HIS1 - SULSO - GREMLIN Contacts

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HIS1 - ATP phosphoribosyltransferase

UniProt:	O33771	Sequences: MVRNLKIAIPNKGRLQQPTLQFLQSVGIKPLASDDRALIVPTSWEGVQLVMIRTEDIPNIVETGATELGITGHDYVIESSADVEELIKLDFGRSKIVLAVPQTWRENSVDELKGKEFRVATKYYNIAKEYVRRRELNAKVVKISGAAEVMPSLGAAEAIIDVMSTGTTLKLHGLKAIDVIMDSYAVVIGNRNWIKNDEADRINLLLTMMKGAIAAKGKKMIFMNVPDNKLDGVINSLPAMLAPAITRLSRSDIWEVITVAEEDILPEVIAKVKAAGARDIVVIDIEKVVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	290 (278)
Sequences:	1489 (789)
Seq/√Len:	47.3

ECOLI - HIS1
BACSU - HIS1
HALSA - HIS1
SULSO - HIS1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
113_K	137_N	5.680	1.00
88_K	184_Y	5.120	1.00
131_V	138_A	4.830	1.00
229_K	232_G	4.160	1.00
227_D	254_W	4.129	1.00
112_L	158_A	3.714	1.00
129_E	133_R	3.609	1.00
230_L	256_V	3.404	1.00
82_D	191_R	3.287	1.00
225_V	233_V	3.218	1.00
226_P	229_K	3.001	1.00
119_V	131_V	2.995	1.00
73_H	85_E	2.978	1.00
98_L	130_Y	2.955	1.00
107_N	111_E	2.923	1.00
127_A	160_I	2.849	1.00
179_V	182_D	2.794	1.00
228_N	252_D	2.763	1.00
61_V	188_I	2.710	1.00
222_F	257_I	2.659	1.00
109_V	130_Y	2.633	1.00
125_N	128_K	2.628	1.00
28_I	42_T	2.430	1.00
90_D	184_Y	2.415	1.00
227_D	252_D	2.366	1.00
76_V	83_V	2.325	1.00
100_V	104_W	2.296	1.00
17_Q	21_Q	2.284	1.00
95_K	176_A	2.269	1.00
110_D	134_R	2.264	1.00
85_E	186_V	2.200	1.00
97_V	176_A	2.192	1.00
102_Q	173_G	2.158	1.00
237_L	258_T	2.134	1.00
200_D	274_A	2.122	1.00
108_S	111_E	2.100	1.00
73_H	88_K	2.072	1.00
128_K	132_R	2.056	1.00
199_A	203_N	2.000	0.99
97_V	163_M	1.961	0.99
264_I	267_E	1.923	0.99
57_I	161_D	1.854	0.99
232_G	235_N	1.844	0.99
241_L	278_R	1.833	0.99
233_V	275_A	1.766	0.99
68_L	187_V	1.765	0.99
130_Y	178_D	1.722	0.98
80_S	129_E	1.707	0.98
100_V	175_K	1.704	0.98
84_E	191_R	1.677	0.98
267_E	271_K	1.673	0.98
218_K	261_E	1.631	0.98
224_N	241_L	1.623	0.97
86_L	189_G	1.623	0.97
87_I	210_K	1.600	0.97
109_V	136_L	1.580	0.97
11_N	146_A	1.575	0.97
240_M	279_D	1.569	0.97
37_A	171_L	1.539	0.97
96_I	162_V	1.537	0.96
259_V	285_I	1.528	0.96
99_A	169_L	1.519	0.96
105_R	175_K	1.513	0.96
77_I	129_E	1.419	0.94
93_R	164_S	1.412	0.94
154_G	168_T	1.388	0.94
104_W	111_E	1.386	0.94
261_E	264_I	1.335	0.92
98_L	112_L	1.325	0.92
103_T	175_K	1.323	0.92
147_A	163_M	1.306	0.92
22_F	209_M	1.275	0.91
219_K	286_E	1.254	0.90
282_V	286_E	1.251	0.90
30_P	40_V	1.250	0.90
225_V	275_A	1.249	0.90
54_T	71_T	1.232	0.89
87_I	206_L	1.221	0.89
131_V	160_I	1.210	0.88
77_I	181_M	1.203	0.88
110_D	136_L	1.201	0.88
227_D	250_R	1.186	0.87
231_D	234_I	1.177	0.87
83_V	188_I	1.174	0.87
167_T	171_L	1.173	0.87
232_G	236_S	1.162	0.86
100_V	112_L	1.140	0.85
122_K	147_A	1.130	0.84
77_I	80_S	1.128	0.84
227_D	247_R	1.125	0.84
123_Y	126_I	1.120	0.84
131_V	134_R	1.116	0.84
98_L	127_A	1.092	0.82
128_K	140_V	1.082	0.82
42_T	47_V	1.077	0.81
242_A	248_L	1.077	0.81
112_L	119_V	1.057	0.80
271_K	274_A	1.052	0.80
49_L	57_I	1.048	0.80
232_G	275_A	1.043	0.79
55_E	75_Y	1.040	0.79
235_N	274_A	1.024	0.78
95_K	182_D	1.020	0.78
220_M	257_I	1.016	0.77
246_T	257_I	1.015	0.77
223_M	237_L	1.011	0.77
10_P	74_D	1.011	0.77
15_L	185_A	1.008	0.77
210_K	214_A	0.994	0.76
265_L	282_V	0.986	0.75
223_M	258_T	0.984	0.75
98_L	160_I	0.980	0.75
71_T	74_D	0.973	0.74
134_R	178_D	0.969	0.74
229_K	275_A	0.968	0.74
88_K	186_V	0.962	0.73
151_P	172_H	0.958	0.73
104_W	175_K	0.958	0.73
225_V	256_V	0.957	0.73
68_L	206_L	0.954	0.73
211_G	269_I	0.953	0.73
241_L	279_D	0.947	0.72
107_N	128_K	0.947	0.72
33_S	37_A	0.939	0.72
10_P	54_T	0.938	0.72
19_T	91_F	0.934	0.71
99_A	120_A	0.934	0.71
242_A	250_R	0.931	0.71
14_R	164_S	0.931	0.71
200_D	204_L	0.929	0.71
30_P	49_L	0.928	0.71
75_Y	160_I	0.925	0.70
87_I	213_I	0.925	0.70
77_I	85_E	0.923	0.70
233_V	237_L	0.919	0.70
163_M	208_M	0.913	0.69
9_I	20_L	0.899	0.68
244_A	255_E	0.892	0.68
100_V	177_I	0.891	0.68
146_A	201_R	0.886	0.67
281_V	285_I	0.878	0.66
73_H	186_V	0.873	0.66
203_N	206_L	0.870	0.66
231_D	235_N	0.869	0.66
56_D	143_I	0.867	0.65
119_V	180_I	0.866	0.65
58_P	96_I	0.866	0.65
46_G	201_R	0.863	0.65
44_W	201_R	0.863	0.65
26_V	214_A	0.856	0.64
167_T	211_G	0.852	0.64
238_P	281_V	0.847	0.64
204_L	270_A	0.846	0.64
107_N	175_K	0.841	0.63
278_R	285_I	0.840	0.63
77_I	126_I	0.839	0.63
122_K	163_M	0.834	0.62
109_V	271_K	0.832	0.62
102_Q	175_K	0.831	0.62
73_H	77_I	0.827	0.62
62_E	83_V	0.824	0.61
113_K	136_L	0.821	0.61
6_K	136_L	0.821	0.61
38_L	143_I	0.818	0.61
25_S	212_A	0.818	0.61
36_R	69_G	0.817	0.61
12_K	218_K	0.812	0.60
229_K	245_I	0.811	0.60
70_I	185_A	0.808	0.60
97_V	179_V	0.806	0.60
232_G	271_K	0.805	0.60
147_A	208_M	0.805	0.60
82_D	137_N	0.804	0.60
244_A	248_L	0.803	0.59
192_N	263_D	0.803	0.59
27_G	120_A	0.801	0.59
151_P	159_I	0.799	0.59
83_V	86_L	0.797	0.59
35_D	130_Y	0.797	0.59
165_T	176_A	0.793	0.59
16_Q	19_T	0.791	0.58
54_T	96_I	0.791	0.58
16_Q	143_I	0.791	0.58
163_M	176_A	0.789	0.58
84_E	192_N	0.786	0.58
102_Q	129_E	0.785	0.58
149_V	164_S	0.783	0.58
68_L	109_V	0.774	0.57
86_L	202_I	0.774	0.57
262_E	287_K	0.774	0.57
160_I	180_I	0.771	0.56
128_K	210_K	0.768	0.56
110_D	113_K	0.768	0.56
82_D	251_S	0.767	0.56
224_N	248_L	0.766	0.56
47_V	58_P	0.766	0.56
41_P	216_K	0.765	0.56
30_P	100_V	0.761	0.55
115_K	158_A	0.761	0.55
165_T	173_G	0.761	0.55
39_I	202_I	0.759	0.55
128_K	137_N	0.757	0.55
225_V	229_K	0.757	0.55
21_Q	25_S	0.755	0.55
234_I	249_S	0.746	0.54
9_I	23_L	0.746	0.54
8_A	66_T	0.745	0.54
171_L	211_G	0.745	0.54
10_P	71_T	0.745	0.54
14_R	151_P	0.745	0.54
206_L	210_K	0.742	0.54
141_V	165_T	0.741	0.53
68_L	202_I	0.740	0.53
144_S	279_D	0.740	0.53
109_V	134_R	0.738	0.53
227_D	251_S	0.736	0.53
20_L	24_Q	0.736	0.53
113_K	135_E	0.733	0.53
36_R	171_L	0.729	0.52
125_N	129_E	0.727	0.52
164_S	176_A	0.726	0.52
84_E	199_A	0.725	0.52
5_L	167_T	0.724	0.52
105_R	132_R	0.722	0.52
91_F	185_A	0.719	0.51
30_P	172_H	0.718	0.51
120_A	156_A	0.716	0.51
224_N	243_P	0.715	0.51
41_P	68_L	0.715	0.51
124_Y	171_L	0.710	0.50
12_K	26_V	0.708	0.50
143_I	147_A	0.707	0.50
73_H	181_M	0.705	0.50
39_I	282_V	0.703	0.50
8_A	282_V	0.702	0.50
226_P	252_D	0.701	0.49
120_A	141_V	0.701	0.49
101_P	105_R	0.699	0.49
23_L	49_L	0.699	0.49
59_N	141_V	0.698	0.49
129_E	192_N	0.694	0.49
57_I	118_R	0.692	0.49
7_I	49_L	0.691	0.48
231_D	250_R	0.691	0.48
63_T	284_D	0.688	0.48
48_Q	167_T	0.686	0.48
225_V	230_L	0.686	0.48
224_N	278_R	0.686	0.48
85_E	88_K	0.685	0.48
248_L	253_I	0.683	0.48
97_V	147_A	0.679	0.47
58_P	79_S	0.678	0.47
96_I	123_Y	0.677	0.47
233_V	259_V	0.676	0.47
28_I	47_V	0.676	0.47
164_S	168_T	0.675	0.47
169_L	183_S	0.673	0.47
100_V	105_R	0.672	0.47
189_G	202_I	0.672	0.47
11_N	60_I	0.671	0.46
99_A	151_P	0.669	0.46
51_M	171_L	0.669	0.46
36_R	188_I	0.665	0.46
29_K	213_I	0.665	0.46
54_T	69_G	0.663	0.46
120_A	143_I	0.658	0.45
262_E	284_D	0.658	0.45
114_G	137_N	0.656	0.45
228_N	232_G	0.654	0.45
128_K	229_K	0.654	0.45
37_A	164_S	0.654	0.45
113_K	232_G	0.653	0.45
53_R	138_A	0.652	0.45
94_S	146_A	0.651	0.44
69_G	126_I	0.650	0.44
190_N	193_W	0.647	0.44
73_H	183_S	0.646	0.44
110_D	263_D	0.645	0.44
220_M	259_V	0.644	0.44
82_D	113_K	0.643	0.44
247_R	254_W	0.642	0.44
86_L	230_L	0.642	0.44
192_N	228_N	0.641	0.43
20_L	30_P	0.639	0.43
69_G	188_I	0.639	0.43
204_L	274_A	0.630	0.42
77_I	93_R	0.629	0.42
80_S	135_E	0.628	0.42
239_A	243_P	0.626	0.42
96_I	144_S	0.623	0.42
169_L	172_H	0.621	0.42
54_T	75_Y	0.617	0.41
38_L	42_T	0.615	0.41
151_P	156_A	0.615	0.41
23_L	209_M	0.614	0.41
220_M	283_I	0.614	0.41
61_V	69_G	0.611	0.41
151_P	222_F	0.608	0.40
112_L	121_T	0.607	0.40
264_I	271_K	0.605	0.40
131_V	136_L	0.602	0.40
94_S	162_V	0.600	0.40
208_M	270_A	0.598	0.39
139_K	231_D	0.598	0.39
118_R	165_T	0.597	0.39
217_G	245_I	0.596	0.39
80_S	125_N	0.595	0.39
137_N	271_K	0.595	0.39
67_E	198_E	0.594	0.39
52_I	248_L	0.594	0.39
95_K	177_I	0.594	0.39
17_Q	264_I	0.592	0.39
14_R	127_A	0.591	0.39
132_R	137_N	0.591	0.39
43_S	115_K	0.591	0.39
189_G	199_A	0.590	0.39
193_W	202_I	0.586	0.38
109_V	178_D	0.585	0.38
51_M	191_R	0.585	0.38
54_T	171_L	0.584	0.38
14_R	28_I	0.583	0.38
14_R	18_P	0.581	0.38
26_V	160_I	0.580	0.38
125_N	235_N	0.579	0.38
14_R	78_E	0.579	0.38
203_N	274_A	0.578	0.37
130_Y	134_R	0.577	0.37
224_N	244_A	0.577	0.37
86_L	194_I	0.577	0.37
42_T	49_L	0.576	0.37
40_V	172_H	0.576	0.37
226_P	275_A	0.576	0.37
52_I	57_I	0.575	0.37
69_G	96_I	0.575	0.37
12_K	74_D	0.574	0.37
29_K	87_I	0.573	0.37
220_M	281_V	0.572	0.37
73_H	184_Y	0.570	0.37
17_Q	184_Y	0.570	0.37
152_S	165_T	0.569	0.37
50_V	151_P	0.568	0.36
86_L	206_L	0.567	0.36
119_V	158_A	0.566	0.36
221_I	261_E	0.566	0.36
125_N	133_R	0.566	0.36
227_D	249_S	0.565	0.36
74_D	266_P	0.564	0.36
140_V	171_L	0.563	0.36
53_R	169_L	0.559	0.36
119_V	217_G	0.558	0.36
26_V	218_K	0.557	0.35
71_T	131_V	0.557	0.35
129_E	275_A	0.556	0.35
259_V	281_V	0.555	0.35
125_N	132_R	0.554	0.35
23_L	93_R	0.553	0.35
51_M	268_V	0.552	0.35
159_I	178_D	0.551	0.35
200_D	203_N	0.550	0.35
8_A	57_I	0.549	0.35
44_W	167_T	0.549	0.35
53_R	99_A	0.547	0.35
84_E	189_G	0.547	0.35
28_I	49_L	0.546	0.34
137_N	228_N	0.546	0.34
124_Y	174_L	0.546	0.34
28_I	144_S	0.545	0.34
76_V	236_S	0.544	0.34
226_P	242_A	0.542	0.34
93_R	182_D	0.542	0.34
240_M	250_R	0.541	0.34
211_G	279_D	0.541	0.34
6_K	18_P	0.540	0.34
143_I	150_M	0.537	0.34
190_N	268_V	0.537	0.34
74_D	123_Y	0.535	0.34
54_T	74_D	0.534	0.33
223_M	239_A	0.534	0.33
129_E	193_W	0.530	0.33
192_N	245_I	0.530	0.33
138_A	160_I	0.527	0.33
6_K	80_S	0.527	0.33
260_A	268_V	0.527	0.33
24_Q	180_I	0.527	0.33
56_D	239_A	0.525	0.33
38_L	56_D	0.525	0.33
221_I	265_L	0.524	0.33
10_P	13_G	0.523	0.32
80_S	128_K	0.523	0.32
215_A	269_I	0.522	0.32
252_D	279_D	0.522	0.32
172_H	284_D	0.521	0.32
121_T	150_M	0.520	0.32
58_P	81_A	0.520	0.32
102_Q	255_E	0.516	0.32
219_K	282_V	0.515	0.32
6_K	284_D	0.514	0.32
243_P	248_L	0.513	0.32
139_K	228_N	0.512	0.31
61_V	190_N	0.511	0.31
129_E	234_I	0.510	0.31
238_P	258_T	0.510	0.31
40_V	149_V	0.509	0.31
104_W	115_K	0.509	0.31
108_S	177_I	0.508	0.31
56_D	150_M	0.507	0.31
193_W	199_A	0.506	0.31
10_P	266_P	0.505	0.31
172_H	221_I	0.504	0.31
222_F	283_I	0.504	0.31
19_T	44_W	0.504	0.31
122_K	208_M	0.504	0.31
103_T	107_N	0.503	0.31
80_S	271_K	0.502	0.31
123_Y	265_L	0.501	0.31
65_A	68_L	0.500	0.30
147_A	150_M	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1h3dA	4	0.9621	100	0.09	Contact Map
1nh8A	5	0.9483	100	0.092	Contact Map
2vd3A	5	0.9862	100	0.093	Contact Map
2vd2A	2	0.7207	100	0.34	Contact Map
1z7mE	2	0.6966	100	0.358	Contact Map
1ve4A	1	0.6897	100	0.359	Contact Map
1o63A	2	0.7	100	0.361	Contact Map
3qslA	1	0.9276	99	0.883	Contact Map
4nmyA	1	0.9103	98.8	0.892	Contact Map
3ix1A	2	0.8931	98.8	0.892	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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