GREMLIN Database
HIS1 - ATP phosphoribosyltransferase
UniProt: O33771 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (278)
Sequences: 1489 (789)
Seq/√Len: 47.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_K137_N5.6801.00
88_K184_Y5.1201.00
131_V138_A4.8301.00
229_K232_G4.1601.00
227_D254_W4.1291.00
112_L158_A3.7141.00
129_E133_R3.6091.00
230_L256_V3.4041.00
82_D191_R3.2871.00
225_V233_V3.2181.00
226_P229_K3.0011.00
119_V131_V2.9951.00
73_H85_E2.9781.00
98_L130_Y2.9551.00
107_N111_E2.9231.00
127_A160_I2.8491.00
179_V182_D2.7941.00
228_N252_D2.7631.00
61_V188_I2.7101.00
222_F257_I2.6591.00
109_V130_Y2.6331.00
125_N128_K2.6281.00
28_I42_T2.4301.00
90_D184_Y2.4151.00
227_D252_D2.3661.00
76_V83_V2.3251.00
100_V104_W2.2961.00
17_Q21_Q2.2841.00
95_K176_A2.2691.00
110_D134_R2.2641.00
85_E186_V2.2001.00
97_V176_A2.1921.00
102_Q173_G2.1581.00
237_L258_T2.1341.00
200_D274_A2.1221.00
108_S111_E2.1001.00
73_H88_K2.0721.00
128_K132_R2.0561.00
199_A203_N2.0000.99
97_V163_M1.9610.99
264_I267_E1.9230.99
57_I161_D1.8540.99
232_G235_N1.8440.99
241_L278_R1.8330.99
233_V275_A1.7660.99
68_L187_V1.7650.99
130_Y178_D1.7220.98
80_S129_E1.7070.98
100_V175_K1.7040.98
84_E191_R1.6770.98
267_E271_K1.6730.98
218_K261_E1.6310.98
224_N241_L1.6230.97
86_L189_G1.6230.97
87_I210_K1.6000.97
109_V136_L1.5800.97
11_N146_A1.5750.97
240_M279_D1.5690.97
37_A171_L1.5390.97
96_I162_V1.5370.96
259_V285_I1.5280.96
99_A169_L1.5190.96
105_R175_K1.5130.96
77_I129_E1.4190.94
93_R164_S1.4120.94
154_G168_T1.3880.94
104_W111_E1.3860.94
261_E264_I1.3350.92
98_L112_L1.3250.92
103_T175_K1.3230.92
147_A163_M1.3060.92
22_F209_M1.2750.91
219_K286_E1.2540.90
282_V286_E1.2510.90
30_P40_V1.2500.90
225_V275_A1.2490.90
54_T71_T1.2320.89
87_I206_L1.2210.89
131_V160_I1.2100.88
77_I181_M1.2030.88
110_D136_L1.2010.88
227_D250_R1.1860.87
231_D234_I1.1770.87
83_V188_I1.1740.87
167_T171_L1.1730.87
232_G236_S1.1620.86
100_V112_L1.1400.85
122_K147_A1.1300.84
77_I80_S1.1280.84
227_D247_R1.1250.84
123_Y126_I1.1200.84
131_V134_R1.1160.84
98_L127_A1.0920.82
128_K140_V1.0820.82
42_T47_V1.0770.81
242_A248_L1.0770.81
112_L119_V1.0570.80
271_K274_A1.0520.80
49_L57_I1.0480.80
232_G275_A1.0430.79
55_E75_Y1.0400.79
235_N274_A1.0240.78
95_K182_D1.0200.78
220_M257_I1.0160.77
246_T257_I1.0150.77
223_M237_L1.0110.77
10_P74_D1.0110.77
15_L185_A1.0080.77
210_K214_A0.9940.76
265_L282_V0.9860.75
223_M258_T0.9840.75
98_L160_I0.9800.75
71_T74_D0.9730.74
134_R178_D0.9690.74
229_K275_A0.9680.74
88_K186_V0.9620.73
151_P172_H0.9580.73
104_W175_K0.9580.73
225_V256_V0.9570.73
68_L206_L0.9540.73
211_G269_I0.9530.73
241_L279_D0.9470.72
107_N128_K0.9470.72
33_S37_A0.9390.72
10_P54_T0.9380.72
19_T91_F0.9340.71
99_A120_A0.9340.71
242_A250_R0.9310.71
14_R164_S0.9310.71
200_D204_L0.9290.71
30_P49_L0.9280.71
75_Y160_I0.9250.70
87_I213_I0.9250.70
77_I85_E0.9230.70
233_V237_L0.9190.70
163_M208_M0.9130.69
9_I20_L0.8990.68
244_A255_E0.8920.68
100_V177_I0.8910.68
146_A201_R0.8860.67
281_V285_I0.8780.66
73_H186_V0.8730.66
203_N206_L0.8700.66
231_D235_N0.8690.66
56_D143_I0.8670.65
119_V180_I0.8660.65
58_P96_I0.8660.65
46_G201_R0.8630.65
44_W201_R0.8630.65
26_V214_A0.8560.64
167_T211_G0.8520.64
238_P281_V0.8470.64
204_L270_A0.8460.64
107_N175_K0.8410.63
278_R285_I0.8400.63
77_I126_I0.8390.63
122_K163_M0.8340.62
109_V271_K0.8320.62
102_Q175_K0.8310.62
73_H77_I0.8270.62
62_E83_V0.8240.61
113_K136_L0.8210.61
6_K136_L0.8210.61
38_L143_I0.8180.61
25_S212_A0.8180.61
36_R69_G0.8170.61
12_K218_K0.8120.60
229_K245_I0.8110.60
70_I185_A0.8080.60
97_V179_V0.8060.60
232_G271_K0.8050.60
147_A208_M0.8050.60
82_D137_N0.8040.60
244_A248_L0.8030.59
192_N263_D0.8030.59
27_G120_A0.8010.59
151_P159_I0.7990.59
83_V86_L0.7970.59
35_D130_Y0.7970.59
165_T176_A0.7930.59
16_Q19_T0.7910.58
54_T96_I0.7910.58
16_Q143_I0.7910.58
163_M176_A0.7890.58
84_E192_N0.7860.58
102_Q129_E0.7850.58
149_V164_S0.7830.58
68_L109_V0.7740.57
86_L202_I0.7740.57
262_E287_K0.7740.57
160_I180_I0.7710.56
128_K210_K0.7680.56
110_D113_K0.7680.56
82_D251_S0.7670.56
224_N248_L0.7660.56
47_V58_P0.7660.56
41_P216_K0.7650.56
30_P100_V0.7610.55
115_K158_A0.7610.55
165_T173_G0.7610.55
39_I202_I0.7590.55
128_K137_N0.7570.55
225_V229_K0.7570.55
21_Q25_S0.7550.55
234_I249_S0.7460.54
9_I23_L0.7460.54
8_A66_T0.7450.54
171_L211_G0.7450.54
10_P71_T0.7450.54
14_R151_P0.7450.54
206_L210_K0.7420.54
141_V165_T0.7410.53
68_L202_I0.7400.53
144_S279_D0.7400.53
109_V134_R0.7380.53
227_D251_S0.7360.53
20_L24_Q0.7360.53
113_K135_E0.7330.53
36_R171_L0.7290.52
125_N129_E0.7270.52
164_S176_A0.7260.52
84_E199_A0.7250.52
5_L167_T0.7240.52
105_R132_R0.7220.52
91_F185_A0.7190.51
30_P172_H0.7180.51
120_A156_A0.7160.51
224_N243_P0.7150.51
41_P68_L0.7150.51
124_Y171_L0.7100.50
12_K26_V0.7080.50
143_I147_A0.7070.50
73_H181_M0.7050.50
39_I282_V0.7030.50
8_A282_V0.7020.50
226_P252_D0.7010.49
120_A141_V0.7010.49
101_P105_R0.6990.49
23_L49_L0.6990.49
59_N141_V0.6980.49
129_E192_N0.6940.49
57_I118_R0.6920.49
7_I49_L0.6910.48
231_D250_R0.6910.48
63_T284_D0.6880.48
48_Q167_T0.6860.48
225_V230_L0.6860.48
224_N278_R0.6860.48
85_E88_K0.6850.48
248_L253_I0.6830.48
97_V147_A0.6790.47
58_P79_S0.6780.47
96_I123_Y0.6770.47
233_V259_V0.6760.47
28_I47_V0.6760.47
164_S168_T0.6750.47
169_L183_S0.6730.47
100_V105_R0.6720.47
189_G202_I0.6720.47
11_N60_I0.6710.46
99_A151_P0.6690.46
51_M171_L0.6690.46
36_R188_I0.6650.46
29_K213_I0.6650.46
54_T69_G0.6630.46
120_A143_I0.6580.45
262_E284_D0.6580.45
114_G137_N0.6560.45
228_N232_G0.6540.45
128_K229_K0.6540.45
37_A164_S0.6540.45
113_K232_G0.6530.45
53_R138_A0.6520.45
94_S146_A0.6510.44
69_G126_I0.6500.44
190_N193_W0.6470.44
73_H183_S0.6460.44
110_D263_D0.6450.44
220_M259_V0.6440.44
82_D113_K0.6430.44
247_R254_W0.6420.44
86_L230_L0.6420.44
192_N228_N0.6410.43
20_L30_P0.6390.43
69_G188_I0.6390.43
204_L274_A0.6300.42
77_I93_R0.6290.42
80_S135_E0.6280.42
239_A243_P0.6260.42
96_I144_S0.6230.42
169_L172_H0.6210.42
54_T75_Y0.6170.41
38_L42_T0.6150.41
151_P156_A0.6150.41
23_L209_M0.6140.41
220_M283_I0.6140.41
61_V69_G0.6110.41
151_P222_F0.6080.40
112_L121_T0.6070.40
264_I271_K0.6050.40
131_V136_L0.6020.40
94_S162_V0.6000.40
208_M270_A0.5980.39
139_K231_D0.5980.39
118_R165_T0.5970.39
217_G245_I0.5960.39
80_S125_N0.5950.39
137_N271_K0.5950.39
67_E198_E0.5940.39
52_I248_L0.5940.39
95_K177_I0.5940.39
17_Q264_I0.5920.39
14_R127_A0.5910.39
132_R137_N0.5910.39
43_S115_K0.5910.39
189_G199_A0.5900.39
193_W202_I0.5860.38
109_V178_D0.5850.38
51_M191_R0.5850.38
54_T171_L0.5840.38
14_R28_I0.5830.38
14_R18_P0.5810.38
26_V160_I0.5800.38
125_N235_N0.5790.38
14_R78_E0.5790.38
203_N274_A0.5780.37
130_Y134_R0.5770.37
224_N244_A0.5770.37
86_L194_I0.5770.37
42_T49_L0.5760.37
40_V172_H0.5760.37
226_P275_A0.5760.37
52_I57_I0.5750.37
69_G96_I0.5750.37
12_K74_D0.5740.37
29_K87_I0.5730.37
220_M281_V0.5720.37
73_H184_Y0.5700.37
17_Q184_Y0.5700.37
152_S165_T0.5690.37
50_V151_P0.5680.36
86_L206_L0.5670.36
119_V158_A0.5660.36
221_I261_E0.5660.36
125_N133_R0.5660.36
227_D249_S0.5650.36
74_D266_P0.5640.36
140_V171_L0.5630.36
53_R169_L0.5590.36
119_V217_G0.5580.36
26_V218_K0.5570.35
71_T131_V0.5570.35
129_E275_A0.5560.35
259_V281_V0.5550.35
125_N132_R0.5540.35
23_L93_R0.5530.35
51_M268_V0.5520.35
159_I178_D0.5510.35
200_D203_N0.5500.35
8_A57_I0.5490.35
44_W167_T0.5490.35
53_R99_A0.5470.35
84_E189_G0.5470.35
28_I49_L0.5460.34
137_N228_N0.5460.34
124_Y174_L0.5460.34
28_I144_S0.5450.34
76_V236_S0.5440.34
226_P242_A0.5420.34
93_R182_D0.5420.34
240_M250_R0.5410.34
211_G279_D0.5410.34
6_K18_P0.5400.34
143_I150_M0.5370.34
190_N268_V0.5370.34
74_D123_Y0.5350.34
54_T74_D0.5340.33
223_M239_A0.5340.33
129_E193_W0.5300.33
192_N245_I0.5300.33
138_A160_I0.5270.33
6_K80_S0.5270.33
260_A268_V0.5270.33
24_Q180_I0.5270.33
56_D239_A0.5250.33
38_L56_D0.5250.33
221_I265_L0.5240.33
10_P13_G0.5230.32
80_S128_K0.5230.32
215_A269_I0.5220.32
252_D279_D0.5220.32
172_H284_D0.5210.32
121_T150_M0.5200.32
58_P81_A0.5200.32
102_Q255_E0.5160.32
219_K282_V0.5150.32
6_K284_D0.5140.32
243_P248_L0.5130.32
139_K228_N0.5120.31
61_V190_N0.5110.31
129_E234_I0.5100.31
238_P258_T0.5100.31
40_V149_V0.5090.31
104_W115_K0.5090.31
108_S177_I0.5080.31
56_D150_M0.5070.31
193_W199_A0.5060.31
10_P266_P0.5050.31
172_H221_I0.5040.31
222_F283_I0.5040.31
19_T44_W0.5040.31
122_K208_M0.5040.31
103_T107_N0.5030.31
80_S271_K0.5020.31
123_Y265_L0.5010.31
65_A68_L0.5000.30
147_A150_M0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h3dA 4 0.9621 100 0.09 Contact Map
1nh8A 5 0.9483 100 0.092 Contact Map
2vd3A 5 0.9862 100 0.093 Contact Map
2vd2A 2 0.7207 100 0.34 Contact Map
1z7mE 2 0.6966 100 0.358 Contact Map
1ve4A 1 0.6897 100 0.359 Contact Map
1o63A 2 0.7 100 0.361 Contact Map
3qslA 1 0.9276 99 0.883 Contact Map
4nmyA 1 0.9103 98.8 0.892 Contact Map
3ix1A 2 0.8931 98.8 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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