GREMLIN Database
SYL2 - Leucine--tRNA ligase 2
UniProt: O33768 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 944 (814)
Sequences: 762 (464)
Seq/√Len: 16.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_F150_F8.6851.00
63_R711_T5.9031.00
458_A595_I5.6641.00
10_T14_E5.1571.00
60_K65_Y4.8821.00
13_E131_R4.4291.00
16_K19_E4.0861.00
541_D544_M4.0161.00
559_I564_I3.9981.00
395_L410_F3.9661.00
240_S264_E3.9481.00
345_K349_E3.9011.00
235_M268_K3.8131.00
235_M270_K3.6421.00
550_L554_S3.6371.00
758_T782_Q3.3830.99
540_W544_M3.3660.99
62_M765_T3.3500.99
550_L553_I3.1610.99
697_K800_D3.1150.99
546_G550_L3.1100.99
577_L594_F3.0840.99
534_K540_W3.0090.98
9_Q770_H2.9660.98
250_E268_K2.9450.98
547_I550_L2.9130.98
206_N209_K2.8960.98
540_W543_V2.8530.98
57_A67_V2.8470.98
544_M550_L2.8110.97
535_L540_W2.7830.97
594_F611_I2.7410.97
534_K538_E2.7350.97
176_W181_H2.6430.96
539_F542_Y2.6370.96
546_G549_N2.6320.96
535_L541_D2.5940.96
546_G554_S2.5800.96
409_N413_S2.5700.96
552_E555_E2.5540.96
536_T541_D2.5390.95
530_L534_K2.5270.95
530_L541_D2.5240.95
536_T540_W2.5190.95
714_M767_F2.5150.95
321_K356_D2.4950.95
538_E541_D2.4920.95
346_D350_K2.4780.95
652_S723_V2.4740.95
534_K541_D2.4530.94
468_I610_A2.4520.94
543_V546_G2.4490.94
530_L535_L2.4400.94
549_N554_S2.4400.94
111_R117_F2.4310.94
398_L406_L2.4140.94
95_I98_F2.3950.94
11_R777_H2.3800.93
536_T542_Y2.3780.93
532_P536_T2.3600.93
539_F543_V2.3460.93
462_L480_I2.3440.93
283_I411_L2.3230.93
524_K567_F2.3010.92
541_D545_L2.2830.92
541_D546_G2.2810.92
534_K542_Y2.2790.92
547_I554_S2.2600.91
535_L544_M2.2560.91
542_Y545_L2.2380.91
544_M549_N2.2020.90
708_S796_G2.1960.90
15_D785_Y2.1610.89
536_T539_F2.1590.89
535_L539_F2.1490.89
545_L548_G2.1360.89
127_K131_R2.1350.89
535_L543_V2.1150.88
530_L544_M2.1120.88
532_P541_D2.1010.88
535_L538_E2.0910.88
550_L555_E2.0840.88
158_F506_I2.0830.88
99_K103_E2.0710.87
531_S536_T2.0660.87
539_F544_M2.0630.87
95_I99_K2.0570.87
530_L538_E2.0560.87
394_S410_F2.0370.86
532_P540_W2.0310.86
530_L536_T2.0270.86
544_M554_S2.0250.86
58_R136_G2.0110.86
538_E542_Y2.0090.86
545_L550_L2.0050.86
275_V292_G2.0030.85
532_P538_E2.0000.85
362_L365_Y1.9920.85
764_I772_A1.9790.85
178_P437_V1.9720.85
544_M547_I1.9680.84
95_I103_E1.9560.84
532_P535_L1.9380.83
530_L540_W1.9120.83
577_L611_I1.9040.82
32_T577_L1.8950.82
536_T543_V1.8850.82
542_Y546_G1.8800.82
367_Y371_Y1.8780.81
5_A643_V1.8750.81
534_K544_M1.8710.81
231_N234_E1.8670.81
371_Y376_L1.8640.81
458_A461_S1.8600.81
96_E100_D1.8490.80
531_S534_K1.8490.80
532_P542_Y1.8420.80
540_W546_G1.8370.80
551_E554_S1.8370.80
535_L542_Y1.8350.80
530_L542_Y1.8280.80
549_N553_I1.8240.79
549_N552_E1.8080.79
11_R15_D1.7960.78
160_K163_S1.7950.78
533_S536_T1.7920.78
551_E555_E1.7780.78
534_K543_V1.7780.78
708_S712_R1.7660.77
542_Y550_L1.7600.77
278_K287_H1.7480.76
540_W545_L1.7460.76
538_E544_M1.7350.76
59_Y715_E1.7210.75
55_I651_S1.7190.75
542_Y548_G1.7050.75
701_S804_L1.6890.74
372_N376_L1.6850.74
546_G553_I1.6810.73
711_T791_W1.6810.73
546_G551_E1.6740.73
465_I595_I1.6640.73
168_V448_D1.6560.72
784_T789_E1.6530.72
711_T715_E1.6490.72
460_K463_S1.6380.71
547_I553_I1.6340.71
452_K456_E1.6290.71
540_W550_L1.6230.71
530_L533_S1.6220.71
534_K539_F1.6200.71
530_L539_F1.6180.70
252_A255_K1.6150.70
169_K443_D1.6020.70
536_T544_M1.6000.70
532_P544_M1.5960.69
476_F480_I1.5720.68
543_V550_L1.5720.68
537_Q544_M1.5660.68
367_Y374_G1.5620.68
459_R481_E1.5560.67
535_L545_L1.5520.67
703_I759_I1.5500.67
546_G552_E1.5490.67
537_Q540_W1.5460.67
544_M553_I1.5450.67
541_D555_E1.5430.67
465_I593_F1.5410.67
541_D547_I1.5350.66
687_Y690_D1.5320.66
548_G551_E1.5270.66
132_E639_K1.5210.66
98_F103_E1.5160.65
543_V548_G1.5110.65
425_N429_Y1.5110.65
158_F597_N1.5090.65
537_Q541_D1.5000.64
708_S794_V1.5000.64
535_L546_G1.4910.64
530_L543_V1.4900.64
544_M548_G1.4870.64
815_E819_S1.4810.63
762_K789_E1.4760.63
133_I646_M1.4750.63
541_D550_L1.4680.63
3_N7_K1.4610.62
687_Y691_I1.4530.62
548_G554_S1.4500.62
532_P543_V1.4460.62
411_L414_K1.4410.61
159_H537_Q1.4390.61
538_E543_V1.4380.61
456_E460_K1.4370.61
542_Y554_S1.4330.61
536_T546_G1.4320.61
547_I551_E1.4320.61
685_D688_T1.4270.60
258_F437_V1.4230.60
222_I306_M1.4190.60
231_N296_V1.4180.60
533_S537_Q1.4150.60
531_S535_L1.4100.59
59_Y711_T1.4070.59
3_N6_Y1.4060.59
486_R593_F1.4020.59
638_L643_V1.3960.59
62_M791_W1.3940.59
712_R716_A1.3910.58
541_D554_S1.3820.58
532_P539_F1.3810.58
544_M552_E1.3760.58
542_Y555_E1.3720.57
212_F274_L1.3650.57
388_Y400_V1.3600.57
531_S541_D1.3570.56
267_E273_K1.3530.56
274_L290_V1.3480.56
213_P306_M1.3470.56
491_T504_W1.3430.56
710_T726_L1.3400.55
539_F546_G1.3390.55
62_M762_K1.3390.55
296_V602_F1.3380.55
229_W307_S1.3370.55
463_S477_E1.3330.55
543_V554_S1.3260.55
548_G553_I1.3210.54
34_A577_L1.3180.54
60_K63_R1.3150.54
455_K459_R1.3110.54
539_F545_L1.3080.54
399_P402_K1.3070.54
547_I552_E1.2980.53
776_W780_L1.2960.53
579_I610_A1.2930.53
548_G552_E1.2930.53
533_S544_M1.2920.53
538_E546_G1.2890.53
735_D738_F1.2870.52
18_Y58_R1.2860.52
537_Q542_Y1.2820.52
461_S599_A1.2820.52
758_T762_K1.2810.52
398_L402_K1.2790.52
545_L549_N1.2760.52
6_Y639_K1.2730.52
527_Q531_S1.2680.51
199_E203_I1.2600.51
701_S704_Y1.2580.51
541_D548_G1.2580.51
531_S538_E1.2530.50
544_M555_E1.2520.50
42_W126_I1.2460.50
15_D789_E1.2460.50
543_V547_I1.2440.50
58_R67_V1.2410.50
538_E545_L1.2410.50
543_V555_E1.2410.50
59_Y63_R1.2400.50
740_M807_H1.2390.50
534_K546_G1.2350.49
480_I596_F1.2350.49
187_H586_L1.2300.49
462_L477_E1.2290.49
34_A727_L1.2280.49
96_E103_E1.2230.49
152_S521_I1.2220.49
565_K569_E1.2170.48
241_M246_M1.2090.48
697_K817_I1.2080.48
533_S541_D1.2070.48
761_L772_A1.2060.48
83_M115_P1.2040.48
534_K537_Q1.2040.48
583_G628_L1.2030.48
371_Y375_V1.2020.47
347_V370_E1.1970.47
531_S542_Y1.1970.47
425_N428_V1.1950.47
561_S565_K1.1910.47
367_Y376_L1.1900.47
185_G617_V1.1880.47
367_Y370_E1.1870.47
556_K609_K1.1840.46
279_V290_V1.1820.46
637_G646_M1.1820.46
94_L99_K1.1780.46
94_L98_F1.1770.46
545_L554_S1.1760.46
535_L550_L1.1750.46
127_K142_E1.1710.46
582_S586_L1.1700.46
58_R628_L1.1680.45
533_S538_E1.1660.45
533_S542_Y1.1660.45
94_L97_T1.1640.45
559_I562_N1.1590.45
175_G438_V1.1560.45
212_F247_I1.1490.44
544_M551_E1.1470.44
546_G555_E1.1450.44
367_Y375_V1.1420.44
707_T759_I1.1410.44
533_S540_W1.1350.44
535_L554_S1.1310.43
34_A227_A1.1310.43
562_N775_I1.1310.43
283_I410_F1.1290.43
542_Y547_I1.1250.43
279_V288_I1.1200.43
539_F555_E1.1200.43
543_V549_N1.1190.43
233_S270_K1.1190.43
538_E555_E1.1180.43
266_E691_I1.1150.42
521_I597_N1.1140.42
622_K628_L1.1140.42
541_D551_E1.1110.42
461_S465_I1.1090.42
537_Q543_V1.1030.42
833_I836_L1.1030.42
571_F575_Y1.1010.42
96_E99_K1.1010.42
58_R421_F1.0990.42
582_S585_D1.0980.41
59_Y167_I1.0950.41
572_L606_L1.0950.41
234_E298_V1.0930.41
29_F799_M1.0900.41
709_S725_E1.0890.41
539_F550_L1.0830.41
98_F102_Y1.0810.40
207_S210_G1.0800.40
347_V351_N1.0740.40
734_L738_F1.0740.40
640_M664_E1.0740.40
12_W36_P1.0690.40
136_G787_V1.0680.40
177_C432_C1.0670.40
602_F606_L1.0660.40
226_T309_P1.0660.40
542_Y551_E1.0610.39
46_H490_R1.0600.39
455_K481_E1.0590.39
736_E740_M1.0580.39
553_I556_K1.0570.39
540_W548_G1.0510.39
558_G563_I1.0480.39
528_Y531_S1.0480.39
9_Q12_W1.0460.39
457_L460_K1.0430.38
232_P295_F1.0390.38
403_G407_I1.0380.38
39_N617_V1.0340.38
28_K578_D1.0340.38
533_S543_V1.0320.38
167_I452_K1.0310.38
540_W555_E1.0300.38
342_A345_K1.0280.38
534_K545_L1.0260.37
43_H46_H1.0250.37
17_I62_M1.0230.37
542_Y552_E1.0210.37
554_S557_T1.0210.37
681_F775_I1.0190.37
543_V551_E1.0180.37
553_I558_G1.0130.37
518_Y522_S1.0130.37
759_I763_L1.0130.37
658_S665_S1.0120.37
736_E807_H1.0120.37
568_R572_L1.0070.36
542_Y553_I1.0070.36
7_K774_E1.0060.36
766_P792_P1.0040.36
540_W554_S1.0020.36
67_V285_G1.0020.36
516_M580_R0.9990.36
540_W547_I0.9990.36
290_V387_E0.9990.36
225_A306_M0.9980.36
831_I834_Y0.9970.36
376_L386_E0.9960.36
688_T691_I0.9960.36
14_E802_L0.9940.36
122_F161_L0.9930.36
335_T341_N0.9880.35
581_H614_N0.9880.35
133_I638_L0.9870.35
567_F570_E0.9860.35
237_V265_I0.9850.35
642_G645_V0.9850.35
94_L103_E0.9850.35
545_L553_I0.9840.35
175_G189_T0.9830.35
132_E638_L0.9820.35
97_T101_I0.9790.35
505_I512_S0.9790.35
519_Y523_H0.9790.35
545_L555_E0.9770.35
93_E98_F0.9750.35
15_D777_H0.9720.35
18_Y787_V0.9700.34
155_T159_H0.9690.34
491_T503_K0.9680.34
543_V552_E0.9680.34
565_K568_R0.9670.34
516_M520_T0.9640.34
765_T786_I0.9630.34
465_I786_I0.9610.34
360_K364_E0.9600.34
428_V562_N0.9590.34
38_P42_W0.9580.34
398_L472_S0.9560.34
123_K146_I0.9560.34
799_M804_L0.9480.33
448_D451_N0.9470.33
619_Y628_L0.9470.33
144_T469_P0.9460.33
195_P426_K0.9450.33
206_N280_E0.9450.33
38_P596_F0.9440.33
530_L537_Q0.9440.33
318_Y356_D0.9430.33
62_M269_I0.9400.33
711_T763_L0.9400.33
370_E374_G0.9380.33
537_Q546_G0.9380.33
593_F602_F0.9370.33
370_E376_L0.9360.33
73_F142_E0.9350.33
541_D549_N0.9350.33
514_I517_A0.9340.33
84_A770_H0.9330.32
165_G545_L0.9300.32
447_L728_F0.9300.32
648_I768_A0.9280.32
75_Y583_G0.9280.32
828_P834_Y0.9270.32
186_M584_K0.9220.32
208_E240_S0.9150.32
356_D365_Y0.9150.32
831_I835_A0.9120.31
707_T763_L0.9120.31
796_G801_E0.9110.31
764_I768_A0.9100.31
397_G400_V0.9080.31
368_R371_Y0.9070.31
367_Y372_N0.9010.31
239_A248_L0.9010.31
681_F757_L0.9010.31
755_E758_T0.9000.31
37_Y43_H0.8990.31
202_L213_P0.8970.31
320_K588_P0.8970.31
187_H582_S0.8950.31
448_D485_K0.8930.30
108_V111_R0.8930.30
37_Y45_G0.8920.30
465_I611_I0.8920.30
547_I555_E0.8910.30
530_L546_G0.8910.30
566_E569_E0.8900.30
316_Y320_K0.8900.30
684_L753_L0.8880.30
532_P537_Q0.8870.30
18_Y443_D0.8860.30
11_R715_E0.8860.30
461_S595_I0.8820.30
533_S539_F0.8820.30
47_G133_I0.8810.30
31_T53_G0.8790.30
687_Y799_M0.8790.30
546_G568_R0.8780.30
402_K406_L0.8760.30
200_F203_I0.8750.30
318_Y321_K0.8730.29
93_E103_E0.8720.29
531_S539_F0.8720.29
272_S275_V0.8700.29
536_T545_L0.8700.29
368_R372_N0.8690.29
163_S707_T0.8680.29
388_Y403_G0.8660.29
377_R602_F0.8620.29
10_T13_E0.8590.29
735_D739_G0.8590.29
372_N375_V0.8580.29
528_Y536_T0.8570.29
351_N365_Y0.8570.29
87_I118_M0.8570.29
227_A307_S0.8550.29
489_A504_W0.8550.29
38_P48_R0.8540.29
38_P126_I0.8540.29
3_N14_E0.8540.29
238_V247_I0.8540.29
30_F34_A0.8530.29
95_I101_I0.8530.29
179_V720_R0.8520.28
185_G492_R0.8510.28
96_E101_I0.8510.28
535_L547_I0.8510.28
97_T100_D0.8480.28
831_I836_L0.8470.28
32_T580_R0.8470.28
506_I510_S0.8470.28
361_K364_E0.8460.28
536_T550_L0.8460.28
472_S613_V0.8450.28
707_T794_V0.8450.28
372_N377_R0.8440.28
375_V386_E0.8430.28
536_T555_E0.8430.28
175_G613_V0.8420.28
514_I601_I0.8420.28
530_L552_E0.8410.28
110_P497_P0.8410.28
642_G827_T0.8390.28
4_I496_T0.8350.28
543_V553_I0.8350.28
95_I102_Y0.8350.28
173_P249_S0.8340.28
541_D553_I0.8300.27
320_K324_K0.8290.27
483_L592_T0.8280.27
98_F101_I0.8260.27
559_I563_I0.8250.27
682_K778_E0.8240.27
539_F553_I0.8230.27
489_A502_K0.8220.27
127_K709_S0.8210.27
539_F548_G0.8200.27
614_N626_K0.8190.27
457_L603_Q0.8180.27
581_H631_I0.8180.27
387_E399_P0.8170.27
762_K765_T0.8160.27
358_D371_Y0.8140.27
536_T554_S0.8130.27
534_K548_G0.8120.27
104_I110_P0.8120.27
529_K534_K0.8090.26
99_K102_Y0.8090.26
701_S795_E0.8090.26
462_L467_V0.8080.26
458_A674_L0.8070.26
437_V637_G0.8070.26
62_M790_G0.8060.26
567_F571_F0.8060.26
506_I513_T0.8030.26
250_E265_I0.8030.26
32_T37_Y0.8030.26
336_V343_L0.8030.26
456_E459_R0.8010.26
159_H163_S0.8000.26
183_P650_V0.7990.26
676_K683_S0.7980.26
152_S155_T0.7980.26
386_E400_V0.7980.26
58_R469_P0.7980.26
193_V436_I0.7970.26
187_H585_D0.7960.26
93_E99_K0.7950.26
425_N430_C0.7950.26
393_K396_G0.7930.26
373_K377_R0.7920.26
550_L556_K0.7910.26
143_F580_R0.7910.26
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80_I667_V0.5180.15
163_S572_L0.5170.15
779_I791_W0.5170.15
396_G561_S0.5170.15
133_I403_G0.5170.15
190_K657_G0.5170.15
527_Q535_L0.5170.15
362_L367_Y0.5160.15
551_E561_S0.5160.15
175_G645_V0.5160.15
99_K293_A0.5160.15
386_E404_R0.5160.15
150_F346_D0.5150.15
3_N273_K0.5150.15
107_D709_S0.5150.15
472_S480_I0.5150.15
485_K765_T0.5150.15
167_I447_L0.5150.15
189_T192_D0.5140.15
29_F610_A0.5140.15
707_T801_E0.5140.15
365_Y404_R0.5140.15
104_I775_I0.5130.15
232_P358_D0.5130.15
75_Y126_I0.5120.15
264_E465_I0.5120.15
316_Y330_I0.5120.15
247_I274_L0.5120.15
685_D691_I0.5110.15
235_M777_H0.5110.15
706_I725_E0.5110.15
11_R783_K0.5110.15
24_P812_R0.5110.15
247_I610_A0.5110.15
69_F137_I0.5110.15
530_L555_E0.5110.15
506_I509_L0.5100.15
398_L403_G0.5100.15
293_A312_A0.5100.15
408_T419_K0.5100.15
331_I334_I0.5090.15
231_N421_F0.5090.15
340_G584_K0.5090.15
776_W789_E0.5090.15
413_S552_E0.5080.15
834_Y837_N0.5080.15
388_Y806_E0.5080.15
7_K176_W0.5080.15
707_T784_T0.5080.15
235_M250_E0.5070.15
288_I788_N0.5060.15
66_N785_Y0.5060.15
230_I765_T0.5060.15
32_T679_E0.5050.15
204_Y276_G0.5050.15
428_V750_N0.5050.15
456_E831_I0.5040.15
550_L557_T0.5040.15
107_D691_I0.5030.15
615_G722_A0.5030.15
170_D498_L0.5030.15
361_K365_Y0.5030.15
536_T548_G0.5020.15
540_W553_I0.5020.15
692_L746_R0.5020.15
21_N570_E0.5020.15
534_K554_S0.5020.15
341_N789_E0.5010.15
510_S568_R0.5010.15
692_L697_K0.5010.15
250_E765_T0.5010.15
238_V267_E0.5000.15
211_I214_A0.5000.15
508_S626_K0.5000.15
490_R493_G0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wz2A 1 0.9587 100 0.31 Contact Map
1wkbA 1 0.7977 100 0.419 Contact Map
1ffyA 1 0.8739 100 0.423 Contact Map
1gaxA 1 0.8665 100 0.449 Contact Map
1ileA 1 0.7998 100 0.459 Contact Map
2v0cA 1 0.7034 100 0.51 Contact Map
4arcA 1 0.7288 100 0.521 Contact Map
3ziuA 1 0.6028 100 0.629 Contact Map
1rqgA 2 0.5826 100 0.714 Contact Map
4qreA 1 0.5159 100 0.724 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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