120.99
122_L164_I1.3050.99
94_H177_E1.2980.99
43_T92_F1.2940.99
126_E129_G1.2810.99
89_I110_I1.2720.99
139_F152_I1.2660.99
72_A137_H1.2610.99
68_V134_N1.2450.99
18_V78_A1.2350.99
64_D131_A1.2310.99
142_F148_I1.2300.99
104_V154_Q1.2170.99
33_P60_L1.1880.98
28_V42_I1.1820.98
17_E55_S1.1650.98
25_K51_T1.1610.98
176_Y179_T1.1550.98
77_L81_T1.1510.98
133_E160_T1.1410.98
72_A141_S1.1330.98
80_K86_K1.1250.98
7_I74_T1.1250.98
34_I64_D1.1220.98
99_M107_S1.1070.97
87_R184_N1.1040.97
3_R23_D1.1040.97
7_I81_T1.1020.97
41_L52_A1.1010.97
123_K163_I1.0950.97
47_Y172_G1.0920.97
4_S19_L1.0900.97
96_I107_S1.0860.97
133_E159_N1.0830.97
104_V163_I1.0770.97
176_Y180_R1.0770.97
12_K42_I1.0760.97
49_N176_Y1.0720.97
131_A134_N1.0720.97
106_V171_L1.0650.97
72_A138_F1.0590.97
126_E131_A1.0500.96
18_V74_T1.0250.96
124_R133_E1.0230.96
114_G144_Y1.0180.96
94_H107_S1.0110.95
60_L64_D1.0080.95
68_V130_L1.0020.95
32_T38_N0.9920.95
96_I155_L0.9920.95
64_D129_G0.9850.95
44_L172_G0.9840.95
31_S57_T0.9840.95
139_F167_S0.9650.94
4_S21_D0.9610.94
98_P103_L0.9600.94
104_V167_S0.9570.94
32_T54_V0.9560.94
152_I171_L0.9490.94
60_L67_I0.9460.94
154_Q163_I0.9430.93
118_V135_V0.9360.93
30_V42_I0.9300.93
97_I170_A0.9290.93
140_Q144_Y0.9210.93
32_T71_V0.9130.92
50_S179_T0.9110.92
7_I78_A0.9080.92
124_R160_T0.9060.92
79_I175_L0.9040.92
44_L175_L0.8960.92
111_S149_T0.8890.91
20_L79_I0.8860.91
27_E51_T0.8810.91
122_L160_T0.8650.90
43_T74_T0.8550.90
137_H140_Q0.8540.89
44_L48_M0.8490.89
35_P129_G0.8480.89
18_V75_L0.8470.89
154_Q166_A0.8450.89
120_L154_Q0.8430.89
116_A143_A0.8400.89
21_D51_T0.8360.88
110_I146_S0.8360.88
127_I160_T0.8260.88
37_F138_F0.8250.88
125_S160_T0.8250.88
118_V122_L0.8240.88
34_I60_L0.8070.87
101_D149_T0.8040.86
143_A150_L0.8040.86
49_N182_V0.8020.86
54_V71_V0.7920.86
93_S174_A0.7920.86
120_L163_I0.7910.86
42_I61_P0.7800.85
64_D126_E0.7790.85
49_N187_R0.7730.84
131_A159_N0.7730.84
44_L50_S0.7710.84
31_S38_N0.7690.84
105_L156_S0.7690.84
134_N137_H0.7660.84
114_G147_G0.7620.83
33_P67_I0.7600.83
157_G163_I0.7590.83
119_N156_S0.7580.83
64_D127_I0.7550.83
45_L48_M0.7540.83
141_S145_N0.7500.82
93_S177_E0.7490.82
83_L89_I0.7480.82
50_S79_I0.7420.82
45_L52_A0.7320.81
44_L99_M0.7320.81
35_P60_L0.7310.81
115_M140_Q0.7190.80
102_A157_G0.7150.79
103_L107_S0.7100.79
45_L50_S0.7090.79
110_I149_T0.7070.79
124_R127_I0.7010.78
38_N61_P0.6970.78
95_Q177_E0.6910.77
102_A154_Q0.6900.77
154_Q167_S0.6900.77
79_I148_I0.6880.77
75_L142_F0.6820.76
127_I132_T0.6800.76
64_D135_V0.6770.76
68_V138_F0.6750.75
126_E133_E0.6670.74
116_A141_S0.6650.74
101_D158_Y0.6610.74
124_R132_T0.6600.74
90_K176_Y0.6580.73
104_V156_S0.6570.73
108_L150_L0.6550.73
48_M172_G0.6540.73
8_T55_S0.6530.73
34_I129_G0.6520.73
36_F40_M0.6520.73
38_N60_L0.6510.73
186_I192_I0.6510.73
102_A158_Y0.6500.73
37_F135_V0.6480.72
150_L171_L0.6470.72
131_A137_H0.6470.72
20_L50_S0.6440.72
35_P56_A0.6410.72
47_Y173_L0.6400.71
7_I77_L0.6370.71
116_A136_P0.6360.71
176_Y182_V0.6320.70
5_A81_T0.6290.70
30_V38_N0.6260.70
48_M176_Y0.6260.70
124_R131_A0.6240.69
49_N183_D0.6200.69
125_S131_A0.6190.69
86_K89_I0.6170.69
28_V51_T0.6080.67
42_I46_T0.6050.67
34_I130_L0.6040.67
86_K112_N0.6040.67
116_A120_L0.6040.67
103_L155_L0.6040.67
87_R186_I0.5990.66
96_I103_L0.5980.66
5_A82_A0.5920.65
161_H165_E0.5920.65
84_G89_I0.5920.65
95_Q173_L0.5920.65
151_H156_S0.5920.65
94_H105_L0.5910.65
71_V74_T0.5910.65
125_S132_T0.5860.65
96_I153_S0.5850.65
37_F72_A0.5800.64
118_V140_Q0.5780.64
40_M168_F0.5780.64
79_I108_L0.5770.63
5_A74_T0.5720.63
177_E180_R0.5690.62
37_F41_L0.5680.62
114_G145_N0.5660.62
62_Y67_I0.5650.62
18_V71_V0.5580.61
50_S175_L0.5580.61
107_S189_T0.5570.61
162_H165_E0.5560.61
20_L52_A0.5550.60
43_T106_V0.5520.60
43_T173_L0.5520.60
111_S193_I0.5520.60
102_A156_S0.5500.60
63_D128_G0.5490.60
37_F74_T0.5490.60
106_V167_S0.5460.59
75_L79_I0.5460.59
65_H70_D0.5450.59
49_N180_R0.5440.59
5_A20_L0.5440.59
12_K191_G0.5430.59
115_M136_P0.5430.59
137_H158_Y0.5400.58
36_F39_H0.5380.58
39_H161_H0.5370.58
141_S144_Y0.5360.58
28_V172_G0.5360.58
114_G143_A0.5330.57
132_T160_T0.5320.57
102_A166_A0.5320.57
12_K62_Y0.5310.57
107_S153_S0.5300.57
91_R109_D0.5280.57
25_K185_E0.5280.57
138_F142_F0.5270.57
59_K62_Y0.5210.56
93_S110_I0.5190.55
92_F97_I0.5160.55
101_D151_H0.5160.55
64_D137_H0.5160.55
43_T99_M0.5130.55
87_R181_I0.5130.55
122_L125_S0.5130.55
17_E53_I0.5110.54
28_V46_T0.5090.54
175_L179_T0.5090.54
39_H162_H0.5080.54
74_T78_A0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rhyA 4 0.9119 100 -0.009 Contact Map
4mu3A 6 0.9534 100 -0.006 Contact Map
2ae8A 5 0.8964 100 -0.006 Contact Map
4gquA 6 0.9482 100 0.001 Contact Map
4jifA 2 0.4145 22.2 0.962 Contact Map
4kyzA 1 0.3057 13.3 0.966 Contact Map
1sq1A 4 0.1917 10.8 0.967 Contact Map
3f0wA 2 0.4404 10.7 0.967 Contact Map
1wguA 1 0.4352 10.7 0.967 Contact Map
1n3hA 1 0.456 10.6 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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