GREMLIN Database
PURK - N5-carboxyaminoimidazole ribonucleotide synthase
UniProt: O06457 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (345)
Sequences: 23643 (13043)
Seq/√Len: 702.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_E160_D3.4681.00
118_R178_E3.2621.00
10_K33_T3.2091.00
159_N162_E3.1441.00
130_K164_Y3.0121.00
227_E231_R2.9851.00
249_V252_K2.8751.00
341_G346_E2.7581.00
81_E97_E2.6301.00
138_N160_D2.5851.00
230_R234_E2.5681.00
124_D127_E2.5441.00
120_Y135_E2.4531.00
54_S57_D2.4521.00
343_N346_E2.4171.00
81_E85_Y2.3271.00
109_Y232_L2.2281.00
283_R288_M2.2231.00
26_E29_K2.2181.00
223_Q227_E2.1241.00
158_F162_E2.0821.00
82_Y86_S2.0711.00
111_Q235_E2.0351.00
156_F179_Y1.9461.00
160_D164_Y1.9421.00
76_Y100_R1.9221.00
279_E283_R1.9161.00
59_K86_S1.9031.00
104_K107_L1.8601.00
218_G272_G1.8561.00
325_K328_V1.8521.00
13_I24_V1.8501.00
132_L136_F1.8471.00
224_N252_K1.8461.00
132_L135_E1.8071.00
342_N346_E1.7911.00
192_R198_F1.7881.00
107_L111_Q1.7781.00
164_Y168_R1.7701.00
228_I253_V1.7631.00
103_Y107_L1.7451.00
194_K239_V1.7421.00
97_E104_K1.7311.00
55_P82_Y1.7231.00
323_Y326_S1.7191.00
107_L110_R1.6991.00
280_Q291_G1.6971.00
103_Y121_V1.6891.00
130_K160_D1.6621.00
274_L296_L1.6271.00
98_L108_F1.6251.00
321_Y324_S1.6211.00
92_R95_S1.6061.00
125_G130_K1.6021.00
224_N227_E1.5951.00
57_D60_E1.5761.00
158_F181_K1.5681.00
27_G34_F1.5681.00
29_K279_E1.5581.00
140_G176_V1.5551.00
106_K177_E1.5341.00
191_A280_Q1.5241.00
302_V351_I1.5191.00
133_R138_N1.5111.00
110_R118_R1.5081.00
109_Y255_I1.5061.00
125_G164_Y1.5011.00
231_R234_E1.4961.00
186_A248_V1.4921.00
98_L104_K1.4841.00
131_I135_E1.4821.00
145_S173_K1.4801.00
26_E279_E1.4801.00
193_D197_V1.4751.00
226_V230_R1.4731.00
82_Y85_Y1.4621.00
55_P59_K1.4591.00
11_I89_L1.4431.00
125_G168_R1.4431.00
322_W325_K1.4321.00
120_Y132_L1.4311.00
84_E93_L1.4241.00
101_E145_S1.4241.00
165_Q169_E1.4201.00
222_N226_V1.4191.00
115_P252_K1.4191.00
130_K134_E1.4141.00
108_F111_Q1.4121.00
271_D338_N1.4111.00
191_A241_I1.4081.00
228_I231_R1.4071.00
319_K322_W1.4021.00
108_F112_H1.3981.00
319_K324_S1.3981.00
232_L235_E1.3911.00
105_E109_Y1.3771.00
108_F235_E1.3481.00
178_E254_L1.3411.00
271_D340_V1.3371.00
28_R50_D1.3341.00
112_H235_E1.3221.00
110_R116_T1.3211.00
56_Q82_Y1.3131.00
123_E127_E1.3111.00
191_A284_A1.3081.00
11_I27_G1.3071.00
25_L29_K1.3061.00
312_V316_K1.3041.00
125_G167_L1.3041.00
141_V156_F1.3031.00
94_N98_L1.3001.00
11_I32_F1.2881.00
123_E173_K1.2861.00
345_E349_Q1.2821.00
292_P295_I1.2821.00
107_L119_F1.2711.00
84_E92_R1.2651.00
53_F61_F1.2631.00
231_R235_E1.2591.00
30_Y283_R1.2541.00
198_F230_R1.2371.00
103_Y145_S1.2341.00
133_R140_G1.2311.00
190_I233_S1.2301.00
319_K323_Y1.2281.00
138_N159_N1.2221.00
131_I134_E1.2191.00
79_A83_A1.2091.00
10_K35_Y1.2081.00
180_V256_N1.2041.00
224_N228_I1.2021.00
12_G37_L1.1871.00
155_Y169_E1.1661.00
337_V354_I1.1651.00
320_V325_K1.1631.00
99_K258_F1.1601.00
68_I83_A1.1581.00
352_D356_Q1.1571.00
50_D53_F1.1551.00
121_V173_K1.1541.00
188_I225_I1.1541.00
126_E130_K1.1531.00
274_L294_T1.1521.00
323_Y327_E1.1521.00
346_E350_K1.1481.00
33_T51_R1.1471.00
324_S327_E1.1451.00
341_G350_K1.1411.00
339_V351_I1.1371.00
12_G62_V1.1341.00
305_L332_R1.1291.00
223_Q226_V1.1261.00
118_R135_E1.1241.00
83_A88_K1.1191.00
106_K116_T1.1181.00
190_I242_M1.1091.00
190_I229_A1.1081.00
92_R239_V1.1051.00
302_V336_H1.1021.00
23_I69_T1.1011.00
248_V253_V1.0981.00
138_N163_K1.0921.00
341_G347_V1.0921.00
184_F205_Y1.0911.00
110_R119_F1.0911.00
319_K326_S1.0891.00
141_V179_Y1.0881.00
313_E316_K1.0881.00
118_R136_F1.0861.00
83_A86_S1.0841.00
318_G321_Y1.0841.00
38_E43_A1.0811.00
155_Y166_F1.0751.00
31_P279_E1.0691.00
126_E131_I1.0681.00
228_I232_L1.0651.00
81_E94_N1.0631.00
321_Y325_K1.0611.00
10_K66_D1.0581.00
181_K250_N1.0561.00
348_K352_D1.0531.00
190_I244_V1.0521.00
308_D311_P1.0521.00
323_Y328_V1.0461.00
60_E63_D1.0441.00
129_L163_K1.0411.00
224_N231_R1.0391.00
195_R289_E1.0321.00
320_V324_S1.0311.00
161_V165_Q1.0281.00
136_F140_G1.0261.00
115_P228_I1.0251.00
32_F286_I1.0251.00
114_L255_I1.0211.00
127_E131_I1.0161.00
320_V323_Y1.0101.00
94_N97_E1.0061.00
192_R234_E1.0021.00
122_A132_L0.9921.00
350_K353_K0.9901.00
232_L236_L0.9901.00
81_E93_L0.9871.00
134_E164_Y0.9861.00
122_A129_L0.9831.00
199_I292_P0.9811.00
233_S236_L0.9791.00
209_E212_I0.9741.00
59_K82_Y0.9721.00
324_S328_V0.9681.00
270_L338_N0.9671.00
206_N212_I0.9651.00
188_I226_V0.9641.00
103_Y173_K0.9631.00
353_K356_Q0.9571.00
318_G326_S0.9551.00
31_P282_L0.9491.00
229_A244_V0.9461.00
312_V315_L0.9451.00
27_G282_L0.9441.00
275_I280_Q0.9391.00
202_P218_G0.9361.00
165_Q168_R0.9341.00
296_L340_V0.9321.00
282_L286_I0.9311.00
157_I166_F0.9301.00
30_Y279_E0.9291.00
262_V277_Q0.9281.00
81_E84_E0.9271.00
61_F65_S0.9241.00
322_W327_E0.9241.00
319_K327_E0.9221.00
99_K236_L0.9201.00
56_Q60_E0.9091.00
280_Q283_R0.9081.00
141_V154_Q0.9081.00
101_E146_K0.9021.00
140_G157_I0.9001.00
225_I228_I0.8941.00
320_V328_V0.8941.00
244_V258_F0.8891.00
80_L88_K0.8881.00
298_P342_N0.8871.00
11_I282_L0.8851.00
231_R236_L0.8821.00
181_K249_V0.8821.00
247_F256_N0.8811.00
229_A246_V0.8781.00
349_Q353_K0.8761.00
339_V354_I0.8761.00
36_V49_A0.8721.00
162_E165_Q0.8651.00
198_F234_E0.8641.00
228_I246_V0.8641.00
188_I229_A0.8611.00
129_L167_L0.8601.00
233_S242_M0.8601.00
142_I166_F0.8591.00
167_L174_M0.8571.00
44_P48_I0.8571.00
288_M291_G0.8561.00
69_T281_H0.8561.00
205_Y221_N0.8541.00
12_G65_S0.8521.00
142_I174_M0.8511.00
208_N213_L0.8501.00
322_W326_S0.8451.00
30_Y276_S0.8431.00
142_I157_I0.8431.00
10_K51_R0.8421.00
40_D43_A0.8381.00
133_R163_K0.8351.00
318_G322_W0.8341.00
27_G69_T0.8281.00
197_V234_E0.8271.00
318_G323_Y0.8221.00
208_N212_I0.8201.00
339_V347_V0.8181.00
49_A52_C0.8161.00
321_Y326_S0.8141.00
200_S226_V0.8131.00
92_R237_D0.8071.00
55_P79_A0.8051.00
227_E230_R0.8051.00
321_Y327_E0.8051.00
321_Y328_V0.8041.00
206_N209_E0.8031.00
180_V254_L0.8021.00
110_R120_Y0.8011.00
24_V34_F0.7991.00
95_S237_D0.7951.00
226_V229_A0.7941.00
180_V249_V0.7941.00
73_E76_Y0.7891.00
318_G325_K0.7891.00
315_L318_G0.7871.00
305_L355_M0.7861.00
229_A233_S0.7861.00
267_H270_L0.7851.00
104_K108_F0.7791.00
161_V164_Y0.7741.00
133_R137_N0.7731.00
191_A201_Y0.7711.00
43_A46_C0.7701.00
303_N306_G0.7691.00
192_R233_S0.7611.00
14_L79_A0.7601.00
178_E249_V0.7601.00
62_V68_I0.7601.00
146_K171_K0.7591.00
225_I253_V0.7591.00
184_F248_V0.7581.00
80_L84_E0.7551.00
115_P254_L0.7551.00
101_E173_K0.7531.00
13_I27_G0.7521.00
28_R34_F0.7521.00
239_V284_A0.7501.00
195_R287_G0.7451.00
312_V317_Y0.7451.00
10_K34_F0.7381.00
57_D61_F0.7381.00
346_E349_Q0.7371.00
202_P222_N0.7351.00
249_V254_L0.7341.00
145_S175_V0.7341.00
217_Y344_L0.7301.00
229_A232_L0.7271.00
196_G234_E0.7251.00
283_R291_G0.7211.00
215_Y218_G0.7121.00
313_E347_V0.7101.00
318_G324_S0.7091.00
84_E94_N0.7061.00
188_I203_P0.7061.00
298_P340_V0.7051.00
21_W47_R0.6991.00
300_G347_V0.6981.00
101_E104_K0.6971.00
53_F63_D0.6961.00
83_A87_G0.6951.00
301_M306_G0.6911.00
36_V47_R0.6911.00
136_F178_E0.6881.00
313_E317_Y0.6861.00
142_I167_L0.6851.00
26_E30_Y0.6851.00
345_E348_K0.6851.00
320_V327_E0.6831.00
59_K62_V0.6831.00
322_W328_V0.6811.00
32_F282_L0.6811.00
307_T310_I0.6791.00
320_V326_S0.6771.00
133_R160_D0.6751.00
189_I241_I0.6751.00
84_E239_V0.6751.00
75_V78_K0.6721.00
103_Y175_V0.6711.00
157_I163_K0.6691.00
38_E52_C0.6671.00
62_V83_A0.6651.00
192_R239_V0.6621.00
129_L176_V0.6611.00
226_V232_L0.6601.00
289_E292_P0.6591.00
27_G32_F0.6591.00
79_A82_Y0.6581.00
251_G254_L0.6531.00
34_F50_D0.6531.00
238_Y242_M0.6521.00
306_G310_I0.6511.00
35_Y65_S0.6511.00
84_E88_K0.6491.00
124_D167_L0.6491.00
49_A53_F0.6481.00
351_I355_M0.6451.00
178_E252_K0.6431.00
142_I176_V0.6421.00
205_Y217_Y0.6421.00
307_T311_P0.6421.00
319_K328_V0.6411.00
276_S279_E0.6411.00
129_L132_L0.6401.00
55_P62_V0.6401.00
314_V317_Y0.6391.00
241_I262_V0.6361.00
214_V217_Y0.6301.00
36_V61_F0.6281.00
257_E261_R0.6281.00
281_H285_I0.6271.00
125_G163_K0.6261.00
130_K168_R0.6251.00
189_I243_G0.6241.00
120_Y127_E0.6241.00
204_T216_N0.6231.00
306_G311_P0.6221.00
74_H77_E0.6201.00
122_A125_G0.6191.00
347_V351_I0.6181.00
157_I162_E0.6171.00
207_Y215_Y0.6161.00
10_K64_S0.6111.00
203_P220_Y0.6111.00
268_Y271_D0.6101.00
51_R63_D0.6091.00
283_R286_I0.6071.00
207_Y212_I0.6061.00
82_Y87_G0.6051.00
24_V49_A0.6041.00
107_L121_V0.6041.00
115_P224_N0.6011.00
58_Y83_A0.6011.00
158_F179_Y0.6011.00
319_K325_K0.5991.00
80_L83_A0.5961.00
196_G200_S0.5951.00
190_I200_S0.5951.00
282_L285_I0.5951.00
38_E41_K0.5951.00
117_P180_V0.5931.00
35_Y39_N0.5931.00
119_F177_E0.5931.00
197_V289_E0.5901.00
109_Y258_F0.5881.00
186_A225_I0.5871.00
39_N43_A0.5861.00
98_L111_Q0.5861.00
93_L97_E0.5861.00
339_V350_K0.5841.00
318_G327_E0.5821.00
306_G309_K0.5811.00
130_K133_R0.5801.00
300_G348_K0.5801.00
303_N311_P0.5801.00
58_Y61_F0.5791.00
26_E276_S0.5771.00
105_E255_I0.5761.00
142_I163_K0.5751.00
224_N253_V0.5741.00
180_V183_D0.5741.00
344_L348_K0.5731.00
214_V305_L0.5711.00
132_L176_V0.5711.00
218_G268_Y0.5691.00
34_F38_E0.5681.00
138_N158_F0.5681.00
96_V260_P0.5681.00
67_V285_I0.5671.00
317_Y350_K0.5651.00
244_V255_I0.5641.00
125_G129_L0.5641.00
38_E48_I0.5641.00
183_D250_N0.5631.00
274_L297_S0.5631.00
188_I200_S0.5621.00
318_G335_G0.5611.00
318_G328_V0.5601.00
198_F233_S0.5601.00
189_I204_T0.5601.00
186_A246_V0.5591.00
56_Q59_K0.5591.00
186_A220_Y0.5591.00
94_N237_D0.5541.00
162_E166_F0.5521.00
137_N160_D0.5521.00
95_S239_V0.5511.00
81_E86_S0.5461.00
301_M348_K0.5461.00
45_A48_I0.5451.00
108_F232_L0.5451.00
30_Y282_L0.5441.00
304_I307_T0.5431.00
200_S230_R0.5411.00
33_T50_D0.5411.00
62_V65_S0.5411.00
226_V231_R0.5401.00
166_F169_E0.5401.00
304_I311_P0.5391.00
19_L262_V0.5391.00
248_V251_G0.5381.00
113_N231_R0.5371.00
228_I236_L0.5331.00
108_F236_L0.5321.00
102_R143_K0.5321.00
11_I67_V0.5321.00
67_V70_F0.5291.00
302_V305_L0.5271.00
68_I88_K0.5261.00
80_L93_L0.5261.00
114_L228_I0.5251.00
95_S98_L0.5251.00
58_Y68_I0.5251.00
184_F220_Y0.5241.00
197_V200_S0.5241.00
94_N104_K0.5241.00
139_V179_Y0.5231.00
277_Q281_H0.5221.00
204_T218_G0.5171.00
121_V145_S0.5161.00
106_K117_P0.5151.00
188_I246_V0.5151.00
133_R136_F0.5151.00
11_I278_F0.5141.00
290_L293_S0.5120.99
196_G201_Y0.5110.99
272_G299_S0.5090.99
179_Y247_F0.5090.99
232_L258_F0.5090.99
186_A203_P0.5090.99
209_E214_V0.5080.99
37_L44_P0.5080.99
301_M304_I0.5080.99
55_P58_Y0.5080.99
206_N211_G0.5030.99
267_H301_M0.5020.99
206_N213_L0.5020.99
193_D287_G0.5010.99
204_T220_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mamA 2 0.9589 100 0.275 Contact Map
3aw8A 2 0.9425 100 0.281 Contact Map
2dwcA 4 0.9781 100 0.287 Contact Map
3ax6A 2 0.9205 100 0.291 Contact Map
3orqA 2 0.9753 100 0.291 Contact Map
1kjqA 2 0.9753 100 0.292 Contact Map
3q2oA 2 0.9808 100 0.293 Contact Map
4e4tA 2 0.9836 100 0.297 Contact Map
1a9xA 3 0.989 100 0.298 Contact Map
3u9tA 3 0.9644 100 0.302 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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