HIS4 - SULSO - GREMLIN Contacts

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HIS4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

UniProt:	O33772	Sequences: MNEIIPSIDISFGKAVKRIRGVRGTGLVLGNPIELANKLYNEGYSRIHVVDLDAAEGVGNNEMYIKEICKIGFDWIQVGGGIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIGNNRVIVSIDYDDTKRVLISGWKERSMEIIDGIKKVNELELLGIILTYVTNEGTVKGIDYSVKDYAKLIRGVKEYAGGVSSDSDITFLKNVGFDYIIVGMAFYLNKIRGTNVV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	232 (225)
Sequences:	5794 (3075)
Seq/√Len:	205.0

ECOLI - HIS4 HIS6
BACSU - HIS6 HIS4
HALSA - HIS4 HIS6
SULSO - HIS4 HIS6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
88_A	115_I	3.356	1.00
139_S	143_E	2.620	1.00
113_Y	158_L	2.538	1.00
19_I	173_T	2.534	1.00
128_I	152_I	2.436	1.00
156_N	190_G	2.408	1.00
84_D	87_K	2.386	1.00
126_V	155_V	2.336	1.00
108_N	114_N	2.316	1.00
135_R	144_R	2.300	1.00
37_N	71_I	2.298	1.00
154_K	158_L	2.292	1.00
14_K	28_V	2.255	1.00
89_K	93_S	2.196	1.00
37_N	41_N	2.169	1.00
107_T	139_S	2.152	1.00
135_R	147_E	2.090	1.00
38_K	42_E	2.042	1.00
202_S	205_T	2.029	1.00
174_V	225_K	1.994	1.00
202_S	206_F	1.992	1.00
40_Y	73_F	1.966	1.00
227_R	230_N	1.938	1.00
115_I	124_V	1.882	1.00
62_E	90_R	1.873	1.00
82_I	91_L	1.863	1.00
88_A	124_V	1.803	1.00
106_F	138_I	1.790	1.00
147_E	150_D	1.764	1.00
31_N	34_E	1.729	1.00
156_N	189_R	1.715	1.00
20_R	173_T	1.711	1.00
89_K	118_E	1.709	1.00
182_K	186_K	1.681	1.00
85_V	115_I	1.674	1.00
217_V	221_F	1.650	1.00
179_Y	206_F	1.607	1.00
201_D	226_I	1.582	1.00
42_E	229_T	1.579	1.00
31_N	67_E	1.562	1.00
198_V	207_L	1.558	1.00
47_I	74_D	1.543	1.00
146_M	154_K	1.539	1.00
153_K	187_L	1.528	1.00
12_F	53_D	1.521	1.00
61_N	64_Y	1.505	1.00
127_S	164_I	1.498	1.00
220_A	226_I	1.494	1.00
217_V	220_A	1.490	1.00
200_S	203_D	1.488	1.00
101_F	104_I	1.487	1.00
98_A	125_I	1.485	1.00
63_M	66_K	1.478	1.00
154_K	157_E	1.451	1.00
110_N	114_N	1.449	1.00
137_L	144_R	1.447	1.00
185_A	192_K	1.422	1.00
104_I	111_L	1.421	1.00
69_C	76_I	1.415	1.00
92_I	123_R	1.414	1.00
85_V	118_E	1.405	1.00
22_V	25_T	1.392	1.00
206_F	209_N	1.381	1.00
5_I	46_R	1.368	1.00
67_E	70_K	1.362	1.00
6_P	44_Y	1.353	1.00
85_V	114_N	1.326	1.00
130_Y	165_L	1.321	1.00
203_D	206_F	1.320	1.00
167_Y	178_D	1.314	1.00
19_I	25_T	1.308	1.00
46_R	98_A	1.294	1.00
113_Y	117_R	1.282	1.00
49_V	68_I	1.280	1.00
186_K	211_G	1.269	1.00
86_E	89_K	1.267	1.00
88_A	99_L	1.267	1.00
105_V	126_V	1.266	1.00
204_I	220_A	1.249	1.00
3_E	46_R	1.234	1.00
226_I	231_V	1.229	1.00
38_K	41_N	1.222	1.00
65_I	78_V	1.212	1.00
204_I	217_V	1.211	1.00
42_E	227_R	1.207	1.00
66_K	70_K	1.200	1.00
152_I	184_Y	1.189	1.00
165_L	184_Y	1.188	1.00
182_K	209_N	1.184	1.00
127_S	166_T	1.184	1.00
66_K	94_L	1.167	1.00
125_I	164_I	1.158	1.00
138_I	143_E	1.144	1.00
38_K	224_N	1.139	1.00
106_F	146_M	1.136	1.00
103_T	107_T	1.136	1.00
164_I	216_I	1.136	1.00
207_L	215_I	1.131	1.00
149_I	187_L	1.127	1.00
201_D	231_V	1.122	1.00
132_D	169_T	1.113	1.00
161_L	191_V	1.103	1.00
11_S	23_R	1.099	1.00
3_E	45_S	1.099	1.00
183_D	186_K	1.091	1.00
15_A	35_L	1.081	1.00
163_I	190_G	1.080	1.00
184_Y	192_K	1.074	1.00
153_K	157_E	1.069	1.00
177_I	198_V	1.065	1.00
126_V	160_L	1.063	1.00
46_R	75_W	1.059	1.00
207_L	212_F	1.058	1.00
181_V	185_A	1.049	1.00
133_T	137_L	1.047	1.00
107_T	138_I	1.041	1.00
29_L	35_L	1.031	1.00
179_Y	182_K	1.030	1.00
33_I	64_Y	1.028	1.00
78_V	91_L	1.027	1.00
130_Y	148_I	1.025	1.00
110_N	113_Y	1.023	1.00
183_D	187_L	1.016	1.00
107_T	143_E	1.012	1.00
89_K	119_I	0.998	1.00
205_T	209_N	0.997	1.00
179_Y	210_V	0.994	1.00
69_C	96_V	0.994	1.00
156_N	188_I	0.992	1.00
109_F	154_K	0.991	1.00
111_L	115_I	0.980	1.00
162_G	191_V	0.978	1.00
201_D	205_T	0.978	1.00
152_I	188_I	0.969	1.00
148_I	184_Y	0.966	1.00
125_I	162_G	0.960	0.99
116_V	160_L	0.959	0.99
78_V	96_V	0.956	0.99
35_L	38_K	0.955	0.99
33_I	67_E	0.950	0.99
132_D	180_S	0.946	0.99
148_I	152_I	0.939	0.99
86_E	90_R	0.936	0.99
46_R	125_I	0.927	0.99
55_A	103_T	0.922	0.99
185_A	212_F	0.917	0.99
112_F	126_V	0.909	0.99
59_G	90_R	0.903	0.99
14_K	30_G	0.903	0.99
69_C	97_N	0.903	0.99
17_K	219_M	0.902	0.99
4_I	217_V	0.894	0.99
182_K	210_V	0.892	0.99
40_Y	72_G	0.887	0.99
77_Q	100_I	0.882	0.99
37_N	40_Y	0.881	0.99
149_I	183_D	0.881	0.99
72_G	75_W	0.876	0.99
201_D	230_N	0.869	0.99
101_F	115_I	0.867	0.99
39_L	222_Y	0.864	0.99
150_D	154_K	0.864	0.99
149_I	153_K	0.863	0.99
92_I	119_I	0.862	0.99
138_I	145_S	0.859	0.99
90_R	94_L	0.858	0.99
219_M	223_L	0.858	0.99
65_I	96_V	0.857	0.99
131_D	169_T	0.855	0.99
185_A	210_V	0.854	0.99
131_D	137_L	0.854	0.99
63_M	67_E	0.851	0.99
66_K	90_R	0.846	0.99
50_V	164_I	0.843	0.99
198_V	215_I	0.836	0.99
59_G	87_K	0.835	0.99
185_A	213_D	0.825	0.98
199_S	203_D	0.824	0.98
208_K	211_G	0.818	0.98
45_S	75_W	0.815	0.98
205_T	208_K	0.815	0.98
112_F	155_V	0.807	0.98
88_A	119_I	0.806	0.98
113_Y	154_K	0.802	0.98
106_F	151_G	0.801	0.98
75_W	97_N	0.788	0.98
11_S	53_D	0.788	0.98
85_V	119_I	0.788	0.98
200_S	204_I	0.787	0.98
42_E	228_G	0.787	0.98
162_G	213_D	0.786	0.98
180_S	183_D	0.785	0.98
200_S	225_K	0.783	0.98
67_E	71_I	0.780	0.98
54_A	60_N	0.780	0.98
85_V	89_K	0.777	0.98
19_I	219_M	0.774	0.98
40_Y	74_D	0.772	0.98
137_L	168_V	0.771	0.98
87_K	90_R	0.765	0.97
3_E	214_Y	0.762	0.97
149_I	152_I	0.762	0.97
11_S	24_G	0.760	0.97
59_G	83_R	0.759	0.97
133_T	144_R	0.754	0.97
53_D	57_G	0.753	0.97
33_I	71_I	0.752	0.97
207_L	210_V	0.750	0.97
191_V	213_D	0.748	0.97
133_T	183_D	0.743	0.97
150_D	153_K	0.741	0.97
29_L	223_L	0.739	0.97
170_N	175_K	0.738	0.97
227_R	231_V	0.736	0.97
122_N	161_L	0.735	0.97
128_I	151_G	0.723	0.96
62_E	66_K	0.721	0.96
50_V	166_T	0.718	0.96
98_A	161_L	0.717	0.96
5_I	193_E	0.715	0.96
153_K	156_N	0.713	0.96
117_R	157_E	0.712	0.96
156_N	163_I	0.712	0.96
181_V	192_K	0.712	0.96
108_N	111_L	0.710	0.96
193_E	214_Y	0.710	0.96
34_E	38_K	0.702	0.96
5_I	125_I	0.699	0.96
4_I	215_I	0.697	0.96
136_V	151_G	0.697	0.96
170_N	173_T	0.696	0.96
133_T	147_E	0.695	0.96
116_V	120_G	0.685	0.95
69_C	94_L	0.682	0.95
120_G	162_G	0.680	0.95
204_I	226_I	0.680	0.95
62_E	91_L	0.676	0.95
23_R	142_K	0.675	0.95
56_E	60_N	0.673	0.95
204_I	215_I	0.661	0.94
82_I	88_A	0.659	0.94
30_G	35_L	0.659	0.94
100_I	164_I	0.658	0.94
126_V	163_I	0.655	0.94
152_I	163_I	0.655	0.94
97_N	122_N	0.650	0.94
68_I	76_I	0.646	0.93
88_A	101_F	0.646	0.93
82_I	101_F	0.645	0.93
44_Y	228_G	0.644	0.93
164_I	193_E	0.643	0.93
104_I	108_N	0.643	0.93
114_N	117_R	0.640	0.93
88_A	123_R	0.640	0.93
64_Y	68_I	0.639	0.93
204_I	221_F	0.638	0.93
66_K	93_S	0.638	0.93
221_F	231_V	0.637	0.93
88_A	92_I	0.635	0.93
5_I	77_Q	0.631	0.93
184_Y	188_I	0.627	0.92
185_A	211_G	0.619	0.92
53_D	61_N	0.618	0.92
36_A	68_I	0.617	0.92
34_E	37_N	0.615	0.92
60_N	65_I	0.615	0.92
97_N	123_R	0.613	0.92
181_V	194_Y	0.613	0.92
218_G	222_Y	0.613	0.92
181_V	207_L	0.611	0.91
177_I	199_S	0.611	0.91
90_R	93_S	0.611	0.91
128_I	136_V	0.610	0.91
59_G	91_L	0.605	0.91
101_F	112_F	0.604	0.91
10_I	49_V	0.597	0.91
10_I	68_I	0.596	0.90
138_I	142_K	0.595	0.90
104_I	115_I	0.594	0.90
17_K	171_E	0.594	0.90
49_V	76_I	0.593	0.90
44_Y	231_V	0.592	0.90
132_D	178_D	0.591	0.90
56_E	59_G	0.589	0.90
153_K	188_I	0.588	0.90
98_A	162_G	0.586	0.90
198_V	217_V	0.584	0.90
57_G	61_N	0.583	0.89
120_G	123_R	0.579	0.89
210_V	213_D	0.575	0.89
146_M	150_D	0.572	0.89
204_I	231_V	0.568	0.88
86_E	93_S	0.566	0.88
78_V	82_I	0.565	0.88
199_S	225_K	0.564	0.88
162_G	193_E	0.563	0.88
10_I	64_Y	0.560	0.88
54_A	59_G	0.560	0.88
5_I	98_A	0.554	0.87
35_L	39_L	0.552	0.87
116_V	126_V	0.552	0.87
83_R	107_T	0.550	0.87
172_G	197_G	0.544	0.86
177_I	203_D	0.544	0.86
159_E	190_G	0.543	0.86
38_K	229_T	0.542	0.86
3_E	213_D	0.540	0.86
20_R	25_T	0.539	0.86
3_E	122_N	0.532	0.85
166_T	195_A	0.532	0.85
59_G	62_E	0.531	0.85
18_R	24_G	0.529	0.84
113_Y	157_E	0.529	0.84
18_R	141_W	0.527	0.84
16_V	21_G	0.527	0.84
198_V	226_I	0.527	0.84
72_G	76_I	0.527	0.84
64_Y	76_I	0.527	0.84
18_R	102_S	0.526	0.84
177_I	204_I	0.524	0.84
51_D	57_G	0.523	0.84
172_G	176_G	0.521	0.84
198_V	204_I	0.516	0.83
25_T	223_L	0.516	0.83
127_S	193_E	0.516	0.83
20_R	169_T	0.516	0.83
54_A	58_V	0.516	0.83
181_V	212_F	0.516	0.83
7_S	166_T	0.512	0.83
50_V	127_S	0.509	0.82
115_I	119_I	0.509	0.82
105_V	112_F	0.508	0.82
7_S	216_I	0.507	0.82
36_A	72_G	0.507	0.82
32_P	64_Y	0.506	0.82
149_I	188_I	0.503	0.81
176_G	197_G	0.501	0.81
152_I	187_L	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2agkA	1	0.8836	100	0.266	Contact Map
1jvnA	1	0.9569	100	0.302	Contact Map
4gj1A	1	0.931	100	0.448	Contact Map
1qo2A	1	0.9784	100	0.449	Contact Map
2y88A	1	0.9914	100	0.474	Contact Map
4x2rA	1	0.9698	100	0.491	Contact Map
4u28A	1	0.9655	100	0.497	Contact Map
1thfD	2	0.9914	100	0.512	Contact Map
4axkA	1	0.9784	100	0.517	Contact Map
4evzA	1	0.9914	100	0.522	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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