GREMLIN Database
HMDH - 3-hydroxy-3-methylglutaryl-coenzyme A reductase
UniProt: O08424 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (356)
Sequences: 1416 (819)
Seq/√Len: 43.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_N374_E6.0891.00
83_N121_A4.8201.00
164_S167_G4.4811.00
330_V377_A4.3501.00
337_V376_I4.0511.00
153_L171_S4.0481.00
157_R169_L3.8451.00
81_R90_D3.7821.00
296_T306_V3.5181.00
152_N155_K3.4861.00
113_V119_V3.4581.00
116_S251_K3.2081.00
232_T331_T3.0601.00
85_D371_K3.0241.00
63_A103_I2.9711.00
156_I205_V2.9301.00
249_L325_D2.8241.00
74_L352_A2.8051.00
93_V379_T2.7951.00
157_R161_N2.7781.00
121_A246_A2.7601.00
335_L377_A2.6871.00
300_I306_V2.6591.00
372_L376_I2.6141.00
82_V375_I2.5911.00
121_A374_E2.5701.00
145_F181_V2.5051.00
299_F376_I2.4711.00
156_I208_F2.3991.00
296_T309_I2.1851.00
153_L157_R2.1811.00
298_I376_I2.1741.00
291_F315_G2.0400.99
77_V80_I2.0300.99
262_N265_L1.9630.99
185_F205_V1.9420.99
90_D114_T1.9350.99
35_L39_K1.9230.99
251_K254_V1.9220.99
161_N169_L1.9210.99
95_M106_V1.9140.99
76_I355_I1.8670.99
91_F371_K1.8580.99
116_S254_V1.8550.99
72_I96_A1.8540.99
130_R202_V1.8480.99
175_F184_R1.8360.99
95_M298_I1.8350.98
82_V93_V1.8200.98
146_L150_E1.8190.98
256_R262_N1.8150.98
159_I208_F1.8130.98
252_K263_A1.8120.98
299_F309_I1.8110.98
155_K158_N1.7920.98
332_L377_A1.7830.98
95_M297_A1.7820.98
198_V202_V1.7730.98
113_V248_A1.7610.98
77_V107_N1.7560.98
74_L96_A1.7530.98
119_V382_S1.7510.98
97_T306_V1.7340.98
121_A377_A1.7330.98
208_F211_E1.7210.98
70_I74_L1.6910.97
136_F145_F1.6860.97
299_F304_Q1.6610.97
292_A313_S1.6230.97
225_M285_S1.6220.97
227_S282_G1.6090.97
264_Q321_V1.5800.96
371_K375_I1.5510.96
70_I96_A1.5260.95
298_I379_T1.5260.95
29_A32_A1.5250.95
187_F201_A1.5250.95
302_T356_M1.5250.95
113_V250_I1.5060.95
37_L41_V1.5040.95
191_D353_L1.4760.94
30_M34_R1.4690.94
354_S359_Y1.4650.94
295_V332_L1.4590.94
141_Q144_N1.4520.94
252_K324_E1.4500.94
170_K188_E1.4420.94
109_G386_N1.4150.93
270_N385_L1.4000.93
81_R114_T1.3940.92
44_G354_S1.3930.92
339_T353_L1.3860.92
113_V116_S1.3760.92
263_A321_V1.3620.92
161_N168_K1.3600.91
169_L201_A1.3580.91
91_F375_I1.3570.91
120_R247_E1.3420.91
219_L273_K1.3410.91
77_V93_V1.3390.91
128_M226_C1.3360.91
154_E158_N1.3240.90
93_V298_I1.3120.90
230_K331_T1.3030.90
158_N162_S1.2950.89
75_G103_I1.2940.89
274_N278_T1.2910.89
141_Q215_S1.2720.88
199_T397_G1.2530.88
350_K354_S1.2510.88
75_G96_A1.2510.88
302_T339_T1.2320.87
97_T296_T1.2240.86
309_I313_S1.2220.86
270_N274_N1.2200.86
371_K374_E1.2190.86
350_K359_Y1.2120.86
264_Q324_E1.2100.86
127_E186_S1.1880.85
264_Q268_D1.1860.85
275_W279_A1.1850.85
308_Q336_E1.1800.84
252_K264_Q1.1750.84
189_T229_K1.1700.84
101_A199_T1.1690.84
37_L76_I1.1660.84
82_V356_M1.1580.83
91_F356_M1.1520.83
38_E45_L1.1520.83
209_I217_D1.1460.83
250_I385_L1.1430.82
271_L274_N1.1380.82
255_I263_A1.1280.81
100_G404_G1.1260.81
298_I302_T1.1230.81
210_E213_F1.1020.80
257_N263_A1.0930.79
80_I110_I1.0910.79
178_G275_W1.0900.79
207_E211_E1.0890.79
121_A378_S1.0820.79
231_Q283_S1.0810.79
159_I204_K1.0800.79
127_E228_D1.0780.78
266_I393_N1.0720.78
252_K325_D1.0550.77
131_A175_F1.0520.77
77_V379_T1.0430.76
182_W276_L1.0380.76
93_V375_I1.0380.76
368_N371_K1.0290.75
63_A75_G1.0180.74
246_A377_A1.0160.74
37_L40_I1.0150.74
169_L185_F1.0120.74
247_E329_S1.0070.74
394_K398_K0.9990.73
126_D189_T0.9950.73
32_A35_L0.9800.71
109_G385_L0.9650.70
383_G387_L0.9650.70
248_A407_M0.9630.70
155_K208_F0.9610.70
133_V180_N0.9600.70
108_R389_A0.9590.70
31_V35_L0.9590.70
387_L396_L0.9580.70
207_E210_E0.9570.70
82_V378_S0.9530.69
137_D217_D0.9520.69
226_C312_S0.9510.69
101_A403_L0.9480.69
82_V91_F0.9460.69
108_R112_A0.9430.68
229_K405_R0.9370.68
160_A201_A0.9310.67
312_S315_G0.9300.67
62_N128_M0.9290.67
200_I401_A0.9280.67
221_V397_G0.9230.67
77_V382_S0.9160.66
62_N346_L0.9160.66
267_H271_L0.9120.66
290_H383_G0.9090.66
135_K217_D0.9040.65
220_A391_L0.9010.65
203_E290_H0.9010.65
129_T186_S0.9000.65
66_V103_I0.8990.65
149_I323_G0.8970.65
356_M375_I0.8910.64
101_A397_G0.8870.64
312_S347_P0.8860.64
77_V106_V0.8850.64
345_R349_Q0.8840.63
84_G155_K0.8820.63
315_G380_V0.8810.63
68_G74_L0.8810.63
375_I379_T0.8800.63
358_V375_I0.8790.63
207_E215_S0.8770.63
126_D375_I0.8760.63
268_D271_L0.8720.62
80_I379_T0.8710.62
80_I93_V0.8650.62
339_T357_G0.8600.61
104_A193_M0.8540.61
228_D282_G0.8530.61
195_M308_Q0.8530.61
189_T218_C0.8500.60
113_V385_L0.8490.60
108_R343_G0.8490.60
112_A389_A0.8480.60
83_N371_K0.8430.60
159_I162_S0.8430.60
189_T386_N0.8360.59
187_F198_V0.8280.58
266_I389_A0.8280.58
85_D91_F0.8270.58
252_K267_H0.8250.58
28_A36_A0.8230.58
72_I103_I0.8220.58
104_A342_G0.8190.57
298_I356_M0.8160.57
93_V183_L0.8160.57
122_K247_E0.8130.57
134_F145_F0.8110.57
228_D313_S0.8110.57
247_E327_Y0.8100.57
356_M385_L0.8060.56
291_F380_V0.8060.56
369_A372_L0.8050.56
285_S315_G0.8010.56
195_M222_S0.7950.55
126_D229_K0.7950.55
102_L386_N0.7930.55
276_L279_A0.7920.55
111_K258_I0.7880.55
136_F266_I0.7870.54
200_I397_G0.7870.54
72_I144_N0.7860.54
168_K188_E0.7850.54
187_F202_V0.7820.54
123_V374_E0.7810.54
302_T352_A0.7780.54
229_K373_A0.7760.53
168_K221_V0.7750.53
141_Q214_P0.7750.53
285_S336_E0.7710.53
75_G104_A0.7700.53
296_T310_V0.7690.53
212_N300_I0.7660.52
77_V82_V0.7650.52
31_V40_I0.7650.52
127_E170_K0.7630.52
193_M288_N0.7630.52
128_M312_S0.7620.52
306_V310_V0.7620.52
290_H384_E0.7610.52
145_F215_S0.7600.52
322_R325_D0.7580.52
252_K323_G0.7570.52
80_I369_A0.7560.52
208_F212_N0.7560.52
373_A405_R0.7560.52
343_G349_Q0.7550.51
121_A392_S0.7540.51
290_H387_L0.7520.51
222_S396_L0.7520.51
265_L268_D0.7480.51
231_Q270_N0.7470.51
195_M273_K0.7450.50
229_K407_M0.7440.50
159_I354_S0.7440.50
160_A187_F0.7420.50
322_R327_Y0.7410.50
222_S226_C0.7410.50
203_E397_G0.7410.50
179_N275_W0.7370.50
147_K150_E0.7370.50
260_H395_E0.7360.50
126_D338_G0.7360.50
43_V48_I0.7360.50
72_I85_D0.7350.50
123_V331_T0.7340.49
267_H319_T0.7340.49
45_L49_G0.7300.49
129_T223_G0.7280.49
289_A387_L0.7260.49
149_I209_I0.7260.49
232_T329_S0.7250.49
294_I379_T0.7240.48
126_D190_G0.7210.48
28_A32_A0.7170.48
398_K402_K0.7130.47
285_S335_L0.7120.47
145_F209_I0.7110.47
100_G406_A0.7070.47
113_V117_G0.7060.47
358_V371_K0.7050.47
299_F335_L0.7020.46
165_H197_M0.7020.46
397_G401_A0.7000.46
70_I352_A0.7000.46
134_F183_L0.6970.46
321_V324_E0.6960.46
129_T226_C0.6950.46
59_K66_V0.6940.46
132_P205_V0.6930.46
191_D336_E0.6930.46
197_M343_G0.6910.45
191_D344_T0.6880.45
351_E355_I0.6850.45
112_A250_I0.6830.45
295_V309_I0.6820.44
246_A374_E0.6810.44
36_A40_I0.6810.44
128_M189_T0.6810.44
184_R312_S0.6800.44
120_R309_I0.6780.44
195_M396_L0.6740.44
42_G53_I0.6730.44
54_D59_K0.6710.43
101_A399_A0.6710.43
246_A330_V0.6700.43
134_F161_N0.6680.43
116_S250_I0.6670.43
313_S332_L0.6640.43
267_H321_V0.6610.43
352_A386_N0.6600.42
35_L209_I0.6600.42
62_N348_T0.6580.42
171_S174_P0.6570.42
172_I183_L0.6550.42
218_C323_G0.6520.42
359_Y375_I0.6480.41
148_F152_N0.6450.41
189_T197_M0.6430.41
246_A332_L0.6430.41
105_S187_F0.6420.41
43_V47_S0.6380.40
189_T346_L0.6370.40
112_A385_L0.6360.40
81_R350_K0.6350.40
270_N388_L0.6350.40
218_C225_M0.6340.40
227_S295_V0.6330.40
44_G155_K0.6320.40
131_A225_M0.6320.40
229_K338_G0.6290.40
197_M407_M0.6290.40
193_M308_Q0.6280.39
71_Q348_T0.6250.39
310_V317_T0.6240.39
287_F391_L0.6240.39
222_S273_K0.6230.39
128_M336_E0.6220.39
339_T356_M0.6210.39
72_I91_F0.6210.39
155_K159_I0.6200.39
132_P185_F0.6180.39
80_I107_N0.6170.38
332_L335_L0.6150.38
277_G287_F0.6140.38
150_E174_P0.6130.38
82_V121_A0.6120.38
118_G382_S0.6120.38
154_E157_R0.6120.38
66_V69_A0.6100.38
182_W316_Y0.6070.38
226_C230_K0.6060.37
71_Q198_V0.6050.37
275_W278_T0.6020.37
162_S204_K0.6020.37
308_Q396_L0.6020.37
197_M346_L0.6020.37
220_A273_K0.6020.37
63_A74_L0.6010.37
193_M203_E0.6000.37
222_S289_A0.6000.37
27_N385_L0.6000.37
197_M353_L0.5990.37
111_K115_L0.5990.37
206_C220_A0.5970.37
55_Y58_I0.5960.37
200_I299_F0.5960.37
111_K379_T0.5950.36
294_I380_V0.5930.36
294_I298_I0.5930.36
96_A185_F0.5920.36
229_K304_Q0.5900.36
355_I393_N0.5890.36
78_G92_Y0.5890.36
232_T279_A0.5890.36
395_E399_A0.5880.36
178_G320_E0.5870.36
120_R327_Y0.5870.36
72_I306_V0.5870.36
156_I160_A0.5870.36
97_T300_I0.5860.36
138_S268_D0.5850.36
57_E207_E0.5840.36
34_R231_Q0.5830.35
152_N212_N0.5830.35
126_D370_K0.5830.35
250_I377_A0.5830.35
78_G346_L0.5820.35
300_I355_I0.5820.35
253_D256_R0.5820.35
72_I90_D0.5810.35
95_M199_T0.5780.35
253_D262_N0.5780.35
210_E217_D0.5780.35
75_G342_G0.5780.35
149_I172_I0.5770.35
70_I348_T0.5760.35
151_E154_E0.5750.35
319_T388_L0.5740.35
268_D272_R0.5730.35
374_E378_S0.5720.34
392_S407_M0.5720.34
343_G347_P0.5720.34
251_K325_D0.5720.34
160_A169_L0.5710.34
335_L376_I0.5700.34
97_T297_A0.5700.34
98_T101_A0.5690.34
55_Y59_K0.5680.34
269_I392_S0.5670.34
101_A401_A0.5670.34
105_S397_G0.5660.34
67_I76_I0.5660.34
232_T278_T0.5630.34
156_I345_R0.5620.34
148_F151_E0.5610.34
74_L103_I0.5610.34
289_A396_L0.5600.33
82_V357_G0.5580.33
138_S141_Q0.5580.33
47_S54_D0.5580.33
343_G353_L0.5570.33
52_V337_V0.5570.33
380_V401_A0.5560.33
79_P206_C0.5560.33
291_F317_T0.5550.33
296_T300_I0.5550.33
330_V380_V0.5540.33
72_I97_T0.5530.33
37_L67_I0.5530.33
289_A388_L0.5530.33
149_I183_L0.5520.33
25_E28_A0.5510.33
104_A107_N0.5510.33
125_K170_K0.5500.33
39_K84_G0.5490.33
76_I181_V0.5480.32
273_K396_L0.5470.32
329_S368_N0.5470.32
216_A357_G0.5470.32
197_M228_D0.5450.32
303_G372_L0.5450.32
166_H221_V0.5430.32
48_I56_S0.5430.32
105_S108_R0.5420.32
222_S387_L0.5420.32
121_A247_E0.5420.32
202_V205_V0.5420.32
344_T353_L0.5420.32
75_G349_Q0.5410.32
179_N322_R0.5380.32
96_A311_E0.5380.32
222_S284_L0.5370.32
145_F149_I0.5370.32
135_K265_L0.5360.31
126_D407_M0.5360.31
248_A328_I0.5360.31
128_M197_M0.5350.31
46_P151_E0.5340.31
44_G47_S0.5340.31
370_K374_E0.5340.31
39_K44_G0.5330.31
270_N289_A0.5310.31
349_Q353_L0.5310.31
145_F183_L0.5310.31
348_T372_L0.5300.31
134_F352_A0.5300.31
131_A184_R0.5290.31
253_D257_N0.5290.31
299_F381_L0.5280.31
163_T167_G0.5280.31
147_K324_E0.5260.31
276_L385_L0.5260.31
159_I375_I0.5250.31
179_N320_E0.5250.31
203_E401_A0.5250.31
319_T328_I0.5230.30
154_E212_N0.5220.30
225_M369_A0.5210.30
43_V82_V0.5200.30
384_E387_L0.5190.30
169_L353_L0.5190.30
222_S380_V0.5190.30
112_A258_I0.5190.30
316_Y395_E0.5180.30
43_V354_S0.5170.30
151_E155_K0.5160.30
275_W379_T0.5150.30
203_E395_E0.5150.30
37_L162_S0.5130.30
142_I230_K0.5130.30
181_V276_L0.5130.30
65_N193_M0.5110.29
317_T321_V0.5090.29
140_E144_N0.5090.29
228_D339_T0.5090.29
31_V158_N0.5080.29
220_A269_I0.5080.29
199_T396_L0.5080.29
169_L346_L0.5080.29
187_F205_V0.5080.29
157_R172_I0.5070.29
338_G341_G0.5070.29
72_I310_V0.5050.29
155_K212_N0.5040.29
31_V38_E0.5040.29
289_A317_T0.5040.29
309_I381_L0.5030.29
31_V37_L0.5030.29
39_K154_E0.5010.29
192_A326_L0.5010.29
72_I303_G0.5010.29
151_E324_E0.5010.29
142_I181_V0.5000.29
137_D345_R0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r4fA 4 0.9535 100 0.137 Contact Map
3qaeA 2 0.8386 100 0.178 Contact Map
4i6yA 2 0.8582 100 0.192 Contact Map
3fxhA 2 0.2347 18.6 0.98 Contact Map
1qw2A 3 0.2494 10.2 0.982 Contact Map
4x9tA 1 0.3252 9.6 0.982 Contact Map
2jdjA 2 0.2421 8.9 0.982 Contact Map
2qpqA 1 0.3399 8.7 0.982 Contact Map
2dvzA 1 0.3399 8.6 0.982 Contact Map
2lw4A 1 0.1002 7.5 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.